Slc6a8 (solute carrier family 6 (neurotransmitter transporter, creatine), member 8) - Rat Genome Database

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Gene: Slc6a8 (solute carrier family 6 (neurotransmitter transporter, creatine), member 8) Mus musculus
Analyze
Symbol: Slc6a8
Name: solute carrier family 6 (neurotransmitter transporter, creatine), member 8
RGD ID: 733405
MGI Page MGI
Description: Enables creatine:sodium symporter activity. Predicted to be involved in several processes, including creatine transmembrane transport; protein catabolic process; and sodium ion transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study cerebral creatine deficiency syndrome 1. Human ortholog(s) of this gene implicated in cerebral creatine deficiency syndrome 1 and intellectual disability. Orthologous to human SLC6A8 (solute carrier family 6 member 8).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA589632; CR; Cre; Creat; creatine transporter 1; creatine transporter SLC6A8 variant D; creatine transporter, solute carrier family 6, member 8; CRT; CRTR; CT1; CTR5; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 member 8; solute carrier family 6, member 8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,716,739 - 72,726,108 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,716,756 - 72,726,108 (+)EnsemblGRCm39 Ensembl
GRCm38X73,673,133 - 73,682,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,673,150 - 73,682,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X70,918,472 - 70,927,841 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,925,870 - 69,935,222 (+)NCBIMGSCv36mm8
CeleraX64,926,949 - 64,936,317 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonia  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atenolol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diflunisal  (EXP)
dioxygen  (ISO)
diquat  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
folpet  (EXP)
glyphosate  (EXP)
graphite  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
naphthalenes  (ISO)
Nutlin-3  (ISO)
orphenadrine  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
toluene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal dentate gyrus morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal GABAergic neuron morphology  (IAGP)
abnormal ion homeostasis  (IAGP)
abnormal motor learning  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal neuron proliferation  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal response to novel object  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal synapse morphology  (IAGP)
decreased aerobic running capacity  (IAGP)
decreased body length  (IAGP)
decreased body mass index  (IAGP)
decreased body weight  (IAGP)
decreased circulating creatine level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased creatine level  (IAGP)
decreased fasting circulating glucose level  (IAGP)
decreased grip strength  (IAGP)
decreased hippocampus volume  (IAGP)
decreased locomotor activity  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased urine creatine level  (IAGP)
hyperactivity  (IAGP)
hypotonia  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired long-term object recognition memory  (IAGP)
impaired short-term object recognition memory  (IAGP)
impaired spatial learning  (IAGP)
impaired swimming  (IAGP)
improved glucose tolerance  (IAGP)
increased grooming behavior  (IAGP)
increased lean body mass  (IAGP)
increased serotonin level  (IAGP)
increased urine creatine level  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lipofuscinosis  (IAGP)
microgliosis  (IAGP)
muscle weakness  (IAGP)
skeletal muscle fiber atrophy  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28. Hahn KA, etal., Am J Hum Genet. 2002 May;70(5):1349-56. Epub 2002 Mar 15.
