Lmna (lamin A) - Rat Genome Database

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Gene: Lmna (lamin A) Mus musculus
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Symbol: Lmna
Name: lamin A
RGD ID: 732791
MGI Page MGI
Description: Predicted to enable identical protein binding activity and protein phosphatase 1 binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including establishment or maintenance of microtubule cytoskeleton polarity; negative regulation of cardiac muscle hypertrophy in response to stress; and protein localization to nucleus. Acts upstream of or within several processes, including negative regulation of apoptotic signaling pathway; protein import into nucleus; and ventricular cardiac muscle cell development. Located in lamin filament and nuclear membrane. Is expressed in several structures, including embryo mesenchyme; epithelium; heart; immune system; and musculature. Used to study several diseases, including Charcot-Marie-Tooth disease type 2B1; achalasia; dilated cardiomyopathy 1A; muscular dystrophy (multiple); and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Dhe; lamin A/C; lamin C; lamin-A/C; prelamin-A/C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)EnsemblGRCm39 Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBIMGSCv36mm8
Celera388,521,102 - 88,543,289 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (IAGP)
aortic valve disease 2  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
arteriosclerosis  (ISO)
atrioventricular block  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 2  (IMP,ISO)
autosomal dominant intellectual developmental disorder 44  (ISO)
autosomal recessive Emery-Dreifuss muscular dystrophy 3  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
autosomal recessive nonsyndromic deafness 4  (ISO)
Cardiac Arrhythmias  (IAGP)
Cardiac Conduction Disease with or without Dilated Cardiomyopathy  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
cerebrovascular disease  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 2B1  (IAGP,ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Microtia  (ISO)
congenital muscular dystrophy  (ISO)
congenital muscular dystrophy due to LMNA mutation  (IAGP,ISO)
Craniofacial Abnormalities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (IAGP,ISO)
dilated cardiomyopathy 1A  (IAGP,ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome  (ISO)
disease of metabolism  (ISO)
Dwarfism  (ISO)
Emery-Dreifuss muscular dystrophy  (IAGP,ISO)
familial hypertrophic cardiomyopathy  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 2  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Heart-Hand Syndrome, Slovenian Type  (ISO)
Hereditary Motor Neuropathy with Myopathic Features  (ISO)
hereditary neuropathy with liability to pressure palsies  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Hypercholesterolemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
immunodeficiency 42  (ISO)
Insulin Resistance  (ISO)
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans  (ISO)
Laminopathies  (ISO)
left ventricular noncompaction  (ISO)
limb-girdle muscular dystrophy  (ISO)
lipoatrophic diabetes mellitus  (ISO)
lipodystrophy  (ISO)
localized scleroderma  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
mandibuloacral dysplasia  (ISO)
mandibuloacral dysplasia type A lipodystrophy  (ISO)
maturity-onset diabetes of the young  (ISO)
Metabolic Syndrome  (ISO)
MHC class II deficiency  (ISO)
muscular dystrophy  (ISO)
neuromuscular disease  (ISO)
neuropathy  (ISO)
Noonan syndrome 8  (ISO)
nuclear type mitochondrial complex I deficiency 16  (ISO)
otitis media  (IAGP)
parathyroid carcinoma  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
polycystic ovary syndrome  (ISO)
polyneuropathy  (ISO)
progeria  (IAGP,IMP,ISO)
Progeria Syndrome, Childhood-Onset  (ISO)
restrictive dermopathy  (ISO)
restrictive dermopathy 1  (ISO)
restrictive dermopathy 2  (ISO)
severe congenital neutropenia 3  (ISO)
severe congenital neutropenia 5  (ISO)
Sinoatrial Block  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brodifacoum  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chelerythrine  (ISO)
chloromethylisothiazolinone  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fumonisin B1  (EXP)
genistein  (ISO)
gentamycin  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lonafarnib  (ISO)
lopinavir  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin RR  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
staurosporine  (ISO)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta smooth muscle morphology  (IAGP)
abnormal aorta tunica adventitia morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal auditory bulla morphology  (IAGP)
abnormal auditory tube morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cholinergic neuron morphology  (IAGP)
