Pik3c3 (phosphatidylinositol 3-kinase catalytic subunit type 3) - Rat Genome Database

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Gene: Pik3c3 (phosphatidylinositol 3-kinase catalytic subunit type 3) Mus musculus
Analyze
Symbol: Pik3c3
Name: phosphatidylinositol 3-kinase catalytic subunit type 3
RGD ID: 732995
MGI Page MGI
Description: Enables protein kinase activity. Involved in cellular response to glucose starvation; macroautophagy; and synaptic vesicle endocytosis. Acts upstream of or within cellular response to starvation; phosphatidylinositol-3-phosphate biosynthetic process; and protein localization to phagophore assembly site. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is active in GABA-ergic synapse; endosome; and glutamatergic synapse. Is expressed in several structures, including Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5330434F23Rik; phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI3-kinase type 3; PI3K type 3; ptdIns-3-kinase type 3; Vp; Vps34
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391830,390,441 - 30,481,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1830,405,800 - 30,481,179 (+)EnsemblGRCm39 Ensembl
GRCm381830,265,615 - 30,348,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1830,272,747 - 30,348,126 (+)EnsemblGRCm38mm10GRCm38
MGSCv371830,432,550 - 30,507,774 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361830,415,906 - 30,491,130 (+)NCBIMGSCv36mm8
Celera1830,744,294 - 30,819,480 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
ABT-737  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
carmustine  (ISO)
CCCP  (ISO)
celecoxib  (ISO)
ceritinib  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
deoxycholic acid  (ISO)
Deoxyschizandrin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diquat  (EXP)
emodin  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
flavonoids  (ISO)
flurbiprofen  (EXP)
FR900359  (ISO)
furan  (ISO)
gentamycin  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
gossypetin  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mirtazapine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (ISO)
oxaliplatin  (ISO)
oxycodone  (ISO)
ozone  (EXP)
paraquat  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phlorizin  (EXP)
pioglitazone  (ISO)
procyanidin B2  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autophagy  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal lens fiber morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal posture  (IAGP)
abnormal proprioceptive neuron morphology  (IAGP)
abnormal sensory neuron morphology  (IAGP)
abnormal T cell number  (IAGP)
abnormal vacuole morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent mesoderm  (IAGP)
axon degeneration  (IAGP)
cataract  (IAGP)
congestive heart failure  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IEA)
decreased cardiac muscle contractility  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating aspartate transaminase level  (IEA)
decreased embryo size  (IAGP)
decreased grip strength  (IEA)
decreased liver glycogen level  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased sensory neuron number  (IAGP)
disorganized embryonic tissue  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and placentation, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
failure of primitive streak formation  (IAGP)
failure to gastrulate  (IAGP)
hepatic steatosis  (IAGP)
hindlimb paralysis  (IAGP)
impaired autophagy  (IAGP)
impaired coordination  (IAGP)
increased heart left ventricle weight  (IAGP)
increased heart weight  (IAGP)
increased neuron apoptosis  (IAGP)
increased T cell apoptosis  (IAGP)
microphthalmia  (IAGP)
neurodegeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
oxidative stress  (IAGP)
pale liver  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
small lens  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. Ito N, etal., J Biol Chem 2002 Nov 22;277(47):44898-904.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
11. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
Additional References at PubMed
PMID:8663140   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12520002   PMID:14681479   PMID:15010863   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16467569   PMID:16514418   PMID:16670302   PMID:17589504   PMID:18755982   PMID:19047410   PMID:20114047   PMID:20142477   PMID:20439739   PMID:20562532  
PMID:20885446   PMID:20955765   PMID:21267068   PMID:21283715   PMID:21677750   PMID:21873635   PMID:22021616   PMID:22308354   PMID:22493499   PMID:22592798   PMID:22696681   PMID:22745922  
PMID:23291473   PMID:23332761   PMID:23447692   PMID:23479732   PMID:23492732   PMID:23569248   PMID:23596309   PMID:23621784   PMID:23974797   PMID:24098492   PMID:24705551   PMID:24726497  
PMID:24849286   PMID:25275521   PMID:25327288   PMID:25533844   PMID:25578879   PMID:25619930   PMID:25851780   PMID:26139536   PMID:26242203   PMID:26387534   PMID:26590968   PMID:26636486  
PMID:26687681   PMID:26834238   PMID:27245220   PMID:27411398   PMID:27541856   PMID:27548528   PMID:27793976   PMID:27994061   PMID:28059666   PMID:28097232   PMID:28617998   PMID:28716903  
PMID:28844862   PMID:28903944   PMID:29180704   PMID:29311744   PMID:29348617   PMID:29558368   PMID:29695642   PMID:30237523   PMID:30242175   PMID:30245008   PMID:30686098   PMID:31059511  
PMID:31257024   PMID:31260037   PMID:31904289   PMID:32029275   PMID:32325033   PMID:32474911   PMID:33235386   PMID:33751937   PMID:33960279   PMID:34428398   PMID:35318705   PMID:35997680  
PMID:36394336   PMID:36574710   PMID:37450577   PMID:38355793   PMID:38544346  


