IDE (insulin degrading enzyme) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IDE (insulin degrading enzyme) Homo sapiens
Analyze
Symbol: IDE
Name: insulin degrading enzyme
RGD ID: 732801
HGNC Page HGNC:5381
Description: Enables several functions, including insulin binding activity; ion binding activity; and protein homodimerization activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; bradykinin catabolic process; and protein catabolic process. Located in several cellular components, including basolateral plasma membrane; external side of plasma membrane; and peroxisome. Implicated in type 2 diabetes mellitus. Biomarker of Alzheimer's disease and diabetic encephalopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Abeta-degrading protease; FLJ35968; insulin protease; insulin-degrading enzyme; insulinase; insulysin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: INSUL25_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,451,684 - 92,574,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,451,684 - 92,574,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36Build 36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-nitrofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-(3,4-dihydroxyphenyl)propanoic acid  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
ceftriaxone  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (EXP)
D-glucose  (ISO)
DDT  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
fenthion  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
glucose  (ISO)
ivermectin  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
notoginsenoside R1  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
rac-lactic acid  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (EXP)
scopolin  (EXP)
sodium arsenate  (EXP,ISO)
succimer  (ISO)
sumatriptan  (ISO)
sunitinib  (EXP)
testosterone  (EXP)
thapsigargin  (ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vanillic acid  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Treadmill Running and Rutin Reverse High Fat Diet Induced Cognitive Impairment in Diet Induced Obese Mice. Cheng J, etal., J Nutr Health Aging. 2016;20(5):503-8. doi: 10.1007/s12603-015-0616-7.
2. Change in INSR, APBA2 and IDE Gene Expressions in Brains of Alzheimer's Disease Patients. da Costa IB, etal., Curr Alzheimer Res. 2017;14(7):760-765. doi: 10.2174/1567205014666170203100734.
3. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Fakhrai-Rad H, etal., Hum Mol Genet 2000 Sep 1;9(14):2149-58.
4. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Farris W, etal., Proc Natl Acad Sci U S A 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12.
5. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Florez JC, etal., Diabetes. 2006 Jan;55(1):128-35.
6. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. Ghareeb DA, etal., Evid Based Complement Alternat Med. 2015;2015:361847. doi: 10.1155/2015/361847. Epub 2015 Oct 20.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Karamohamed S, etal., Diabetes. 2003 Jun;52(6):1562-7.
9. Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes. Kazkayasi I, etal., Pharmacol Rep. 2018 Aug;70(4):677-683. doi: 10.1016/j.pharep.2018.01.008. Epub 2018 Feb 1.
10. Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. Khodadadi D, etal., Neurochem Res. 2018 Aug;43(8):1561-1574. doi: 10.1007/s11064-018-2571-2. Epub 2018 Jun 11.
11. Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and invivo models of Alzheimer's disease. Kim DH, etal., Biochem Biophys Res Commun. 2018 Sep 14. pii: S0006-291X(18)31922-3. doi: 10.1016/j.bbrc.2018.09.012.
12. Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-a and IL-1ß in an Aß25-35-induced Rat Model of Alzheimer's Disease. Li L, etal., J Alzheimers Dis. 2017;56(4):1403-1417. doi: 10.3233/JAD-160587.
13. Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Marlowe L, etal., Neurodegener Dis. 2006;3(6):320-6.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. Son SM, etal., Autophagy. 2016 May 3;12(5):784-800. doi: 10.1080/15548627.2016.1159375. Epub 2016 Mar 10.
17. Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment. Sun J, etal., Curr Alzheimer Res. 2016;13(12):1337-1345.
18. Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation. Wang N, etal., Neural Regen Res. 2017 Apr;12(4):654-659. doi: 10.4103/1673-5374.205107.
19. Pioglitazone ameliorates Aß42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3ß activation. Yang S, etal., Mol Med Rep. 2017 May;15(5):2588-2594. doi: 10.3892/mmr.2017.6342. Epub 2017 Mar 16.