abnormal chromosomal synapsis  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal colon morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal cranium size  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal distortion product otoacoustic emission  (IAGP)
abnormal DNA replication  (IAGP)
abnormal double-strand DNA break repair  (IAGP)
abnormal ear development  (IAGP)
abnormal ear morphology  (IAGP)
abnormal ear physiology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermal melanocyte morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal esophageal smooth muscle morphology  (IAGP)
abnormal esophageal squamous epithelium morphology  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal female meiosis  (IAGP)
abnormal frontonasal suture morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gastrocnemius morphology  (IAGP)
abnormal hair cycle anagen phase  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hard palate morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hypaxial muscle morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal interstitial cell of Cajal morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal lambdoid suture morphology  (IAGP)
abnormal meiosis  (IAGP)
abnormal middle ear epithelium morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitosis  (IAGP)
abnormal mitotic spindle assembly checkpoint  (IAGP)
abnormal muscle development  (IAGP)
abnormal muscle tone  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nasopharynx morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal nuclear lamina morphology  (IAGP)
abnormal peritoneal macrophage morphology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin morphology  (IAGP)
abnormal soleus morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tibialis anterior morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tympanic membrane morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vasodilation  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
absent subcutaneous adipose tissue  (IAGP)
alopecia  (IAGP)
aneuploidy  (IAGP)
arrest of male meiosis  (IAGP)
atherosclerotic lesions  (IAGP)
azoospermia  (IAGP)
bradykinesia  (IAGP)
calcified aorta  (IAGP)
calcified aortic arch  (IAGP)
calcified thoracic aorta  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cardiac muscle degeneration  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
congestive heart failure  (IAGP)
cornea ulcer  (IEA)
decreased abdominal adipose tissue amount  (IAGP)
decreased body height  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone volume  (IAGP)
decreased capillary density  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac output  (IAGP)
decreased circulating carnitine level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating lactate level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased core body temperature  (IAGP)
decreased cranium height  (IAGP)
decreased cranium width  (IAGP)
decreased eccrine gland number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased grip strength  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart left ventricle weight  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased liver glycogen level  (IAGP)
decreased locomotor activity  (IAGP)
decreased myocardial fiber number  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased quadriceps weight  (IAGP)
decreased sebaceous gland number  (IAGP)
decreased skeletal muscle fiber diameter  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to bone fracture  (IAGP)
decreased total body fat amount  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased vascular endothelial cell number  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased white adipose tissue amount  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated esophagus  (IAGP)
dilated heart atrium  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
disheveled coat  (IAGP)
distended cecum  (IAGP)
duodenum polyps  (IAGP)
dystrophic muscle  (IAGP)
enhanced exercise endurance  (IAGP)
enlarged heart  (IAGP)
enlarged heart atrium  (IAGP)
epidermal hyperplasia  (IAGP)
esophageal achalasia  (IAGP)
exophthalmos  (IAGP)
female infertility  (IAGP)
flaky skin  (IAGP)
hunched posture  (IAGP)
hyperkeratosis  (IAGP)
hypoglycemia  (IAGP)
impaired coordination  (IAGP)
impaired exercise endurance  (IAGP)
impaired hearing  (IAGP)
improved glucose tolerance  (IEA)
increased aorta wall thickness  (IAGP)
increased bone trabecular spacing  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased circulating growth hormone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating phosphate level  (IAGP)
increased middle ear goblet cell number  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased susceptibility to otitis media  (IAGP)
