Plau (plasminogen activator, urokinase) - Rat Genome Database

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Gene: Plau (plasminogen activator, urokinase) Mus musculus
Analyze
Symbol: Plau
Name: plasminogen activator, urokinase
RGD ID: 733174
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Part of serine-type endopeptidase complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; hepatocellular carcinoma; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: u; u-; u-PA; U-plasminogen activator; uPA; urokinase-type plasminogen activator
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,886,730 - 20,893,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,886,728 - 20,893,453 (+)EnsemblGRCm39 Ensembl
GRCm381420,836,662 - 20,843,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,836,660 - 20,843,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,655,884 - 21,662,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,625,259 - 19,631,940 (+)NCBIMGSCv36mm8
Celera1417,217,270 - 17,223,995 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (IAGP,IDA,ISO)
Alzheimer's disease 1  (ISO)
Angina Pectoris  (ISO)
anuria  (ISO)
appendicitis  (ISO)
Arterial Occlusive Diseases  (ISO)
Asthenozoospermia  (ISO)
asthma  (ISO)
atherosclerosis  (IMP,ISO)
Bone Neoplasms  (ISO)
brain edema  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
cerebrovascular disease  (ISO)
cholesterol embolism  (ISO)
Chronic Allograft Nephropathy  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colonic Neoplasms  (ISO)
Coronary Disease  (ISO)
Diabetic Nephropathies  (ISO)
Eczema  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (IMP)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
familial hyperlipidemia  (IEP)
Genitopatellar Syndrome  (ISO)
gliosarcoma  (IMP)
Graft Occlusion, Vascular  (ISO)
Heart Rupture, Post-Infarction  (ISO)
Hematuria  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (IAGP)
high grade glioma  (ISO)
Hirschsprung's disease  (ISO)
Hyperoxia  (ISO)
Hypotension  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (IMP,ISO)
intermediate coronary syndrome  (ISO)
intracranial aneurysm  (IDA)
Intracranial Embolism and Thrombosis  (ISO)
Intracranial Hemorrhages  (ISO)
ischemia  (IMP,ISO)
Jaw Cysts  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (IMP)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
meningitis  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephritis  (ISO)
Optic Nerve Injuries  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
papillary thyroid carcinoma  (ISO)
Peripheral Nerve Injuries  (ISO)
peritonitis  (ISO)
pleural empyema  (ISO)
prion disease  (IEP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (IMP,ISO)
Quebec platelet disorder  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (IDA,IMP)
Reperfusion Injury  (IDA,ISO)
rhinitis  (IEP)
sagittal sinus thrombosis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (IMP)
squamous cell carcinoma  (ISO)
status epilepticus  (IMP,ISO)
steatotic liver disease  (IAGP)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Strongylida Infections  (ISO)
Thromboembolism  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
urolithiasis  (ISO)
Venous Thrombosis  (ISO)
Ventricular Fibrillation  (ISO)
Viral Myocarditis  (IEP)
visual epilepsy  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,10-phenanthroline  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allyl isothiocyanate  (ISO)
alpha-D-galactose  (ISO)
alpha-Zearalanol  (ISO)
amiloride  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
andrographolide  (ISO)
anethole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
ATP  (EXP)
avobenzone  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benazepril  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbendazim  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
casticin  (EXP)
chlordecone  (EXP)
chloropicrin  (ISO)
choline  (EXP)
chrysin  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
Cytochalasin H  (ISO)
D-glucose  (ISO)
DDE  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
dieckol  (ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenamidone  (EXP)
flavonol  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
furan  (ISO)
galactose  (ISO)
gefitinib  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (ISO)
glucose  (ISO)
graphene oxide  (ISO)
heparin  (ISO)
Hispolon  (ISO)
hyaluronic acid  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
Licochalcone A  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lovastatin  (EXP)
LY294002  (ISO)
malathion  (ISO)
mangiferin  (ISO)