Genomics

Comparative Map Data
Pik3c3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391830,390,441 - 30,481,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1830,405,800 - 30,481,179 (+)EnsemblGRCm39 Ensembl
GRCm381830,265,615 - 30,348,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1830,272,747 - 30,348,126 (+)EnsemblGRCm38mm10GRCm38
MGSCv371830,432,550 - 30,507,774 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361830,415,906 - 30,491,130 (+)NCBIMGSCv36mm8
Celera1830,744,294 - 30,819,480 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.41NCBI
PIK3C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381841,955,234 - 42,087,830 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1841,955,234 - 42,087,830 (+)EnsemblGRCh38hg38GRCh38
GRCh371839,535,199 - 39,667,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361837,789,197 - 37,915,446 (+)NCBINCBI36Build 36hg18NCBI36
Build 341837,789,196 - 37,915,442NCBI
Celera1836,343,751 - 36,469,999 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
HuRef1836,394,067 - 36,520,574 (+)NCBIHuRef
CHM1_11839,462,215 - 39,588,448 (+)NCBICHM1_1
T2T-CHM13v2.01842,146,975 - 42,279,510 (+)NCBIT2T-CHM13v2.0
Pik3c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81822,119,677 - 22,203,546 (+)NCBIGRCr8
mRatBN7.21821,845,282 - 21,934,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1821,845,295 - 21,929,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1821,980,005 - 22,057,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01822,758,425 - 22,836,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01822,068,675 - 22,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01822,964,121 - 23,047,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01822,694,862 - 22,778,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41822,495,197 - 22,579,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11822,521,842 - 22,606,301 (+)NCBI
Celera1821,624,416 - 21,707,267 (+)NCBICelera
Cytogenetic Map18p12NCBI
Pik3c3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540228,081,098 - 28,196,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540228,081,150 - 28,195,305 (+)NCBIChiLan1.0ChiLan1.0
PIK3C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21759,346,533 - 59,473,026 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11845,039,112 - 45,168,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01835,203,896 - 35,336,512 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11838,754,789 - 38,882,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1838,754,789 - 38,882,037 (+)Ensemblpanpan1.1panPan2
PIK3C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1748,663,381 - 48,800,350 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl748,663,381 - 48,800,437 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha748,073,292 - 48,210,175 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0748,617,615 - 48,754,695 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl748,614,671 - 48,754,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1748,315,599 - 48,452,309 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0748,357,572 - 48,494,156 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0748,638,915 - 48,775,800 (-)NCBIUU_Cfam_GSD_1.0
Pik3c3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494444,700,595 - 44,818,119 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365174,033,247 - 4,145,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365174,009,938 - 4,145,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6125,890,712 - 126,043,157 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16125,890,598 - 126,038,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26117,947,967 - 118,097,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11838,785,476 - 38,914,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1838,787,717 - 38,914,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605013,268,474 - 13,404,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3c3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477916,307,800 - 16,434,169 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477916,307,875 - 16,435,567 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pik3c3
3327 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1117
Count of miRNA genes:560
Interacting mature miRNAs:676
Transcripts:ENSMUST00000091978, ENSMUST00000115811, ENSMUST00000115812, ENSMUST00000131405
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
12910787Pwbwq18_mpost-weaning body weight QTL 18 (mouse)181826552930570819Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
12910805Pwbwq17_mpost-weaning body weight QTL 17 (mouse)181826552930570819Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
12910819Ogrq6_moverall growth rate QTL 6 (mouse)181826552930570819Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182156868236187740Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131720756Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
12801462Intim3_mintima modifier 3 (mouse)18131720756Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse


Expression


Sequence


Ensembl Acc Id: ENSMUST00000091978   ⟹   ENSMUSP00000089601
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1830,405,925 - 30,476,169 (+)Ensembl
GRCm38.p6 Ensembl1830,272,872 - 30,343,116 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115811   ⟹   ENSMUSP00000111478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1830,405,923 - 30,464,021 (+)Ensembl
GRCm38.p6 Ensembl1830,272,870 - 30,330,968 (+)Ensembl
Ensembl Acc Id: ENSMUST00000115812   ⟹   ENSMUSP00000111479
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1830,405,800 - 30,481,179 (+)Ensembl
GRCm38.p6 Ensembl1830,272,747 - 30,348,126 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131405   ⟹   ENSMUSP00000128927
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1830,405,980 - 30,481,173 (+)Ensembl
GRCm38.p6 Ensembl1830,272,927 - 30,348,120 (+)Ensembl
RefSeq Acc Id: NM_181414   ⟹   NP_852079
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391830,405,918 - 30,481,179 (+)NCBI
GRCm381830,272,865 - 30,348,126 (+)NCBI
MGSCv371830,432,550 - 30,507,774 (+)RGD
Celera1830,744,294 - 30,819,480 (+)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_151699
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391830,405,918 - 30,481,179 (+)NCBI
GRCm381830,272,865 - 30,348,126 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250424   ⟹   XP_030106284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391830,400,571 - 30,481,179 (+)NCBI
GRCm381830,267,518 - 30,348,126 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250425   ⟹   XP_030106285
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391830,390,441 - 30,481,179 (+)NCBI
GRCm381830,265,615 - 30,348,126 (+)NCBI
Sequence:
RefSeq Acc Id: NP_852079   ⟸   NM_181414
- UniProtKB: Q8R3S8 (UniProtKB/Swiss-Prot),   Q6PF93 (UniProtKB/Swiss-Prot),   E9QLS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030106285   ⟸   XM_030250425
- Peptide Label: isoform X1
- UniProtKB: Q6PF93 (UniProtKB/Swiss-Prot),   Q8R3S8 (UniProtKB/Swiss-Prot),   E9QLS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030106284   ⟸   XM_030250424
- Peptide Label: isoform X1
- UniProtKB: Q6PF93 (UniProtKB/Swiss-Prot),   Q8R3S8 (UniProtKB/Swiss-Prot),   E9QLS6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000089601   ⟸   ENSMUST00000091978
Ensembl Acc Id: ENSMUSP00000128927   ⟸   ENSMUST00000131405
Ensembl Acc Id: ENSMUSP00000111478   ⟸   ENSMUST00000115811
Ensembl Acc Id: ENSMUSP00000111479   ⟸   ENSMUST00000115812
Protein Domains
C2 PI3K-type   PI3K/PI4K catalytic   PIK helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PF93-F1-model_v2 AlphaFold Q6PF93 1-887 view protein structure

Promoters
RGD ID:13677284
Promoter ID:EPDNEW_M22791
Type:initiation region
Name:Pik3c3_1
Description:Mus musculus phosphatidylinositol 3-kinase catalytic subunittype 3 , transcript variant 2, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381830,272,877 - 30,272,937EPDNEW
RGD ID:6829463
Promoter ID:MM_KWN:24814
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000115811,   OTTMUST00000050105,   OTTMUST00000050114,   OTTMUST00000050115
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361830,432,271 - 30,432,771 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2445019 AgrOrtholog
Ensembl Genes ENSMUSG00000033628 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000091978.12 UniProtKB/TrEMBL
  ENSMUST00000115811.8 UniProtKB/TrEMBL
  ENSMUST00000115812 ENTREZGENE
  ENSMUST00000115812.10 UniProtKB/Swiss-Prot
  ENSMUST00000131405 ENTREZGENE
  ENSMUST00000131405.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_Vps34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
KEGG Report mmu:225326 UniProtKB/Swiss-Prot
MGD MGI:2445019 ENTREZGENE
NCBI Gene 225326 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3c3 PhenoGen
PIRSF PI3K_Vps34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YZ98_MOUSE UniProtKB/TrEMBL
  E9Q824_MOUSE UniProtKB/TrEMBL
  E9QLS6 ENTREZGENE, UniProtKB/TrEMBL
  PK3C3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8R3S8 ENTREZGENE
UniProt Secondary Q8R3S8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pik3c3  phosphatidylinositol 3-kinase catalytic subunit type 3    phosphoinositide-3-kinase, class 3  Symbol and/or name change 5135510 APPROVED