Cdkn1a (cyclin dependent kinase inhibitor 1A)

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Gene: Cdkn1a (cyclin dependent kinase inhibitor 1A) Mus musculus

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Symbol:

Cdkn1a

Name:

cyclin dependent kinase inhibitor 1A

RGD ID:

732911

MGI Page

MGI

Description:

Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including cellular response to UV-B; cellular response to amino acid starvation; and negative regulation of cardiac muscle tissue regeneration. Acts upstream of or within several processes, including cellular response to gamma radiation; regulation of macromolecule biosynthetic process; and signal transduction by p53 class mediator. Located in cytosol. Part of cyclin-dependent protein kinase holoenzyme complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study hepatocellular carcinoma; systemic lupus erythematosus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

CAP; CAP20; CDK; CDK-interacting protein 1; CDKI; Cdkn; Cdkn1; CI; CIP1; cyclin dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; mda; mda6; melanoma differentiation-associated protein; P2; P21; p21; p21C; p21Cip1; p21W; p21WAF; SD; SDI1; Waf; Waf1

RGD Orthologs

Alliance Orthologs

More Info

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Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	29,309,953 - 29,319,696 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	29,309,950 - 29,319,701 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	29,090,979 - 29,100,722 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	29,090,976 - 29,100,727 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	29,227,931 - 29,237,667 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	28,821,439 - 28,828,386 (+)	NCBI		MGSCv36	mm8
Celera	17	29,647,617 - 29,657,304 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	15.12	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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