St14 (suppression of tumorigenicity 14 (colon carcinoma)) - Rat Genome Database

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Gene: St14 (suppression of tumorigenicity 14 (colon carcinoma)) Mus musculus
Analyze
Symbol: St14
Name: suppression of tumorigenicity 14 (colon carcinoma)
RGD ID: 733375
MGI Page MGI
Description: Enables serine-type endopeptidase activity. Involved in proteolysis. Acts upstream of or within epithelial cell morphogenesis involved in placental branching and neural tube closure. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Epi; Epithin; matr; matriptase; matriptase/MT-SP1; mCAP3; MT-S; MT-SP1; Pr; protease, serine, 14 (epithin); Prss14; serine protease 14; suppressor of tumorigenicity 14 protein homolog; Tmpr; Tmprss14
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39930,999,886 - 31,043,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl931,000,698 - 31,043,149 (-)EnsemblGRCm39 Ensembl
GRCm38931,088,590 - 31,131,811 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl931,089,402 - 31,131,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv37930,896,175 - 30,939,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36930,838,155 - 30,881,364 (-)NCBIMGSCv36mm8
Celera928,347,788 - 28,391,153 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
choline  (EXP)
cisplatin  (EXP,ISO)
cyclophosphamide  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (ISO)
folic acid  (EXP)
folpet  (EXP)
fonofos  (ISO)
furan  (ISO)
gentamycin  (ISO)
hypochlorous acid  (EXP)
indole-3-methanol  (ISO)
isobutanol  (ISO)
L-methionine  (EXP)
leflunomide  (EXP)
lidocaine  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mitomycin C  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
ozone  (EXP)
panobinostat  (ISO)
parathion  (ISO)
parathion-methyl  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (ISO)
terbufos  (ISO)
Tesaglitazar  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal chemokine secretion  (IAGP)
abnormal colon morphology  (IAGP)
abnormal corneocyte morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal embryo size  (IEA)
abnormal enterocyte morphology  (IAGP)
abnormal enterocyte physiology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal eye morphology  (IEA)
abnormal facial morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair shaft morphology  (IAGP)
abnormal hard palate morphology  (IAGP)
abnormal keratinocyte differentiation  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal limb bud morphology  (IEA)
abnormal liver size  (IEA)
abnormal neural tube morphology  (IAGP)
abnormal piliary canal morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placenta size  (IEA)
abnormal salivary gland physiology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal snout morphology  (IAGP)
abnormal stratum corneum lipid matrix formation  (IAGP)
abnormal tongue epithelium morphology  (IAGP)
abnormal vibrissa follicle morphology  (IAGP)
absent digestive secretion  (IAGP)
absent gastric milk in neonates  (IAGP)
absent placental labyrinth  (IAGP)
absent vibrissae  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
cachexia  (IAGP)
chronic diarrhea  (IAGP)
colitis  (IAGP)
curly tail  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased salivation  (IAGP)
decreased tear production  (IAGP)
dehydration  (IAGP)
dry skin  (IAGP)
embryonic growth retardation  (IEA)
embryonic lethality between implantation and placentation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged corneocyte envelope  (IAGP)
exencephaly  (IAGP)
hyperkeratosis  (IAGP)
impaired skin barrier function  (IAGP)
impaired stratum corneum desquamation  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased autoantibody level  (IAGP)
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IAGP)
increased effector memory CD8-positive, alpha-beta T cell number  (IAGP)
increased thymocyte apoptosis  (IAGP)
intestinal edema  (IAGP)
lacrimal gland inflammation  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
megacolon  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
pale liver  (IEA)
pale yolk sac  (IEA)
pallor  (IEA)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality prior to heart atrial septation  (IEA)
preweaning lethality, complete penetrance  (IEA)
reddish skin  (IAGP)
scaly skin  (IAGP)
shiny skin  (IAGP)
skin fibrosis  (IAGP)
spina bifida  (IAGP)
submandibular gland inflammation  (IAGP)
thick epidermis  (IAGP)
thin epidermis  (IAGP)
underdeveloped hair follicles  (IAGP)
weight loss  (IAGP)
wrinkled skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression of the serine protease, matriptase, in breast ductal carcinoma of Chinese women: correlation with clinicopathological parameters. Jin JS, etal., Histol Histopathol. 2007 Mar;22(3):305-9.
2. Expression of serine protease matriptase in renal cell carcinoma: correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters. Jin JS, etal., Int J Surg Pathol. 2006 Jan;14(1):65-72.
3. Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. Jin JS, etal., Mod Pathol. 2006 Mar;19(3):447-52.
4. Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia. Lee JW, etal., Hum Pathol. 2005 Jun;36(6):626-33.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Expression of matriptase and clinical outcome of human endometrial cancer. Nakamura K, etal., Anticancer Res. 2009 May;29(5):1685-90.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Protein expression of matriptase and its cognate inhibitor HAI-1 in human prostate cancer: a tissue microarray and automated quantitative analysis. Warren M, etal., Appl Immunohistochem Mol Morphol. 2009 Jan;17(1):23-30.
15. The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Welm AL, etal., Proc Natl Acad Sci U S A. 2007 May 1;104(18):7570-5. Epub 2007 Apr 24.
Additional References at PubMed
PMID:10199918   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11567025   PMID:12032844   PMID:12149280   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14638864  
PMID:14747469   PMID:15489334   PMID:15629466   PMID:15848395   PMID:16103220   PMID:16141072   PMID:16141073   PMID:16170303   PMID:16428450   PMID:16524950   PMID:16651618   PMID:16980306  
PMID:16983341   PMID:17174946   PMID:17228523   PMID:17328885   PMID:17471493   PMID:17940283   PMID:17967808   PMID:18402552   PMID:18554416   PMID:18713750   PMID:18799693   PMID:18832587  
PMID:19156209   PMID:19387477   PMID:19389929   PMID:19592578   PMID:19717635   PMID:19853659   PMID:20142489   PMID:20152175   PMID:20398629   PMID:20652801   PMID:20657595   PMID:21149451  
PMID:21217780   PMID:21267068   PMID:21873635   PMID:22081509   PMID:22139080   PMID:22514623   PMID:22952456   PMID:24194600   PMID:24469043   PMID:24551030   PMID:24685580   PMID:24962579  
PMID:25078604   PMID:25245289   PMID:25486433   PMID:25873032   PMID:26599507   PMID:27385010   PMID:28094766   PMID:28490634   PMID:30559294   PMID:31628112   PMID:32907879   PMID:37539662  
PMID:37830556   PMID:38355793  