increased triglyceride level  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
jejunum polyps  (IAGP)
keratoconjunctivitis sicca  (IAGP)
kinked tail  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lordokyphosis  (IAGP)
male infertility  (IAGP)
malocclusion  (IAGP)
mandible hypoplasia  (IAGP)
meteorism  (IAGP)
micrognathia  (IAGP)
muscle degeneration  (IAGP)
muscle weakness  (IAGP)
muscular atrophy  (IAGP)
myocardial fiber degeneration  (IAGP)
myocardium necrosis  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypotelorism  (IAGP)
oligozoospermia  (IAGP)
orthokeratosis  (IAGP)
osteoporosis  (IAGP)
penis prolapse  (IAGP)
poor grooming  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
progressive muscle weakness  (IAGP)
prolonged P wave  (IAGP)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged RR interval  (IAGP)
prominent ears  (IAGP)
pulmonary edema  (IAGP)
pulmonary hypertension  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
rib fractures  (IAGP)
rough coat  (IAGP)
sebaceous gland hypoplasia  (IAGP)
shallow orbits  (IAGP)
short ears  (IAGP)
short maxilla  (IAGP)
short snout  (IAGP)
short tibia  (IEA)
short upper incisors  (IAGP)
sinoatrial block  (IAGP)
skeletal muscle degeneration  (IAGP)
skeletal muscle fibrosis  (IAGP)
slow postnatal weight gain  (IAGP)
small cranium  (IAGP)
small gonad  (IAGP)
small heart  (IAGP)
small lower incisors  (IAGP)
small myocardial fiber  (IAGP)
small seminiferous tubules  (IAGP)
small spleen  (IAGP)
small testis  (IAGP)
small thymus  (IAGP)
small xiphoid process  (IAGP)
sparse hair  (IAGP)
tachypnea  (IAGP)
thick epidermis  (IAGP)
thin dermal layer  (IAGP)
thin myocardium  (IAGP)
thymus atrophy  (IAGP)
tympanic membrane retraction  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
weight loss  (IAGP)
wide cranial sutures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Laminopathies and atherosclerosis. Al-Shali KZ and Hegele RA, Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1591-5. Epub 2004 Jun 17.
2. Proteomic analysis of rat aorta during atherosclerosis induced by high cholesterol diet and injection of vitamin D3. Almofti MR, etal., Clin Exp Pharmacol Physiol. 2006 Apr;33(4):305-9.
3. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Bonne G, etal., Nat Genet. 1999 Mar;21(3):285-8.
4. Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Cao H and Hegele RA, Hum Mol Genet. 2000 Jan 1;9(1):109-12.
5. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). Cao H and Hegele RA, J Hum Genet. 2003;48(5):271-4. Epub 2003 Apr 3.
6. LMNA mutations in atypical Werner's syndrome. Chen L, etal., Lancet. 2003 Aug 9;362(9382):440-5.
7. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
8. Lamin a truncation in Hutchinson-Gilford progeria. De Sandre-Giovannoli A, etal., Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.
9. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. Fatkin D, etal., N Engl J Med. 1999 Dec 2;341(23):1715-24.
10. Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy. Filesi I, etal., Physiol Genomics. 2005 Oct 17;23(2):150-8. Epub 2005 Jul 26.
11. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Fong LG, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. Epub 2004 Dec 17.
12. Clinical and functional characterization of a novel mutation in lamin a/c gene in a multigenerational family with arrhythmogenic cardiac laminopathy. Forleo C, etal., PLoS One. 2015 Apr 2;10(4):e0121723. doi: 10.1371/journal.pone.0121723. eCollection 2015.
13. Atypical progeroid syndrome due to heterozygous missense LMNA mutations. Garg A, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4971-83. doi: 10.1210/jc.2009-0472. Epub 2009 Oct 29.
14. Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. Grewal N, etal., J Thorac Cardiovasc Surg. 2014 Oct;148(4):1583-90. doi: 10.1016/j.jtcvs.2014.01.027. Epub 2014 Jan 25.
15. Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy. Hegele RA, etal., Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):111-6.
16. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
17. Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes. Liang H, etal., Clin Endocrinol (Oxf). 2005 Sep;63(3):317-22.
18. A novel mutation in the central rod domain of lamin A/C producing a phenotype resembling the Emery-Dreifuss muscular dystrophy phenotype. Maioli MA, etal., Muscle Nerve. 2007 Dec;36(6):828-32.
19. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. McClintock D, etal., Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. Epub 2006 Feb 6.
20. Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. Mesa JL, etal., Diabetes. 2007 Mar;56(3):884-9.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. A progeroid syndrome in mice is caused by defects in A-type lamins. Mounkes LC, etal., Nature 2003 May 15;423(6937):298-301.
25. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Muchir A, etal., Hum Mol Genet. 2000 May 22;9(9):1453-9.
26. Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. Muchir A, etal., J Clin Invest. 2007 May;117(5):1282-93. Epub 2007 Apr 19.
27. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Long-term outcome and risk stratification in dilated cardiolaminopathies. Pasotti M, etal., J Am Coll Cardiol. 2008 Oct 7;52(15):1250-60.
30. Congenital muscular dystrophy with dropped head linked to the LMNA gene in a Brazilian cohort. Pasqualin LM, etal., Pediatr Neurol. 2014 Apr;50(4):400-6. doi: 10.1016/j.pediatrneurol.2013.11.010. Epub 2013 Nov 21.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Homozygous missense mutation in the lamin A/C gene causes autosomal recessive Hutchinson-Gilford progeria syndrome. Plasilova M, etal., J Med Genet. 2004 Aug;41(8):609-14.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Shackleton S, etal., Nat Genet. 2000 Feb;24(2):153-6.
37. Identification of novel mutations in LMNA associated with familial forms of dilated cardiomyopathy. Stallmeyer B, etal., Genet Test Mol Biomarkers. 2012 Jun;16(6):543-9. doi: 10.1089/gtmb.2011.0214. Epub 2012 Jan 6.
38. Variation in the lamin A/C gene: associations with metabolic syndrome. Steinle NI, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1708-13. Epub 2004 Jun 17.
39. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. Taylor MR, etal., J Am Coll Cardiol. 2003 Mar 5;41(5):771-80.
40. Phenotypic variability in autosomal recessive axonal Charcot-Marie-Tooth disease due to the R298C mutation in lamin A/C. Tazir M, etal., Brain 2004 Jan;127(Pt 1):154-63. Epub 2003 Nov 7.
41. Lamin A/C mutations with lipodystrophy, cardiac abnormalities, and muscular dystrophy. van der Kooi AJ, etal., Neurology. 2002 Aug 27;59(4):620-3.
42. A G613A missense in the Hutchinson's progeria lamin A/C gene causes a lone, autosomal dominant atrioventricular block. Villa F, etal., Immun Ageing. 2014 Nov 26;11(1):19. doi: 10.1186/s12979-014-0019-3. eCollection 2014.
43. Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites. Wegner L, etal., Diabetes. 2007 Mar;56(3):694-8.
44. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. Wolf CM, etal., J Mol Cell Cardiol. 2008 Feb;44(2):293-303. Epub 2007 Dec 3.
Additional References at PubMed
PMID:1959608   PMID:2583287   PMID:2680424   PMID:2719959   PMID:3046911   PMID:7680212   PMID:7781761   PMID:7916626   PMID:8032679   PMID:8187835   PMID:8889548   PMID:10349636  
PMID:10579712   PMID:10740265   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11092755   PMID:11739632   PMID:11799477   PMID:11855819   PMID:12235369   PMID:12467752   PMID:12477932  
PMID:12670476   PMID:12783988   PMID:12904583   PMID:14610273   PMID:14755333   PMID:14755334   PMID:14996939   PMID:15159393   PMID:15210943   PMID:15219855   PMID:15234001   PMID:15356259  
PMID:15367494   PMID:15489334   PMID:15548545   PMID:15703219   PMID:15782199   PMID:15972724   PMID:15980864   PMID:16014412   PMID:16079796   PMID:16115815   PMID:16141072   PMID:16141073  
PMID:16339967   PMID:16380439   PMID:16403804   PMID:16445279   PMID:16452087   PMID:16476058   PMID:16481476   PMID:16511598   PMID:16511604   PMID:16602821   PMID:16630578   PMID:16648470  
PMID:16731532   PMID:16809772   PMID:16825190   PMID:16862216   PMID:17110338   PMID:17123807   PMID:17164264   PMID:17321498   PMID:17488709   PMID:17513488   PMID:17565040   PMID:17567779  
PMID:17631533   PMID:17676639   PMID:17893180   PMID:17896003   PMID:17980036   PMID:18082640   PMID:18178963   PMID:18294630   PMID:18396346   PMID:18442998   PMID:18443001   PMID:18497856  
PMID:18524819   PMID:18606848   PMID:18664494   PMID:18757838   PMID:18769635   PMID:18799693   PMID:18808171   PMID:18809582   PMID:18836436   PMID:18847334   PMID:18849980   PMID:18927124  
PMID:18951892   PMID:19013199   PMID:19015316   PMID:19022376   PMID:19124654   PMID:19423573   PMID:19509342   PMID:19629036   PMID:19850871   PMID:19913544   PMID:19915186   PMID:19933576  
