Cfh (complement component factor h) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cfh (complement component factor h) Mus musculus
Analyze
Symbol: Cfh
Name: complement component factor h
RGD ID: 733427
MGI Page MGI
Description: Enables complement component C3b binding activity and heparin binding activity. Acts upstream of or within with a positive effect on retina development in camera-type eye. Acts upstream of or within several processes, including complement activation; retina development in camera-type eye; and skeletal system development. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; hemolymphoid system; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: complement factor H; complement factor H related protein 3A4/5G4; Mud-1; NOM; protein beta-1-H; S; Sa; Sas-1; Sas1
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm16332  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1140,012,446 - 140,111,502 (-)EnsemblGRCm39 Ensembl
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBIMGSCv36mm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 4  (IAGP,ISO)
amphetamine abuse  (ISO)
anterior uveitis  (ISO)
atypical hemolytic-uremic syndrome  (IAGP,ISO)
Bacteremia  (ISO)
basal laminar drusen  (ISO)
brain infarction  (ISO)
C3 Glomerulopathy 3  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic kidney disease  (ISO)
Complement Factor H Deficiency  (ISO)
COVID-19  (ISO)
diabetic retinopathy  (ISO)
Experimental Arthritis  (IDA)
focal segmental glomerulosclerosis  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (IMP)
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency  (IMP,ISO)
hemolytic-uremic syndrome  (IAGP,ISO)
Hemorrhagic Shock  (ISO)
Intestinal Ischemia  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
maturity-onset diabetes of the young type 5  (ISO)
membranoproliferative glomerulonephritis  (IAGP,ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
multiple sclerosis  (ISO)
nephrosis  (ISO)
obstructive jaundice  (ISO)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
Pneumococcal Infections  (IMP,ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
posterior uveitis  (ISO)
primary immunodeficiency disease  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinal drusen  (ISO)
sarcoidosis  (ISO)
Sepsis  (ISO)
squamous cell carcinoma  (ISO)
Stroke  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
Thrombotic Microangiopathies  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
astemizole  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
dextran sulfate  (EXP)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
diquat  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP,ISO)
ethanol  (EXP,ISO)
flutamide  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
inulin  (EXP)
isoprenaline  (EXP)
lipopolysaccharide  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
olanzapine  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
senecionine  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
tamoxifen  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of membrane attack complex  (IMP)
angiogenesis  (IMP)
ATP metabolic process  (IMP)
bone development  (IGI)
cartilage development  (IGI)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (IGI,ISO)
cellular response to type II interferon  (ISO)
complement activation  (IBA,IDA,IGI,IMP,ISO)
complement activation, alternative pathway  (IGI,IMP)
determination of adult lifespan  (IMP)
gene expression  (IMP)
glomerulus development  (IGI,IMP)
immune complex clearance  (IGI)
immune response  (IMP)
immune system process  (IEA)
immunoglobulin mediated immune response  (IGI)
inflammatory response  (IGI,IMP)
inflammatory response to wounding  (IGI)
innate immune response  (IEA)
kidney development  (IGI,IMP)
mitochondrial DNA metabolic process  (IMP)
mitochondrial gene expression  (IMP)
mitochondrion organization  (IMP)
monocyte aggregation  (IMP)
neuromuscular process  (IMP)
neutrophil homeostasis  (IGI)
organ or tissue specific immune response  (IGI)
organelle localization  (IMP)
photoreceptor cell differentiation  (IMP)
platelet aggregation  (IMP)
proteolysis  (ISO)
regulation of complement activation  (IMP,ISO)
regulation of complement activation, alternative pathway  (ISO)
regulation of complement-dependent cytotoxicity  (ISO)
response to cytokine  (IDA)
response to dietary excess  (IMP)
retina development in camera-type eye  (IGI,IMP)
retinal pigment epithelium development  (IMP)
retinal rod cell development  (IMP)
vascular associated smooth muscle cell differentiation  (IGI,IMP)
visual perception  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal brain thrombosis  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal circulating complement protein level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal complement protein level  (IAGP)
