Tnfsf10 (tumor necrosis factor (ligand) superfamily, member 10) - Rat Genome Database

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Gene: Tnfsf10 (tumor necrosis factor (ligand) superfamily, member 10) Mus musculus
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Symbol: Tnfsf10
Name: tumor necrosis factor (ligand) superfamily, member 10
RGD ID: 732827
MGI Page MGI
Description: Enables TRAIL binding activity and tumor necrosis factor receptor superfamily binding activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in central nervous system; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A330042I21Rik; AI448571; AP; APO-2L; Ly81; T; TL2; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand; Tnlg6a; Trail; TRAIL/APO2L; tumor necrosis factor ligand 6a; tumor necrosis factor ligand superfamily member 10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,371,226 - 27,393,814 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,371,177 - 27,396,576 (+)EnsemblGRCm39 Ensembl
GRCm38327,317,077 - 27,339,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,317,028 - 27,342,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv37327,215,999 - 27,238,587 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36327,508,150 - 27,530,738 (+)NCBIMGSCv36mm8
Celera327,279,765 - 27,300,536 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-matairesinol  (ISO)
(R)-lipoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-trinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (EXP,ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
actinomycin D  (ISO)
adenosine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aluminium oxide  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Auriculasin  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bepridil  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
bortezomib  (EXP,ISO)
brefeldin A  (ISO)
bromoacetate  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
carboxy-PTIO  (ISO)
carmustine  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cholesterol  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
chrysazin  (ISO)
chrysene  (EXP)
chrysin  (ISO)
cibenzoline  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
coformycin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dacarbazine  (ISO)
daunorubicin  (ISO)
deoxycholic acid  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dichloroacetic acid  (EXP)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dihydroxyacetone  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenoldopam  (ISO)
flavonoids  (ISO)
formaldehyde  (ISO)
fumonisin B1  (EXP)
furan  (EXP)
furosemide  (ISO)
Fusarenone X  (EXP)
gadolinium trichloride  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gingerol  (ISO)
glucose  (ISO)
Glutathione ethyl ester  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
Ilimaquinone  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
Maduramicin  (ISO)
masoprocol  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methyltestosterone  (ISO)
mevalonic acid  (ISO)
mifepristone  (ISO)
mithramycin  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
morphine  (EXP)
Myrtucommulone A  (EXP)
N,N-dimethylformamide  (ISO)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
NS-398  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (EXP)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
Protolichesterinic acid  (ISO)
pyrethrins  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
riddelliine  (ISO)
rifampicin  (EXP)
Ro 31-8220  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
SM-164  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
styrene  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sumatriptan  (ISO)
Sunset Yellow FCF  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thalidomide  (ISO)
thioacetamide  (ISO)
thiophenes  (ISO)
titanium dioxide  (EXP)
tofacitinib  (ISO)
tranilast  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
venom  (ISO)
Vicanicin  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. [Effects of valsartan, mycophenolate mofetil and their combined application on TRAIL and nuclear factor-kappaB expression in the kidneys of diabetic rats] Chen B, etal., Zhonghua Yi Xue Za Zhi. 2008 Feb 26;88(8):540-5.
2. Adenovirus-Mediated TRAIL Gene (Ad5hTRAIL) Delivery into Pancreatic Islets Prolongs Normoglycemia in Streptozotocin-Induced Diabetic Rats. Dirice E, etal., Hum Gene Ther. 2009 Aug 21.
3. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
4. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Lamhamedi-Cherradi SE, etal., Nat Immunol. 2003 Mar;4(3):255-60. Epub 2003 Feb 10.
5. TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. Lee SW, etal., Arthritis Rheum. 2004 Feb;50(2):534-42.
6. The death ligand TRAIL in diabetic nephropathy. Lorz C, etal., J Am Soc Nephrol. 2008 May;19(5):904-14. Epub 2008 Feb 20.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice. Mi QS, etal., Diabetes. 2003 Aug;52(8):1967-75.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Increased expression of TRAIL and its receptors on peripheral T-cells in type 1 diabetic patients. Salehi E, etal., Iran J Immunol. 2007 Dec;4(4):197-205.
17. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Secchiero P, etal., Circulation. 2006 Oct 3;114(14):1522-30. Epub 2006 Sep 25.
18. Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. Tang X, etal., Life Sci. 2009 Apr 10;84(15-16):552-7.
19. [Therapeutic effects of recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand on non-small lung cell cancer: an experimental with rats] Tang YM, etal., Zhonghua Yi Xue Za Zhi. 2005 Aug 3;85(29):2021-5.
20. Apoptosis and expression of protein TRAIL in granulosa cells of rats with polycystic ovarian syndrome. Zhang J, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):311-4.
Additional References at PubMed
PMID:8777713   PMID:8786139   PMID:9930856   PMID:9930862   PMID:10349636   PMID:10442092   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11239407   PMID:11241200   PMID:11801676  
PMID:11805143   PMID:12088418   PMID:12209599   PMID:12209637   PMID:12391182   PMID:12444124   PMID:12466268   PMID:12477932   PMID:12517799   PMID:12842625   PMID:12900523   PMID:12941766  
PMID:14560009   PMID:14645705   PMID:14688317   PMID:14702109   PMID:14702523   PMID:14764669   PMID:14983036   PMID:14996723   PMID:15128592   PMID:15163747   PMID:15213096   PMID:15494516  
PMID:15632112   PMID:15744305   PMID:15919918   PMID:15967825   PMID:16129707   PMID:16141072   PMID:16141073   PMID:16174101   PMID:16178278   PMID:16237043   PMID:16602821   PMID:16604076  
PMID:16636669   PMID:16772303   PMID:16818756   PMID:16888019   PMID:16955144   PMID:17202353   PMID:17236235   PMID:17237443   PMID:17312109   PMID:17470784   PMID:17571163   PMID:17620297  
PMID:17703232   PMID:17762882   PMID:17934471   PMID:17947462   PMID:18070069   PMID:18079967   PMID:18089829   PMID:18178624   PMID:18192669   PMID:18206242   PMID:18220275   PMID:18268032  
PMID:18287559   PMID:18354179   PMID:18362335   PMID:18362888   PMID:18667695   PMID:18802095   PMID:18830416   PMID:18988676   PMID:19064696   PMID:19119023   PMID:19361506   PMID:19373582  
PMID:19454664   PMID:19481529   PMID:19633419   PMID:19635861   PMID:19893042   PMID:19901518   PMID:19955659   PMID:20062539   PMID:20107429   PMID:20150555   PMID:20185587   PMID:20190248  
PMID:20213318   PMID:20483771   PMID:20505139   PMID:20706988   PMID:20711434   PMID:20807702   PMID:20921531   PMID:21047948   PMID:21169546   PMID:21187341   PMID:21209944   PMID:21225479  
PMID:21267068   PMID:21324463   PMID:21426505   PMID:21463519   PMID:21470210   PMID:21562052   PMID:21627969   PMID:21654829   PMID:21677750   PMID:21712396   PMID:21788440   PMID:21832159  
PMID:21846721   PMID:21873635   PMID:21940678   PMID:21965021   PMID:22013112   PMID:22116828   PMID:22131069   PMID:22415975   PMID:22616837   PMID:22719861   PMID:22740407   PMID:23071253  
PMID:23071256   PMID:23108456   PMID:23275602   PMID:23347256   PMID:23408429   PMID:23430714   PMID:23497038   PMID:23982205   PMID:24040204   PMID:24045576   PMID:24097299   PMID:24194600  
PMID:24439895   PMID:24484417   PMID:24487434   PMID:24509861   PMID:24667560   PMID:24736722   PMID:24804996   PMID:24887152   PMID:25031778   PMID:25356750   PMID:25607248   PMID:25827060  
PMID:26491108   PMID:26555706   PMID:26572549   PMID:26646413   PMID:26783750   PMID:26935795   PMID:27142480   PMID:27617958   PMID:27742702   PMID:27836899   PMID:28055006   PMID:28070143  
PMID:28233863   PMID:28392572   PMID:28461078   PMID:28507343   PMID:29088306   PMID:29124251   PMID:29391475   PMID:29403497   PMID:29596938   PMID:29661825   PMID:30165101   PMID:30732588  
PMID:31076664   PMID:31355333   PMID:31742873   PMID:31894448   PMID:31995154   PMID:32012249   PMID:32234472   PMID:32410328   PMID:32485960   PMID:32645396   PMID:32734619   PMID:33408417  
PMID:33483333   PMID:33875613   PMID:33932348   PMID:34843580   PMID:34933177   PMID:35139355   PMID:35726345   PMID:35840556   PMID:37702066   PMID:38273071   PMID:38355793   PMID:39365855  


