PRKG2 (protein kinase cGMP-dependent 2) - Rat Genome Database

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Gene: PRKG2 (protein kinase cGMP-dependent 2) Homo sapiens
Analyze
Symbol: PRKG2
Name: protein kinase cGMP-dependent 2
RGD ID: 733228
HGNC Page HGNC:9416
Description: Enables cGMP-dependent protein kinase activity; mitogen-activated protein kinase binding activity; and protein serine kinase activity. Involved in protein phosphorylation and signal transduction. Predicted to be located in cytosol. Implicated in acromesomelic dysplasia-4 and spondylometaphyseal dysplasia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AMD4; cGK 2; cGK2; cGKII; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; PKG2; PRKGR2; protein kinase, cgmp- dependent, type ii; SMDP; testicular tissue protein Li 99
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38481,087,370 - 81,217,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl481,087,370 - 81,215,222 (-)EnsemblGRCh38hg38GRCh38
GRCh37482,008,524 - 82,136,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36482,228,861 - 82,345,239 (-)NCBINCBI36Build 36hg18NCBI36
Build 34482,367,015 - 82,483,394NCBI
Celera479,302,549 - 79,418,932 (-)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef477,753,401 - 77,870,008 (-)NCBIHuRef
CHM1_1481,986,323 - 82,102,706 (-)NCBICHM1_1
T2T-CHM13v2.0484,417,063 - 84,544,924 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Chikuda H, etal., Genes Dev. 2004 Oct 1;18(19):2418-29. doi: 10.1101/gad.1224204.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. Tsuchida A, etal., Comp Med. 2008 Dec;58(6):560-7.
Additional References at PubMed
PMID:6547441   PMID:7493990   PMID:7498513   PMID:7543493   PMID:8607838   PMID:9535793   PMID:10531334   PMID:11076863   PMID:11278298   PMID:12054676   PMID:12477932   PMID:12571245  
PMID:12764134   PMID:15555551   PMID:15905169   PMID:16344560   PMID:16990611   PMID:18262053   PMID:18391951   PMID:18606955   PMID:18678579   PMID:19343178   PMID:19359370   PMID:19543319  
PMID:19953087   PMID:20379614   PMID:21873635   PMID:22012247   PMID:22174851   PMID:22303795   PMID:22427012   PMID:22556146   PMID:22791569   PMID:22939624   PMID:22940826   PMID:23404188  
PMID:23449627   PMID:23563607   PMID:23602568   PMID:23755100   PMID:23940030   PMID:24534906   PMID:24549567   PMID:24882840   PMID:25070890   PMID:25189868   PMID:25688884   PMID:26186194  
PMID:26676300   PMID:26769964   PMID:27147579   PMID:27173435   PMID:28514442   PMID:28793191   PMID:29401205   PMID:29517905   PMID:31395339   PMID:32521860   PMID:33106379   PMID:33961781  
PMID:34745083   PMID:34782440  


Genomics

Comparative Map Data
PRKG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38481,087,370 - 81,217,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl481,087,370 - 81,215,222 (-)EnsemblGRCh38hg38GRCh38
GRCh37482,008,524 - 82,136,376 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36482,228,861 - 82,345,239 (-)NCBINCBI36Build 36hg18NCBI36
Build 34482,367,015 - 82,483,394NCBI
Celera479,302,549 - 79,418,932 (-)NCBICelera
Cytogenetic Map4q21.21NCBI
HuRef477,753,401 - 77,870,008 (-)NCBIHuRef
CHM1_1481,986,323 - 82,102,706 (-)NCBICHM1_1
T2T-CHM13v2.0484,417,063 - 84,544,924 (-)NCBIT2T-CHM13v2.0
Prkg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39599,077,632 - 99,185,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl599,077,632 - 99,185,210 (-)EnsemblGRCm39 Ensembl
GRCm38598,929,773 - 99,037,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl598,929,773 - 99,037,351 (-)EnsemblGRCm38mm10GRCm38
MGSCv37599,358,792 - 99,466,098 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36599,171,570 - 99,277,381 (-)NCBIMGSCv36mm8
Celera596,252,278 - 96,360,518 (-)NCBICelera
Cytogenetic Map5E3NCBI
cM Map548.35NCBI
Prkg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21410,559,882 - 10,668,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1410,559,882 - 10,666,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1410,540,037 - 10,640,477 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01411,839,852 - 11,940,298 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01410,529,813 - 10,630,458 (+)NCBIRnor_WKY