medroxyprogesterone acetate  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nonanedioic acid  (ISO)
notoginsenoside R1  (ISO)
oleanolic acid  (ISO)
ornidazole  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
PD 0325901  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
Phytolaccoside E  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
ryanodine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium hydroxide  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
succimer  (EXP,ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-anethole  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tubocurarine  (EXP)
ursolic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal acute phase protein level  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal cytokine level  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal facial skin morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal outer ear skin morphology  (IAGP)
abnormal perineum morphology  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal response to injury  (IAGP)
abnormal thrombosis  (IAGP)
abnormal trachea morphology  (IAGP)
abnormal tumor morphology  (IAGP)
aortic elastic tissue lesions  (IAGP)
cachexia  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cellular necrosis  (IAGP)
chronic inflammation  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased exploration in new environment  (IEA)
decreased grip strength  (IEA)
decreased inflammatory response  (IAGP)
decreased litter size  (IAGP)
decreased liver glycogen level  (IAGP)
decreased metastatic potential  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased response of heart to induced stress  (IAGP)
decreased susceptibility to atherosclerosis  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased T cell proliferation  (IAGP)
decreased total body fat amount  (IAGP)
decreased tumor growth/size  (IAGP)
embryonic lethality  (IAGP)
herniated seminal vesicle  (IAGP)
impaired granulocyte bactericidal activity  (IAGP)
impaired macrophage chemotaxis  (IAGP)
impaired neutrophil phagocytosis  (IAGP)
impaired skeletal muscle regeneration  (IAGP)
increased carcinoma incidence  (IAGP)
increased heart left ventricle muscle contractility  (IAGP)
increased inflammatory response  (IAGP)
increased lymphocyte cell number  (IAGP)
increased monocyte cell number  (IEA)
increased neutrophil cell number  (IEA)
increased susceptibility to fungal infection  (IAGP)
increased susceptibility to induced thrombosis  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
myopathy  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
pulmonary interstitial fibrosis  (IAGP)
rectal prolapse  (IAGP)
reduced fertility  (IAGP)
reduced thrombolysis  (IAGP)
respiratory distress  (IAGP)
trachea fibrosis  (IAGP)
trachea inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR). Aceves C, etal., Mol Cancer. 2009 Jun 6;8:33. doi: 10.1186/1476-4598-8-33.
2. Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Adhami F, etal., Am J Pathol. 2008 Jun;172(6):1704-16. Epub 2008 May 8.
3. Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease. Akhter H, etal., J Alzheimers Dis. 2011;26(4):767-78.
4. Association between urokinase haplotypes and outcome from infection-associated acute lung injury. Arcaroli J, etal., Intensive Care Med. 2008 Feb;34(2):300-7. Epub 2007 Nov 10.
5. Activators and inhibitors of the plasminogen system in Alzheimer's disease. Barker R, etal., J Cell Mol Med. 2012 Apr;16(4):865-76. doi: 10.1111/j.1582-4934.2011.01394.x.
6. Transcriptional activation of endothelial cells by TGFbeta coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury. Benton RL, etal., ASN Neuro. 2009 Aug 26;1(3). pii: e00015. doi: 10.1042/AN20090008.
7. Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. Bueno M, etal., J Gene Med. 2006 Nov;8(11):1291-9.
8. Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. Burk J, etal., Brain Res. 2008 Aug 21;1226:248-55. Epub 2008 Jun 16.
9. Both tissue-type plasminogen activator and urokinase prevent intraabdominal abscess formation after surgical treatment of peritonitis in the rat. Buyne OR, etal., Surgery. 2008 Jul;144(1):66-73. Epub 2008 May 21.
10. Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. Calenda G, etal., BJU Int. 2012 May;109(10):1552-64. doi: 10.1111/j.1464-410X.2011.10705.x. Epub 2012 Feb 2.
11. [Effects of Qinggan Huoxue Recipe and its separated recipes on urokinase-type plasminogen activator and plasminogen activator inhibitor-1 fibrinolytic system in rats with alcoholic liver fibrosis]. Chen JM, etal., Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):642-50. doi: 10.3736/jcim20090708.