PMID:20019332   PMID:20069564   PMID:20106865   PMID:20130288   PMID:20376364   PMID:20388542   PMID:20405040   PMID:20421363   PMID:20439468   PMID:20457914   PMID:20685963   PMID:20726853  
PMID:20833363   PMID:21088111   PMID:21151901   PMID:21156181   PMID:21173262   PMID:21267068   PMID:21327075   PMID:21327095   PMID:21350821   PMID:21364987   PMID:21464947   PMID:21498514  
PMID:21547077   PMID:21565611   PMID:21575749   PMID:21677750   PMID:21701264   PMID:21750527   PMID:21818413   PMID:21831885   PMID:21873635   PMID:21875900   PMID:21884692   PMID:21902803  
PMID:21976703   PMID:21982926   PMID:22030750   PMID:22068161   PMID:22090424   PMID:22116031   PMID:22119912   PMID:22223883   PMID:22251972   PMID:22293021   PMID:22308344   PMID:22331516  
PMID:22349700   PMID:22443097   PMID:22541428   PMID:22610065   PMID:22773734   PMID:22819531   PMID:22837537   PMID:22837538   PMID:22886301   PMID:22893709   PMID:22895093   PMID:22905185  
PMID:23019125   PMID:23029315   PMID:23044536   PMID:23048029   PMID:23064282   PMID:23071752   PMID:23095062   PMID:23213392   PMID:23217256   PMID:23261543   PMID:23324457   PMID:23374351  
PMID:23382700   PMID:23418438   PMID:23427149   PMID:23430973   PMID:23444379   PMID:23451281   PMID:23455585   PMID:23535822   PMID:23575224   PMID:23631840   PMID:23644458   PMID:23650370  
PMID:23686339   PMID:23690466   PMID:23695662   PMID:23917225   PMID:23933734   PMID:23990565   PMID:23998933   PMID:24153156   PMID:24203701   PMID:24294364   PMID:24305605   PMID:24457600  
PMID:24523288   PMID:24639560   PMID:24672053   PMID:24757177   PMID:25118303   PMID:25218145   PMID:25237101   PMID:25246615   PMID:25312645   PMID:25343989   PMID:25380821   PMID:25437426  
PMID:25450615   PMID:25535984   PMID:25559185   PMID:25578479   PMID:25609380   PMID:25652409   PMID:25852735   PMID:26045045   PMID:26102067   PMID:26204409   PMID:26234751   PMID:26359759  
PMID:26436652   PMID:26496610   PMID:26510501   PMID:26553927   PMID:26644582   PMID:26657864   PMID:26900797   PMID:26999604   PMID:27131347   PMID:27221609   PMID:27270425   PMID:27287550  
PMID:27498076   PMID:27617860   PMID:27626380   PMID:27746211   PMID:27766308   PMID:27798115   PMID:27798236   PMID:27926859   PMID:27984723   PMID:28062850   PMID:28069793   PMID:28088180  
PMID:28237702   PMID:28246125   PMID:28374669   PMID:28378742   PMID:28533284   PMID:28595999   PMID:28674081   PMID:28702670   PMID:28803787   PMID:28854361   PMID:28872940   PMID:28930673  
PMID:29242553   PMID:29311549   PMID:29317431   PMID:29360543   PMID:29466729   PMID:29565969   PMID:29668927   PMID:29703891   PMID:29719249   PMID:29849091   PMID:29878125   PMID:29893868  
PMID:29923310   PMID:29982513   PMID:30053027   PMID:30157432   PMID:30199159   PMID:30257952   PMID:30282816   PMID:30283351   PMID:30284086   PMID:30342008   PMID:30457570   PMID:30550785  
PMID:30575733   PMID:30696354   PMID:30718289   PMID:30778239   PMID:30906869   PMID:30968547   PMID:31009944   PMID:31042484   PMID:31128203   PMID:31147383   PMID:31162944   PMID:31220270  
PMID:31332389   PMID:31341969   PMID:31372995   PMID:31397869   PMID:31430335   PMID:31668660   PMID:31690656   PMID:31740672   PMID:31794718   PMID:31833196   PMID:31844279   PMID:31941672  
PMID:31999646   PMID:32005707   PMID:32128409   PMID:32175648   PMID:32244403   PMID:32313136   PMID:32325033   PMID:32343699   PMID:32404427   PMID:32455813   PMID:32479501   PMID:32484798  
PMID:32540097   PMID:32554809   PMID:32581210   PMID:32698523   PMID:32805188   PMID:32807790   PMID:32815283   PMID:32817327   PMID:32875720   PMID:32968282   PMID:33049978   PMID:33388782  
PMID:33393189   PMID:33393499   PMID:33398110   PMID:33413510   PMID:33514739   PMID:33526168   PMID:33570570   PMID:33605210   PMID:33624748   PMID:33687998   PMID:33907225   PMID:33972393  
PMID:34012019   PMID:34029594   PMID:34088712   PMID:34205295   PMID:34354059   PMID:34423791   PMID:34433058   PMID:34453483   PMID:34648766   PMID:34694158   PMID:34775987   PMID:34799629  