Rnor_6.01412,217,121 - 12,313,616 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1412,218,553 - 12,315,229 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01412,159,378 - 12,255,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41411,888,101 - 12,005,547 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11411,888,100 - 12,005,547 (+)NCBI
Celera1410,666,687 - 10,755,836 (+)NCBICelera
Cytogenetic Map14p22NCBI
Prkg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554335,286,153 - 5,491,924 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554335,286,594 - 5,387,571 (-)NCBIChiLan1.0ChiLan1.0
PRKG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1448,836,953 - 48,960,383 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl448,836,953 - 48,960,383 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0442,987,217 - 43,114,993 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRKG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1325,266,435 - 5,365,396 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl325,266,442 - 5,365,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3236,517,409 - 36,617,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0325,294,681 - 5,395,076 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl325,294,693 - 5,395,085 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1325,324,348 - 5,424,902 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0325,231,256 - 5,331,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03234,635,113 - 34,735,693 (+)NCBIUU_Cfam_GSD_1.0
Prkg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052856,966,547 - 7,070,004 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936749900,208 - 991,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8136,755,469 - 136,852,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18136,754,698 - 136,854,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28146,048,858 - 146,148,011 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1729,511,796 - 29,629,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl729,511,380 - 29,618,330 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660378,011,684 - 8,129,346 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247579,798,808 - 9,906,517 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247579,799,777 - 9,904,825 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRKG2
3 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q21.1-21.23(chr4:75453111-84094295)x1 copy number loss See cases [RCV000050786] Chr4:75453111..84094295 [GRCh38]
Chr4:76378321..85015448 [GRCh37]
Chr4:76597345..85234472 [NCBI36]
Chr4:4q21.1-21.23		 pathogenic
GRCh38/hg38 4q12-22.3(chr4:51831622-97505618)x3 copy number gain See cases [RCV000051772] Chr4:51831622..97505618 [GRCh38]
Chr4:52697788..98426769 [GRCh37]
Chr4:52392545..98645792 [NCBI36]
Chr4:4q12-22.3		 pathogenic
GRCh38/hg38 4q13.2-21.23(chr4:67869564-85517308)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053294]|See cases [RCV000053294] Chr4:67869564..85517308 [GRCh38]
Chr4:68735282..86438461 [GRCh37]
Chr4:68417877..86657485 [NCBI36]
Chr4:4q13.2-21.23		 pathogenic
GRCh38/hg38 4q13.3-21.22(chr4:71079179-81802208)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053295]|See cases [RCV000053295] Chr4:71079179..81802208 [GRCh38]
Chr4:71944896..82723361 [GRCh37]
Chr4:72163760..82942385 [NCBI36]
Chr4:4q13.3-21.22		 pathogenic
GRCh38/hg38 4q13.3-22.1(chr4:74031395-90421127)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053296]|See cases [RCV000053296] Chr4:74031395..90421127 [GRCh38]
Chr4:74897112..91342278 [GRCh37]
Chr4:75115976..91561301 [NCBI36]
Chr4:4q13.3-22.1		 pathogenic
GRCh38/hg38 4q21.21-22.1(chr4:79575748-92412449)x1 copy number loss See cases [RCV000053297] Chr4:79575748..92412449 [GRCh38]
Chr4:80496902..93333600 [GRCh37]
Chr4:80715926..93552623 [NCBI36]
