Fgfr3 (fibroblast growth factor receptor 3) - Rat Genome Database

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Gene: Fgfr3 (fibroblast growth factor receptor 3) Mus musculus
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Symbol: Fgfr3
Name: fibroblast growth factor receptor 3
RGD ID: 733045
MGI Page MGI
Description: Enables fibroblast growth factor receptor activity and miRNA binding activity. Involved in several processes, including bone development; post-anal tail morphogenesis; and response to sodium phosphate. Acts upstream of or within several processes, including epithelial cell differentiation; negative regulation of cell differentiation; and nervous system development. Located in cytoplasmic side of plasma membrane; lysosome; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skeleton. Used to study Muenke Syndrome; achondroplasia; hypochondroplasia; scoliosis; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD333; Fgfr-; Fgfr-3; Flg-2; FR3; HBGF; HBGFR; heparin-binding growth factor receptor; Mfr3; sa; sam3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Fgfr3-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,879,068 - 33,894,412 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,879,018 - 33,894,412 (+)EnsemblGRCm39 Ensembl
GRCm38533,721,724 - 33,737,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,721,674 - 33,737,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,064,373 - 34,079,713 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,038,581 - 34,053,924 (+)NCBIMGSCv36mm8
Celera531,197,840 - 31,213,180 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46, XY Disorders of Sex Development  (ISO)
absence epilepsy  (ISO)
acanthosis nigricans  (ISO)
achondroplasia  (IAGP,ISO)
Achondroplastic Dwarfism  (ISO)
acrocephalosyndactylia  (ISO)
asphyxiating thoracic dystrophy  (ISO)
autism spectrum disorder  (ISO)
autosomal dominant disease  (IAGP)
bladder urothelial carcinoma  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
camptodactyly-tall stature-scoliosis-hearing loss syndrome  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
cervix carcinoma  (ISO)
cherubism  (ISO)
chondrosarcoma  (ISO)
chronic myeloid leukemia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
connective tissue disease  (ISO)
craniosynostosis  (ISO)
craniosynostosis 3  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (ISO)
Crouzon syndrome-acanthosis nigricans syndrome  (ISO)
demyelinating disease  (IEP)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
Dwarfism  (IMP,ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
epilepsy  (ISO)
Facial Asymmetry  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
Hamartoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
Hodgkin's lymphoma  (ISO)
hypochondroplasia  (IAGP,ISO)
Knee Osteoarthritis  (IMP)
lacrimoauriculodentodigital syndrome 1  (ISO)
lacrimoauriculodentodigital syndrome 2  (ISO)
LADD syndrome  (ISO)
Larsen syndrome  (ISO)
lung squamous cell carcinoma  (ISO)
Merkel cell carcinoma  (ISO)
Muenke syndrome  (IAGP,ISO)
multiple myeloma  (ISO)
Nervous System Malformations  (ISO)
neuroblastoma  (ISO)
oral squamous cell carcinoma  (ISO)
osteochondrodysplasia  (ISO)
papillomavirus infectious disease  (ISO)
Paraproteinemias  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
plasma cell neoplasm  (ISO)
SADDAN  (ISO)
Saethre-Chotzen syndrome  (ISO)
sarcoma  (ISO)
scoliosis  (IAGP)
seborrheic keratosis  (ISO)
seminoma  (ISO)
spermatocytoma  (ISO)
syndromic microphthalmia 5  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
thanatophoric dysplasia  (IAGP,IMP,ISO)
Thanatophoric Dysplasia, Type I  (ISO)
Thanatophoric Dysplasia, Type II  (ISO)
tongue cancer  (ISO)
tonsil squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antimonite  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chlorthalidone  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dimercaprol  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
Evodiamine  (ISO)
fenamidone  (EXP)
FR900359  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
Glabrene  (ISO)
gossypol  (ISO)
heparan sulfate  (EXP)
heparin  (EXP)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
inulin  (EXP)
isobutanol  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketamine  (ISO)