Additional References at PubMed
PMID:758022   PMID:1607078   PMID:1733942   PMID:1743072   PMID:2293021   PMID:3059494   PMID:6401723   PMID:7731996   PMID:8051160   PMID:8077210   PMID:8425612   PMID:9070242  
PMID:9231799   PMID:9830016   PMID:10684867   PMID:11145591   PMID:11809755   PMID:12161276   PMID:12477932   PMID:12507914   PMID:12716770   PMID:12746301   PMID:12850277   PMID:14517947  
PMID:14702039   PMID:14744259   PMID:14755451   PMID:14764804   PMID:15024728   PMID:15088150   PMID:15181249   PMID:15277398   PMID:15277615   PMID:15285718   PMID:15489232   PMID:15590928  
PMID:15718037   PMID:15850385   PMID:15858813   PMID:15858821   PMID:15911128   PMID:16344560   PMID:16385451   PMID:16511862   PMID:16574064   PMID:16675064   PMID:16876916   PMID:16914266  
PMID:17051221   PMID:17055432   PMID:17143514   PMID:17192785   PMID:17244626   PMID:17293876   PMID:17463249   PMID:17496198   PMID:17579348   PMID:17601350   PMID:17613531   PMID:17715127  
PMID:17804762   PMID:17827400   PMID:17913278   PMID:17953957   PMID:17964527   PMID:17971426   PMID:18212765   PMID:18226493   PMID:18411275   PMID:18426861   PMID:18448515   PMID:18591388  
PMID:18602473   PMID:18618095   PMID:18621727   PMID:18633108   PMID:18719881   PMID:18783335   PMID:18813847   PMID:18977241   PMID:18984664   PMID:18986166   PMID:18996360   PMID:19019493  
PMID:19053027   PMID:19082521   PMID:19139842   PMID:19228808   PMID:19239107   PMID:19321446   PMID:19383491   PMID:19396426   PMID:19453261   PMID:19592050   PMID:19592620   PMID:19602701  
PMID:19606063   PMID:19622614   PMID:19741166   PMID:19785409   PMID:19794065   PMID:19808678   PMID:19808892   PMID:19809796   PMID:19862325   PMID:19864391   PMID:19864659   PMID:19889475  
PMID:19896952   PMID:19913121   PMID:19933996   PMID:20033747   PMID:20082125   PMID:20098734   PMID:20161779   PMID:20178365   PMID:20203524   PMID:20360068   PMID:20362553   PMID:20364150  
PMID:20380468   PMID:20384434   PMID:20460429   PMID:20490451   PMID:20581827   PMID:20628086   PMID:20663017   PMID:20703447   PMID:20724036   PMID:20816152   PMID:20877624   PMID:20880607  
PMID:20927120   PMID:20959807   PMID:20971110   PMID:21098034   PMID:21185309   PMID:21232820   PMID:21343292   PMID:21731745   PMID:21800051   PMID:21873424   PMID:21873635   PMID:21903422  
PMID:21992747   PMID:22036964   PMID:22107728   PMID:22267728   PMID:22383525   PMID:22502914   PMID:22837378   PMID:22863883   PMID:23036584   PMID:23416320   PMID:23525105   PMID:23597493  
PMID:23797320   PMID:23922390   PMID:24059301   PMID:24355596   PMID:24477584   PMID:24509480   PMID:24516642   PMID:24778252   PMID:25105907   PMID:25414272   PMID:25544563   PMID:25921289  
PMID:26186194   PMID:26186340   PMID:26344197   PMID:26389662   PMID:26496610   PMID:26816005   PMID:26968463   PMID:27432908   PMID:27499296   PMID:27806189   PMID:27880917   PMID:27982586  
PMID:28514442   PMID:28611215   PMID:28675297   PMID:29093479   PMID:29273204   PMID:29509190   PMID:29596046   PMID:29987050   PMID:30021884   PMID:30561431   PMID:30649986   PMID:30948266  
PMID:31056398   PMID:31182584   PMID:31409639   PMID:31594818   PMID:32235678   PMID:32353859   PMID:32416252   PMID:32628020   PMID:32687490   PMID:32707033   PMID:32807901   PMID:32814053  
PMID:32857715   PMID:32877691   PMID:32963011   PMID:33060197   PMID:33631143   PMID:33637726   PMID:33865867   PMID:33961781   PMID:34732716   PMID:35163673   PMID:35236268   PMID:35271311  
PMID:35509820   PMID:35546756   PMID:35552390   PMID:35831314   PMID:35944360   PMID:36215168   PMID:36551314   PMID:36724073   PMID:37371470   PMID:37466059   PMID:37827155  


Genomics

Comparative Map Data
IDE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,451,684 - 92,574,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,451,684 - 92,574,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36Build 36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBIT2T-CHM13v2.0
Ide
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,246,140 - 37,341,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,246,142 - 37,340,010 (-)EnsemblGRCm39 Ensembl
GRCm381937,268,743 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBIMGSCv36mm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
Ide
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21235,002,984 - 235,102,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,995,351 - 235,102,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,391,715 - 243,489,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,321,195 - 250,419,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,159,390 - 243,257,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,914,447 - 256,013,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
Ide
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425847,615 - 926,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955425819,461 - 926,440 (+)NCBIChiLan1.0ChiLan1.0
IDE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan110104,492,478 - 104,617,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,196,295 - 89,320,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,714,343 - 92,833,430 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,716,540 - 92,833,353 (-)Ensemblpanpan1.1panPan2
IDE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,844,480 - 6,967,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,022,845 - 7,145,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,097,078 - 7,242,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,826,499 - 6,949,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,860,782 - 6,983,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,025,500 - 7,148,346 (-)NCBIUU_Cfam_GSD_1.0