12. Intravesical administration of plasminogen activator inhibitor type-1 inhibits in vivo bladder tumor invasion and progression. Chen SC, etal., J Urol. 2009 Jan;181(1):336-42. Epub 2008 Nov 17.
13. Neuroprotection by urokinase plasminogen activator in the hippocampus. Cho E, etal., Neurobiol Dis. 2012 Apr;46(1):215-24. Epub 2012 Jan 24.
14. Association between urokinase-plasminogen activator gene T4065C polymorphism and risk of mitral valve prolapse. Chou HT, etal., Int J Cardiol. 2004 Aug;96(2):165-70.
15. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Colmenero J, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Oct;297(4):G726-34. Epub 2009 Jul 23.
16. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Connolly BM, etal., Blood. 2010 Sep 2;116(9):1593-603. Epub 2010 May 13.
17. No replication of genetic association between candidate polymorphisms and Alzheimer's disease. Cousin E, etal., Neurobiol Aging. 2011 Aug;32(8):1443-51. Epub 2009 Nov 3.
18. Thrombus versus Wall Biological Activities in Experimental Aortic Aneurysms. Coutard M, etal., J Vasc Res. 2009 Dec 16;47(4):355-366.
19. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Cozen AE, etal., Circulation. 2004 May 4;109(17):2129-35. Epub 2004 Apr 19.
20. Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation. Cunningham O, etal., Glia. 2009 Dec;57(16):1802-14.
21. Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models. De Nardo CM, etal., Arthritis Res Ther. 2010;12(5):R199. Epub 2010 Oct 25.
22. Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. Diaz JA, etal., J Vasc Surg. 2012 Mar;55(3):815-22. Epub 2011 Nov 25.
23. Effect of dietary beta carotene on cerebral aneurysm and subarachnoid haemorrhage in the brain apo E-/- mice. Gopal K, etal., J Thromb Thrombolysis. 2011 Oct;32(3):343-55.
24. [Effect of amiloride on the pathology of a rat model of chronic obstructive pulmonary disease]. Han XD, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2007 May;30(5):363-7.
25. Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model. Hart DA, etal., Clin Invest Med. 1994 Apr;17(2):69-76.
26. Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-beta gene. Hasegawa Y, etal., Mol Ther. 2010 Oct;18(10):1778-86. doi: 10.1038/mt.2010.138. Epub 2010 Jul 6.
27. Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Heymans S, etal., Am J Pathol. 2005 Jan;166(1):15-25.
28. Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats. Ho TJ, etal., Eur J Appl Physiol. 2012 Aug;112(8):2943-55. doi: 10.1007/s00421-011-2270-z. Epub 2011 Dec 9.
29. Prognostic role of urokinase-type plasminogen activator in human gliomas. Hsu DW, etal., Am J Pathol. 1995 Jul;147(1):114-23.
30. Tissue-type plasminogen activator depletion affects the nasal mucosa matrix reconstruction in allergic rhinitis mice. Hua H, etal., Allergol Immunopathol (Madr). 2011 Jul-Aug;39(4):206-11. doi: 10.1016/j.aller.2010.09.010. Epub 2011 Feb 19.
31. Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity - clinical relevance and prognostic value. Hundsdorfer B, etal., J Craniomaxillofac Surg. 2005 Jun;33(3):191-6. Epub 2005 Apr 22.
32. Urokinase-type plasminogen activator system and human cationic antimicrobial protein 18 in serum and induced sputum of patients with chronic obstructive pulmonary disease. Jiang Y, etal., Respirology. 2010 Aug;15(6):939-46. Epub 2010 Jul 6.
33. Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. Joossens J, etal., J Med Chem. 2007 Dec 27;50(26):6638-46. Epub 2007 Dec 1.