kojic acid  (ISO)
lead(0)  (ISO)
lenalidomide  (ISO)
Licochalcone B  (ISO)
maneb  (EXP)
masitinib  (ISO)
metacetamol  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
nitrofen  (EXP,ISO)
ozone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
PD173074  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pomalidomide  (ISO)
ponatinib  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (EXP)
retinyl acetate  (EXP)
SB 431542  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triacsin C  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (IGI)
astrocyte differentiation  (IMP)
axonogenesis involved in innervation  (IMP)
bone development  (IMP)
bone maturation  (IMP)
bone mineralization  (IMP)
bone morphogenesis  (IMP)
bone trabecula morphogenesis  (IMP)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
calcium ion homeostasis  (IGI)
cartilage development  (IMP)
cell population proliferation  (IGI,IMP)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
cell surface receptor signaling pathway via JAK-STAT  (ISO)
cell-cell signaling  (ISO)
central nervous system myelination  (IMP)
chromatin remodeling  (IEA)
cochlea development  (IMP)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
digestive tract morphogenesis  (IMP)
endothelial cell proliferation  (IMP)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
epithelial cell fate commitment  (IMP)
epithelial cell proliferation  (IGI,IMP)
ERK1 and ERK2 cascade  (IMP)
fibroblast growth factor receptor apoptotic signaling pathway  (ISO,ISS)
fibroblast growth factor receptor signaling pathway  (IDA,IGI,ISO,ISS)
forebrain development  (IMP)
hepatocyte growth factor receptor signaling pathway  (IEA)
inner ear auditory receptor cell differentiation  (IGI,IMP)
inner ear development  (IMP)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
lens fiber cell development  (IGI)
lens morphogenesis in camera-type eye  (IMP)
macrophage colony-stimulating factor signaling pathway  (IEA)
MAPK cascade  (IMP)
mitotic nuclear division  (IGI)
morphogenesis of an epithelium  (IMP)
negative regulation of astrocyte differentiation  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of developmental growth  (IMP)
negative regulation of epithelial cell proliferation  (IGI,IMP,ISO)
negative regulation of gene expression  (IMP)
negative regulation of inner ear auditory receptor cell differentiation  (IMP)
negative regulation of mitotic nuclear division  (IGI)
negative regulation of neuroblast proliferation  (IMP)
negative regulation of smoothened signaling pathway  (IMP)
negative regulation of transcription by RNA polymerase II  (IMP)
neuroblast proliferation  (IMP)
neuroepithelial cell differentiation  (IMP)
neuron apoptotic process  (IMP)
oligodendrocyte development  (IMP)
p38MAPK cascade  (IMP)
peptidyl-tyrosine phosphorylation  (IDA)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of bone mineralization  (IMP)
positive regulation of canonical Wnt signaling pathway  (IMP)
positive regulation of cell differentiation  (TAS)
positive regulation of cell population proliferation  (IGI,ISO,ISS)
positive regulation of cell proliferation in bone marrow  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO,ISS)
positive regulation of MAPK cascade  (IBA,IDA,IMP,ISO,ISS)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (IGI)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of phospholipase activity  (ISO,ISS)
positive regulation of protein ubiquitination  (IDA)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO,ISS)
post-anal tail morphogenesis  (IMP)
protein ubiquitination  (IDA)
regulation of bone remodeling  (IMP)
regulation of collagen metabolic process  (IMP)
regulation of ossification  (IMP)
regulation of osteoclast differentiation  (IMP)
response to axon injury  (IMP)
response to sodium phosphate  (IDA,IGI)
somatic stem cell population maintenance  (IMP)
substantia nigra development  (IMP)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal annulus fibrosus morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal chondrocyte differentiation  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal chondrocyte physiology  (IAGP)