Chr4:4q21.21-22.1		 pathogenic
GRCh38/hg38 4q21.21-21.23(chr4:81061483-83332595)x1 copy number loss See cases [RCV000053298] Chr4:81061483..83332595 [GRCh38]
Chr4:81982637..84253748 [GRCh37]
Chr4:82201661..84472772 [NCBI36]
Chr4:4q21.21-21.23		 pathogenic
NM_006259.2(PRKG2):c.1735C>T (p.Pro579Ser) single nucleotide variant Malignant melanoma [RCV000061058] Chr4:81135196 [GRCh38]
Chr4:82056350 [GRCh37]
Chr4:82275374 [NCBI36]
Chr4:4q21.21		 not provided
NM_001282480.1(PRKG2):c.866+1255C>A single nucleotide variant Lung cancer [RCV000095035] Chr4:81103115 [GRCh38]
Chr4:82024269 [GRCh37]
Chr4:4q21.21		 uncertain significance
GRCh38/hg38 4q21.21-22.3(chr4:80879777-94809447)x1 copy number loss See cases [RCV000134977] Chr4:80879777..94809447 [GRCh38]
Chr4:81800931..95730598 [GRCh37]
Chr4:82019955..95949621 [NCBI36]
Chr4:4q21.21-22.3		 pathogenic
GRCh38/hg38 4q21.21-21.22(chr4:79742612-83153725)x1 copy number loss See cases [RCV000135797] Chr4:79742612..83153725 [GRCh38]
Chr4:80663766..84074878 [GRCh37]
Chr4:80882790..84293902 [NCBI36]
Chr4:4q21.21-21.22		 uncertain significance
GRCh38/hg38 4q21.21-21.23(chr4:79786514-85832807)x1 copy number loss See cases [RCV000136865] Chr4:79786514..85832807 [GRCh38]
Chr4:80707668..86753960 [GRCh37]
Chr4:80926692..86972984 [NCBI36]
Chr4:4q21.21-21.23		 pathogenic
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1 copy number loss See cases [RCV000137269] Chr4:80427023..100855441 [GRCh38]
Chr4:81348177..101776598 [GRCh37]
Chr4:81567201..101995621 [NCBI36]
Chr4:4q21.21-24		 pathogenic
GRCh38/hg38 4q21.21-21.23(chr4:80908016-84329610)x1 copy number loss See cases [RCV000137863] Chr4:80908016..84329610 [GRCh38]
Chr4:81829170..85250763 [GRCh37]
Chr4:82048194..85469787 [NCBI36]
Chr4:4q21.21-21.23		 likely pathogenic
GRCh38/hg38 4q13.3-21.3(chr4:72262258-86002147)x3 copy number gain See cases [RCV000138312] Chr4:72262258..86002147 [GRCh38]
Chr4:73127975..86923300 [GRCh37]
Chr4:73346839..87142324 [NCBI36]
Chr4:4q13.3-21.3		 pathogenic
GRCh38/hg38 4q21.21-21.3(chr4:80043949-86948317)x1 copy number loss See cases [RCV000140416] Chr4:80043949..86948317 [GRCh38]
Chr4:80965103..87869469 [GRCh37]
Chr4:81184127..88088493 [NCBI36]
Chr4:4q21.21-21.3		 pathogenic
GRCh38/hg38 4q13.2-22.3(chr4:68686088-95294456)x3 copy number gain See cases [RCV000143458] Chr4:68686088..95294456 [GRCh38]
Chr4:69551806..96215607 [GRCh37]
Chr4:69234401..96434630 [NCBI36]
Chr4:4q13.2-22.3		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q21.21-22.3(chr4:81314915-96636651)x1 copy number loss not provided [RCV000682426] Chr4:81314915..96636651 [GRCh37]
Chr4:4q21.21-22.3		 pathogenic
GRCh37/hg19 4q21.21(chr4:82054033-82054958)x1 copy number loss not provided [RCV000743749] Chr4:82054033..82054958 [GRCh37]
Chr4:4q21.21		 benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:82043901-88334228) copy number loss not provided [RCV000767792] Chr4:82043901..88334228 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
GRCh37/hg19 4q21.21-21.22(chr4:80199183-84074906)x1 copy number loss not provided [RCV000848187] Chr4:80199183..84074906 [GRCh37]
Chr4:4q21.21-21.22		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:80482400-92572499)x1 copy number loss See cases [RCV000790579] Chr4:80482400..92572499 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
GRCh37/hg19 4q21.1-21.23(chr4:78769297-84968832)x1 copy number loss not provided [RCV000846933] Chr4:78769297..84968832 [GRCh37]
Chr4:4q21.1-21.23		 pathogenic
GRCh37/hg19 4q13.2-21.22(chr4:68242784-82991431)x3 copy number gain not provided [RCV000845944] Chr4:68242784..82991431 [GRCh37]
Chr4:4q13.2-21.22		 pathogenic
GRCh37/hg19 4q13.3-21.23(chr4:72680879-86426232)x1 copy number loss not provided [RCV001005556] Chr4:72680879..86426232 [GRCh37]
Chr4:4q13.3-21.23		 pathogenic
GRCh37/hg19 4q13.3-21.3(chr4:71412409-87920784)x1 copy number loss See cases [RCV001263040] Chr4:71412409..87920784 [GRCh37]
Chr4:4q13.3-21.3		 pathogenic
Single allele deletion Kabuki syndrome 1 [RCV002247728] Chr4:67833055..82716065 [GRCh38]