PMID:34944031   PMID:35020601   PMID:35039433   PMID:35065053   PMID:35137145   PMID:35197292   PMID:35309931   PMID:35413292   PMID:35601919   PMID:35714719   PMID:35906707   PMID:36096808  
PMID:36301259   PMID:36333314   PMID:36382717   PMID:36417873   PMID:36450260   PMID:36465100   PMID:36552752   PMID:36583724   PMID:36644279   PMID:36831305  


Genomics

Comparative Map Data
Lmna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)EnsemblGRCm39 Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBIMGSCv36mm8
Celera388,521,102 - 88,543,289 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.84NCBI
LMNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,082,573 - 156,140,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1156,082,573 - 156,140,081 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,052,364 - 156,109,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36Build 36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,481 - 157,505,990 (+)NCBICHM1_1
T2T-CHM13v2.01155,221,038 - 155,278,530 (+)NCBIT2T-CHM13v2.0
Lmna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,083,809 - 181,104,527 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02179,106,174 - 179,126,892 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02173,706,353 - 173,727,003 (-)NCBIRnor_WKY
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
Lmna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,290,037 - 2,313,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,290,076 - 2,310,982 (+)NCBIChiLan1.0ChiLan1.0
LMNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1193,438,136 - 93,463,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,456,819 - 131,482,275 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,253,700 - 135,311,542 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,253,700 - 135,311,539 (+)Ensemblpanpan1.1panPan2
LMNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,702,491 - 41,719,870 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,508,450 - 41,746,931 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,192,089 - 41,209,467 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,569,142 - 41,586,514 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,568,716 - 41,586,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,349,981 - 41,367,355 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,403,350 - 41,420,721 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,687,512 - 41,704,901 (-)NCBIUU_Cfam_GSD_1.0
Lmna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,343,835 - 26,365,060 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,373,974 - 5,395,468 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365805,374,208 - 5,395,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,899,019 - 93,926,320 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,899,019 - 93,927,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,641,459 - 102,668,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4qNCBI
LMNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,723,059 - 7,748,799 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,723,477 - 7,748,780 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,017,993 - 7,044,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,447,395 - 1,467,554 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,423,563 - 1,466,657 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lmna
876 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1821
Count of miRNA genes:609
Interacting mature miRNAs:750
Transcripts:ENSMUST00000029699, ENSMUST00000036252, ENSMUST00000120377, ENSMUST00000135494, ENSMUST00000147537, ENSMUST00000149068, ENSMUST00000150496