abnormal chondrocyte proliferation  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear OHC efferent innervation pattern  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal compact bone lamellar structure  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal costal cartilage morphology  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal Deiters cell morphology  (IAGP)
abnormal endochondral bone ossification  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal foramen magnum morphology  (IAGP)
abnormal gait  (IAGP)
abnormal head size  (IAGP)
abnormal humerus morphology  (IAGP)
abnormal hyaline cartilage morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal intervertebral disk morphology  (IAGP)
abnormal intramembranous bone ossification  (IAGP)
abnormal lambdoid suture morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal long bone epiphyseal ossification zone morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone epiphysis morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone metaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal maxillary zygomatic process morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal occipital bone morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal organ of Corti supporting cell differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal palatine bone horizontal plate morphology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal patterning of the organ of Corti  (IAGP)
abnormal pillar cell differentiation  (IAGP)
abnormal pillar cell morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal premaxilla morphology  (IAGP)
abnormal pulmonary elastic fiber morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal snout morphology  (IAGP)
abnormal spine curvature  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal synchondrosis  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tail position or orientation  (IEA)
abnormal temporal bone morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal thoracic cage shape  (IAGP)
abnormal thoracic vertebrae morphology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal ulna morphology  (IAGP)
abnormal urinary bladder urothelium morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral body morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal vertebral epiphyseal plate morphology  (IAGP)
abnormal zygomatic bone morphology  (IAGP)
absent gastric milk in neonates  (IAGP)
absent jugum limitans  (IAGP)
absent pillar cells  (IAGP)
absent pulmonary alveoli  (IAGP)
absent telencephalon  (IAGP)
absent tunnel of Corti  (IAGP)
bowed femur  (IAGP)
bowed fibula  (IAGP)
bowed humerus  (IAGP)
bowed radius  (IAGP)
bowed tibia  (IAGP)
bowed ulna  (IAGP)
deafness  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineral density of femur  (IAGP)
decreased bone mineral density of vertebrae  (IAGP)
decreased bone stiffness  (IAGP)
decreased bone strength  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone volume  (IAGP)
decreased chondrocyte number  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased compact bone thickness  (IAGP)
decreased cranium height  (IAGP)
decreased cranium length  (IAGP)
decreased energy dissipated prior to femur fracture  (IAGP)
decreased femur compact bone thickness  (IAGP)
decreased femur maximal load  (IAGP)
decreased femur yield load  (IAGP)
decreased length of long bones  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased organ/body region tumor incidence  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased vertebra maximal load  (IAGP)
decreased vertebra stiffness  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
dehydration  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
disorganized long bone epiphyseal plate  (IAGP)
disproportionate dwarf  (IAGP)
domed cranium  (IAGP)
elongated vertebral body  (IAGP)
emphysema  (IAGP)
enhanced osteoblast differentiation  (IAGP)
enlarged interparietal bone  (IAGP)
enlarged vertebral body  (IAGP)
failure of sternum ossification  (IAGP)
foramen magnum stenosis  (IAGP)
fragile skeleton  (IAGP)
impaired hearing  (IAGP)
impaired lung alveolus development  (IAGP)
increased bone ossification  (IAGP)
increased bone trabecular spacing  (IAGP)
increased cell death  (IAGP)
increased chondrocyte proliferation  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased compact bone thickness  (IAGP)
