Fbxo2 (F-box protein 2) - Rat Genome Database

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Gene: Fbxo2 (F-box protein 2) Mus musculus
Analyze
Symbol: Fbxo2
Name: F-box protein 2
RGD ID: 732901
MGI Page MGI
Description: Enables amyloid-beta binding activity; carbohydrate binding activity; and denatured protein binding activity. Involved in protein catabolic process; protein ubiquitination; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Acts upstream of or within ERAD pathway; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol and dendritic spine. Part of SCF ubiquitin ligase complex. Is active in glutamatergic synapse. Is expressed in brain; testis; and vestibulo-cochlear ganglion. Orthologous to human FBXO2 (F-box protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box only protein 2; FBG1; Fbs; Fbs1; Fbs2; FBX2; MGC54895; NFB4; NFB42; P; prion protein ligand 4; Prpl4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,244,605 - 148,250,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,245,078 - 148,250,881 (+)EnsemblGRCm39 Ensembl
GRCm384148,160,198 - 148,166,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,160,621 - 148,166,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,534,777 - 147,540,526 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,004,468 - 147,010,217 (+)NCBIMGSCv36mm8
Celera4150,422,125 - 150,427,887 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:9173930   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12140560   PMID:12466851   PMID:12939278   PMID:14610273   PMID:14701835   PMID:15489334  
PMID:15723043   PMID:15809437   PMID:16141072   PMID:16141073   PMID:17215248   PMID:17389369   PMID:17494702   PMID:20854419   PMID:21267068   PMID:21677750   PMID:21779340   PMID:21873635  
PMID:22794259   PMID:22917612   PMID:24469452   PMID:25878288   PMID:26295339   PMID:27487926   PMID:27507650   PMID:27626380   PMID:27932386   PMID:28671696   PMID:28706196   PMID:30179592  
PMID:32325033   PMID:34215698   PMID:36587458   PMID:36982617  


Genomics

Comparative Map Data
Fbxo2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,244,605 - 148,250,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,245,078 - 148,250,881 (+)EnsemblGRCm39 Ensembl
GRCm384148,160,198 - 148,166,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,160,621 - 148,166,424 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,534,777 - 147,540,526 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,004,468 - 147,010,217 (+)NCBIMGSCv36mm8
Celera4150,422,125 - 150,427,887 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.68NCBI
FBXO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,648,387 - 11,654,429 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,637,018 - 11,655,785 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,708,444 - 11,714,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,631,035 - 11,637,326 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,642,715 - 11,649,005NCBI
Celera110,820,505 - 10,826,801 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,862,510 - 10,868,984 (-)NCBIHuRef
CHM1_1111,696,402 - 11,702,875 (-)NCBICHM1_1
T2T-CHM13v2.0111,192,423 - 11,198,481 (-)NCBIT2T-CHM13v2.0
Fbxo2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25158,592,926 - 158,598,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,592,925 - 158,598,355 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,309,703 - 161,315,130 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,131,494 - 163,136,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,087,839 - 163,093,286 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,972,483 - 164,977,912 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,972,480 - 164,977,916 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,630,521 - 168,635,950 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,239,080 - 165,244,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,249,267 - 165,254,697 (+)NCBI
Celera5156,871,142 - 156,876,571 (+)NCBICelera
Cytogenetic Map5q36NCBI
Fbxo2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,212,001 - 2,218,017 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,212,001 - 2,217,260 (+)NCBIChiLan1.0ChiLan1.0
FBXO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11215,217,956 - 215,224,017 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,408,853 - 10,415,174 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,626,713 - 11,633,171 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,626,713 - 11,633,171 (-)Ensemblpanpan1.1panPan2
FBXO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,563,256 - 84,568,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,556,547 - 84,568,491 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,095,467 - 81,100,690 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,226,074 - 85,231,298 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,226,182 - 85,231,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,975,039 - 81,980,259 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,975,760 - 82,980,978 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,038,529 - 84,043,752 (+)NCBIUU_Cfam_GSD_1.0
Fbxo2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,696,457 - 34,701,333 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474521,123 - 526,959 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474521,235 - 526,151 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,740,677 - 71,748,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,740,647 - 71,747,265 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,660,557 - 65,663,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,136,630 - 120,144,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,136,702 - 120,144,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605424,005,047 - 24,011,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,299,067 - 1,309,667 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,300,191 - 1,311,245 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo2
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:183
Interacting mature miRNAs:193
Transcripts:ENSMUST00000047951
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse

Markers in Region
RH136768  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,166,304 - 148,166,396UniSTSGRCm38
MGSCv374147,540,413 - 147,540,505UniSTSGRCm37
Celera4150,427,774 - 150,427,866UniSTS
Cytogenetic Map4E2UniSTS
cM Map471.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000047951   ⟹   ENSMUSP00000037377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,245,078 - 148,250,881 (+)Ensembl
GRCm38.p6 Ensembl4148,160,621 - 148,166,424 (+)Ensembl
RefSeq Acc Id: NM_001419436   ⟹   NP_001406365
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,244,705 - 148,250,874 (+)NCBI
RefSeq Acc Id: NM_001419437   ⟹   NP_001406366
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,244,605 - 148,250,874 (+)NCBI
RefSeq Acc Id: NM_176848   ⟹   NP_789818
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,245,079 - 148,250,874 (+)NCBI
GRCm384148,160,668 - 148,166,417 (+)NCBI
MGSCv374147,534,777 - 147,540,526 (+)RGD
Celera4150,422,125 - 150,427,887 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_185083
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,245,079 - 148,250,874 (+)NCBI
RefSeq Acc Id: NP_789818   ⟸   NM_176848
- UniProtKB: Q8R0D2 (UniProtKB/Swiss-Prot),   Q80UW2 (UniProtKB/Swiss-Prot),   Q3USR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000037377   ⟸   ENSMUST00000047951
RefSeq Acc Id: NP_001406366   ⟸   NM_001419437
- UniProtKB: Q80UW2 (UniProtKB/Swiss-Prot),   Q8R0D2 (UniProtKB/Swiss-Prot),   Q3USR5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406365   ⟸   NM_001419436
- UniProtKB: Q80UW2 (UniProtKB/Swiss-Prot),   Q8R0D2 (UniProtKB/Swiss-Prot),   Q3USR5 (UniProtKB/TrEMBL)
Protein Domains
F-box   FBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80UW2-F1-model_v2 AlphaFold Q80UW2 1-297 view protein structure

Promoters
RGD ID:6835314
Promoter ID:MM_KWN:40810
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0
Transcripts:OTTMUST00000025652
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,534,516 - 147,535,016 (+)MPROMDB
RGD ID:6849169
Promoter ID:MM_XEF:5238
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_001075569,   NM_001173089
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,538,121 - 147,538,621 (+)MPROMDB
RGD ID:6885514
Promoter ID:EPDNEW_M6208
Type:initiation region
Name:Fbxo2_1
Description:Mus musculus F-box protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384148,160,622 - 148,160,682EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2446216 AgrOrtholog
Ensembl Genes ENSMUSG00000041556 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047951 ENTREZGENE
  ENSMUST00000047951.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro F-box-assoc_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box_only UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:230904 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2446216 ENTREZGENE
NCBI Gene 230904 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12125 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbxo2 PhenoGen
PROSITE FBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FBA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt FBX2_MOUSE UniProtKB/Swiss-Prot
  Q3USR5 ENTREZGENE, UniProtKB/TrEMBL
  Q80UW2 ENTREZGENE
  Q8R0D2 ENTREZGENE
UniProt Secondary Q8R0D2 UniProtKB/Swiss-Prot