abnormal glomerular capillary endothelium morphology  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glomerular capillary thrombosis  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal hepatic portal vein thrombosis  (IAGP)
abnormal kidney capillary morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney thrombosis  (IAGP)
abnormal kidney vasculature morphology  (IAGP)
abnormal kidney venous thrombosis  (IAGP)
abnormal lung thrombosis  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina rod bipolar cell morphology  (IAGP)
abnormal retina vasculature morphology  (IAGP)
abnormal thrombosis  (IAGP)
albuminuria  (IAGP)
amyloid beta deposits  (IAGP)
anasarca  (IAGP)
anemia  (IAGP)
artery occlusion  (IAGP)
brain ischemia  (IAGP)
circling  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body size  (IAGP)
decreased circulating complement protein level  (IAGP)
decreased complement C5 level  (IAGP)
decreased hemoglobin content  (IAGP)
decreased serum complement activity  (IAGP)
decreased visual acuity  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
expanded mesangial matrix  (IAGP)
glomerulonephritis  (IAGP)
hematuria  (IAGP)
hindlimb paralysis  (IAGP)
impaired muscle relaxation  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased creatine level  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased mesangial cell number  (IAGP)
increased susceptibility to type III hypersensitivity reaction  (IAGP)
increased susceptilbility to retina ischemic injury  (IAGP)
increased urine protein level  (IAGP)
intracerebral hemorrhage  (IAGP)
kidney failure  (IAGP)
mesangial cell interposition  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
renal glomerular immunoglobulin deposits  (IAGP)
renal glomerular protein deposits  (IAGP)
reticulocytosis  (IAGP)
retina detachment  (IAGP)
schistocytosis  (IAGP)
thrombocytopenia  (IAGP)
white pupil  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Association of Single Nucleotide Polymorphisms in CFH, ARMS2 and HTRA1 Genes with Risk of Age-related Macular Degeneration in Egyptian Patients. Abbas RO and Azzazy HM, Ophthalmic Genet. 2013 Jan 30.
2. Genetic variability in complement activation modulates the systemic inflammatory response syndrome in children. Agbeko RS, etal., Pediatr Crit Care Med. 2010 Sep;11(5):561-7.
3. Mouse podocyte complement factor H: the functional analog to human complement receptor 1. Alexander JJ, etal., J Am Soc Nephrol. 2007 Apr;18(4):1157-66. Epub 2007 Mar 7.
4. Complement Factor H Y402H polymorphism is associated with an increased risk of mortality after intracerebral hemorrhage. Appelboom G, etal., J Clin Neurosci. 2011 Nov;18(11):1439-43. Epub 2011 Aug 25.
5. Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. Arakawa S, etal., Nat Genet. 2011 Sep 11;43(10):1001-4. doi: 10.1038/ng.938.
6. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. Banda NK, etal., J Immunol. 2009 Nov 1;183(9):5928-37. Epub 2009 Oct 14.
7. Complement factor H mutations and gene polymorphisms in haemolytic uraemic syndrome: the C-257T, the A2089G and the G2881T polymorphisms are strongly associated with the disease. Caprioli J, etal., Hum Mol Genet. 2003 Dec 15;12(24):3385-95. Epub 2003 Oct 28.
8. Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion. Carrizo GJ, etal., Surgery. 2007 Feb;141(2):245-53. Epub 2006 Sep 14.
9. Major single nucleotide polymorphisms in polypoidal choroidal vasculopathy: a comparative analysis between Thai and other Asian populations. Chantaren P, etal., Clin Ophthalmol. 2012;6:465-71. doi: 10.2147/OPTH.S30529. Epub 2012 Mar 22.
10. Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. Chaung WW, etal., Mol Med. 2011;17(9-10):1075-83. doi: 10.2119/molmed.2010.00104. Epub 2011 Jun 17.
11. Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Collier RJ, etal., Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8108-16. doi: 10.1167/iovs.10-6418.
12. CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) Gene Polymorphisms are Associated with AMD Risk in Spanish Patients. Cruz-Gonzalez F, etal., Ophthalmic Genet. 2013 Mar 27.
13. Analysis of major alleles associated with age-related macular degeneration in patients with multifocal choroiditis: strong association with complement factor H. Ferrara DC, etal., Arch Ophthalmol. 2008 Nov;126(11):1562-6. doi: 10.1001/archopht.126.11.1562.
14. No association between complement factor H gene polymorphism and exudative age-related macular degeneration in Japanese. Gotoh N, etal., Hum Genet. 2006 Aug;120(1):139-43. Epub 2006 May 19.
15. Binding of complement factor H (fH) to Neisseria meningitidis is specific for human fH and inhibits complement activation by rat and rabbit sera. Granoff DM, etal., Infect Immun. 2009 Feb;77(2):764-9. doi: 10.1128/IAI.01191-08. Epub 2008 Dec 1.