increased compact bone volume  (IAGP)
increased cranium width  (IAGP)
increased Deiters cell number  (IAGP)
increased diameter of femur  (IAGP)
increased diameter of long bones  (IAGP)
increased fibroblast proliferation  (IAGP)
increased hyoid bone size  (IAGP)
increased long bone epiphyseal plate size  (IAGP)
increased lung tumor incidence  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased osteoclast cell number  (IAGP)
increased skin papilloma incidence  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
infertility  (IAGP)
kinked tail  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
large femur head  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
long femur  (IAGP)
long humerus  (IAGP)
long incisors  (IAGP)
long limbs  (IAGP)
long radius  (IAGP)
long tail  (IAGP)
long tibia  (IAGP)
long ulna  (IAGP)
male infertility  (IAGP)
malocclusion  (IAGP)
maxillary retrognathia  (IAGP)
megacephaly  (IAGP)
midface hypoplasia  (IAGP)
misaligned incisors  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature cranial synchondrosis closure  (IAGP)
premature craniofacial suture closure  (IAGP)
premature death  (IAGP)
premature endochondral bone ossification  (IAGP)
premature metopic suture closure  (IAGP)
premature sphenooccipital synchondrosis closure  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prognathia  (IAGP)
reduced female fertility  (IAGP)
respiratory distress  (IAGP)
rhizomelic limb  (IAGP)
round head  (IAGP)
scoliosis  (IAGP)
sensorineural hearing loss  (IAGP)
short basicranium  (IAGP)
short femur  (IAGP)
short frontal bone  (IAGP)
short humerus  (IAGP)
short limbs  (IAGP)
short lumbar vertebrae  (IAGP)
short nasal bone  (IAGP)
short radius  (IAGP)
short ribs  (IAGP)
short snout  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
short vertebral body  (IAGP)
short vertebral column  (IAGP)
small caudal vertebrae  (IAGP)
small interparietal bone  (IAGP)
small occipital bone  (IAGP)
small presphenoid bone  (IAGP)
small snout  (IAGP)
small thoracic cage  (IAGP)
small thoracic cavity  (IAGP)
small vertebrae  (IAGP)
synostosis  (IAGP)
thin frontal bone  (IAGP)
thin parietal bone  (IAGP)
vertebral compression  (IAGP)
wavy tail  (IAGP)
wide sternum  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur. Barbisan F, etal., Cancer. 2008 Feb 1;112(3):636-44.
2. Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. Bellus GA, etal., Am J Med Genet. 1999 Jul 2;85(1):53-65.
3. Overexpression of FGFR3 in HPV-positive Tonsillar and Base of Tongue Cancer Is Correlated to Outcome. Bersani C, etal., Anticancer Res. 2018 Aug;38(8):4683-4690. doi: 10.21873/anticanres.12774.
4. Prediction of Progression of Non-Muscle-Invasive Bladder Cancer by WHO 1973 and 2004 Grading and by FGFR3 Mutation Status: A Prospective Study. Burger M, etal., Eur Urol. 2008 Oct;54(4):835-44. Epub 2007 Dec 26.
5. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Cappellen D, etal., Nat Genet. 1999 Sep;23(1):18-20.
6. Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene? Castro-Feijoo L, etal., Eur J Endocrinol. 2008 Sep;159(3):243-9. doi: 10.1530/EJE-08-0393. Epub 2008 Jun 26.
7. A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Chen L, etal., Hum Mol Genet. 2001 Mar 1;10(5):457-65.
8. Abnormal FGFR 3 expression in cartilage of thanatophoric dysplasia fetuses. Delezoide AL, etal., Hum Mol Genet. 1997 Oct;6(11):1899-906.
9. Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Dvorak P, etal., Leukemia. 2003 Dec;17(12):2418-25. doi: 10.1038/sj.leu.2403152.
10. Human papillomavirus and the landscape of secondary genetic alterations in oral cancers. Gillison ML, etal., Genome Res. 2019 Jan;29(1):1-17. doi: 10.1101/gr.241141.118. Epub 2018 Dec 18.
11. Expression of FGFR3 Protein and Gene Amplification in Urinary Bladder Lesions in Relation to Schistosomiasis. Hammam O, etal., Open Access Maced J Med Sci. 2017 Apr 8;5(2):160-166. doi: 10.3889/oamjms.2017.048. eCollection 2017 Apr 15.
12. Fibroblast growth factor receptor 3 mutations in bladder tumors correlate with low frequency of chromosome alterations. Junker K, etal., Neoplasia. 2008 Jan;10(1):1-7.
13. Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. Martinez-Torrecuadrada JL, etal., Mol Cancer Ther. 2008 Apr;7(4):862-73.
14. Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene. Matsushita M, etal., Endocrinology. 2015 Feb;156(2):548-54. doi: 10.1210/en.2014-1914. Epub 2014 Dec 2.
15. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. Messersmith DJ, etal., J Neurosci Res. 2000 Oct 15;62(2):241-56.
16. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Meyers GA, etal., Nat Genet. 1995 Dec;11(4):462-4.
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. New Zealand Maori family with the pro250arg fibroblast growth factor receptor 3 mutation associated with craniosynostosis. Moko SB and Blandin de Chalain TM, J Craniomaxillofac Surg. 2001 Feb;29(1):22-4.
20. Indian hedgehog signaling pathway differences between swarm rat chondrosarcoma and native rat chondrocytes. Oji GS, etal., Iowa Orthop J. 2007;27:9-16.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Rousseau F, etal., Nature. 1994 Sep 15;371(6494):252-4.
27. Prenatal diagnosis of thanatophoric dysplasia by mutational analysis of the fibroblast growth factor receptor 3 gene and a proposed correction of previously published PCR results. Sawai H, etal., Prenat Diagn. 1999 Jan;19(1):21-4.
28. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Seiwert TY, etal., Clin Cancer Res. 2015 Feb 1;21(3):632-41. doi: 10.1158/1078-0432.CCR-13-3310. Epub 2014 Jul 23.
29. Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas. Shotelersuk V, etal., Oncol Rep. 2001 Nov-Dec;8(6):1301-4. doi: 10.3892/or.8.6.1301.
30. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Sibley K, etal., Oncogene. 2001 Feb 8;20(6):686-91.
31. Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours. Sibley K, etal., Oncogene. 2001 Jul 19;20(32):4416-8.
32. Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice. Tang J, etal., Arthritis Rheumatol. 2016 Oct;68(10):2432-43. doi: 10.1002/art.39739.
33. Aberrant expression of ALK and EZH2 in Merkel cell carcinoma. Veija T, etal., BMC Cancer. 2017 Mar 31;17(1):236. doi: 10.1186/s12885-017-3233-5.
34. Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancer. Zammit C, etal., J Pathol. 2001 May;194(1):27-34.
Additional References at PubMed
PMID:1379594   PMID:1648703   PMID:7512569   PMID:7670477   PMID:7670492   PMID:7919654   PMID:7959747   PMID:8083748   PMID:8375495   PMID:8382556   PMID:8432397   PMID:8521822  
PMID:8585128   PMID:8586414   PMID:8601314   PMID:8619928   PMID:8630492   PMID:8640234   PMID:8883961   PMID:8889548   PMID:8889551   PMID:8901049   PMID:8959336   PMID:9010207  
PMID:9013630   PMID:9032024   PMID:9069288   PMID:9073074   PMID:9090377   PMID:9124710   PMID:9126476   PMID:9136983   PMID:9286594   PMID:9300656   PMID:9385055   PMID:9585583  
PMID:9664689   PMID:9716527   PMID:9771645   PMID:9811582   PMID:9859898   PMID:9887329   PMID:10200283   PMID:10341082   PMID:10349636   PMID:10366448   PMID:10545953   PMID:10571691  
PMID:10572038   PMID:10572046   PMID:10587515   PMID:10607835   PMID:10704861   PMID:10751173   PMID:10843805   PMID:10861287   PMID:11042159   PMID:11071758   PMID:11076861   PMID:11114734  
PMID:11134040   PMID:11152656   PMID:11165488   PMID:11217851   PMID:11285272   PMID:11290300   PMID:11325814   PMID:11331379   PMID:11335076   PMID:11406607   PMID:11566361   PMID:11566859  
PMID:11585811   PMID:11597144   PMID:11698278   PMID:11702786   PMID:11731698   PMID:11739261   PMID:11742142   PMID:11827956   PMID:11937494   PMID:12000792   PMID:12194867   PMID:12203718  
PMID:12361972   PMID:12393593   PMID:12417662   PMID:12421703   PMID:12421715   PMID:12441294   PMID:12460940   PMID:12466851   PMID:12477932   PMID:12514106   PMID:12571102   PMID:12574417  
