Apaf1 (apoptotic peptidase activating factor 1) - Rat Genome Database

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Gene: Apaf1 (apoptotic peptidase activating factor 1) Mus musculus
Analyze
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
RGD ID: 733294
MGI Page MGI
Description: Enables cysteine-type endopeptidase activator activity involved in apoptotic process and identical protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nervous system development; and regulation of apoptotic DNA fragmentation. Located in cytosol and nucleus. Is expressed in several structures, including inner cell mass; inner ear; limb interdigital region; liver; and vibrissa. Used to study Noonan syndrome. Orthologous to human APAF1 (apoptotic peptidase activating factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6230400I06Rik; Ap; Apaf-1; Apaf1l; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; fog; forebrain overgrowth; KIAA0413; mKIAA0413
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391090,825,173 - 90,918,688 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1090,825,173 - 90,918,632 (-)EnsemblGRCm39 Ensembl
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1090,989,311 - 91,082,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBIMGSCv36mm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-D  (EXP)
2,4-dinitrophenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenol  (EXP)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-Methoxyflavone  (ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azadirachtin A  (ISO)
bafilomycin A1  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
butachlor  (EXP)
Butylbenzyl phthalate  (EXP)
butyric acid  (EXP)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP)
casticin  (ISO)
ceric oxide  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
coenzyme Q10  (EXP)
colistin  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (ISO)
epichlorohydrin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (EXP)
eugenol  (EXP)
flavone  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
furosemide  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
gingerol  (ISO)
ginsenoside Rg1  (ISO)
glucaric acid  (EXP)
glucose  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyurea  (EXP)
indole-3-methanol  (EXP)
isoflurane  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
ketoconazole  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
leptomycin B  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP)
mangiferin  (EXP)
MeIQx  (ISO)
melatonin  (ISO)
melittin  (EXP,ISO)
metformin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (EXP)
morin  (ISO)
Muraglitazar  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
neomycin  (EXP)
nickel atom  (ISO)
nicotinamide  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
ouabain  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-?  (ISO)
pirinixic acid  (EXP)
propofol  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
safrole  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sinapic acid  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
tanespimycin  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
WIN 55212-2  (ISO)
zearalenone  (EXP)
zebularine  (ISO)
zinc oxide  (EXP)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal apoptosis  (IAGP)
abnormal brain development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain ventricle morphology  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal cortical marginal zone morphology  (IAGP)
abnormal cranial flexure morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal fibroblast apoptosis  (IAGP)
abnormal folding of telencephalic vesicles  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal forehead shape  (IAGP)
abnormal fourth ventricle morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal head shape  (IAGP)
abnormal hindbrain morphology  (IAGP)
abnormal hypothalamus morphology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal lens polarity  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal nasal septum morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal otic vesicle development  (IAGP)
abnormal palate morphology  (IAGP)
abnormal presphenoid bone morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal thalamus morphology  (IAGP)
abnormal third ventricle morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal viscerocranium morphology  (IAGP)