16. Complement factor H-related protein 1 deficiency and factor H antibodies in pediatric patients with atypical hemolytic uremic syndrome. Hofer J, etal., Clin J Am Soc Nephrol. 2013 Mar;8(3):407-15. doi: 10.2215/CJN.01260212. Epub 2012 Dec 14.
17. Complement regulator factor H in multiple sclerosis. Ingram G, etal., J Cell Biochem. 2011 Oct;112(10):2653-4. doi: 10.1002/jcb.23204.
18. Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. Jonsen A, etal., Arthritis Res Ther. 2011 Dec 15;13(6):R206.
19. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
20. Intravitreal human complement factor H in a rat model of laser-induced choroidal neovascularisation. Kim SJ, etal., Br J Ophthalmol. 2013 Mar;97(3):367-70. doi: 10.1136/bjophthalmol-2012-302307. Epub 2012 Dec 19.
21. Association of the Y402H polymorphism in complement factor H gene and neovascular age-related macular degeneration in Chinese patients. Lau LI, etal., Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3242-6.
22. Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation. Le Quintrec M, etal., Am J Transplant. 2008 Aug;8(8):1694-701. doi: 10.1111/j.1600-6143.2008.02297.x. Epub 2008 Jun 28.
23. Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy. Lee KY, etal., Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2613-9. doi: 10.1167/iovs.07-0860.
24. Genetic factors for choroidal neovascularization associated with high myopia. Leveziel N, etal., Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):5004-9. doi: 10.1167/iovs.12-9538.
25. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. Maga TK, etal., Hum Mutat. 2010 Jun;31(6):E1445-60. doi: 10.1002/humu.21256.
26. MGDs mouse GO annotations MGD data from the GO Consortium
27. MGD IEA MGD IEA
28. Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1. Miwa T, etal., Immunogenetics 1998 Nov-Dec;48(6):363-71.
29. Hypocomplementemic autosomal recessive hemolytic uremic syndrome with decreased factor H. Ohali M, etal., Pediatr Nephrol. 1998 Oct;12(8):619-24.
30. Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis. Ohkohchi K, etal., Tohoku J Exp Med. 1988 Apr;154(4):315-21.
31. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. Pickering MC, etal., J Exp Med. 2007 Jun 11;204(6):1249-56. Epub 2007 May 21.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. Purification and characterization of human adrenomedullin binding protein-1. Qiang X, etal., Mol Med. 2008 Jul-Aug;14(7-8):443-50. doi: 10.2119/2008-00015.Qiang.
36. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
37. A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. Raychaudhuri S, etal., Nat Genet. 2011 Oct 23;43(12):1232-6. doi: 10.1038/ng.976.
38. Rat glomerular epithelial cells produce and bear factor H on their surface that is up-regulated under complement attack. Ren G, etal., Kidney Int. 2003 Sep;64(3):914-22.
39. Mouse MP Annotation Import Pipeline RGD automated import pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Complement factor H: a biomarker for progression of cutaneous squamous cell carcinoma. Riihila PM, etal., J Invest Dermatol. 2014 Feb;134(2):498-506. doi: 10.1038/jid.2013.346. Epub 2013 Aug 12.
43. Peripheral retinal drusen and reticular pigment: association with CFHY402H and CFHrs1410996 genotypes in family and twin studies. Seddon JM, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):586-91. doi: 10.1167/iovs.08-2514. Epub 2008 Oct 20.
44. Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration. Seddon JM, etal., JAMA. 2007 Apr 25;297(16):1793-800.
45. Attenuation of renal ischemia and reperfusion injury by human adrenomedullin and its binding protein. Shah KG, etal., J Surg Res. 2010 Sep;163(1):110-7. doi: 10.1016/j.jss.2010.03.064. Epub 2010 Apr 24.
46. Fusion protein comprising factor H domains 6 and 7 and human IgG1 Fc as an antibacterial immunotherapeutic. Shaughnessy J, etal., Clin Vaccine Immunol. 2014 Oct;21(10):1452-9. doi: 10.1128/CVI.00444-14. Epub 2014 Aug 20.
47. Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction. Shi WL, etal., Neurosci Lett. 2012 Sep 6;525(1):23-8. doi: 10.1016/j.neulet.2012.07.026. Epub 2012 Jul 31.
48. Y402H complement factor H polymorphism associated with exudative age-related macular degeneration in the French population. Souied EH, etal., Mol Vis. 2005 Dec 19;11:1135-40.
49. Oxidative stress and the regulation of complement activation in human glaucoma. Tezel G, etal., Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5071-82. doi: 10.1167/iovs.10-5289. Epub 2010 May 19.
50. Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis. Thompson IA, etal., Am J Ophthalmol. 2013 Jun;155(6):1068-1074.e1. doi: 10.1016/j.ajo.2013.01.019. Epub 2013 Mar 14.
51. [Role of CFH and ARMS2 polymorphisms in retinopathy and coronary artery disease in type 1 diabetes]. Toni M, etal., An Sist Sanit Navar. 2012 Sep-Dec;35(3):425-32.
52. Clinical evaluation of 3 families with basal laminar drusen caused by novel mutations in the complement factor H gene. van de Ven JP, etal., Arch Ophthalmol. 2012 Aug;130(8):1038-47.
53. Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease. van der Maten E, etal., J Infect Dis. 2016 Jun 1;213(11):1820-7. doi: 10.1093/infdis/jiw029. Epub 2016 Jan 21.
54. Enhanced bacteremia in human factor H transgenic rats infected by Neisseria meningitidis. Vu DM, etal., Infect Immun. 2012 Feb;80(2):643-50. doi: 10.1128/IAI.05604-11. Epub 2011 Nov 21.
55. Association of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patients. Wang J, etal., Mediators Inflamm. 2013;2013:748435. doi: 10.1155/2013/748435. Epub 2013 Jun 24.
56. Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1. Wu R, etal., Ann Surg. 2005 Jul;242(1):115-23.
57. Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein. Wu R, etal., Mol Med. 2009 Jan-Feb;15(1-2):28-33. doi: 10.2119/molmed.2008.00092. Epub 2008 Oct 10.
58. Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock. Wu R, etal., Peptides. 2008 Jul;29(7):1223-30. doi: 10.1016/j.peptides.2008.02.021. Epub 2008 Mar 8.
59. Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion. Yang J, etal., Ann Surg. 2009 Feb;249(2):310-7. doi: 10.1097/SLA.0b013e3181961d43.
60. Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats. Yang J, etal., Peptides. 2010 May;31(5):872-7. doi: 10.1016/j.peptides.2010.01.010. Epub 2010 Feb 2.
61. Association of C2 and CFB polymorphisms with anterior uveitis. Yang MM, etal., Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):4969-74. doi: 10.1167/iovs.12-9478.
62. Complement factor H gene mutation associated with autosomal recessive atypical hemolytic uremic syndrome. Ying L, etal., Am J Hum Genet. 1999 Dec;65(6):1538-46.
63. Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate. Zaferani A, etal., J Biol Chem. 2012 Sep 7;287(37):31471-81. doi: 10.1074/jbc.M112.380386. Epub 2012 Jul 19.
64. Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. Zhao J, etal., PLoS Genet. 2011 May;7(5):e1002079. Epub 2011 May 26.
Additional References at PubMed
PMID:540002   PMID:1311971   PMID:1486806   PMID:1495973   PMID:1689298   PMID:1834169   PMID:2071146   PMID:2136885   PMID:2165966   PMID:2522412   PMID:2533512   PMID:2564419  
PMID:2574151   PMID:2878046   PMID:2892757   PMID:2895697   PMID:2940596   PMID:2972715   PMID:2993224   PMID:3156187   PMID:3384439   PMID:3416634   PMID:4955525   PMID:4992636  
PMID:6308669   PMID:6332054   PMID:6934364   PMID:6967858   PMID:6973596   PMID:7165695   PMID:7410386   PMID:7474114   PMID:7558020   PMID:7894156   PMID:8075500   PMID:8422330  
PMID:8468048   PMID:8482578   PMID:8615824   PMID:10349636   PMID:10693874   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11489951   PMID:11739537   PMID:12091909   PMID:12477932  
PMID:12914820   PMID:15574507   PMID:15582152   PMID:16023208   PMID:16141072   PMID:16141073   PMID:16597679   PMID:16602821   PMID:16769899   PMID:16829211   PMID:16849499   PMID:16936129  
PMID:16944957   PMID:17028856   PMID:17330941   PMID:17410102   PMID:17420242   PMID:17562771   PMID:17921253   PMID:18202746   PMID:18554416   PMID:18947875   PMID:19299737   PMID:19411110  
PMID:19458267   PMID:19541934   PMID:19620346   PMID:20445496   PMID:20538999   PMID:20675597   PMID:20702729   PMID:20813971   PMID:20854881   PMID:20962256   PMID:21148254   PMID:21148255  
PMID:21267068   PMID:21302086   PMID:21544060   PMID:21677750   PMID:21862448   PMID:21873635   PMID:21920606   PMID:21979047   PMID:22174452   PMID:22219359   PMID:22819137   PMID:22832515  
PMID:22875704   PMID:22918646   PMID:23029250   PMID:23133374   PMID:23184055   PMID:23204401   PMID:23436934   PMID:23469078   PMID:23487775   PMID:23747511   PMID:23799019   PMID:23844226  
PMID:24006456   PMID:24279761   PMID:24370827   PMID:24550112   PMID:24664701   PMID:24929970   PMID:25284781   PMID:25447048   PMID:25565310   PMID:25684976   PMID:25921262   PMID:25991857  