Ide
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,597,592 - 40,685,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,230,283 - 2,318,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,230,477 - 2,318,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,992,039 - 104,106,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,992,035 - 104,106,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,505,034 - 113,619,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,722,728 - 85,843,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,721,886 - 85,843,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,459,858 - 46,578,672 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ide
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,835,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,708,309 - 3,822,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IDE
35 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh37/hg19 10q23.31-24.1(chr10:92667881-98970384)x1 copy number loss See cases [RCV000447362] Chr10:92667881..98970384 [GRCh37]
Chr10:10q23.31-24.1
pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q23.32-23.33(chr10:93186527-95820286)x1 copy number loss See cases [RCV000511278] Chr10:93186527..95820286 [GRCh37]
Chr10:10q23.32-23.33
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
NM_004969.4(IDE):c.1904A>G (p.Asn635Ser) single nucleotide variant Inborn genetic diseases [RCV003300220] Chr10:92475975 [GRCh38]
Chr10:94235732 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1652T>C (p.Ile551Thr) single nucleotide variant Inborn genetic diseases [RCV003279992] Chr10:92487200 [GRCh38]
Chr10:94246957 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.32-24.2(chr10:93908171-101809723)x1 copy number loss See cases [RCV000512315] Chr10:93908171..101809723 [GRCh37]
Chr10:10q23.32-24.2
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_004969.4(IDE):c.30C>T (p.His10=) single nucleotide variant not provided [RCV000970406] Chr10:92573990 [GRCh38]
Chr10:94333747 [GRCh37]
Chr10:10q23.33
benign|likely benign
NM_004969.4(IDE):c.723A>G (p.Leu241=) single nucleotide variant not provided [RCV000929121] Chr10:92514981 [GRCh38]
Chr10:94274738 [GRCh37]
Chr10:10q23.33
likely benign
NM_004969.4(IDE):c.2523T>C (p.Asn841=) single nucleotide variant not provided [RCV000953283] Chr10:92463969 [GRCh38]
Chr10:94223726 [GRCh37]
Chr10:10q23.33
benign
NM_004969.4(IDE):c.2373C>A (p.Ile791=) single nucleotide variant not provided [RCV000910501] Chr10:92465791 [GRCh38]
Chr10:94225548 [GRCh37]
Chr10:10q23.33
benign
NM_004969.4(IDE):c.70C>T (p.Arg24Cys) single nucleotide variant Inborn genetic diseases [RCV003242429] Chr10:92573950 [GRCh38]
Chr10:94333707 [GRCh37]
Chr10:10q23.33
uncertain significance
NC_000010.11:g.(?_92483255)_(92632693_?)dup duplication not provided [RCV001033391] Chr10:94243012..94392450 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.850C>G (p.Pro284Ala) single nucleotide variant Inborn genetic diseases [RCV003198205] Chr10:92510097 [GRCh38]
Chr10:94269854 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.31-24.1(chr10:92667881-98970384) copy number loss not specified [RCV002052882] Chr10:92667881..98970384 [GRCh37]
Chr10:10q23.31-24.1
pathogenic
NM_004969.4(IDE):c.884A>G (p.Glu295Gly) single nucleotide variant Inborn genetic diseases [RCV003286241] Chr10:92510063 [GRCh38]
Chr10:94269820 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1168A>G (p.Ile390Val) single nucleotide variant Inborn genetic diseases [RCV003258190] Chr10:92507652 [GRCh38]
Chr10:94267409 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.31-23.33(chr10:89823147-96056941)x1 copy number loss not provided [RCV002472645] Chr10:89823147..96056941 [GRCh37]
Chr10:10q23.31-23.33
pathogenic
NM_004969.4(IDE):c.1381C>T (p.Pro461Ser) single nucleotide variant Inborn genetic diseases [RCV002882435] Chr10:92504843 [GRCh38]
Chr10:94264600 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2353G>A (p.Val785Ile) single nucleotide variant Inborn genetic diseases [RCV002753300] Chr10:92465811 [GRCh38]
Chr10:94225568 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2932A>G (p.Ile978Val) single nucleotide variant Inborn genetic diseases [RCV002978316] Chr10:92455608 [GRCh38]
Chr10:94215365 [GRCh37]
Chr10:10q23.33
likely benign
NM_004969.4(IDE):c.1631C>T (p.Ala544Val) single nucleotide variant Inborn genetic diseases [RCV003000450] Chr10:92487221 [GRCh38]
Chr10:94246978 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1456G>A (p.Glu486Lys) single nucleotide variant Inborn genetic diseases [RCV002924188] Chr10:92490570 [GRCh38]
Chr10:94250327 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2141C>G (p.Ala714Gly) single nucleotide variant Inborn genetic diseases [RCV002977289] Chr10:92470321 [GRCh38]
Chr10:94230078 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.825T>G (p.Phe275Leu) single nucleotide variant Inborn genetic diseases [RCV002955483] Chr10:92510122 [GRCh38]
Chr10:94269879 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1328A>G (p.Tyr443Cys) single nucleotide variant Inborn genetic diseases [RCV002702123] Chr10:92504896 [GRCh38]
Chr10:94264653 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1808C>T (p.Ser603Leu) single nucleotide variant Inborn genetic diseases [RCV002929295] Chr10:92479353 [GRCh38]