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38717045489140094Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001002011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004941291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC145168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW047412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ715532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY140664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D13181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ832702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ832703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000029699   ⟹   ENSMUSP00000029699
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,388,455 - 88,410,642 (-)Ensembl
GRCm38.p6 Ensembl388,481,148 - 88,503,335 (-)Ensembl
RefSeq Acc Id: ENSMUST00000036252   ⟹   ENSMUSP00000040265
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,390,513 - 88,400,619 (-)Ensembl
GRCm38.p6 Ensembl388,483,206 - 88,493,312 (-)Ensembl
RefSeq Acc Id: ENSMUST00000120377   ⟹   ENSMUSP00000113093
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,390,512 - 88,410,614 (-)Ensembl
GRCm38.p6 Ensembl388,483,205 - 88,503,307 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135494
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,389,153 - 88,410,644 (-)Ensembl
GRCm38.p6 Ensembl388,481,846 - 88,503,337 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147537
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,387,454 - 88,391,914 (-)Ensembl
GRCm38.p6 Ensembl388,480,147 - 88,484,607 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149068   ⟹   ENSMUSP00000120784
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,410,060 - 88,417,263 (-)Ensembl
GRCm38.p6 Ensembl388,502,753 - 88,509,956 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150496
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,389,384 - 88,390,171 (-)Ensembl
GRCm38.p6 Ensembl388,482,077 - 88,482,864 (-)Ensembl
RefSeq Acc Id: NM_001002011   ⟹   NP_001002011
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,388,455 - 88,410,659 (-)NCBI
GRCm38388,481,148 - 88,503,352 (-)NCBI
MGSCv37388,285,071 - 88,307,254 (-)RGD
Celera388,521,101 - 88,543,309 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001111102   ⟹   NP_001104572
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,390,512 - 88,410,659 (-)NCBI
GRCm38388,483,205 - 88,503,352 (-)NCBI
MGSCv37388,285,071 - 88,307,254 (-)RGD
Celera388,521,101 - 88,543,309 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_019390   ⟹   NP_062263
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,390,512 - 88,400,619 (-)NCBI
GRCm38388,483,205 - 88,493,312 (-)NCBI
MGSCv37388,285,071 - 88,307,254 (-)RGD
Celera388,521,101 - 88,543,309 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501073   ⟹   XP_006501136
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,388,455 - 88,411,545 (-)NCBI
GRCm38388,481,148 - 88,509,932 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004941291
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,388,455 - 88,413,842 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001002011 (Get FASTA)   NCBI Sequence Viewer  
  NP_001104572 (Get FASTA)   NCBI Sequence Viewer  
  NP_062263 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501136 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH15302 (Get FASTA)   NCBI Sequence Viewer  
  ABI16251 (Get FASTA)   NCBI Sequence Viewer  
  ABI16252 (Get FASTA)   NCBI Sequence Viewer  
  BAA02476 (Get FASTA)   NCBI Sequence Viewer  
  BAA03578 (Get FASTA)   NCBI Sequence Viewer  
  BAA08569 (Get FASTA)   NCBI Sequence Viewer  
  BAA08570 (Get FASTA)   NCBI Sequence Viewer  
  BAA08571 (Get FASTA)   NCBI Sequence Viewer  
  BAB22619 (Get FASTA)   NCBI Sequence Viewer  
  BAB23415 (Get FASTA)   NCBI Sequence Viewer  
  BAC37795 (Get FASTA)   NCBI Sequence Viewer  
  BAE27717 (Get FASTA)   NCBI Sequence Viewer  
  BAE29226 (Get FASTA)   NCBI Sequence Viewer  
  BAE29519 (Get FASTA)   NCBI Sequence Viewer  
  BAE29614 (Get FASTA)   NCBI Sequence Viewer  
  BAE29714 (Get FASTA)   NCBI Sequence Viewer  
  BAE31294 (Get FASTA)   NCBI Sequence Viewer  
  BAE31384 (Get FASTA)   NCBI Sequence Viewer  
  BAE31539 (Get FASTA)   NCBI Sequence Viewer  