PMID:26030099   PMID:26149919   PMID:26374608   PMID:26768663   PMID:27165610   PMID:27397653   PMID:27564415   PMID:27918307   PMID:28057640   PMID:28228282   PMID:28535371   PMID:28819420  
PMID:29070671   PMID:29389016   PMID:29392311   PMID:29858280   PMID:29895552   PMID:30025090   PMID:30107932   PMID:30642982   PMID:30705315   PMID:30711487   PMID:30808757   PMID:30910380  
PMID:30972735   PMID:30973865   PMID:31133737   PMID:31354740   PMID:31409673   PMID:32165615   PMID:32325033   PMID:32369457   PMID:32376801   PMID:32737203   PMID:32849636   PMID:32962822  
PMID:33410734   PMID:33558624   PMID:33708358   PMID:33859044   PMID:33953184   PMID:34054871   PMID:34139209   PMID:34321999   PMID:34775843   PMID:36920550   PMID:37499656   PMID:37940659  
PMID:38355793   PMID:38355799  


Genomics

Comparative Map Data
Cfh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1140,012,446 - 140,111,502 (-)EnsemblGRCm39 Ensembl
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBIMGSCv36mm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
CFH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,652,043 - 196,747,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1196,651,754 - 196,752,476 (+)EnsemblGRCh38hg38GRCh38
GRCh371196,621,173 - 196,716,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,887,764 - 194,983,257 (+)NCBINCBI36Build 36hg18NCBI36
Build 341193,352,831 - 193,448,257NCBI
Celera1169,729,995 - 169,825,611 (+)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1167,862,965 - 167,958,566 (+)NCBIHuRef
CHM1_11198,042,727 - 198,138,292 (+)NCBICHM1_1
T2T-CHM13v2.01195,998,386 - 196,093,925 (+)NCBIT2T-CHM13v2.0
Cfh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81354,063,079 - 54,164,523 (-)NCBIGRCr8
mRatBN7.21351,512,376 - 51,613,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1354,104,450 - 54,199,522 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,392,371 - 55,487,454 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,655,305 - 52,757,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Celera1351,770,541 - 51,871,522 (-)NCBICelera
Cytogenetic Map13q13NCBI
CFH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2153,056,725 - 53,152,308 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1152,576,787 - 52,757,831 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,155,882 - 172,251,632 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,434,107 - 176,507,049 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,455,247 - 176,525,521 (+)Ensemblpanpan1.1panPan2
CFH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,878,677 - 2,956,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,970,756 - 3,047,389 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,876,209 - 2,953,077 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,875,485 - 2,953,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,869,120 - 2,945,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0383,262,568 - 3,340,656 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,463,162 - 3,540,549 (-)NCBIUU_Cfam_GSD_1.0
CFH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21024,337,539 - 24,406,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,557,697 - 32,744,763 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247983,332,549 - 3,414,435 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfh
2515 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:546
Count of miRNA genes:243
Interacting mature miRNAs:262
Transcripts:ENSMUST00000066859, ENSMUST00000111976, ENSMUST00000111977, ENSMUST00000123238, ENSMUST00000148225
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse

Markers in Region
Cfh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381140,162,588 - 140,163,133UniSTSGRCm38
MGSCv371142,059,165 - 142,059,710UniSTSGRCm37
Celera1142,791,271 - 142,791,816UniSTS
Cytogenetic Map1FUniSTS
cM Map174.1UniSTS
Cfh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381139,774,492 - 139,774,577UniSTSGRCm38
MGSCv371141,671,069 - 141,671,154UniSTSGRCm37
Celera1142,421,498 - 142,421,583UniSTS
Cytogenetic Map1FUniSTS
Cfh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1FUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000066859   ⟹   ENSMUSP00000066677