Chr10:94239110 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.732C>A (p.Phe244Leu) single nucleotide variant Inborn genetic diseases [RCV002787965] Chr10:92514972 [GRCh38]
Chr10:94274729 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2218G>C (p.Gly740Arg) single nucleotide variant Inborn genetic diseases [RCV002803364] Chr10:92468981 [GRCh38]
Chr10:94228738 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2779T>C (p.Tyr927His) single nucleotide variant Inborn genetic diseases [RCV002875050] Chr10:92461235 [GRCh38]
Chr10:94220992 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2225T>C (p.Met742Thr) single nucleotide variant Inborn genetic diseases [RCV002892781] Chr10:92468974 [GRCh38]
Chr10:94228731 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.524A>G (p.Asp175Gly) single nucleotide variant Inborn genetic diseases [RCV002955424] Chr10:92531885 [GRCh38]
Chr10:94291642 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2866G>A (p.Val956Ile) single nucleotide variant Inborn genetic diseases [RCV002744903] Chr10:92456389 [GRCh38]
Chr10:94216146 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1352C>T (p.Thr451Ile) single nucleotide variant Inborn genetic diseases [RCV002939798] Chr10:92504872 [GRCh38]
Chr10:94264629 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2718A>C (p.Lys906Asn) single nucleotide variant Inborn genetic diseases [RCV002807910] Chr10:92463774 [GRCh38]
Chr10:94223531 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.622A>G (p.Thr208Ala) single nucleotide variant Inborn genetic diseases [RCV002935676] Chr10:92531787 [GRCh38]
Chr10:94291544 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2890G>T (p.Asp964Tyr) single nucleotide variant Inborn genetic diseases [RCV002921161] Chr10:92456365 [GRCh38]
Chr10:94216122 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1531A>G (p.Lys511Glu) single nucleotide variant Inborn genetic diseases [RCV002961386] Chr10:92490495 [GRCh38]
Chr10:94250252 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1381C>G (p.Pro461Ala) single nucleotide variant Inborn genetic diseases [RCV003195783] Chr10:92504843 [GRCh38]
Chr10:94264600 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.32-24.1(chr10:93281410-97596360)x1 copy number loss See cases [RCV003159569] Chr10:93281410..97596360 [GRCh37]
Chr10:10q23.32-24.1
pathogenic
NM_004969.4(IDE):c.1829C>T (p.Ala610Val) single nucleotide variant Inborn genetic diseases [RCV003210259] Chr10:92479332 [GRCh38]
Chr10:94239089 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.2149C>T (p.Pro717Ser) single nucleotide variant Inborn genetic diseases [RCV003212729] Chr10:92470313 [GRCh38]
Chr10:94230070 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1405G>A (p.Asp469Asn) single nucleotide variant Inborn genetic diseases [RCV003192451] Chr10:92504819 [GRCh38]
Chr10:94264576 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3
pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3
pathogenic
NM_004969.4(IDE):c.1141G>A (p.Glu381Lys) single nucleotide variant Inborn genetic diseases [RCV003378810] Chr10:92508125 [GRCh38]
Chr10:94267882 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1707G>T (p.Leu569Phe) single nucleotide variant Inborn genetic diseases [RCV003367440] Chr10:92483287 [GRCh38]
Chr10:94243044 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_004969.4(IDE):c.1520A>T (p.Asp507Val) single nucleotide variant Inborn genetic diseases [RCV003356190] Chr10:92490506 [GRCh38]
Chr10:94250263 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2
pathogenic
GRCh37/hg19 10q23.32-23.33(chr10:93788061-96452666)x3 copy number gain not provided [RCV003484809] Chr10:93788061..96452666 [GRCh37]
Chr10:10q23.32-23.33
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3210
Count of miRNA genes:1054
Interacting mature miRNAs:1262
Transcripts:ENST00000265986, ENST00000371581, ENST00000436178, ENST00000462988, ENST00000463640, ENST00000478361, ENST00000492362, ENST00000496903
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH80115  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,239,546 - 94,239,778UniSTSGRCh37
Build 361094,229,526 - 94,229,758RGDNCBI36
Celera1087,980,965 - 87,981,197RGD
Cytogenetic Map10q23-q25UniSTS
HuRef1087,865,252 - 87,865,484UniSTS
GeneMap99-GB4 RH Map10443.47UniSTS
GDB:193867  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,214,067 - 94,214,166UniSTSGRCh37
Build 361094,204,047 - 94,204,146RGDNCBI36
Celera1087,955,487 - 87,955,586RGD
Cytogenetic Map10q23-q25UniSTS
HuRef1087,839,884 - 87,839,983UniSTS
STS-T88914  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,313,891 - 94,314,010UniSTSGRCh37
Build 361094,303,871 - 94,303,990RGDNCBI36
Celera1088,055,401 - 88,055,520RGD
Cytogenetic Map10q23-q25UniSTS
HuRef1087,939,594 - 87,939,713UniSTS
GeneMap99-GB4 RH Map10443.37UniSTS
D10S2141  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,214,068 - 94,214,165UniSTSGRCh37
Build 361094,204,048 - 94,204,145RGDNCBI36
Celera1087,955,488 - 87,955,585RGD
Cytogenetic Map10q23-q25UniSTS
HuRef1087,839,885 - 87,839,982UniSTS
Whitehead-YAC Contig Map10 UniSTS
STS-D29519  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,212,051 - 94,212,234UniSTSGRCh37
Build 361094,202,031 - 94,202,214RGDNCBI36
Celera1087,953,471 - 87,953,654RGD
Cytogenetic Map10q23-q25UniSTS
HuRef1087,837,868 - 87,838,051UniSTS
GeneMap99-GB4 RH Map10445.19UniSTS
RH44800  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,314,017 - 94,314,155UniSTSGRCh37
Build 361094,303,997 - 94,304,135RGDNCBI36
Celera1088,055,527 - 88,055,665RGD
Cytogenetic Map10q23-q25UniSTS