2. Effects of creatine and beta-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models. Kim DW, etal., BMC Neurosci. 2010 Oct 28;11:141. doi: 10.1186/1471-2202-11-141.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7953292   PMID:8889548   PMID:9403069   PMID:10922068   PMID:12439290   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199   PMID:15930147   PMID:16033648   PMID:16125675  
PMID:16602821   PMID:16873409   PMID:16949212   PMID:18515020   PMID:19196713   PMID:19913546   PMID:20462973   PMID:21249153   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22751104  
PMID:23754746   PMID:24561156   PMID:25206338   PMID:25485098   PMID:26496610   PMID:27401086   PMID:27466184   PMID:27820600   PMID:29384270   PMID:30013483   PMID:30635645   PMID:31029731  
PMID:31209903   PMID:31399282   PMID:31520365   PMID:31542396   PMID:32433978   PMID:33110151   PMID:33389772   PMID:34324436   PMID:35235777   PMID:36882863   PMID:37063368   PMID:38030104  


Genomics

Comparative Map Data
Slc6a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,716,739 - 72,726,108 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,716,756 - 72,726,108 (+)EnsemblGRCm39 Ensembl
GRCm38X73,673,133 - 73,682,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,673,150 - 73,682,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X70,918,472 - 70,927,841 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X69,925,870 - 69,935,222 (+)NCBIMGSCv36mm8
CeleraX64,926,949 - 64,936,317 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.38NCBI
SLC6A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,687,926 - 153,696,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,687,926 - 153,696,588 (+)EnsemblGRCh38hg38GRCh38
GRCh37X152,953,381 - 152,962,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,606,586 - 152,615,234 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X152,474,238 - 152,482,887NCBI
CeleraX153,187,436 - 153,195,732 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,612,842 - 141,619,133 (+)NCBIHuRef
CHM1_1X152,828,182 - 152,836,459 (+)NCBICHM1_1
T2T-CHM13v2.0X151,961,591 - 151,970,260 (+)NCBIT2T-CHM13v2.0
Slc6a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,536,017 - 156,545,321 (+)NCBIGRCr8
mRatBN7.2X151,384,675 - 151,393,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,384,675 - 151,393,979 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,525,847 - 153,535,151 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,089,078 - 157,098,382 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,760,908 - 154,770,212 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,129,987 - 157,139,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,879,305 - 152,888,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,570,789 - 159,580,093 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,645,625 - 159,654,519 (+)NCBI
Celera1136,495,566 - 136,504,870 (-)NCBICelera
Cytogenetic MapXq37NCBI
Slc6a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955580419,696 - 426,727 (+)NCBIChiLan1.0ChiLan1.0
SLC6A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X153,728,332 - 153,737,003 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X153,731,936 - 153,740,609 (+)NCBINHGRI_mPanPan1
SLC6A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,505,117 - 121,511,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,505,141 - 121,510,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,832,742 - 106,841,046 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,644,861 - 124,653,192 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X120,414,322 - 120,422,627 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X122,929,312 - 122,937,588 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,691,440 - 122,699,746 (+)NCBIUU_Cfam_GSD_1.0
Slc6a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X118,833,463 - 118,840,527 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936809571,234 - 578,298 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,294,856 - 124,452,182 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,435,282 - 124,452,182 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,008,693 - 142,016,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,116,490 - 128,124,899 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,116,944 - 128,124,918 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606565,978,641 - 65,987,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946389,806 - 396,653 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc6a8
212 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5831
Count of miRNA genes:936
Interacting mature miRNAs:1277