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,597 - 140,111,149 (-)Ensembl
GRCm38.p6 Ensembl1140,085,859 - 140,183,411 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111976   ⟹   ENSMUSP00000107607
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,593 - 140,111,149 (-)Ensembl
GRCm38.p6 Ensembl1140,085,855 - 140,183,411 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111977   ⟹   ENSMUSP00000107608
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,596 - 140,111,058 (-)Ensembl
GRCm38.p6 Ensembl1140,085,858 - 140,183,320 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123238   ⟹   ENSMUSP00000115166
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,617 - 140,111,060 (-)Ensembl
GRCm38.p6 Ensembl1140,085,879 - 140,183,322 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,072,957 - 140,111,149 (-)Ensembl
GRCm38.p6 Ensembl1140,145,219 - 140,183,411 (-)Ensembl
Ensembl Acc Id: ENSMUST00000192880   ⟹   ENSMUSP00000141209
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,012,446 - 140,111,018 (-)Ensembl
GRCm38.p6 Ensembl1140,084,708 - 140,183,280 (-)Ensembl
Ensembl Acc Id: ENSMUST00000192919   ⟹   ENSMUSP00000141634
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,013,600 - 140,075,550 (-)Ensembl
GRCm38.p6 Ensembl1140,085,862 - 140,147,812 (-)Ensembl
Ensembl Acc Id: ENSMUST00000194688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1140,110,872 - 140,111,502 (-)Ensembl
GRCm38.p6 Ensembl1140,183,134 - 140,183,764 (-)Ensembl
RefSeq Acc Id: NM_009888   ⟹   NP_034018
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391140,013,593 - 140,111,149 (-)NCBI
GRCm381140,085,855 - 140,183,411 (-)ENTREZGENE
MGSCv371141,982,432 - 142,079,988 (-)RGD
Celera1142,720,865 - 142,812,024 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034018   ⟸   NM_009888
- Peptide Label: precursor
- UniProtKB: Q6NZK3 (UniProtKB/Swiss-Prot),   P06909 (UniProtKB/Swiss-Prot),   E9Q8I0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000066677   ⟸   ENSMUST00000066859
Ensembl Acc Id: ENSMUSP00000107607   ⟸   ENSMUST00000111976
Ensembl Acc Id: ENSMUSP00000107608   ⟸   ENSMUST00000111977
Ensembl Acc Id: ENSMUSP00000141209   ⟸   ENSMUST00000192880
Ensembl Acc Id: ENSMUSP00000141634   ⟸   ENSMUST00000192919
Ensembl Acc Id: ENSMUSP00000115166   ⟸   ENSMUST00000123238
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06909-F1-model_v2 AlphaFold P06909 1-1234 view protein structure

Promoters
RGD ID:6875162
Promoter ID:EPDNEW_M1031
Type:initiation region
Name:Cfh_1
Description:Mus musculus complement component factor h , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381140,183,301 - 140,183,361EPDNEW
RGD ID:6817506
Promoter ID:MM_KWN:2322
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:NM_009888,   OTTMUST00000060597,   OTTMUST00000060599,   UC007CWT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361142,079,571 - 142,080,071 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88385 AgrOrtholog
Ensembl Genes ENSMUSG00000026365 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066859.13 UniProtKB/Swiss-Prot
  ENSMUST00000111976 ENTREZGENE
  ENSMUST00000111976.9 UniProtKB/TrEMBL
  ENSMUST00000111977.8 UniProtKB/TrEMBL
  ENSMUST00000123238.2 UniProtKB/TrEMBL
  ENSMUST00000192880.6 UniProtKB/TrEMBL
  ENSMUST00000192919.6 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ComplSys_Reg/VirEntry_Med UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12628 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88385 ENTREZGENE
NCBI Gene 12628 ENTREZGENE
PANTHER COMPLEMENT FACTOR H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COMPLEMENT FACTOR H-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COMPLEMENT FACTOR H-RELATED UniProtKB/TrEMBL
  COMPLEMENT FACTOR H-RELATED PROTEIN 1-RELATED UniProtKB/TrEMBL
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfh PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YVP8_MOUSE UniProtKB/TrEMBL
  A0A0A6YWP4_MOUSE UniProtKB/TrEMBL
  CFAH_MOUSE UniProtKB/Swiss-Prot
  D6RGQ0_MOUSE UniProtKB/TrEMBL
  E9Q8H9_MOUSE UniProtKB/TrEMBL
  E9Q8I0 ENTREZGENE, UniProtKB/TrEMBL
  P06909 ENTREZGENE
  Q6NZK3 ENTREZGENE
  Q8C5S1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q6NZK3 UniProtKB/Swiss-Prot