HuRef1087,939,720 - 87,939,858UniSTS
GeneMap99-GB4 RH Map10441.46UniSTS
WI-17525  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,212,025 - 94,212,174UniSTSGRCh37
Build 361094,202,005 - 94,202,154RGDNCBI36
Celera1087,953,445 - 87,953,594RGD
Cytogenetic Map10q23-q25UniSTS
HuRef1087,837,842 - 87,837,991UniSTS
GeneMap99-GB4 RH Map10443.37UniSTS
Whitehead-RH Map10533.3UniSTS
IDE  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371094,268,501 - 94,268,602UniSTSGRCh37
Celera1088,009,917 - 88,010,018UniSTS
HuRef1087,894,203 - 87,894,304UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1382 1164 934 240 815 171 3489 1485 511 211 1144 1142 82 415 2308 4
Low 1050 1791 789 382 1110 293 867 704 3197 207 306 466 89 789 480
Below cutoff 1 29 24 5 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_013012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001165946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001410974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_136399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017016187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017016188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017016189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017016190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047425175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054365752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001747103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_945727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL356128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF780766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK824565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA643304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA879845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB204538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB219527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB445060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB485919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000265986   ⟹   ENSP00000265986
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,451,684 - 92,574,093 (-)Ensembl
RefSeq Acc Id: ENST00000371581   ⟹   ENSP00000360637
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,451,684 - 92,497,761 (-)Ensembl
RefSeq Acc Id: ENST00000436178   ⟹   ENSP00000408850
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,510,133 - 92,541,353 (-)Ensembl
RefSeq Acc Id: ENST00000462988
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,475,972 - 92,479,735 (-)Ensembl
RefSeq Acc Id: ENST00000463640
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,475,945 - 92,479,587 (-)Ensembl
RefSeq Acc Id: ENST00000478361   ⟹   ENSP00000473506
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,474,472 - 92,574,067 (-)Ensembl
RefSeq Acc Id: ENST00000492362
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,480,557 - 92,497,749 (-)Ensembl
RefSeq Acc Id: ENST00000496903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,454,269 - 92,497,733 (-)Ensembl
RefSeq Acc Id: ENST00000650060   ⟹   ENSP00000497272
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,451,684 - 92,574,093 (-)Ensembl
RefSeq Acc Id: ENST00000676540   ⟹   ENSP00000504633
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,266 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000676626
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,270 - 92,556,086 (-)Ensembl
RefSeq Acc Id: ENST00000676816   ⟹   ENSP00000504709
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,574,019 (-)Ensembl
RefSeq Acc Id: ENST00000676987
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,506,595 (-)Ensembl
RefSeq Acc Id: ENST00000677079   ⟹   ENSP00000503417
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,376 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000677096   ⟹   ENSP00000503793
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,256 - 92,574,056 (-)Ensembl
RefSeq Acc Id: ENST00000677193
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,508,516 (-)Ensembl
RefSeq Acc Id: ENST00000677196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,482,968 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000677434   ⟹   ENSP00000503274
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,388 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000677569   ⟹   ENSP00000503462
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,451,937 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000677953
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,483,195 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000677978   ⟹   ENSP00000503310
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,482,949 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000678026
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,270 - 92,556,086 (-)Ensembl
RefSeq Acc Id: ENST00000678082
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,270 - 92,476,197 (-)Ensembl
RefSeq Acc Id: ENST00000678097
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,259 - 92,456,833 (-)Ensembl
RefSeq Acc Id: ENST00000678248
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,469,463 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000678410
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,472,979 - 92,506,560 (-)Ensembl
RefSeq Acc Id: ENST00000678458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,555,424 (-)Ensembl
RefSeq Acc Id: ENST00000678673   ⟹   ENSP00000503082