Genomics

Comparative Map Data
St14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39930,999,886 - 31,043,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl931,000,698 - 31,043,149 (-)EnsemblGRCm39 Ensembl
GRCm38931,088,590 - 31,131,811 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl931,089,402 - 31,131,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv37930,896,175 - 30,939,384 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36930,838,155 - 30,881,364 (-)NCBIMGSCv36mm8
Celera928,347,788 - 28,391,153 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.61NCBI
ST14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811130,159,782 - 130,210,362 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11130,159,782 - 130,210,362 (+)EnsemblGRCh38hg38GRCh38
GRCh3711130,029,677 - 130,080,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,534,892 - 129,585,467 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411129,534,932 - 129,585,466NCBI
Celera11127,197,379 - 127,248,136 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11125,980,949 - 126,032,941 (+)NCBIHuRef
CHM1_111129,915,529 - 129,966,064 (+)NCBICHM1_1
T2T-CHM13v2.011130,195,451 - 130,246,169 (+)NCBIT2T-CHM13v2.0
St14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,798,994 - 37,839,881 (-)NCBIGRCr8
mRatBN7.2829,540,805 - 29,581,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,540,811 - 29,581,517 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx833,610,130 - 33,650,868 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,904,527 - 31,945,265 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,772,418 - 29,813,130 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,240,113 - 32,280,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,240,133 - 32,280,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0832,266,158 - 32,305,925 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4830,916,769 - 30,932,214 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1830,925,535 - 30,940,977 (-)NCBI
Celera831,002,596 - 31,042,887 (-)NCBICelera
Cytogenetic Map8q13NCBI
St14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541231,090,504 - 31,129,050 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541231,091,313 - 31,129,050 (+)NCBIChiLan1.0ChiLan1.0
ST14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29130,837,315 - 130,888,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111131,948,013 - 131,998,803 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011125,001,771 - 125,021,371 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111128,890,780 - 128,913,559 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11128,888,124 - 128,913,559 (+)Ensemblpanpan1.1panPan2
ST14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.154,652,493 - 4,666,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl54,651,863 - 4,691,069 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha54,713,365 - 4,749,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.054,612,444 - 4,648,611 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl54,611,806 - 4,650,812 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.154,678,704 - 4,709,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.054,655,178 - 4,691,362 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.054,682,587 - 4,719,117 (-)NCBIUU_Cfam_GSD_1.0
St14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947112,267,586 - 112,312,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365722,137,332 - 2,182,742 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365722,137,820 - 2,182,674 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl956,888,246 - 56,929,767 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1956,888,246 - 56,929,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2963,158,988 - 63,198,157 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ST14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,238,666 - 121,290,528 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,238,643 - 121,290,007 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660434,817,343 - 4,869,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248124,583,946 - 4,620,547 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248124,584,043 - 4,620,410 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in St14
1235 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:851
Count of miRNA genes:536
Interacting mature miRNAs:610
Transcripts:ENSMUST00000034478, ENSMUST00000123557, ENSMUST00000133904, ENSMUST00000148789
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
14700787Ncdq1_mnevus cell density QTL 1 (mouse)92811129636111296Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92850333341799326Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1558949Igan3_mIgA nephropathy 3 (mouse)Not determined93041469440565914Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse

Markers in Region
St14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38931,095,703 - 31,096,537UniSTSGRCm38
MGSCv37930,903,288 - 30,904,122UniSTSGRCm37
Celera928,354,904 - 28,355,738UniSTS
Cytogenetic Map9A4UniSTS
cM Map917.0UniSTS
cM Map917.0UniSTS
G38154  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38931,107,465 - 31,109,062UniSTSGRCm38
MGSCv37930,915,050 - 30,916,647UniSTSGRCm37
Celera928,366,819 - 28,368,416UniSTS
Cytogenetic Map9A4UniSTS
cM Map917.0UniSTS
St14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A4UniSTS
cM Map917.0UniSTS
St14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A4UniSTS
St14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A4UniSTS
St14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38931,089,737 - 31,089,874UniSTSGRCm38
MGSCv37930,897,322 - 30,897,459UniSTSGRCm37
Celera928,348,935 - 28,349,072UniSTS
Cytogenetic Map9A4UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000034478   ⟹   ENSMUSP00000034478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl931,000,698 - 31,043,149 (-)Ensembl
GRCm38.p6 Ensembl931,089,402 - 31,131,853 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123557   ⟹   ENSMUSP00000121971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl931,017,447 - 31,043,092 (-)Ensembl
GRCm38.p6 Ensembl931,106,151 - 31,131,796 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133904
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl931,011,300 - 31,014,216 (-)Ensembl
GRCm38.p6 Ensembl931,100,004 - 31,102,920 (-)Ensembl
Ensembl Acc Id: ENSMUST00000148789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl931,010,700 - 31,043,092 (-)Ensembl
GRCm38.p6 Ensembl931,099,404 - 31,131,796 (-)Ensembl
Ensembl Acc Id: ENSMUST00000214418   ⟹   ENSMUSP00000150666
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl931,017,440 - 31,043,023 (-)Ensembl
GRCm38.p6 Ensembl931,106,144 - 31,131,727 (-)Ensembl
Ensembl Acc Id: ENSMUST00000217404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl931,011,285 - 31,014,834 (-)Ensembl
GRCm38.p6 Ensembl931,099,989 - 31,103,538 (-)Ensembl
RefSeq Acc Id: NM_011176   ⟹   NP_035306
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39930,999,886 - 31,043,095 (-)NCBI
GRCm38931,088,590 - 31,131,799 (-)NCBI
MGSCv37930,896,175 - 30,939,384 (-)RGD
Celera928,347,788 - 28,391,153 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510098   ⟹   XP_006510161
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39931,000,703 - 31,043,138 (-)NCBI
GRCm38931,089,407 - 31,131,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510099   ⟹   XP_006510162
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39931,000,703 - 31,043,136 (-)NCBI
GRCm38931,089,407 - 31,131,805 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154704   ⟹   XP_036010597
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39931,000,703 - 31,032,233 (-)NCBI
Sequence:
RefSeq Acc Id: NP_035306   ⟸   NM_011176
- UniProtKB: P56677 (UniProtKB/Swiss-Prot),   Q543E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510161   ⟸   XM_006510098
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006510162   ⟸   XM_006510099
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSMUSP00000034478   ⟸   ENSMUST00000034478
Ensembl Acc Id: ENSMUSP00000121971   ⟸   ENSMUST00000123557
Ensembl Acc Id: ENSMUSP00000150666   ⟸   ENSMUST00000214418
RefSeq Acc Id: XP_036010597   ⟸   XM_036154704
- Peptide Label: isoform X1
Protein Domains
CUB   LDL-receptor class A   Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56677-F1-model_v2 AlphaFold P56677 1-855 view protein structure

Promoters
RGD ID:6845216
Promoter ID:MM_KWN:56731
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney
Transcripts:OTTMUST00000073883,   OTTMUST00000073884,   OTTMUST00000073885
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36930,938,976 - 30,939,476 (-)MPROMDB
RGD ID:8669108
Promoter ID:EPDNEW_M12585
Type:initiation region
Name:St14_1
Description:Mus musculus suppression of tumorigenicity 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38931,131,796 - 31,131,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338881 AgrOrtholog
Ensembl Genes ENSMUSG00000031995 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034478 ENTREZGENE
  ENSMUST00000034478.3 UniProtKB/Swiss-Prot
  ENSMUST00000123557.2 UniProtKB/TrEMBL
  ENSMUST00000214418.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A_matripase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19143 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1338881 ENTREZGENE
NCBI Gene 19143 ENTREZGENE
PANTHER ACROSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen St14 PhenoGen
PIRSF ST14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CUB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82671 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SU89_MOUSE UniProtKB/TrEMBL
  D6RIN3_MOUSE UniProtKB/TrEMBL
  P56677 ENTREZGENE
  Q543E3 ENTREZGENE, UniProtKB/TrEMBL
  ST14_MOUSE UniProtKB/Swiss-Prot