absent ethmoid bone  (IAGP)
absent interparietal bone  (IAGP)
absent neurocranium  (IAGP)
absent parietal bone  (IAGP)
absent presphenoid bone  (IAGP)
absent supraoccipital bone  (IAGP)
absent vomer bone  (IAGP)
azoospermia  (IAGP)
broad face  (IAGP)
broad frontonasal prominence  (IAGP)
choroid plexus hyperplasia  (IAGP)
cranioschisis  (IAGP)
curly tail  (IAGP)
decreased apoptosis  (IAGP)
decreased fibroblast apoptosis  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased sensitivity to induced cell death  (IAGP)
decreased survivor rate  (IAGP)
delayed neural tube closure  (IAGP)
diencephalon hyperplasia  (IAGP)
encephalomeningocele  (IAGP)
exencephaly  (IAGP)
facial cleft  (IAGP)
failure of eyelid fusion  (IAGP)
flat head  (IAGP)
hydrocephaly  (IAGP)
hyperactivity  (IAGP)
hypothalamus hyperplasia  (IAGP)
impaired ossification of basisphenoid bone  (IAGP)
increased cell proliferation  (IAGP)
increased cochlear hair cell number  (IAGP)
increased embryonic neuroepithelium thickness  (IAGP)
increased locomotor activity  (IAGP)
increased neuron apoptosis  (IAGP)
increased vestibular hair cell number  (IAGP)
interdigital webbing  (IAGP)
intracerebral hemorrhage  (IAGP)
kinked tail  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
male infertility  (IAGP)
microcephaly  (IAGP)
midbrain hyperplasia  (IAGP)
midline facial cleft  (IAGP)
motor neuron degeneration  (IAGP)
no abnormal phenotype detected  (IEA)
open neural tube  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistence of hyaloid vascular system  (IAGP)
persistence of medial edge epithelium during palatal shelf fusion  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
reduced female fertility  (IAGP)
reduced male fertility  (IAGP)
retina fold  (IAGP)
retina hyperplasia  (IAGP)
short snout  (IAGP)
small embryonic telencephalon  (IAGP)
small lens  (IAGP)
spina bifida  (IAGP)
spina bifida occulta  (IAGP)
thalamus hyperplasia  (IAGP)
thickened cerebral cortex  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Baker DJ and Hepple RT, Exp Gerontol. 2006 Nov;41(11):1149-56. Epub 2006 Oct 6.
2. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
3. Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance. Corvaro M, etal., Cancer Biol Ther. 2007 Feb;6(2):209-17. Epub 2007 Feb 25.
4. Comparison of combined antioxidants and thymoquinone in the prevention of testis ischemia - reperfusion injury. Erol B, etal., Andrology. 2017 Jan;5(1):119-124. doi: 10.1111/andr.12268. Epub 2016 Oct 16.
5. The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats. Erol B, etal., Kaohsiung J Med Sci. 2015 Sep;31(9):454-62. doi: 10.1016/j.kjms.2015.06.005. Epub 2015 Jul 22.
6. Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death. Henshall DC, etal., Cell Death Differ. 2001 Dec;8(12):1169-81.
7. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Immunohistochemical localization of apoptosome-related proteins in Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Kawamoto Y, etal., Brain Res. 2014 Jul 7;1571:39-48. doi: 10.1016/j.brainres.2014.05.007. Epub 2014 May 13.
9. p53- and Bax-mediated apoptosis in injured rat spinal cord. Kotipatruni RR, etal., Neurochem Res. 2011 Nov;36(11):2063-74. doi: 10.1007/s11064-011-0530-2. Epub 2011 Jul 7.
10. MiR-484 promotes non-small-cell lung cancer (NSCLC) progression through inhibiting Apaf-1 associated with the suppression of apoptosis. Li T, etal., Biomed Pharmacother. 2017 Dec;96:153-164. doi: 10.1016/j.biopha.2017.09.102. Epub 2017 Oct 2.
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease. Mochizuki H, etal., Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10918-23. doi: 10.1073/pnas.191107398. Epub 2001 Sep 4.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. Orzáez M, etal., PLoS One. 2014 Oct 20;9(10):e110979. doi: 10.1371/journal.pone.0110979. eCollection 2014.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathway. Saini MK, etal., Nutr Cancer. 2012 Apr;64(3):409-18. doi: 10.1080/01635581.2012.655402. Epub 2012 Feb 27.
20. Identification of the apoptosis activation cascade induced in mammary carcinomas by energy restriction. Thompson HJ, etal., Cancer Res. 2004 Feb 15;64(4):1541-5.
21. Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. Xu XH, etal., Acta Pharmacol Sin. 2007 Aug;28(8):1097-104.
22. Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. Yagmurdur H, etal., Acta Anaesthesiol Scand. 2008 Mar;52(3):350-7. Epub 2008 Jan 16.
23. Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. Yakovlev AG, etal., J Neurosci. 2001 Oct 1;21(19):7439-46.
24. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Yoshida H, etal., Cell 1998 Sep 18;94(6):739-50.
25. Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Zhang S, etal., Neurochem Int. 2013 Nov;63(5):522-32. doi: 10.1016/j.neuint.2013.08.008. Epub 2013 Sep 4.
26. Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. Zhang Z, etal., Exp Eye Res. 2012 Jan;94(1):98-108. Epub 2011 Nov 28.
Additional References at PubMed
PMID:9092658   PMID:9216040   PMID:9708735   PMID:9753320   PMID:9988219   PMID:10101687   PMID:10206961   PMID:10342853   PMID:10349636   PMID:10403638   PMID:10421635   PMID:10452843  
PMID:10508592   PMID:10656767   PMID:10830166   PMID:11042159   PMID:11067867   PMID:11076861   PMID:11119689   PMID:11279485   PMID:11423996   PMID:11504943   PMID:11566499   PMID:11731416  
PMID:11859117   PMID:11859416   PMID:11919205   PMID:12062423   PMID:12107826   PMID:12121437   PMID:12147675   PMID:12351193   PMID:12374983   PMID:12477932   PMID:12520002   PMID:12660414  
PMID:12773531   PMID:12883670   PMID:14561754   PMID:14610273   PMID:14709542   PMID:14713951   PMID:14747474   PMID:15105372   PMID:15118096   PMID:15210730   PMID:15257302   PMID:15262985  
PMID:15271982   PMID:15371421   PMID:15649468   PMID:15703386   PMID:15776018   PMID:15843406   PMID:15861188   PMID:15907471   PMID:16021178   PMID:16086359   PMID:16141072   PMID:16141073  
PMID:16183742   PMID:16183747   PMID:16215690   PMID:16291596   PMID:16294213   PMID:16317003   PMID:16397188   PMID:16407291   PMID:16465443   PMID:16514420   PMID:16537572   PMID:16595687  
PMID:16670300   PMID:16777102   PMID:16799012   PMID:16917506   PMID:16919269   PMID:16932756   PMID:16954146   PMID:17079275   PMID:17218955   PMID:17218959   PMID:17274640   PMID:17348858  
PMID:17380155   PMID:17562856   PMID:17576813   PMID:17652622   PMID:18032672   PMID:18037375   PMID:18042457   PMID:18056406   PMID:18093951   PMID:18256270   PMID:18272486   PMID:18480964  
PMID:18483489   PMID:18497877   PMID:18562310   PMID:18663378   PMID:18951482   PMID:19139631   PMID:19144853   PMID:19420217   PMID:19675677   PMID:19913007   PMID:19914347   PMID:19960021  
PMID:20349273   PMID:20624980   PMID:20720205   PMID:20966962   PMID:21221781   PMID:21267068   PMID:21431351   PMID:21677750   PMID:21827944   PMID:21873635   PMID:21984814   PMID:22162136  
PMID:22206758   PMID:22226830   PMID:23197294   PMID:23892366   PMID:24369835   PMID:24412373   PMID:24416260   PMID:24632563   PMID:24651435   PMID:25028717   PMID:25285627   PMID:25349173  
PMID:25525875   PMID:25827332   PMID:25940086   PMID:25975226   PMID:26290316   PMID:26334721   PMID:26374523   PMID:27001308   PMID:27580417   PMID:27789626   PMID:29068314   PMID:29596528  
PMID:30938680   PMID:31178404   PMID:31212066   PMID:32325033   PMID:32979334   PMID:33278357   PMID:33308446   PMID:34298080   PMID:34437534   PMID:34518561  


Genomics

Comparative Map Data
Apaf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391090,825,173 - 90,918,688 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1090,825,173 - 90,918,632 (-)EnsemblGRCm39 Ensembl
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1090,989,311 - 91,082,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBIMGSCv36mm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.47NCBI
APAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381298,645,290 - 98,735,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1298,645,149 - 98,735,433 (+)EnsemblGRCh38hg38GRCh38
GRCh371299,039,068 - 99,129,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361297,563,209 - 97,653,342 (+)NCBINCBI36Build 36hg18NCBI36
Build 341297,541,545 - 97,631,678NCBI
Celera1298,703,974 - 98,794,106 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1296,100,029 - 96,190,306 (+)NCBIHuRef
CHM1_11299,004,024 - 99,094,151 (+)NCBICHM1_1
T2T-CHM13v2.01298,618,230 - 98,708,377 (+)NCBIT2T-CHM13v2.0
Apaf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,381,392 - 27,466,772 (-)NCBIGRCr8
mRatBN7.2725,494,143 - 25,579,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,494,609 - 25,579,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx727,489,053 - 27,573,980 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,651,444 - 29,736,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,428,845 - 29,513,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,699,309 - 31,784,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,699,885 - 31,784,192 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0731,791,073 - 31,872,984 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4727,932,908 - 28,020,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1727,953,178 - 28,040,804 (-)NCBI