34. Renal synthesis of urokinase type-plasminogen activator, its receptor, and plasminogen activator inhibitor-1 in diabetic nephropathy in rats: modulation by angiotensin-converting-enzyme inhibitor. Kenichi M, etal., J Lab Clin Med. 2004 Aug;144(2):69-77.
35. Localization of plasminogen activators in human colon cancer by immunoperoxidase staining. Kohga S, etal., Cancer Res. 1985 Apr;45(4):1787-96.
36. [Effects of acupoint-embedment of medicated-thread and acupoint-injection on expression of cortical urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in rats with cerebral ischemia-reperfusion injury]. Kong LH, etal., Zhen Ci Yan Jiu. 2010 Dec;35(6):409-14.
37. Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients. Kowal K, etal., Folia Histochem Cytobiol. 2008;46(2):193-8.
38. Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis. Lahtinen L, etal., Eur J Neurosci. 2006 Oct;24(7):1935-45. Epub 2006 Oct 16.
39. Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus. Lahtinen L, etal., Neurobiol Dis. 2010 Mar;37(3):692-703. Epub 2009 Dec 21.
40. Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus. Lahtinen L, etal., Neuroscience. 2009 Sep 29;163(1):316-28. Epub 2009 Jun 12.
41. Angiostrongylus cantonensis: induction of urokinase-type PA and degradation of type IV collagen in rat lung granulomatous fibrosis. Lan KP and Lai SC, Exp Parasitol. 2008 Apr;118(4):472-7. Epub 2007 Oct 22.
42. [Association of uPA and uPAR expression with invasive behaviors of urinary transitional cell carcinoma]. Li YJ, etal., Ai Zheng. 2004 Jun;23(6):704-6.
43. Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. Liu R, etal., J Pharmacol Exp Ther. 2010 Mar;332(3):1006-12. doi: 10.1124/jpet.109.160937. Epub 2009 Dec 1.
44. [Changes of u-PA and PAI-1 expression in the lung tissue of neonatal rats after inhaling high concentration oxygen] Liu XY and Xue XD, Zhonghua Er Ke Za Zhi. 2008 Jun;46(6):458-63.
45. [Correlation of the content and expression of urokinase plasminogen activator with asthenospermia in rat models]. Liu Y, etal., Zhonghua Nan Ke Xue. 2008 Sep;14(9):786-91.
46. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
47. Association of Urokinase Gene 3'-UTR T/C polymorphism with bladder cancer. Manchanda PK, etal., Urol Int. 2006;77(1):81-4.
48. Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice. Matsuo S, etal., Kidney Int. 2005 Jun;67(6):2221-38.
49. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
50. MGDs mouse GO annotations MGD data from the GO Consortium
51. MGD IEA MGD IEA
52. Elevation of urokinase-type plasminogen activator and its receptor densities as new predictors of disease progression and prognosis in men with prostate cancer. Miyake H, etal., Int J Oncol. 1999 Mar;14(3):535-41.
53. Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer. Miyake K, etal., Cancer Chemother Pharmacol. 2009 Oct;64(5):885-92. doi: 10.1007/s00280-009-0937-5. Epub 2009 Feb 12.
54. Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis. Nagata M, etal., Int J Cancer. 2003 Sep 20;106(5):683-9.
55. Immunohistochemical evidence of urokinase-type plasminogen activator in primary and metastatic tumors of pulmonary adenocarcinoma. Oka T, etal., Cancer Res. 1991 Jul 1;51(13):3522-5.
56. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
57. Association of urokinase gene 3'-UTR T/C polymorphism with calcium oxalate urolithiasis in children. Ozturk M, etal., Int Urol Nephrol. 2008;40(3):563-8. doi: 10.1007/s11255-008-9335-x. Epub 2008 Feb 1.
58. Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury. Patel TH, etal., Neurosci Lett. 2008 Oct 31;444(3):222-6. Epub 2008 Aug 13.
59. Identification of a novel biomarker signature associated with risk for bone metastasis in patients with renal cell carcinoma. Paule B, etal., Int J Biol Markers. 2010 Apr-Jun;25(2):112-5.
60. Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment. Pawlak K, etal., Am J Med Sci. 2010 Jan;339(1):5-9.
61. Urokinase-type plasminogen activator and metalloproteinase-2 are independently related to the carotid atherosclerosis in haemodialysis patients. Pawlak K, etal., Thromb Res. 2008;121(4):543-8. Epub 2007 Aug 15.
62. Effects of long-term erythropoietin therapy on fibrinolytic system in haemodialyzed patients. Pawlak K, etal., Thromb Res. 2008;121(6):787-91. Epub 2007 Sep 14.
63. Vascular endothelial growth factor and uPA/suPAR system in early and advanced chronic kidney disease patients: a new link between angiogenesis and hyperfibrinolysis? Pawlak K, etal., Transl Res. 2012 Nov;160(5):346-54. doi: 10.1016/j.trsl.2012.04.004. Epub 2012 May 8.
64. Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. Peng WH, etal., J Ethnopharmacol. 2010 Feb 17;127(3):606-13. Epub 2009 Dec 24.
65. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
66. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
67. Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy. Qin W, etal., BMC Cancer. 2012 Feb 1;12:52. doi: 10.1186/1471-2407-12-52.
68. Mouse MP Annotation Import Pipeline RGD automated import pipeline
69. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
70. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
71. Expression of urokinase plasminogen activator and its receptor during acute renal allograft rejection. Roelofs JJ, etal., Kidney Int. 2003 Nov;64(5):1845-53.
72. Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. Sanpool O, etal., Cytokine. 2010 Sep;51(3):294-7. Epub 2010 Jun 26.
73. Plasminogen activator promotes recovery following spinal cord injury. Seeds N, etal., Cell Mol Neurobiol. 2011 Aug;31(6):961-7. Epub 2011 May 14.
74. The expression of fibrinolytic components in chronic paranasal sinus disease. Sejima T, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):1-6.
75. Urokinase and its receptor in follicular and inflammatory cysts of the jaws. Serrati S, etal., Oral Dis. 2010 Nov;16(8):753-9. doi: 10.1111/j.1601-0825.2010.01679.x.
76. Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA. Shen JL, etal., Evid Based Complement Alternat Med. 2011;2011:378907. doi: 10.1155/2011/378907. Epub 2010 Dec 1.
77. Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer. Shih CM, etal., Clin Chim Acta. 2011 Jan 14;412(1-2):194-8. Epub 2010 Oct 16.
78. Inducible lung-specific urokinase expression reduces fibrosis and mortality after lung injury in mice. Sisson TH, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1023-32.
79. Differential regulation of urokinase-type plasminogen activator expression by fluid shear stress in human coronary artery endothelial cells. Sokabe T, etal., Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2027-34. Epub 2004 Jul 1.
80. Progress of tissue injury in appendicitis involves the serine proteases uPA and PAI-1. Solberg A, etal., Scand J Gastroenterol. 2009;44(5):579-84.
81. Components of the plasminogen activator system and their complexes in renal cell and bladder cancer: comparison between normal and matched cancerous tissues. Span PN, etal., BJU Int. 2008 Jul;102(2):177-82. doi: 10.1111/j.1464-410X.2008.07568.x. Epub 2008 Jul 1.
82. uPA, uPAR and TGFbeta(1) expression during early and late post myocardial infarction period in rat myocardium. Stavropoulou A, etal., In Vivo. 2010 Sep-Oct;24(5):647-52.
83. Evaluation of a pediatric protocol of intrapleural urokinase for pleural empyema: a prospective study. Stefanutti G, etal., Surgery. 2010 Sep;148(3):589-94. Epub 2010 Mar 20.
84. Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host. Szalay G, etal., Circ Res. 2009 Apr 10;104(7):851-9. doi: 10.1161/CIRCRESAHA.109.193805. Epub 2009 Feb 26.
85. Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. Thornton-Wells TA, etal., Genet Epidemiol. 2008 Apr;32(3):187-203.
86. Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. Tomasi S, etal., PLoS One. 2011;6(7):e21999. Epub 2011 Jul 14.
87. Urokinase gene transfer augments angiogenesis in ischemic skeletal and myocardial muscle. Traktuev DO, etal., Mol Ther. 2007 Nov;15(11):1939-46. Epub 2007 Jul 24.
88. Urokinase gene 3'-UTR T/C polymorphism is associated with oral cancer. Tsai MH, etal., J Clin Lab Anal. 2004;18(5):276-9.
89. In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval. Ulisse S, etal., Clin Endocrinol (Oxf). 2012 Nov;77(5):780-6. doi: 10.1111/j.1365-2265.2012.04465.x.
90. Increased stratum corneum serine protease activity in acute eczematous atopic skin. Voegeli R, etal., Br J Dermatol. 2009 Jul;161(1):70-7. Epub 2009 Mar 30.
91. Coexpression of Smad7 and UPA attenuates carbon tetrachloride-induced rat liver fibrosis. Wang B, etal., Med Sci Monit. 2012 Oct;18(10):BR394-401.
92. Inhaled unfractionated heparin improves abnormalities of alveolar coagulation, fibrinolysis and inflammation in endotoxemia-induced lung injury rats. Wang ZY, etal., Chin Med J (Engl). 2013 Jan;126(2):318-24.
93. [Effect of inhalation of aerosolized unfractioned heparin on peri alveolar coagulability and inflammatory response in endotoxin induced acute lung injury rat model]. Wang ZY, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Apr;23(4):239-42.
94. [Curative machanism of Shenle capsule on 5/6 nephrectomy rats]. Wei RB, etal., Zhongguo Zhong Yao Za Zhi. 2004 Aug;29(8):770-3.
95. Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. Wiersinga WJ, etal., J Immunol. 2010 Mar 15;184(6):3079-86. Epub 2010 Feb 8.
96. Association of putative functional variants in the PLAU gene and the PLAUR gene with myocardial infarction. Xu J, etal., Clin Sci (Lond). 2010 Jul 9;119(8):353-9.
97. [Effects of aerosolized earthworm fibrinolytic enzyme on bleomycin induced pulmonary fibrosis in rats]. Xue Y, etal., Zhonghua Yi Xue Za Zhi. 2012 Dec 25;92(48):3429-33.
98. Possible involvement of urokinase-type plasminogen activator release from human peripheral blood lymphocytes in the pathophysiology of chronic allograft nephropathy. Yamaguchi Y, etal., Transplant Proc. 2005 Dec;37(10):4276-81.
99. Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. Yang D, etal., J Neurosci. 2009 Jul 8;29(27):8669-74.
100. Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study. Yang KY, etal., Crit Care. 2011 Jan 10;15(1):R11.
101. The role and mechanism of the up-regulation of fibrinolytic activity in painful peripheral nerve injury. Yong N and Guoping C, Neurochem Res. 2009 Mar;34(3):587-92. Epub 2008 Aug 21.
102. A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis. Zhang G, etal., J Biol Chem. 2009 Oct 16;284(42):29050-64. doi: 10.1074/jbc.M109.010249. Epub 2009 Aug 18.
103. Evaluation of plasma urokinase-type plasminogen activator and urokinase-type plasminogen-activator receptor in patients with acute and chronic hepatitis B. Zhou H, etal., Thromb Res. 2009;123(3):537-42. Epub 2008 Aug 8.
104. Differential patterns of local gene regulation in crush lesions of the rat optic and sciatic nerve: relevance to posttraumatic regeneration. Zickler P, etal., Cell Physiol Biochem. 2010;26(3):483-94. Epub 2010 Aug 24.