Chr4:4q13.2-21.22		 pathogenic
NM_006259.3(PRKG2):c.1705C>T (p.Arg569Ter) single nucleotide variant Acromesomelic dysplasia 4 [RCV001786318] Chr4:81135226 [GRCh38]
Chr4:82056380 [GRCh37]
Chr4:4q21.21		 pathogenic
NM_006259.3(PRKG2):c.2282dup (p.Asp761fs) duplication Spondylometaphyseal dysplasia, pagnamenta type [RCV001786320] Chr4:81089714..81089715 [GRCh38]
Chr4:82010868..82010869 [GRCh37]
Chr4:4q21.21		 pathogenic
NM_006259.3(PRKG2):c.491dup (p.Asn164fs) duplication Acromesomelic dysplasia 4 [RCV001786319] Chr4:81174929..81174930 [GRCh38]
Chr4:82096083..82096084 [GRCh37]
Chr4:4q21.21		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:80467886-93362064)x1 copy number loss not provided [RCV001829208] Chr4:80467886..93362064 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
GRCh37/hg19 4q21.21-22.2(chr4:79780152-94873225) copy number loss not specified [RCV002053432] Chr4:79780152..94873225 [GRCh37]
Chr4:4q21.21-22.2		 pathogenic
GRCh37/hg19 4q21.21-21.22(chr4:80865788-82927188) copy number loss not specified [RCV002053434] Chr4:80865788..82927188 [GRCh37]
Chr4:4q21.21-21.22		 uncertain significance
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21		 pathogenic
GRCh37/hg19 4q21.21-22.1(chr4:81054789-90667421) copy number loss not specified [RCV002053435] Chr4:81054789..90667421 [GRCh37]
Chr4:4q21.21-22.1		 pathogenic
GRCh37/hg19 4q13.3-22.1(chr4:75737340-91131156) copy number gain not specified [RCV002053429] Chr4:75737340..91131156 [GRCh37]
Chr4:4q13.3-22.1		 pathogenic
NM_006259.3(PRKG2):c.2126+5A>G single nucleotide variant not provided [RCV002293107] Chr4:81104365 [GRCh38]
Chr4:82025519 [GRCh37]
Chr4:4q21.21		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1741
Count of miRNA genes:504
Interacting mature miRNAs:565
Transcripts:ENST00000264399, ENST00000395578, ENST00000418486, ENST00000456882, ENST00000509169, ENST00000509474, ENST00000545647
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-X94612  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37482,010,403 - 82,010,634UniSTSGRCh37
Build 36482,229,427 - 82,229,658RGDNCBI36
Celera479,303,115 - 79,303,346RGD
Cytogenetic Map4q13.1-q21.1UniSTS
HuRef477,753,967 - 77,754,198UniSTS
GeneMap99-GB4 RH Map4443.76UniSTS
NCBI RH Map4970.7UniSTS
D4S299  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37482,057,081 - 82,057,332UniSTSGRCh37
Build 36482,276,105 - 82,276,356RGDNCBI36
Celera479,349,797 - 79,350,048RGD
Cytogenetic Map4q13.1-q21.1UniSTS
HuRef477,800,663 - 77,800,914UniSTS
Stanford-G3 RH Map44543.0UniSTS
SHGC-51140  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37482,118,276 - 82,118,578UniSTSGRCh37
Build 36482,337,300 - 82,337,602RGDNCBI36
Celera479,410,993 - 79,411,295RGD
Cytogenetic Map4q13.1-q21.1UniSTS
HuRef477,862,069 - 77,862,371UniSTS
TNG Radiation Hybrid Map448236.0UniSTS
SHGC-51635  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37482,057,183 - 82,057,274UniSTSGRCh37
Build 36482,276,207 - 82,276,298RGDNCBI36
Celera479,349,899 - 79,349,990RGD
Cytogenetic Map4q13.1-q21.1UniSTS
HuRef477,800,765 - 77,800,856UniSTS
TNG Radiation Hybrid Map448197.0UniSTS
AFM318ZC9  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37482,084,984 - 82,085,074UniSTSGRCh37
Build 36482,304,008 - 82,304,098RGDNCBI36
Celera479,377,700 - 79,377,790RGD
Cytogenetic Map4q13.1-q21.1UniSTS
HuRef477,828,566 - 77,828,656UniSTS
Whitehead-YAC Contig Map4 UniSTS
D4S1381  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37482,118,396 - 82,118,569UniSTSGRCh37
Build 36482,337,420 - 82,337,593RGDNCBI36
Celera479,411,113 - 79,411,286RGD
Cytogenetic Map4q13.1-q21.1UniSTS
HuRef477,862,189 - 77,862,362UniSTS
PRKG2__5583  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37482,009,750 - 82,010,653UniSTSGRCh37
Build 36482,228,774 - 82,229,677RGDNCBI36
Celera479,302,462 - 79,303,365RGD
HuRef477,753,314 - 77,754,217UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 138 3 42 33 84 13 3 19 25 4 4
Low 1746 473 423 95 291 22 2486 817 2729 195 990 810 84 619 1216 1