Celera722,620,761 - 22,706,298 (-)NCBICelera
Cytogenetic Map7q13NCBI
Apaf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540534,623,267 - 34,693,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540534,619,780 - 34,693,616 (+)NCBIChiLan1.0ChiLan1.0
APAF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,637,622 - 99,726,946 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensemblpanpan1.1panPan2
APAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11538,026,893 - 38,160,842 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1538,028,132 - 38,114,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1538,408,276 - 38,554,051 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01538,689,945 - 38,835,971 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1538,689,948 - 38,780,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,961,882 - 38,107,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01538,054,503 - 38,200,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01538,328,187 - 38,474,238 (+)NCBIUU_Cfam_GSD_1.0
Apaf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494521,806,281 - 21,891,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649214,816,623 - 14,902,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649214,818,561 - 14,902,231 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl585,166,628 - 85,258,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1585,166,616 - 85,258,751 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2589,443,106 - 89,580,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11193,942,137 - 94,024,728 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1193,942,103 - 94,024,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037151,034,383 - 151,120,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apaf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247508,837,037 - 8,938,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247508,835,521 - 8,940,957 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apaf1
3333 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2178
Count of miRNA genes:737
Interacting mature miRNAs:927
Transcripts:ENSMUST00000020157, ENSMUST00000159110, ENSMUST00000159457, ENSMUST00000160725, ENSMUST00000160788, ENSMUST00000161095, ENSMUST00000161987, ENSMUST00000162618
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
12910789Pwgrq19_mpost-weaning growth rate QTL 19 (mouse)108282870092169056Mouse
1301520Uvbi1_mUVB induced immunosuppression 1 (mouse)Not determined1086909085120909229Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
4142386Tgq20_mtriglyceride QTL 20 (mouse)Not determined88836456122836456Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084079650122041528Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357831Igf1sl2_mIGF-1 serum levels 2 (mouse)Not determined108769412799936278Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
14747004Mancz8_mmandible centroid size 8 (mouse)1082078412116078412Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84079650122041528Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084079650122041528Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84079650122041528Mouse
13208554Lgth11_mbody length 11 (mouse)1090835862120835905Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
1300921Skl4_mskeletal size (tail length) 4 (mouse)Not determined1088088254122088391Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
1300797Sluc22_msusceptibility to lung cancer 22 (mouse)Not determined1086713608120713756Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039516Ltpr5_mLeishmania tropica response 5 (mouse)1090506901125575232Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082309418116309657Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300908Insq4_minsulin QTL 4 (mouse)Not determined1086909085120909229Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83017003117017136Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084079650122041528Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082309418116309657Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082309418116309657Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082309418116309657Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085454982118497353Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1301758Fcsa3_mfemoral cross-sectional area 3 (mouse)Not determined1089927651123927754Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082392803116392952Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84079650122041528Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082309418116309657Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082309418116309657Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
