Ide (insulin degrading enzyme) - Rat Genome Database

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Gene: Ide (insulin degrading enzyme) Mus musculus
Analyze
Symbol: Ide
Name: insulin degrading enzyme
RGD ID: 732802
MGI Page MGI
Description: Enables endopeptidase activity. Involved in insulin catabolic process and insulin receptor recycling. Acts upstream of or within amyloid-beta clearance and response to oxidative stress. Located in extracellular exosome. Is active in endosome lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1300012G03Rik; 4833415K22Rik; AA675336; AI507533; insulin protease; insulin-degrading enzyme; insulinase; insulysin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,246,140 - 37,341,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,246,142 - 37,340,010 (-)EnsemblGRCm39 Ensembl
GRCm381937,268,743 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBIMGSCv36mm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-(3,4-dihydroxyphenyl)propanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
ceftriaxone  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
DDT  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
fenthion  (EXP)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
glucose  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
notoginsenoside R1  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
scopolin  (ISO)
sodium arsenate  (EXP,ISO)
succimer  (EXP)
sumatriptan  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vanillic acid  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Treadmill Running and Rutin Reverse High Fat Diet Induced Cognitive Impairment in Diet Induced Obese Mice. Cheng J, etal., J Nutr Health Aging. 2016;20(5):503-8. doi: 10.1007/s12603-015-0616-7.
2. Change in INSR, APBA2 and IDE Gene Expressions in Brains of Alzheimer's Disease Patients. da Costa IB, etal., Curr Alzheimer Res. 2017;14(7):760-765. doi: 10.2174/1567205014666170203100734.
3. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Fakhrai-Rad H, etal., Hum Mol Genet 2000 Sep 1;9(14):2149-58.
4. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Farris W, etal., Proc Natl Acad Sci U S A 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.
5. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Florez JC, etal., Diabetes. 2006 Jan;55(1):128-35.
6. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. Ghareeb DA, etal., Evid Based Complement Alternat Med. 2015;2015:361847. doi: 10.1155/2015/361847. Epub 2015 Oct 20.
7. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Karamohamed S, etal., Diabetes. 2003 Jun;52(6):1562-7.
8. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
9. Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes. Kazkayasi I, etal., Pharmacol Rep. 2018 Aug;70(4):677-683. doi: 10.1016/j.pharep.2018.01.008. Epub 2018 Feb 1.
10. Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. Khodadadi D, etal., Neurochem Res. 2018 Aug;43(8):1561-1574. doi: 10.1007/s11064-018-2571-2. Epub 2018 Jun 11.
11. Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and invivo models of Alzheimer's disease. Kim DH, etal., Biochem Biophys Res Commun. 2018 Sep 14. pii: S0006-291X(18)31922-3. doi: 10.1016/j.bbrc.2018.09.012.
12. Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-a and IL-1ß in an Aß25-35-induced Rat Model of Alzheimer's Disease. Li L, etal., J Alzheimers Dis. 2017;56(4):1403-1417. doi: 10.3233/JAD-160587.
13. Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Marlowe L, etal., Neurodegener Dis. 2006;3(6):320-6.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Son SM, etal., Autophagy. 2016 May 3;12(5):784-800. doi: 10.1080/15548627.2016.1159375. Epub 2016 Mar 10.
22. Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment. Sun J, etal., Curr Alzheimer Res. 2016;13(12):1337-1345.
23. Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation. Wang N, etal., Neural Regen Res. 2017 Apr;12(4):654-659. doi: 10.4103/1673-5374.205107.
24. Pioglitazone ameliorates Aß42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3ß activation. Yang S, etal., Mol Med Rep. 2017 May;15(5):2588-2594. doi: 10.3892/mmr.2017.6342. Epub 2017 Mar 16.
Additional References at PubMed
PMID:1358795   PMID:1460423   PMID:2293021   PMID:8499657   PMID:8889548   PMID:10349636   PMID:10834841   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12732730  
PMID:12850277   PMID:14610273   PMID:14681479   PMID:15590928   PMID:15800373   PMID:16141072   PMID:16141073   PMID:16292511   PMID:16602821   PMID:17143549   PMID:18032724   PMID:18287559  
PMID:18455870   PMID:18554416   PMID:18614015   PMID:18799693   PMID:19334288   PMID:20061628   PMID:20876579   PMID:21267068   PMID:21491542   PMID:21576244   PMID:21677750   PMID:21695259  
PMID:21862448   PMID:21873424   PMID:21873635   PMID:22227962   PMID:22509294   PMID:22586115   PMID:23200833   PMID:23349488   PMID:23684818   PMID:23912999   PMID:24847884   PMID:25036874  
PMID:25999473   PMID:26637123   PMID:26791739   PMID:27125672   PMID:27404391   PMID:27467214   PMID:27703010   PMID:28378742   PMID:28771808   PMID:29093479   PMID:29222348   PMID:30098324  
PMID:30807788   PMID:30973865   PMID:31198829   PMID:31479304   PMID:32916153   PMID:33631143   PMID:34831163   PMID:34906895   PMID:35053342   PMID:35350789   PMID:35652923   PMID:37817156  