PMID:12642494   PMID:12644244   PMID:12666204   PMID:12737212   PMID:12821644   PMID:12842915   PMID:12872126   PMID:12917109   PMID:12960068   PMID:12966031   PMID:12966207   PMID:14517998  
PMID:14522949   PMID:14602678   PMID:14681299   PMID:14681479   PMID:14699054   PMID:14751559   PMID:14871928   PMID:14962737   PMID:14964469   PMID:14993235   PMID:15039943   PMID:15108315  
PMID:15132997   PMID:15177029   PMID:15201220   PMID:15226823   PMID:15229180   PMID:15240797   PMID:15292251   PMID:15329346   PMID:15340846   PMID:15470137   PMID:15543141   PMID:15680361  
PMID:15690367   PMID:15708559   PMID:15713743   PMID:15772091   PMID:15781473   PMID:15784730   PMID:15809037   PMID:15830353   PMID:15963767   PMID:15987787   PMID:16009496   PMID:16049112  
PMID:16079159   PMID:16123981   PMID:16141072   PMID:16141073   PMID:16151852   PMID:16172976   PMID:16284117   PMID:16284245   PMID:16291796   PMID:16291864   PMID:16309667   PMID:16436388  
PMID:16476447   PMID:16504022   PMID:16537572   PMID:16602821   PMID:16624844   PMID:16772167   PMID:16801131   PMID:16818446   PMID:16900517   PMID:16962305   PMID:16972271   PMID:16989989  
PMID:17117437   PMID:17150206   PMID:17181553   PMID:17192470   PMID:17196193   PMID:17234579   PMID:17304337   PMID:17360456   PMID:17555714   PMID:17557302   PMID:17634195   PMID:17660199  
PMID:17687036   PMID:17957151   PMID:18061568   PMID:18165280   PMID:18187602   PMID:18286540   PMID:18455718   PMID:18524904   PMID:18566132   PMID:18577465   PMID:18625063   PMID:18652815  
PMID:18653561   PMID:18725516   PMID:18753255   PMID:18776942   PMID:18789890   PMID:18818193   PMID:18832069   PMID:18923003   PMID:19073250   PMID:19086028   PMID:19192266   PMID:19218784  
PMID:19219044   PMID:19223461   PMID:19224984   PMID:19232523   PMID:19233265   PMID:19363220   PMID:19375967   PMID:19383940   PMID:19389367   PMID:19389374   PMID:19407216   PMID:19515808  
PMID:19544582   PMID:19723505   PMID:19728793   PMID:19762422   PMID:19815519   PMID:19838179   PMID:19966287   PMID:20046871   PMID:20053668   PMID:20081193   PMID:20093646   PMID:20111592  
PMID:20131355   PMID:20200945   PMID:20237272   PMID:20348033   PMID:20386946   PMID:20405041   PMID:20530870   PMID:20553372   PMID:20582225   PMID:20673820   PMID:20713021   PMID:20833365  
PMID:20847738   PMID:20920500   PMID:20934536   PMID:21074523   PMID:21139072   PMID:21172336   PMID:21223962   PMID:21267068   PMID:21451043   PMID:21487019   PMID:21491541   PMID:21494559  
PMID:21504907   PMID:21513905   PMID:21518438   PMID:21561999   PMID:21571225   PMID:21633168   PMID:21655085   PMID:21674058   PMID:21731673   PMID:21784065   PMID:21873635   PMID:21876757  
PMID:21911092   PMID:22016144   PMID:22031906   PMID:22071102   PMID:22072392   PMID:22076636   PMID:22110055   PMID:22155508   PMID:22206015   PMID:22232070   PMID:22235033   PMID:22235191  
PMID:22328578   PMID:22360967   PMID:22366163   PMID:22367969   PMID:22622662   PMID:22632802   PMID:22634226   PMID:22843502   PMID:22872265   PMID:22889265   PMID:22916278   PMID:23014564  
PMID:23026747   PMID:23047985   PMID:23147113   PMID:23185502   PMID:23200862   PMID:23223237   PMID:23267415   PMID:23431145   PMID:23523568   PMID:23536097   PMID:23592779   PMID:23696738  
PMID:23850221   PMID:23867472   PMID:23946445   PMID:24026051   PMID:24048522   PMID:24115909   PMID:24145799   PMID:24161523   PMID:24198358   PMID:24349082   PMID:24419316   PMID:24470103  
PMID:24519156   PMID:24657641   PMID:24796693   PMID:24824078   PMID:24859004   PMID:24887312   PMID:24930703   PMID:24952961   PMID:24983448   PMID:25002516   PMID:25285789   PMID:25432534  
PMID:25446537   PMID:25467980   PMID:25533675   PMID:25600960   PMID:25852647   PMID:25859222   PMID:25916825   PMID:25936505   PMID:26091072   PMID:26116392   PMID:26134413   PMID:26180198  