Transcripts:ENSMUST00000033752, ENSMUST00000114464, ENSMUST00000114465, ENSMUST00000114467, ENSMUST00000146796, ENSMUST00000164449, ENSMUST00000166200, ENSMUST00000167828, ENSMUST00000168764, ENSMUST00000168831, ENSMUST00000170574, ENSMUST00000170614, ENSMUST00000171398
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13464140Hdlq108_mHDL QTL 108 (mouse)X5777196091771960Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
25314311Syncl3_msynaptonemal complex length 3 (mouse)X5198887789743606Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7054360696543606Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
25314316Mlh1fc3_mMLH1 foci count 3 (mouse)X6134360689843606Mouse
10412108Desp5_mdespair 5 (mouse)Not determinedX5472235188722351Mouse
1357730Hstx1_mhybrid sterility, X chromosome 1 (mouse)Not determinedX7145385277600812Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse

Markers in Region
AI326946  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X73,681,154 - 73,681,296UniSTSGRCm38
MGSCv37X70,926,493 - 70,926,635UniSTSGRCm37
CeleraX64,934,969 - 64,935,111UniSTS
Cytogenetic MapXA7.3UniSTS
Whitehead/MRC_RHX849.44UniSTS
Slc6a8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X73,681,324 - 73,682,362UniSTSGRCm38
MGSCv37X70,926,663 - 70,927,701UniSTSGRCm37
CeleraX64,935,139 - 64,936,177UniSTS
Cytogenetic MapXA7.3UniSTS
cM MapX29.5UniSTS
D19322  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X73,682,319 - 73,682,478UniSTSGRCm38
MGSCv37X70,927,658 - 70,927,817UniSTSGRCm37
CeleraX64,936,134 - 64,936,293UniSTS
Cytogenetic MapXA7.3UniSTS
Whitehead_YACX UniSTS
RH125026  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X73,681,928 - 73,682,137UniSTSGRCm38
MGSCv37X70,927,267 - 70,927,476UniSTSGRCm37
CeleraX64,935,743 - 64,935,952UniSTS
Cytogenetic MapXA7.3UniSTS
Slc6a8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X73,679,946 - 73,681,058UniSTSGRCm38
MGSCv37X70,925,285 - 70,926,397UniSTSGRCm37
CeleraX64,933,761 - 64,934,873UniSTS
Cytogenetic MapXA7.3UniSTS
cM MapX29.5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001142810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB077327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF459435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF459436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ748650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL805924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB245363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU523148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC994641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000033752   ⟹   ENSMUSP00000033752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,716,756 - 72,726,108 (+)Ensembl
GRCm38.p6 EnsemblX73,673,150 - 73,682,502 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114464   ⟹   ENSMUSP00000110108
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,720,452 - 72,726,108 (+)Ensembl
GRCm38.p6 EnsemblX73,676,846 - 73,682,502 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114465   ⟹   ENSMUSP00000110109
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,717,391 - 72,726,108 (+)Ensembl
GRCm38.p6 EnsemblX73,673,785 - 73,682,502 (+)Ensembl
Ensembl Acc Id: ENSMUST00000114467   ⟹   ENSMUSP00000110111
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,716,848 - 72,725,246 (+)Ensembl
GRCm38.p6 EnsemblX73,673,242 - 73,681,640 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,717,525 - 72,720,931 (+)Ensembl
GRCm38.p6 EnsemblX73,673,919 - 73,677,325 (+)Ensembl
Ensembl Acc Id: ENSMUST00000164449   ⟹   ENSMUSP00000126076
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,717,313 - 72,724,897 (+)Ensembl
GRCm38.p6 EnsemblX73,673,707 - 73,681,291 (+)Ensembl
Ensembl Acc Id: ENSMUST00000166200
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,722,484 - 72,723,605 (+)Ensembl
GRCm38.p6 EnsemblX73,678,878 - 73,679,999 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167828
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,722,499 - 72,723,608 (+)Ensembl
GRCm38.p6 EnsemblX73,678,893 - 73,680,002 (+)Ensembl
Ensembl Acc Id: ENSMUST00000168764
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,720,665 - 72,723,374 (+)Ensembl
GRCm38.p6 EnsemblX73,677,059 - 73,679,768 (+)Ensembl
Ensembl Acc Id: ENSMUST00000168831   ⟹   ENSMUSP00000132921
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,717,564 - 72,724,895 (+)Ensembl
GRCm38.p6 EnsemblX73,673,958 - 73,681,289 (+)Ensembl
Ensembl Acc Id: ENSMUST00000170574
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,722,499 - 72,723,521 (+)Ensembl
GRCm38.p6 EnsemblX73,678,893 - 73,679,915 (+)Ensembl