4141382Ssrq4_mstress response QTL 4 (mouse)Not determined8249093890856102Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
13524528Bodwtq9_mbody wweight QTL 9 (mouse)108764311793193117Mouse

Markers in Region
D10Mit231  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381091,020,120 - 91,020,240UniSTSGRCm38
MGSCv371090,482,865 - 90,482,985UniSTSGRCm37
Celera1093,014,342 - 93,014,458UniSTS
Cytogenetic Map10C3-D1UniSTS
cM Map1052.0UniSTS
Whitehead Genetic1051.4UniSTS
Whitehead/MRC_RH101056.17UniSTS
Whitehead_YAC10 UniSTS
Apaf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381090,990,805 - 90,990,888UniSTSGRCm38
MGSCv371090,453,550 - 90,453,633UniSTSGRCm37
Celera1092,985,109 - 92,985,192UniSTS
Cytogenetic Map10C3-D1UniSTS
cM Map1048.0UniSTS
AF064071  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381090,991,022 - 90,991,152UniSTSGRCm38
MGSCv371090,453,767 - 90,453,897UniSTSGRCm37
Celera1092,985,326 - 92,985,456UniSTS
Cytogenetic Map10C3-D1UniSTS
Whitehead/MRC_RH101054.76UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC138719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF064071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ970309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY293164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF539822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ160169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DT924066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020157   ⟹   ENSMUSP00000020157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,825,180 - 90,918,632 (-)Ensembl
GRCm38.p6 Ensembl1090,989,318 - 91,082,770 (-)Ensembl
Ensembl Acc Id: ENSMUST00000159110   ⟹   ENSMUSP00000125291
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,825,173 - 90,918,524 (-)Ensembl
GRCm38.p6 Ensembl1090,989,311 - 91,082,662 (-)Ensembl
Ensembl Acc Id: ENSMUST00000159457
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,831,595 - 90,836,273 (-)Ensembl
GRCm38.p6 Ensembl1090,995,733 - 91,000,411 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,825,175 - 90,827,452 (-)Ensembl
GRCm38.p6 Ensembl1090,989,313 - 90,991,590 (-)Ensembl
Ensembl Acc Id: ENSMUST00000160788   ⟹   ENSMUSP00000124968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,902,752 - 90,918,632 (-)Ensembl
GRCm38.p6 Ensembl1091,066,890 - 91,082,770 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161095
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,832,602 - 90,835,581 (-)Ensembl
GRCm38.p6 Ensembl1090,996,740 - 90,999,719 (-)Ensembl
Ensembl Acc Id: ENSMUST00000161987   ⟹   ENSMUSP00000124422
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,901,254 - 90,918,291 (-)Ensembl
GRCm38.p6 Ensembl1091,065,392 - 91,082,429 (-)Ensembl
Ensembl Acc Id: ENSMUST00000162618   ⟹   ENSMUSP00000124134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1090,826,464 - 90,918,566 (-)Ensembl
GRCm38.p6 Ensembl1090,990,602 - 91,082,704 (-)Ensembl
RefSeq Acc Id: NM_001042558   ⟹   NP_001036023
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391090,825,173 - 90,918,605 (-)NCBI
GRCm381090,989,311 - 91,082,743 (-)ENTREZGENE
MGSCv371090,452,056 - 90,545,488 (-)RGD
Celera1092,983,615 - 93,080,742 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001282947   ⟹   NP_001269876
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391090,825,173 - 90,918,605 (-)NCBI
GRCm381090,989,311 - 91,082,743 (-)NCBI
Celera1092,983,615 - 93,080,742 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009684   ⟹   NP_033814
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391090,825,173 - 90,918,605 (-)NCBI
GRCm381090,989,311 - 91,082,743 (-)ENTREZGENE
MGSCv371090,452,056 - 90,545,488 (-)RGD
Celera1092,983,615 - 93,080,742 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036155560   ⟹   XP_036011453
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391090,825,173 - 90,918,669 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155561   ⟹   XP_036011454