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000678715   ⟹   ENSP00000503025
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,573,910 (-)Ensembl
RefSeq Acc Id: ENST00000678824   ⟹   ENSP00000503571
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,453,515 - 92,497,741 (-)Ensembl
RefSeq Acc Id: ENST00000678844   ⟹   ENSP00000504561
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000678977
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000679069
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000679089   ⟹   ENSP00000504067
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,451,936 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000679174   ⟹   ENSP00000504758
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000679222   ⟹   ENSP00000504070
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,259 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000679232   ⟹   ENSP00000503818
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,574,096 (-)Ensembl
RefSeq Acc Id: ENST00000679304
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,452,272 - 92,508,493 (-)Ensembl
RefSeq Acc Id: ENST00000679312   ⟹   ENSP00000504442
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1092,451,684 - 92,574,093 (-)Ensembl
RefSeq Acc Id: NM_001165946   ⟹   NP_001159418
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,497,764 (-)NCBI
GRCh371094,211,441 - 94,333,852 (-)ENTREZGENE
HuRef1087,837,258 - 87,960,004 (-)ENTREZGENE
CHM1_11094,493,176 - 94,539,254 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,377,051 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322793   ⟹   NP_001309722
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
CHM1_11094,493,176 - 94,615,858 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322794   ⟹   NP_001309723
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
CHM1_11094,493,176 - 94,615,858 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322795   ⟹   NP_001309724
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
CHM1_11094,493,176 - 94,615,858 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322796   ⟹   NP_001309725
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,573,506 (-)NCBI
CHM1_11094,493,176 - 94,615,269 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,452,842 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001322797   ⟹   NP_001309726
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,497,764 (-)NCBI
CHM1_11094,493,176 - 94,539,254 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,377,051 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001410974   ⟹   NP_001397903
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBI
RefSeq Acc Id: NM_004969   ⟹   NP_004960
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
GRCh371094,211,441 - 94,333,852 (-)ENTREZGENE
Build 361094,203,580 - 94,323,832 (-)NCBI Archive
HuRef1087,837,258 - 87,960,004 (-)ENTREZGENE
CHM1_11094,493,176 - 94,615,858 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBI
Sequence:
RefSeq Acc Id: NR_136399
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
CHM1_11094,493,176 - 94,615,858 (-)NCBI
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017016187   ⟹   XP_016871676
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,541,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017016188   ⟹   XP_016871677
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,573,632 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017016190   ⟹   XP_016871679
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047425169   ⟹   XP_047281125
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
RefSeq Acc Id: XM_047425171   ⟹   XP_047281127
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,451,684 - 92,574,093 (-)NCBI
RefSeq Acc Id: XM_047425172   ⟹   XP_047281128
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,478,687 - 92,574,093 (-)NCBI
RefSeq Acc Id: XM_047425173   ⟹   XP_047281129
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,479,318 - 92,574,093 (-)NCBI
RefSeq Acc Id: XM_047425174   ⟹   XP_047281130
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,478,686 - 92,574,093 (-)NCBI
RefSeq Acc Id: XM_047425175   ⟹   XP_047281131
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,479,318 - 92,574,093 (-)NCBI
RefSeq Acc Id: XM_054365744   ⟹   XP_054221719
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,330,970 - 93,453,414 (-)NCBI
RefSeq Acc Id: XM_054365745   ⟹   XP_054221720
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,330,970 - 93,420,760 (-)NCBI
RefSeq Acc Id: XM_054365746   ⟹   XP_054221721
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBI
RefSeq Acc Id: XM_054365747   ⟹   XP_054221722
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,330,970 - 93,452,968 (-)NCBI
RefSeq Acc Id: XM_054365748   ⟹   XP_054221723
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,330,970 - 93,453,426 (-)NCBI
RefSeq Acc Id: XM_054365749   ⟹   XP_054221724
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,357,972 - 93,453,414 (-)NCBI
RefSeq Acc Id: XM_054365750   ⟹   XP_054221725
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,358,603 - 93,453,414 (-)NCBI
RefSeq Acc Id: XM_054365751   ⟹   XP_054221726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,357,971 - 93,453,429 (-)NCBI
RefSeq Acc Id: XM_054365752   ⟹   XP_054221727
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01093,358,603 - 93,453,429 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001159418 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309722 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309723 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309724 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309725 (Get FASTA)   NCBI Sequence Viewer  