PMID:26238783   PMID:26311466   PMID:26453795   PMID:26595272   PMID:26745185   PMID:26764350   PMID:26906157   PMID:26990430   PMID:27041063   PMID:27046834   PMID:27064282   PMID:27078042  
PMID:27133954   PMID:27157475   PMID:27206683   PMID:27260401   PMID:27489502   PMID:27506979   PMID:27729453   PMID:27732085   PMID:27806288   PMID:28009287   PMID:28027321   PMID:28094278  
PMID:28169396   PMID:28230213   PMID:28336912   PMID:28389228   PMID:28465335   PMID:28467822   PMID:28483978   PMID:28520086   PMID:28802681   PMID:28924384   PMID:28938467   PMID:29040558  
PMID:29097598   PMID:29104492   PMID:29122839   PMID:29132503   PMID:29184127   PMID:29323153   PMID:29342370   PMID:29360039   PMID:29472441   PMID:29513653   PMID:29545125   PMID:29718910  
PMID:29720668   PMID:30043421   PMID:30086379   PMID:30202094   PMID:30352686   PMID:30418981   PMID:30561639   PMID:30763178   PMID:30782830   PMID:30889310   PMID:30980466   PMID:31073041  
PMID:31175212   PMID:31189094   PMID:31613912   PMID:31662319   PMID:31830366   PMID:32002646   PMID:32060985   PMID:32127497   PMID:32858001   PMID:32916123   PMID:32966879   PMID:33116259  
PMID:33141892   PMID:33246055   PMID:33370388   PMID:33433858   PMID:33580754   PMID:33637561   PMID:33737326   PMID:33784257   PMID:34282140   PMID:34292881   PMID:34321664   PMID:34321999  
PMID:34331943   PMID:34929174   PMID:35175194   PMID:35254402   PMID:36069912   PMID:36542062   PMID:36599929   PMID:36913092   PMID:37096042   PMID:37279265   PMID:37296099   PMID:37345656  
PMID:37462502   PMID:37541847   PMID:38056728   PMID:38466355   PMID:38498715   PMID:38951140   PMID:39012257  


Genomics

Comparative Map Data
Fgfr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,879,068 - 33,894,412 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,879,018 - 33,894,412 (+)EnsemblGRCm39 Ensembl
GRCm38533,721,724 - 33,737,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,721,674 - 33,737,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,064,373 - 34,079,713 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,038,581 - 34,053,924 (+)NCBIMGSCv36mm8
Celera531,197,840 - 31,213,180 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
FGFR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,793,293 - 1,808,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,793,293 - 1,808,872 (+)EnsemblGRCh38hg38GRCh38
GRCh3741,795,020 - 1,810,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,765,421 - 1,780,396 (+)NCBINCBI36Build 36hg18NCBI36
Build 3441,762,853 - 1,777,829NCBI
Celera41,707,555 - 1,723,113 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,725,137 - 1,753,471 (+)NCBIHuRef
CHM1_141,792,977 - 1,808,551 (+)NCBICHM1_1
T2T-CHM13v2.041,791,772 - 1,807,344 (+)NCBIT2T-CHM13v2.0
Fgfr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,211,800 - 81,227,215 (-)NCBIGRCr8
mRatBN7.21476,987,242 - 77,002,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,987,993 - 77,003,341 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,439,608 - 81,454,998 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,680,217 - 82,695,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01479,125,523 - 79,140,901 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,272,322 - 82,287,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,273,070 - 82,287,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,961,882 - 82,977,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,683,191 - 82,697,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,685,581 - 82,699,620 (-)NCBI
Celera1475,911,344 - 75,925,631 (-)NCBICelera
Cytogenetic Map14q21NCBI
Fgfr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,030,244 - 1,038,590 (+)NCBIChiLan1.0ChiLan1.0