Genomics

Comparative Map Data
Tnfsf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,371,226 - 27,393,814 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,371,177 - 27,396,576 (+)EnsemblGRCm39 Ensembl
GRCm38327,317,077 - 27,339,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,317,028 - 27,342,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv37327,215,999 - 27,238,587 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36327,508,150 - 27,530,738 (+)NCBIMGSCv36mm8
Celera327,279,765 - 27,300,536 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map310.82NCBI
TNFSF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383172,505,508 - 172,523,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3172,505,508 - 172,523,475 (-)EnsemblGRCh38hg38GRCh38
GRCh373172,223,298 - 172,241,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,706,158 - 173,723,963 (-)NCBINCBI36Build 36hg18NCBI36
Build 343173,706,166 - 173,723,971NCBI
Celera3170,621,889 - 170,639,888 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,593,908 - 169,611,904 (-)NCBIHuRef
CHM1_13172,186,184 - 172,204,170 (-)NCBICHM1_1
T2T-CHM13v2.03175,290,584 - 175,308,501 (-)NCBIT2T-CHM13v2.0
Tnfsf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82112,136,550 - 112,155,903 (+)NCBIGRCr8
mRatBN7.22110,199,835 - 110,227,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,863,492 - 116,880,479 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02114,976,052 - 114,993,034 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02109,691,219 - 109,708,034 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02113,008,008 - 113,026,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,726,333 - 132,742,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,204,303 - 113,221,550 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12113,149,265 - 113,166,510 (+)NCBI
Celera2105,412,626 - 105,429,375 (+)NCBICelera
Cytogenetic Map2q24NCBI
Tnfsf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,549,142 - 2,566,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554202,550,392 - 2,566,448 (-)NCBIChiLan1.0ChiLan1.0
TNFSF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22170,387,678 - 170,406,039 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13170,392,401 - 170,410,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03169,512,491 - 169,530,706 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13177,693,860 - 177,712,137 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,694,021 - 177,712,137 (-)Ensemblpanpan1.1panPan2
TNFSF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,719,249 - 36,734,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,670,849 - 36,735,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3445,731,787 - 45,747,520 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03436,803,929 - 36,819,723 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,802,389 - 36,820,029 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,742,701 - 36,758,427 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,711,390 - 36,727,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,969,308 - 36,985,009 (-)NCBIUU_Cfam_GSD_1.0
Tnfsf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,391,320 - 103,422,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936593212,532 - 230,651 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936593212,642 - 230,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,983,298 - 111,038,324 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113111,021,952 - 111,103,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,874,763 - 119,882,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNFSF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11516,934,982 - 16,953,155 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1516,934,962 - 16,954,860 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606325,697,846 - 25,715,823 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfsf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473050,531,915 - 50,550,528 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473050,534,284 - 50,550,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnfsf10
748 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1190
Count of miRNA genes:671
Interacting mature miRNAs:799
Transcripts:ENSMUST00000046383, ENSMUST00000174840
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
12904010Cfq8_mconditioned fear QTL 8 (mouse)32476823231332103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
13432186Rotse1_mrotarod training saline/ethanol 1 (mouse)32665522728355227Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse

Markers in Region
AI448571  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38327,339,567 - 27,339,647UniSTSGRCm38
MGSCv37327,238,489 - 27,238,569UniSTSGRCm37
Celera327,300,438 - 27,300,518UniSTS
Cytogenetic Map3A3UniSTS
Whitehead/MRC_RH3303.8UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB052771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC157919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF470537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY734631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN874399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000046383   ⟹   ENSMUSP00000040271
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl327,371,177 - 27,393,814 (+)Ensembl
GRCm38.p6 Ensembl327,317,028 - 27,339,665 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174840   ⟹   ENSMUSP00000133917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl327,371,210 - 27,396,576 (+)Ensembl
GRCm38.p6 Ensembl327,317,061 - 27,342,427 (+)Ensembl
RefSeq Acc Id: NM_009425   ⟹   NP_033451
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39327,371,226 - 27,393,814 (+)NCBI
GRCm38327,317,077 - 27,339,665 (+)ENTREZGENE
MGSCv37327,215,999 - 27,238,587 (+)RGD
Celera327,279,765 - 27,300,536 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033451   ⟸   NM_009425
- UniProtKB: P50592 (UniProtKB/Swiss-Prot),   Q3U5H0 (UniProtKB/TrEMBL),   A0A0U5CJG6 (UniProtKB/TrEMBL),   Q3TZR6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000040271   ⟸   ENSMUST00000046383
Ensembl Acc Id: ENSMUSP00000133917   ⟸   ENSMUST00000174840
Protein Domains
THD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50592-F1-model_v2 AlphaFold P50592 1-291 view protein structure

Promoters
RGD ID:6834557
Promoter ID:MM_KWN:33911
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_009425,   UC008OTN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36327,215,146 - 27,216,097 (+)MPROMDB
RGD ID:6880408
Promoter ID:EPDNEW_M3631
Type:initiation region
Name:Tnfsf10_1
Description:Mus musculus tumor necrosis factor superfamily, member 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38327,317,077 - 27,317,137EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107414 AgrOrtholog
Ensembl Genes ENSMUSG00000039304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000046383 ENTREZGENE
  ENSMUST00000046383.12 UniProtKB/Swiss-Prot
  ENSMUST00000174840.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_ligand_10/11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22035 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107414 ENTREZGENE
NCBI Gene 22035 ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tnfsf10 PhenoGen
PIRSF TNF10_TNF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U5CJG6 ENTREZGENE, UniProtKB/TrEMBL
  G3UY25_MOUSE UniProtKB/TrEMBL
  P50592 ENTREZGENE
  Q3TZR6 ENTREZGENE, UniProtKB/TrEMBL
  Q3U5H0 ENTREZGENE, UniProtKB/TrEMBL
  Q3UQ13_MOUSE UniProtKB/TrEMBL
  TNF10_MOUSE UniProtKB/Swiss-Prot