Npffr2 (neuropeptide FF receptor 2) - Rat Genome Database

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Gene: Npffr2 (neuropeptide FF receptor 2) Mus musculus
Analyze
Symbol: Npffr2
Name: neuropeptide FF receptor 2
RGD ID: 733262
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Predicted to be located in actin cytoskeleton. Predicted to be active in plasma membrane. Is expressed in brain; dorsal root ganglion; and trigeminal ganglion. Orthologous to human NPFFR2 (neuropeptide FF receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 74; G-protein coupled receptor 74; Gpr; Gpr74; HG31; neuropeptide NPFF receptor; NPF; NPFF2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39589,674,805 - 89,731,473 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl589,675,288 - 89,731,599 (+)EnsemblGRCm39 Ensembl
GRCm38589,526,840 - 89,583,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl589,527,429 - 89,583,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv37589,956,454 - 90,012,765 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36590,602,628 - 90,658,939 (+)NCBIMGSCv36mm8
Celera587,701,454 - 87,717,464 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IEA,ISO)
plasma membrane  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10837915   PMID:11042159   PMID:11076861   PMID:11217851   PMID:14696013   PMID:15121216   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17157836   PMID:19944730  
PMID:20554321   PMID:20600636   PMID:21267068   PMID:21873635   PMID:22691552   PMID:24088662   PMID:24266689   PMID:24952961   PMID:25756309   PMID:26641552   PMID:27243477   PMID:27669639  
PMID:28179153   PMID:28581443   PMID:28825666   PMID:29709623   PMID:30413707   PMID:33202667   PMID:34299230   PMID:37191311   PMID:38301284   PMID:38355793  


Genomics

Comparative Map Data
Npffr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39589,674,805 - 89,731,473 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl589,675,288 - 89,731,599 (+)EnsemblGRCm39 Ensembl
GRCm38589,526,840 - 89,583,914 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl589,527,429 - 89,583,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv37589,956,454 - 90,012,765 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36590,602,628 - 90,658,939 (+)NCBIMGSCv36mm8
Celera587,701,454 - 87,717,464 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.32NCBI
NPFFR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38472,032,000 - 72,148,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl472,031,902 - 72,148,305 (+)EnsemblGRCh38hg38GRCh38
GRCh37472,897,717 - 73,014,022 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36473,116,385 - 73,232,642 (+)NCBINCBI36Build 36hg18NCBI36
Build 34473,270,125 - 73,378,813NCBI
Celera470,253,879 - 70,369,821 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef468,702,459 - 68,818,720 (+)NCBIHuRef
CHM1_1472,933,070 - 73,049,409 (+)NCBICHM1_1
T2T-CHM13v2.0475,374,029 - 75,490,284 (+)NCBIT2T-CHM13v2.0
Npffr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81418,794,868 - 18,842,186 (-)NCBIGRCr8
mRatBN7.21418,513,120 - 18,558,074 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1418,513,277 - 18,521,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1418,503,730 - 18,512,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01419,822,615 - 19,831,258 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01418,537,009 - 18,545,776 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01420,148,485 - 20,193,577 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,148,913 - 20,193,083 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,054,945 - 20,099,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,041,856 - 20,050,499 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11420,041,855 - 20,050,499 (-)NCBI
Celera1417,879,584 - 17,888,229 (-)NCBICelera
Cytogenetic Map14p22NCBI
Npffr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554471,112,854 - 1,205,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554471,112,856 - 1,205,051 (-)NCBIChiLan1.0ChiLan1.0
NPFFR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2357,930,645 - 58,049,684 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1458,128,207 - 58,246,527 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0452,073,462 - 52,189,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1458,393,065 - 58,412,577 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl458,393,065 - 58,508,526 (-)Ensemblpanpan1.1panPan2
NPFFR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11361,140,285 - 61,164,966 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1361,148,828 - 61,164,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1360,874,074 - 60,899,431 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01361,950,541 - 61,973,894 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1361,958,652 - 61,973,971 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11361,558,985 - 61,584,534 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01361,050,028 - 61,073,505 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01362,198,644 - 62,224,209 (+)NCBIUU_Cfam_GSD_1.0
Npffr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528514,540,862 - 14,612,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365982,992,780 - 3,003,355 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365982,993,845 - 3,063,891 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPFFR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl868,572,578 - 68,643,756 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1868,572,164 - 68,643,394 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2872,528,102 - 72,559,432 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPFFR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1720,552,443 - 20,664,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl720,646,369 - 20,664,578 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660842,149,982 - 2,168,443 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npffr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248903,562,775 - 3,581,448 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:79
Interacting mature miRNAs:86
Transcripts:ENSMUST00000048557
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
12738408Lfibq5_mliver fibrosis QTL 5 (mouse)58478385389966041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000048557   ⟹   ENSMUSP00000040033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl589,675,288 - 89,731,599 (+)Ensembl
GRCm38.p6 Ensembl589,527,429 - 89,583,740 (+)Ensembl
RefSeq Acc Id: NM_001412387   ⟹   NP_001399316
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39589,674,805 - 89,731,473 (+)NCBI
RefSeq Acc Id: NM_133192   ⟹   NP_573455
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39589,675,238 - 89,731,473 (+)NCBI
GRCm38589,527,429 - 89,583,740 (+)NCBI
MGSCv37589,956,454 - 90,012,765 (+)RGD
Celera587,701,454 - 87,717,464 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001399316 (Get FASTA)   NCBI Sequence Viewer  
  NP_573455 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK58514 (Get FASTA)   NCBI Sequence Viewer  
  AAK94198 (Get FASTA)   NCBI Sequence Viewer  
  BAC34468 (Get FASTA)   NCBI Sequence Viewer  
  EDL05338 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000040033
  ENSMUSP00000040033.3
GenBank Protein Q924H0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_573455   ⟸   NM_133192
- UniProtKB: Q8BKR6 (UniProtKB/Swiss-Prot),   Q924H0 (UniProtKB/Swiss-Prot),   Q924N0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000040033   ⟸   ENSMUST00000048557
RefSeq Acc Id: NP_001399316   ⟸   NM_001412387
- UniProtKB: Q924H0 (UniProtKB/Swiss-Prot),   Q8BKR6 (UniProtKB/Swiss-Prot)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924H0-F1-model_v2 AlphaFold Q924H0 1-417 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1860130 AgrOrtholog
Ensembl Genes ENSMUSG00000035528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048557 ENTREZGENE
  ENSMUST00000048557.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFF_rcpt_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:104443 UniProtKB/Swiss-Prot
MGD MGI:1860130 ENTREZGENE
NCBI Gene Npffr2 ENTREZGENE
PANTHER NEUROPEPTIDE FF RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npffr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFFRECEPTR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt NPFF2_MOUSE UniProtKB/Swiss-Prot
  Q8BKR6 ENTREZGENE
  Q924H0 ENTREZGENE
  Q924N0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8BKR6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Npffr2  neuropeptide FF receptor 2  Gpr74  G protein-coupled receptor 74  Symbol and/or name change 5135510 APPROVED
2024-08-21 Gpr74  G protein-coupled receptor 74  Npffr2  neuropeptide FF receptor 2  Symbol and/or name change 5135510 APPROVED