  NP_001309726 (Get FASTA)   NCBI Sequence Viewer  
  NP_001397903 (Get FASTA)   NCBI Sequence Viewer  
  NP_004960 (Get FASTA)   NCBI Sequence Viewer  
  XP_016871676 (Get FASTA)   NCBI Sequence Viewer  
  XP_016871677 (Get FASTA)   NCBI Sequence Viewer  
  XP_016871679 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281125 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281127 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281128 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281129 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281130 (Get FASTA)   NCBI Sequence Viewer  
  XP_047281131 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221719 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221720 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221721 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221722 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221723 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221724 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221725 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221726 (Get FASTA)   NCBI Sequence Viewer  
  XP_054221727 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA52712 (Get FASTA)   NCBI Sequence Viewer  
  AAH96336 (Get FASTA)   NCBI Sequence Viewer  
  AAH96337 (Get FASTA)   NCBI Sequence Viewer  
  AAH96339 (Get FASTA)   NCBI Sequence Viewer  
  BAD92441 (Get FASTA)   NCBI Sequence Viewer  
  BAG35668 (Get FASTA)   NCBI Sequence Viewer  
  BAG52680 (Get FASTA)   NCBI Sequence Viewer  
  BAH13752 (Get FASTA)   NCBI Sequence Viewer  
  BAH14778 (Get FASTA)   NCBI Sequence Viewer  
  CBA13324 (Get FASTA)   NCBI Sequence Viewer  
  EAW50090 (Get FASTA)   NCBI Sequence Viewer  
  EAW50091 (Get FASTA)   NCBI Sequence Viewer  
  EAW50092 (Get FASTA)   NCBI Sequence Viewer  
  EAW50093 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000265986
  ENSP00000265986.6
  ENSP00000360637
  ENSP00000360637.5
  ENSP00000473506.1
  ENSP00000497272
  ENSP00000497272.1
  ENSP00000503025
  ENSP00000503025.1
  ENSP00000503082.1
  ENSP00000503274
  ENSP00000503274.1
  ENSP00000503310.1
  ENSP00000503417.1
  ENSP00000503462.1
  ENSP00000503571.1
  ENSP00000503793.1
  ENSP00000503818.1
  ENSP00000504053
  ENSP00000504053.1
  ENSP00000504067.1
  ENSP00000504070.1
  ENSP00000504442.1
  ENSP00000504561.1
  ENSP00000504633.1
  ENSP00000504709.1
  ENSP00000504758.1
GenBank Protein P14735 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_004960   ⟸   NM_004969
- Peptide Label: isoform 1
- UniProtKB: D3DR35 (UniProtKB/Swiss-Prot),   B7ZAU2 (UniProtKB/Swiss-Prot),   B2R721 (UniProtKB/Swiss-Prot),   Q5T5N2 (UniProtKB/Swiss-Prot),   P14735 (UniProtKB/Swiss-Prot),   A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159418   ⟸   NM_001165946
- Peptide Label: isoform 2
- UniProtKB: B7Z7W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309723   ⟸   NM_001322794
- Peptide Label: isoform 4
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309722   ⟸   NM_001322793
- Peptide Label: isoform 3
- UniProtKB: A0A3B3ISG5 (UniProtKB/TrEMBL),   A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309724   ⟸   NM_001322795
- Peptide Label: isoform 5
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309725   ⟸   NM_001322796
- Peptide Label: isoform 5
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001309726   ⟸   NM_001322797
- Peptide Label: isoform 6
- UniProtKB: B3KSB8 (UniProtKB/TrEMBL),   B7Z7W6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016871679   ⟸   XM_017016190
- Peptide Label: isoform X2
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016871677   ⟸   XM_017016188
- Peptide Label: isoform X3
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016871676   ⟸   XM_017016187
- Peptide Label: isoform X3
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000360637   ⟸   ENST00000371581
RefSeq Acc Id: ENSP00000473506   ⟸   ENST00000478361
RefSeq Acc Id: ENSP00000497272   ⟸   ENST00000650060
RefSeq Acc Id: ENSP00000408850   ⟸   ENST00000436178
RefSeq Acc Id: ENSP00000265986   ⟸   ENST00000265986
RefSeq Acc Id: ENSP00000504709   ⟸   ENST00000676816
RefSeq Acc Id: ENSP00000504633   ⟸   ENST00000676540
RefSeq Acc Id: ENSP00000503417   ⟸   ENST00000677079
RefSeq Acc Id: ENSP00000503793   ⟸   ENST00000677096
RefSeq Acc Id: ENSP00000503462   ⟸   ENST00000677569
RefSeq Acc Id: ENSP00000503274   ⟸   ENST00000677434
RefSeq Acc Id: ENSP00000503310   ⟸   ENST00000677978
RefSeq Acc Id: ENSP00000503571   ⟸   ENST00000678824
RefSeq Acc Id: ENSP00000504561   ⟸   ENST00000678844
RefSeq Acc Id: ENSP00000503025   ⟸   ENST00000678715
RefSeq Acc Id: ENSP00000503082   ⟸   ENST00000678673
RefSeq Acc Id: ENSP00000504442   ⟸   ENST00000679312
RefSeq Acc Id: ENSP00000504070   ⟸   ENST00000679222
RefSeq Acc Id: ENSP00000503818   ⟸   ENST00000679232
RefSeq Acc Id: ENSP00000504758   ⟸   ENST00000679174
RefSeq Acc Id: ENSP00000504067   ⟸   ENST00000679089
RefSeq Acc Id: XP_047281127   ⟸   XM_047425171
- Peptide Label: isoform X3
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047281125   ⟸   XM_047425169
- Peptide Label: isoform X1
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047281130   ⟸   XM_047425174
- Peptide Label: isoform X6
- UniProtKB: A0A7I2V373 (UniProtKB/TrEMBL),   A0A7I2YQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047281128   ⟸   XM_047425172