Genomics

Comparative Map Data
Ide
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,246,140 - 37,341,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,246,142 - 37,340,010 (-)EnsemblGRCm39 Ensembl
GRCm381937,268,743 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBIMGSCv36mm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
IDE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,451,684 - 92,574,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,451,684 - 92,574,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36Build 36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBIT2T-CHM13v2.0
Ide
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21235,002,984 - 235,102,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,995,351 - 235,102,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,391,715 - 243,489,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,321,195 - 250,419,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,159,390 - 243,257,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,914,447 - 256,013,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
Ide
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425847,615 - 926,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955425819,461 - 926,440 (+)NCBIChiLan1.0ChiLan1.0
IDE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan110104,492,478 - 104,617,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,196,295 - 89,320,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,714,343 - 92,833,430 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,716,540 - 92,833,353 (-)Ensemblpanpan1.1panPan2
IDE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,844,480 - 6,967,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,022,845 - 7,145,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,097,078 - 7,242,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,826,499 - 6,949,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,860,782 - 6,983,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,025,500 - 7,148,346 (-)NCBIUU_Cfam_GSD_1.0
Ide
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,597,592 - 40,685,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,230,283 - 2,318,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,230,477 - 2,318,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,992,039 - 104,106,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,992,035 - 104,106,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,505,034 - 113,619,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,722,728 - 85,843,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,721,886 - 85,843,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,459,858 - 46,578,672 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ide
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,835,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,708,309 - 3,822,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ide
3150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:935
Count of miRNA genes:581
Interacting mature miRNAs:692
Transcripts:ENSMUST00000131070, ENSMUST00000134740, ENSMUST00000150707, ENSMUST00000154308, ENSMUST00000154339
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse

Markers in Region
RH124457  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,277,756 - 37,277,837UniSTSGRCm38
MGSCv371937,352,246 - 37,352,327UniSTSGRCm37
Celera1938,052,961 - 38,053,042UniSTS
Cytogenetic Map19C2UniSTS
cM Map1925.0UniSTS
Ide  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C2UniSTS
cM Map1925.0UniSTS
UniSTS:237931  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,268,819 - 37,268,988UniSTSGRCm38
MGSCv371937,343,309 - 37,343,478UniSTSGRCm37
Celera1938,044,020 - 38,044,194UniSTS
Cytogenetic Map19C2UniSTS
cM Map1925.0UniSTS
AI507533  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,268,743 - 37,268,884UniSTSGRCm38
MGSCv371937,343,233 - 37,343,374UniSTSGRCm37
Cytogenetic Map19C2UniSTS
cM Map1925.0UniSTS
Whitehead/MRC_RH19351.39UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA163502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC137605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02162419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02162420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKR01081015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ278422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU698019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CAAA01166808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN038396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000131070   ⟹   ENSMUSP00000121358
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,246,142 - 37,340,010 (-)Ensembl
GRCm38.p6 Ensembl1937,268,743 - 37,330,613 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134740
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,257,983 - 37,268,277 (-)Ensembl
GRCm38.p6 Ensembl1937,280,584 - 37,290,878 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,279,062 - 37,290,972 (-)Ensembl
GRCm38.p6 Ensembl1937,301,663 - 37,313,573 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154308
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,281,049 - 37,315,251 (-)Ensembl
GRCm38.p6 Ensembl1937,303,650 - 37,337,852 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,247,829 - 37,284,791 (-)Ensembl
GRCm38.p6 Ensembl1937,270,430 - 37,307,392 (-)Ensembl
RefSeq Acc Id: NM_031156   ⟹   NP_112419
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,246,142 - 37,340,056 (-)NCBI
GRCm381937,268,743 - 37,334,544 (-)NCBI
MGSCv371937,343,231 - 37,409,034 (-)RGD
Celera1938,043,942 - 38,138,430 (-)ENTREZGENE
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036161441   ⟹   XP_036017334
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,246,140 - 37,340,090 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161442   ⟹   XP_036017335
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,246,140 - 37,311,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161443   ⟹   XP_036017336
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,246,140 - 37,339,729 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161444   ⟹   XP_036017337
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,246,140 - 37,340,024 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161445   ⟹   XP_036017338
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,246,140 - 37,315,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161446   ⟹   XP_036017339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,246,140 - 37,341,664 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112419   ⟸   NM_031156
- UniProtKB: Q9JHR7 (UniProtKB/Swiss-Prot),   F6RPJ9 (UniProtKB/TrEMBL),   Q8CGB9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000121358   ⟸   ENSMUST00000131070
RefSeq Acc Id: XP_036017339   ⟸   XM_036161446
- Peptide Label: isoform X2
- UniProtKB: Q9JHR7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036017334   ⟸   XM_036161441
- Peptide Label: isoform X1
- UniProtKB: Q9JHR7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036017337   ⟸   XM_036161444
- Peptide Label: isoform X1
- UniProtKB: Q9JHR7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036017336   ⟸   XM_036161443
- Peptide Label: isoform X1
- UniProtKB: Q9JHR7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036017338   ⟸   XM_036161445
- Peptide Label: isoform X1
- UniProtKB: Q9JHR7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036017335   ⟸   XM_036161442
- Peptide Label: isoform X1
- UniProtKB: Q9JHR7 (UniProtKB/Swiss-Prot)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHR7-F1-model_v2 AlphaFold Q9JHR7 1-1019 view protein structure

Promoters
RGD ID:13679384
Promoter ID:EPDNEW_M23841
Type:multiple initiation site
Name:Ide_1
Description:Mus musculus insulin degrading enzyme , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381937,337,852 - 37,337,912EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96412 AgrOrtholog
Ensembl Genes ENSMUSG00000056999 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000131070 ENTREZGENE
  ENSMUST00000131070.3 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15925 UniProtKB/TrEMBL
MGD MGI:96412 ENTREZGENE
NCBI Gene 15925 ENTREZGENE
PANTHER INSULIN-DEGRADING ENZYME-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NARDILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ide PhenoGen
PROSITE INSULINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6RPJ9 ENTREZGENE
  G8FSY5_MOUSE UniProtKB/TrEMBL
  IDE_MOUSE UniProtKB/Swiss-Prot
  Q8CE37_MOUSE UniProtKB/TrEMBL
  Q8CGB9 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHR7 ENTREZGENE
UniProt Secondary F6RPJ9 UniProtKB/TrEMBL