Additional References at PubMed
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Genomics

Comparative Map Data
Plau
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,886,730 - 20,893,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,886,728 - 20,893,453 (+)EnsemblGRCm39 Ensembl
GRCm381420,836,662 - 20,843,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,836,660 - 20,843,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv371421,655,884 - 21,662,610 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361419,625,259 - 19,631,940 (+)NCBIMGSCv36mm8
Celera1417,217,270 - 17,223,995 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
PLAU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,909,164 - 73,917,494 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,909,177 - 73,917,496 (+)EnsemblGRCh38hg38GRCh38
GRCh371075,670,890 - 75,677,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361075,340,896 - 75,347,261 (+)NCBINCBI36Build 36hg18NCBI36
Build 341075,340,895 - 75,347,260NCBI
Celera1068,954,178 - 68,960,575 (+)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,665,797 - 69,672,195 (+)NCBIHuRef
CHM1_11075,952,624 - 75,959,021 (+)NCBICHM1_1
T2T-CHM13v2.01074,779,718 - 74,788,885 (+)NCBIT2T-CHM13v2.0
Plau
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,505,485 - 3,511,987 (-)NCBIGRCr8
mRatBN7.2153,456,230 - 3,462,732 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,456,232 - 3,462,775 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,466,414 - 3,472,916 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,852,895 - 4,859,397 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,465,220 - 3,471,722 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,644,296 - 3,650,765 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,644,769 - 3,650,819 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0153,621,057 - 3,627,467 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4153,680,072 - 3,686,232 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1153,680,073 - 3,686,275 (-)NCBI
Celera151,129,191 - 1,135,694 (+)NCBICelera
Cytogenetic Map15p16NCBI
Plau
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,994,537 - 18,000,209 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543717,995,726 - 18,000,542 (-)NCBIChiLan1.0ChiLan1.0
PLAU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2886,061,272 - 86,069,505 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11086,064,751 - 86,074,824 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01070,433,340 - 70,441,569 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11073,104,808 - 73,113,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1073,105,895 - 73,113,136 (+)Ensemblpanpan1.1panPan2
PLAU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1424,329,139 - 24,333,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl424,328,925 - 24,334,851 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha424,466,425 - 24,471,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0424,609,212 - 24,613,966 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl424,578,978 - 24,727,745 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1424,506,511 - 24,511,263 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,706,941 - 24,711,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0425,061,896 - 25,066,649 (+)NCBIUU_Cfam_GSD_1.0
Plau
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721356,745,370 - 56,751,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,238,093 - 5,243,877 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,238,128 - 5,243,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,629,299 - 76,635,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11476,629,313 - 76,635,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,755,642 - 82,761,502 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap14q24-q26NCBI
PLAU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,452,904 - 57,459,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl957,452,761 - 57,459,286 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,028,912 - 18,035,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plau
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247547,408,983 - 7,416,559 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247547,405,637 - 7,415,870 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plau
210 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:232
Interacting mature miRNAs:258
Transcripts:ENSMUST00000022368
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14127379943Mouse
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14126987934Mouse