- Peptide Label: isoform X4
- UniProtKB: A0A7I2YQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047281131   ⟸   XM_047425175
- Peptide Label: isoform X7
- UniProtKB: A0A7I2V612 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047281129   ⟸   XM_047425173
- Peptide Label: isoform X5
- UniProtKB: A0A7I2V612 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001397903   ⟸   NM_001410974
- Peptide Label: isoform 7
- UniProtKB: A0A7I2V2P6 (UniProtKB/TrEMBL),   A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221721   ⟸   XM_054365746
- Peptide Label: isoform X3
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221723   ⟸   XM_054365748
- Peptide Label: isoform X1
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221719   ⟸   XM_054365744
- Peptide Label: isoform X2
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221722   ⟸   XM_054365747
- Peptide Label: isoform X3
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221720   ⟸   XM_054365745
- Peptide Label: isoform X3
- UniProtKB: A0A7I2V3E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221726   ⟸   XM_054365751
- Peptide Label: isoform X6
- UniProtKB: A0A7I2V373 (UniProtKB/TrEMBL),   A0A7I2YQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221724   ⟸   XM_054365749
- Peptide Label: isoform X4
- UniProtKB: A0A7I2YQS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221727   ⟸   XM_054365752
- Peptide Label: isoform X7
- UniProtKB: A0A7I2V612 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054221725   ⟸   XM_054365750
- Peptide Label: isoform X5
- UniProtKB: A0A7I2V612 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14735-F1-model_v2 AlphaFold P14735 1-1019 view protein structure

Promoters
RGD ID:7218159
Promoter ID:EPDNEW_H14825
Type:initiation region
Name:IDE_1
Description:insulin degrading enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14826  EPDNEW_H14827  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,574,069 - 92,574,129EPDNEW
RGD ID:7218161
Promoter ID:EPDNEW_H14826
Type:initiation region
Name:IDE_2
Description:insulin degrading enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14825  EPDNEW_H14827  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,574,093 - 92,574,153EPDNEW
RGD ID:7218167
Promoter ID:EPDNEW_H14827
Type:initiation region
Name:IDE_3
Description:insulin degrading enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14825  EPDNEW_H14826  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381092,574,520 - 92,574,580EPDNEW
RGD ID:6787770
Promoter ID:HG_KWN:10571
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004969,   OTTHUMT00000049394
Position:
Human AssemblyChrPosition (strand)Source
Build 361094,323,669 - 94,324,169 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5381 AgrOrtholog
COSMIC IDE COSMIC
Ensembl Genes ENSG00000119912 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000265986 ENTREZGENE
  ENST00000265986.11 UniProtKB/Swiss-Prot
  ENST00000371581 ENTREZGENE
  ENST00000371581.9 UniProtKB/Swiss-Prot
  ENST00000478361.6 UniProtKB/TrEMBL
  ENST00000496903 ENTREZGENE
  ENST00000496903.5 UniProtKB/TrEMBL
  ENST00000650060 ENTREZGENE
  ENST00000650060.2 UniProtKB/TrEMBL
  ENST00000676540.1 UniProtKB/TrEMBL
  ENST00000676816.1 UniProtKB/TrEMBL
  ENST00000677079.1 UniProtKB/TrEMBL
  ENST00000677096.1 UniProtKB/TrEMBL
  ENST00000677434 ENTREZGENE
  ENST00000677434.1 UniProtKB/TrEMBL
  ENST00000677569.1 UniProtKB/TrEMBL
  ENST00000677978.1 UniProtKB/TrEMBL
  ENST00000678458 ENTREZGENE
  ENST00000678673.1 UniProtKB/TrEMBL
  ENST00000678715 ENTREZGENE
  ENST00000678715.1 UniProtKB/TrEMBL
  ENST00000678824.1 UniProtKB/TrEMBL
  ENST00000678844 ENTREZGENE
  ENST00000678844.1 UniProtKB/TrEMBL
  ENST00000679089.1 UniProtKB/TrEMBL
  ENST00000679174.1 UniProtKB/TrEMBL
  ENST00000679222.1 UniProtKB/TrEMBL
  ENST00000679232.1 UniProtKB/TrEMBL
  ENST00000679312.1 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000119912 GTEx
HGNC ID HGNC:5381 ENTREZGENE
Human Proteome Map IDE Human Proteome Map
InterPro Metalloenz_LuxS/M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3416 UniProtKB/Swiss-Prot
NCBI Gene 3416 ENTREZGENE
OMIM 146680 OMIM
PANTHER INSULIN-DEGRADING ENZYME-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NARDILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29629 PharmGKB
PROSITE INSULINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3B3ISG5 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V2P6 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V2S1_HUMAN UniProtKB/TrEMBL
  A0A7I2V373 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V3E3 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V3K9_HUMAN UniProtKB/TrEMBL
  A0A7I2V4A4_HUMAN UniProtKB/TrEMBL
  A0A7I2V4Q3_HUMAN UniProtKB/TrEMBL
  A0A7I2V610_HUMAN UniProtKB/TrEMBL
  A0A7I2V612 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V634_HUMAN UniProtKB/TrEMBL
  A0A7I2YQS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2YQV5_HUMAN UniProtKB/TrEMBL
  B2R721 ENTREZGENE
  B3KSB8 ENTREZGENE, UniProtKB/TrEMBL
  B7Z7W6 ENTREZGENE, UniProtKB/TrEMBL
  B7ZAU2 ENTREZGENE
  D3DR35 ENTREZGENE
  IDE_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5T5N2 ENTREZGENE
  R4GN65_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R721 UniProtKB/Swiss-Prot
  B7ZAU2 UniProtKB/Swiss-Prot
  D3DR35 UniProtKB/Swiss-Prot
  Q5T5N2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-10 IDE  insulin degrading enzyme    insulin-degrading enzyme  Symbol and/or name change 5135510 APPROVED