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391090,825,173 - 90,918,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155562   ⟹   XP_036011455
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391090,825,173 - 90,896,148 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936065
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391090,890,242 - 90,918,688 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001036023   ⟸   NM_001042558
- Peptide Label: isoform 1
- UniProtKB: A2RRK8 (UniProtKB/Swiss-Prot),   O88879 (UniProtKB/Swiss-Prot),   Q5DU30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_033814   ⟸   NM_009684
- Peptide Label: isoform 1
- UniProtKB: A2RRK8 (UniProtKB/Swiss-Prot),   O88879 (UniProtKB/Swiss-Prot),   Q5DU30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269876   ⟸   NM_001282947
- Peptide Label: isoform 2
- UniProtKB: G3XA09 (UniProtKB/TrEMBL),   Q5DU30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000125291   ⟸   ENSMUST00000159110
Ensembl Acc Id: ENSMUSP00000020157   ⟸   ENSMUST00000020157
Ensembl Acc Id: ENSMUSP00000124968   ⟸   ENSMUST00000160788
Ensembl Acc Id: ENSMUSP00000124134   ⟸   ENSMUST00000162618
Ensembl Acc Id: ENSMUSP00000124422   ⟸   ENSMUST00000161987
RefSeq Acc Id: XP_036011453   ⟸   XM_036155560
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036011454   ⟸   XM_036155561
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036011455   ⟸   XM_036155562
- Peptide Label: isoform X2
Protein Domains
CARD   NB-ARC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88879-F1-model_v2 AlphaFold O88879 1-1249 view protein structure

Promoters
RGD ID:6818992
Promoter ID:MM_KWN:5329
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000068871
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361090,454,986 - 90,455,486 (-)MPROMDB
RGD ID:6818991
Promoter ID:MM_KWN:5330
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000068869,   OTTMUST00000068870
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361090,462,491 - 90,462,991 (-)MPROMDB
RGD ID:6819821
Promoter ID:MM_KWN:5331
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009684,   NM_026166,   OTTMUST00000068860,   OTTMUST00000068861,   OTTMUST00000068862,   OTTMUST00000068864,   UC007GTI.1,   UC007GTJ.1,   UC007GTK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361090,544,896 - 90,546,097 (+)MPROMDB
RGD ID:8673032
Promoter ID:EPDNEW_M14547
Type:initiation region
Name:Apaf1_1
Description:Mus musculus apoptotic peptidase activating factor 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381091,082,692 - 91,082,752EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1306796 AgrOrtholog
Ensembl Genes ENSMUSG00000019979 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020157 ENTREZGENE
  ENSMUST00000020157.13 UniProtKB/Swiss-Prot
  ENSMUST00000159110 ENTREZGENE
  ENSMUST00000159110.8 UniProtKB/Swiss-Prot
  ENSMUST00000160788.2 UniProtKB/TrEMBL
  ENSMUST00000161987.8 UniProtKB/TrEMBL
  ENSMUST00000162618 ENTREZGENE
  ENSMUST00000162618.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.8.430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Apaf-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APAF1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APAF1_CARD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APAF1_WHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apaf_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NB-ARC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11783 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1306796 ENTREZGENE
NCBI Gene 11783 ENTREZGENE
PANTHER APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/Swiss-Prot
  APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/Swiss-Prot
  APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/TrEMBL
  APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/TrEMBL
Pfam APAF-1-like_WHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APAF1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NB-ARC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apaf1 PhenoGen
PIRSF Apop_pept_activating-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DISEASERSIST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RRK8 ENTREZGENE
  APAF_MOUSE UniProtKB/Swiss-Prot
  G3XA09 ENTREZGENE, UniProtKB/TrEMBL
  O88879 ENTREZGENE
  Q5DU30 ENTREZGENE, UniProtKB/TrEMBL
  Q80VR5_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2RRK8 UniProtKB/Swiss-Prot