Below cutoff 520 2136 1044 354 1147 269 1505 1040 942 162 374 706 87 1 569 1276 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001282480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001282485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047415963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC139722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF508892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D70899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA462272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA569289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB455792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC348270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y16122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000264399   ⟹   ENSP00000264399
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl481,087,375 - 81,215,222 (-)Ensembl
RefSeq Acc Id: ENST00000395578   ⟹   ENSP00000378945
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl481,088,683 - 81,215,034 (-)Ensembl
RefSeq Acc Id: ENST00000456882
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl481,140,628 - 81,154,144 (-)Ensembl
RefSeq Acc Id: ENST00000509169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl481,089,493 - 81,154,157 (-)Ensembl
RefSeq Acc Id: ENST00000509474
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl481,089,597 - 81,154,253 (-)Ensembl
RefSeq Acc Id: ENST00000545647   ⟹   ENSP00000439967
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl481,087,370 - 81,153,732 (-)Ensembl
RefSeq Acc Id: ENST00000628926   ⟹   ENSP00000486129
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl481,089,429 - 81,215,064 (-)Ensembl
RefSeq Acc Id: NM_001282480   ⟹   NP_001269409
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,370 - 81,154,157 (-)NCBI
HuRef477,752,088 - 77,880,064 (-)NCBI
CHM1_1481,985,010 - 82,051,802 (-)NCBI
T2T-CHM13v2.0484,417,063 - 84,483,860 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282481   ⟹   NP_001269410
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,370 - 81,154,157 (-)NCBI
HuRef477,752,088 - 77,880,064 (-)NCBI
CHM1_1481,985,010 - 82,051,802 (-)NCBI
T2T-CHM13v2.0484,417,063 - 84,483,860 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282482   ⟹   NP_001269411
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,370 - 81,154,157 (-)NCBI
HuRef477,752,088 - 77,880,064 (-)NCBI
CHM1_1481,985,010 - 82,051,802 (-)NCBI
T2T-CHM13v2.0484,417,063 - 84,483,860 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282483   ⟹   NP_001269412
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,370 - 81,154,157 (-)NCBI
HuRef477,752,088 - 77,880,064 (-)NCBI
CHM1_1481,985,010 - 82,051,802 (-)NCBI
T2T-CHM13v2.0484,417,063 - 84,483,860 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001282485   ⟹   NP_001269414
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,375 - 81,215,222 (-)NCBI
HuRef477,752,088 - 77,880,064 (-)NCBI
CHM1_1481,985,010 - 82,112,762 (-)NCBI
T2T-CHM13v2.0484,417,068 - 84,544,924 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363401   ⟹   NP_001350330
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,375 - 81,215,222 (-)NCBI
T2T-CHM13v2.0484,417,068 - 84,544,924 (-)NCBI
Sequence:
RefSeq Acc Id: NM_006259   ⟹   NP_006250
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,375 - 81,215,222 (-)NCBI
GRCh37482,008,643 - 82,136,271 (-)NCBI
Build 36482,228,861 - 82,345,239 (-)NCBI Archive
HuRef477,752,088 - 77,880,064 (-)NCBI
CHM1_1481,985,010 - 82,112,762 (-)NCBI
T2T-CHM13v2.0484,417,068 - 84,544,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017008415   ⟹   XP_016863904
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,370 - 81,217,836 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017008416   ⟹   XP_016863905
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,370 - 81,215,651 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017008418   ⟹   XP_016863907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,140,584 - 81,205,060 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047415963   ⟹   XP_047271919