FGFR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,123,500 - 2,139,072 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,060,383 - 2,075,946 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,933,172 - 1,948,742 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,843,780 - 1,858,635 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,843,774 - 1,861,692 (+)Ensemblpanpan1.1panPan2
FGFR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,309,128 - 62,318,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,303,756 - 62,323,896 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,826,871 - 64,841,704 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,784,572 - 62,799,405 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,783,114 - 62,800,195 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,278,095 - 62,292,924 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,481,623 - 62,496,456 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,840,834 - 62,855,656 (-)NCBIUU_Cfam_GSD_1.0
Fgfr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,890,080 - 67,904,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,591,792 - 21,606,296 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,591,772 - 21,606,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8879,159 - 894,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18879,151 - 894,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28336,714 - 341,509 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,958,444 - 46,974,032 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,957,254 - 46,973,392 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,334,868 - 3,350,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgfr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,635,165 - 25,646,932 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,633,690 - 25,647,361 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgfr3
524 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4867
Count of miRNA genes:745
Interacting mature miRNAs:949
Transcripts:ENSMUST00000067150, ENSMUST00000087820, ENSMUST00000114411, ENSMUST00000132724, ENSMUST00000134610, ENSMUST00000142860, ENSMUST00000152661, ENSMUST00000155002, ENSMUST00000164207, ENSMUST00000169212, ENSMUST00000171509, ENSMUST00000181298
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse

Markers in Region
M81342  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38533,736,839 - 33,736,976UniSTSGRCm38
MGSCv37534,079,488 - 34,079,625UniSTSGRCm37
Celera531,212,955 - 31,213,092UniSTS
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
Whitehead/MRC_RH5444.39UniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38533,733,699 - 33,733,902UniSTSGRCm38
MGSCv37534,066,164 - 34,066,317UniSTSGRCm37
MGSCv37534,072,686 - 34,074,049UniSTSGRCm37
Celera531,209,815 - 31,210,018UniSTS
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
cM Map520.0UniSTS
PMC156609P5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38533,734,599 - 33,734,897UniSTSGRCm38
MGSCv37534,077,248 - 34,077,546UniSTSGRCm37
Celera531,210,715 - 31,211,013UniSTS
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38533,730,037 - 33,731,400UniSTSGRCm38
MGSCv37534,072,686 - 34,074,049UniSTSGRCm37
Celera531,206,153 - 31,207,516UniSTS
Cytogenetic Map5BUniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38533,723,515 - 33,723,668UniSTSGRCm38
MGSCv37534,066,164 - 34,066,317UniSTSGRCm37
Celera531,199,631 - 31,199,784UniSTS
Cytogenetic Map5BUniSTS
cM Map520.0UniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS
Fgfr3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5BUniSTS


Expression

RNA-SEQ Expression


Sequence