Ensembl Acc Id: ENSMUST00000170614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,721,760 - 72,724,706 (+)Ensembl
GRCm38.p6 EnsemblX73,678,154 - 73,681,100 (+)Ensembl
Ensembl Acc Id: ENSMUST00000171398   ⟹   ENSMUSP00000128079
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX72,719,113 - 72,720,950 (+)Ensembl
GRCm38.p6 EnsemblX73,675,507 - 73,677,344 (+)Ensembl
RefSeq Acc Id: NM_001142809   ⟹   NP_001136281
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,716,739 - 72,726,108 (+)NCBI
GRCm38X73,673,133 - 73,682,502 (+)ENTREZGENE
MGSCv37X70,918,472 - 70,927,841 (+)RGD
CeleraX64,926,949 - 64,936,317 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001142810   ⟹   NP_001136282
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,716,739 - 72,726,108 (+)NCBI
GRCm38X73,673,133 - 73,682,502 (+)ENTREZGENE
MGSCv37X70,918,472 - 70,927,841 (+)RGD
CeleraX64,926,949 - 64,936,317 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_133987   ⟹   NP_598748
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X72,716,739 - 72,726,108 (+)NCBI
GRCm38X73,673,133 - 73,682,502 (+)NCBI
MGSCv37X70,918,472 - 70,927,841 (+)RGD
CeleraX64,926,949 - 64,936,317 (+)NCBI
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_598748   ⟸   NM_133987
- Peptide Label: isoform 1
- UniProtKB: E9Q151 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001136281   ⟸   NM_001142809
- Peptide Label: isoform 2
- UniProtKB: Q8K4R3 (UniProtKB/Swiss-Prot),   Q80YC9 (UniProtKB/Swiss-Prot),   A2ALM4 (UniProtKB/Swiss-Prot),   Q8R1L0 (UniProtKB/Swiss-Prot),   Q8VBW1 (UniProtKB/Swiss-Prot),   A2ALM6 (UniProtKB/TrEMBL),   E9Q151 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001136282   ⟸   NM_001142810
- Peptide Label: isoform 3
- UniProtKB: E9Q151 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000126076   ⟸   ENSMUST00000164449
Ensembl Acc Id: ENSMUSP00000128079   ⟸   ENSMUST00000171398
Ensembl Acc Id: ENSMUSP00000033752   ⟸   ENSMUST00000033752
Ensembl Acc Id: ENSMUSP00000132921   ⟸   ENSMUST00000168831
Ensembl Acc Id: ENSMUSP00000110111   ⟸   ENSMUST00000114467
Ensembl Acc Id: ENSMUSP00000110109   ⟸   ENSMUST00000114465
Ensembl Acc Id: ENSMUSP00000110108   ⟸   ENSMUST00000114464

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VBW1-F1-model_v2 AlphaFold Q8VBW1 1-640 view protein structure

Promoters
RGD ID:6846380
Promoter ID:MM_KWN:60726
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000114465,   ENSMUST00000114467,   OTTMUST00000042894
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X70,918,211 - 70,919,162 (+)MPROMDB
RGD ID:6846405
Promoter ID:MM_KWN:60727
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000043449,   UC009TMI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X70,920,146 - 70,921,172 (+)MPROMDB
RGD ID:6846381
Promoter ID:MM_KWN:60728
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000114464
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X70,921,531 - 70,922,552 (+)MPROMDB
RGD ID:13680728
Promoter ID:EPDNEW_M24512
Type:multiple initiation site
Name:Slc6a8_1
Description:Mus musculus solute carrier family 6 (neurotransmitter transporter,creatine), member 8 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X73,673,167 - 73,673,227EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2147834 AgrOrtholog
Ensembl Genes ENSMUSG00000019558 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033752 ENTREZGENE
  ENSMUST00000033752.14 UniProtKB/Swiss-Prot
  ENSMUST00000114464.9 UniProtKB/TrEMBL
  ENSMUST00000114465 ENTREZGENE
  ENSMUST00000114465.9 UniProtKB/Swiss-Prot
  ENSMUST00000114467.10 UniProtKB/Swiss-Prot
  ENSMUST00000164449.8 UniProtKB/TrEMBL
  ENSMUST00000168831 ENTREZGENE
  ENSMUST00000168831.8 UniProtKB/TrEMBL
  ENSMUST00000171398.2 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/ntran_symport_creatine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:102857 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2147834 ENTREZGENE
NCBI Gene 102857 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc6a8 PhenoGen
PRINTS CRTTRANSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NANEUSMPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A023JDV8_MOUSE UniProtKB/TrEMBL
  A2ALM4 ENTREZGENE
  A2ALM6 ENTREZGENE, UniProtKB/TrEMBL
  B2LHN0_MOUSE UniProtKB/TrEMBL
  E9Q151 ENTREZGENE, UniProtKB/TrEMBL
  E9Q6T2_MOUSE UniProtKB/TrEMBL
  F6UKB4_MOUSE UniProtKB/TrEMBL
  F7C668_MOUSE UniProtKB/TrEMBL
  Q684J3_MOUSE UniProtKB/TrEMBL
  Q80YC9 ENTREZGENE
  Q8K4R3 ENTREZGENE
  Q8R1L0 ENTREZGENE
  Q8VBW1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2ALM4 UniProtKB/Swiss-Prot
  Q80YC9 UniProtKB/Swiss-Prot
  Q8K4R3 UniProtKB/Swiss-Prot
  Q8R1L0 UniProtKB/Swiss-Prot