4141265Appd2_mAPP associated premature death 2 (mouse)Not determined14594555230114862Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse

Markers in Region
X02389  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,842,740 - 20,842,924UniSTSGRCm38
MGSCv371421,661,962 - 21,662,146UniSTSGRCm37
Celera1417,223,347 - 17,223,531UniSTS
Cytogenetic Map14A3UniSTS
cM Map142.5UniSTS
Whitehead/MRC_RH1413.14UniSTS
Whitehead_YAC14 UniSTS
Plau  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,839,348 - 20,839,840UniSTSGRCm38
MGSCv371421,658,570 - 21,659,062UniSTSGRCm37
Celera1417,219,955 - 17,220,447UniSTS
Cytogenetic Map14A3UniSTS
cM Map142.5UniSTS
D14Nds1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,837,405 - 20,837,582UniSTSGRCm38
MGSCv371421,656,627 - 21,656,804UniSTSGRCm37
Celera1417,218,013 - 17,218,190UniSTS
Cytogenetic Map14A3UniSTS
cM Map142.5UniSTS
Plau  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14A3UniSTS
Plau  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,843,089 - 20,843,264UniSTSGRCm38
MGSCv371421,662,311 - 21,662,486UniSTSGRCm37
Celera1417,223,696 - 17,223,871UniSTS
Cytogenetic Map14A3UniSTS
cM Map142.5UniSTS
Plau  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,839,536 - 20,840,523UniSTSGRCm38
MGSCv371421,658,758 - 21,659,745UniSTSGRCm37
Celera1417,220,143 - 17,221,130UniSTS
Cytogenetic Map14A3UniSTS
cM Map142.5UniSTS
Plau  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,843,136 - 20,843,294UniSTSGRCm38
MGSCv371421,662,358 - 21,662,516UniSTSGRCm37
Celera1417,223,743 - 17,223,901UniSTS
Cytogenetic Map14A3UniSTS
cM Map142.5UniSTS
Plau  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,842,591 - 20,843,120UniSTSGRCm38
MGSCv371421,661,813 - 21,662,342UniSTSGRCm37
Celera1417,223,198 - 17,223,727UniSTS
Cytogenetic Map14A3UniSTS
X02389  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381420,842,564 - 20,842,677UniSTSGRCm38
MGSCv371421,661,786 - 21,661,899UniSTSGRCm37
Celera1417,223,171 - 17,223,284UniSTS
Cytogenetic Map14A3UniSTS
Whitehead/MRC_RH1413.14UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000022368   ⟹   ENSMUSP00000022368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1420,886,728 - 20,893,453 (+)Ensembl
GRCm38.p6 Ensembl1420,836,660 - 20,843,385 (+)Ensembl
Ensembl Acc Id: ENSMUST00000224141   ⟹   ENSMUSP00000153684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1420,886,792 - 20,892,587 (+)Ensembl
GRCm38.p6 Ensembl1420,836,724 - 20,842,519 (+)Ensembl
RefSeq Acc Id: NM_008873   ⟹   NP_032899
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391420,886,730 - 20,893,456 (+)NCBI
GRCm381420,836,662 - 20,843,388 (+)ENTREZGENE
MGSCv371421,655,884 - 21,662,610 (+)RGD
Celera1417,217,270 - 17,223,995 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017315919   ⟹   XP_017171408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391420,886,834 - 20,893,238 (+)NCBI
GRCm381420,836,757 - 20,843,170 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032899   ⟸   NM_008873
- Peptide Label: precursor
- UniProtKB: P06869 (UniProtKB/Swiss-Prot),   Q0VBA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171408   ⟸   XM_017315919
- Peptide Label: isoform X1
- UniProtKB: P06869 (UniProtKB/Swiss-Prot),   Q0VBA8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000153684   ⟸   ENSMUST00000224141
Ensembl Acc Id: ENSMUSP00000022368   ⟸   ENSMUST00000022368
Protein Domains
EGF-like   Kringle   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06869-F1-model_v2 AlphaFold P06869 1-433 view protein structure

Promoters
RGD ID:8681628
Promoter ID:EPDNEW_M18845
Type:multiple initiation site
Name:Plau_1
Description:Mus musculus plasminogen activator, urokinase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381420,836,662 - 20,836,722EPDNEW
RGD ID:6825275
Promoter ID:MM_KWN:15819
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_008873
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361421,655,709 - 21,656,209 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97611 AgrOrtholog
Ensembl Genes ENSMUSG00000021822 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022368 ENTREZGENE
  ENSMUST00000022368.4 UniProtKB/Swiss-Prot
  ENSMUST00000224141.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serine_Proteases_S1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18792 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97611 ENTREZGENE
NCBI Gene 18792 ENTREZGENE
PANTHER PTHR24264:SF38 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kringle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plau PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286YE40_MOUSE UniProtKB/TrEMBL
  P06869 ENTREZGENE
  Q0VBA8 ENTREZGENE, UniProtKB/TrEMBL
  Q8C6L2_MOUSE UniProtKB/TrEMBL
  UROK_MOUSE UniProtKB/Swiss-Prot