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38481,087,370 - 81,214,972 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_006250   ⟸   NM_006259
- Peptide Label: isoform a
- UniProtKB: O60916 (UniProtKB/Swiss-Prot),   Q13237 (UniProtKB/Swiss-Prot),   A0A140VJM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269414   ⟸   NM_001282485
- Peptide Label: isoform e
- UniProtKB: Q13237 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001269411   ⟸   NM_001282482
- Peptide Label: isoform c
- UniProtKB: Q13237 (UniProtKB/Swiss-Prot),   B7ZA25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269412   ⟸   NM_001282483
- Peptide Label: isoform d
- UniProtKB: Q13237 (UniProtKB/Swiss-Prot),   B7ZA25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269410   ⟸   NM_001282481
- Peptide Label: isoform b
- UniProtKB: Q13237 (UniProtKB/Swiss-Prot),   B4DLF9 (UniProtKB/TrEMBL),   B7ZA25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001269409   ⟸   NM_001282480
- Peptide Label: isoform b
- UniProtKB: Q13237 (UniProtKB/Swiss-Prot),   B7ZA25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016863904   ⟸   XM_017008415
- Peptide Label: isoform X1
- UniProtKB: O60916 (UniProtKB/Swiss-Prot),   A0A140VJM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016863905   ⟸   XM_017008416
- Peptide Label: isoform X1
- UniProtKB: O60916 (UniProtKB/Swiss-Prot),   A0A140VJM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016863907   ⟸   XM_017008418
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001350330   ⟸   NM_001363401
- Peptide Label: isoform a
- UniProtKB: O60916 (UniProtKB/Swiss-Prot),   A0A140VJM3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000439967   ⟸   ENST00000545647
RefSeq Acc Id: ENSP00000486129   ⟸   ENST00000628926
RefSeq Acc Id: ENSP00000378945   ⟸   ENST00000395578
RefSeq Acc Id: ENSP00000264399   ⟸   ENST00000264399
RefSeq Acc Id: XP_047271919   ⟸   XM_047415963
- Peptide Label: isoform X1
- UniProtKB: O60916 (UniProtKB/Swiss-Prot),   A0A140VJM3 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   Cyclic nucleotide-binding   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q13237-F1-model_v2 AlphaFold Q13237 1-762 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9416 AgrOrtholog
COSMIC PRKG2 COSMIC
Ensembl Genes ENSG00000138669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000264399 ENTREZGENE
  ENSP00000264399.1 UniProtKB/Swiss-Prot
  ENSP00000378945 ENTREZGENE
  ENSP00000378945.1 UniProtKB/Swiss-Prot
  ENSP00000439967 ENTREZGENE
  ENSP00000439967.1 UniProtKB/TrEMBL
  ENSP00000486129 ENTREZGENE
  ENSP00000486129.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000264399 ENTREZGENE
  ENST00000264399.6 UniProtKB/Swiss-Prot
  ENST00000395578 ENTREZGENE
  ENST00000395578.3 UniProtKB/Swiss-Prot
  ENST00000545647 ENTREZGENE
  ENST00000545647.5 UniProtKB/TrEMBL
  ENST00000628926 ENTREZGENE
  ENST00000628926.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000138669 GTEx
HGNC ID HGNC:9416 ENTREZGENE
Human Proteome Map PRKG2 Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cGMP_dep_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_cGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5593 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5593 ENTREZGENE
OMIM 601591 OMIM
  619636 OMIM
  619638 OMIM
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33778 PharmGKB
PIRSF cGMP-dep_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CGMPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJM3 ENTREZGENE, UniProtKB/TrEMBL
  B4DLF9 ENTREZGENE, UniProtKB/TrEMBL
  B7ZA25 ENTREZGENE, UniProtKB/TrEMBL
  KGP2_HUMAN UniProtKB/Swiss-Prot
  O60916 ENTREZGENE
  Q13237 ENTREZGENE
UniProt Secondary B4DMX3 UniProtKB/Swiss-Prot
  E7EPE6 UniProtKB/Swiss-Prot
  O00125 UniProtKB/Swiss-Prot
  O60916 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-24 PRKG2  protein kinase cGMP-dependent 2    protein kinase, cGMP-dependent, type II  Symbol and/or name change 5135510 APPROVED