  BAE36246 (Get FASTA)   NCBI Sequence Viewer  
  BAE39876 (Get FASTA)   NCBI Sequence Viewer  
  CAA32372 (Get FASTA)   NCBI Sequence Viewer  
  EDL15275 (Get FASTA)   NCBI Sequence Viewer  
  EDL15276 (Get FASTA)   NCBI Sequence Viewer  
  P48678 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002011   ⟸   NM_001002011
- Peptide Label: isoform A precursor
- UniProtKB: Q9DC21 (UniProtKB/Swiss-Prot),   P48678 (UniProtKB/Swiss-Prot),   A0A6P5PC97 (UniProtKB/TrEMBL),   A0A8C6IBX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062263   ⟸   NM_019390
- Peptide Label: isoform C2
- UniProtKB: P48678 (UniProtKB/Swiss-Prot),   A0A8C6N4L5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104572   ⟸   NM_001111102
- Peptide Label: isoform C
- UniProtKB: P48678 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501136   ⟸   XM_006501073
- Peptide Label: isoform X1
- UniProtKB: Q9DC21 (UniProtKB/Swiss-Prot),   P48678 (UniProtKB/Swiss-Prot),   A0A6P5PC97 (UniProtKB/TrEMBL),   A0A8C6IBX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000029699   ⟸   ENSMUST00000029699
RefSeq Acc Id: ENSMUSP00000113093   ⟸   ENSMUST00000120377
RefSeq Acc Id: ENSMUSP00000120784   ⟸   ENSMUST00000149068
RefSeq Acc Id: ENSMUSP00000040265   ⟸   ENSMUST00000036252
Protein Domains
IF rod   LTD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48678-F1-model_v2 AlphaFold P48678 1-665 view protein structure

Promoters
RGD ID:6834030
Promoter ID:MM_KWN:34856
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000075098
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,286,271 - 88,287,737 (-)MPROMDB
RGD ID:6834029
Promoter ID:MM_KWN:34857
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000075097
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,287,986 - 88,289,237 (-)MPROMDB
RGD ID:6847748
Promoter ID:MM_ACW:32270
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung,   MEF_B4,   MEF_B6
Transcripts:LMNA.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,289,981 - 88,290,987 (-)MPROMDB
RGD ID:6834025
Promoter ID:MM_KWN:34858
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000036252
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,296,806 - 88,298,207 (-)MPROMDB
RGD ID:6834027
Promoter ID:MM_KWN:34859
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000120377,   OTTMUST00000075092,   OTTMUST00000075096
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,306,776 - 88,308,087 (-)MPROMDB
RGD ID:6834028
Promoter ID:MM_KWN:34860
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000075095
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,313,704 - 88,314,204 (-)MPROMDB
RGD ID:6881152
Promoter ID:EPDNEW_M4027
Type:initiation region
Name:Lmna_1
Description:Mus musculus lamin A , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38388,503,307 - 88,503,367EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96794 AgrOrtholog
Ensembl Genes ENSMUSG00000028063 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029699 ENTREZGENE
  ENSMUSP00000029699.7 UniProtKB/Swiss-Prot
  ENSMUSP00000040265 ENTREZGENE
  ENSMUSP00000040265.7 UniProtKB/Swiss-Prot
  ENSMUSP00000113093 ENTREZGENE
  ENSMUSP00000113093.2 UniProtKB/Swiss-Prot
  ENSMUSP00000120784.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029699 ENTREZGENE
  ENSMUST00000029699.13 UniProtKB/Swiss-Prot
  ENSMUST00000036252 ENTREZGENE
  ENSMUST00000036252.7 UniProtKB/Swiss-Prot
  ENSMUST00000120377 ENTREZGENE
  ENSMUST00000120377.8 UniProtKB/Swiss-Prot
  ENSMUST00000149068.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  2.60.40.1260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lamin_tail_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lamin_tail_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16905 UniProtKB/Swiss-Prot
MGD MGI:96794 ENTREZGENE
NCBI Gene 16905 ENTREZGENE
PANTHER LAMIN DM0-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRELAMIN-A/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTD UniProtKB/Swiss-Prot
PharmGKB LMNA RGD
PhenoGen Lmna PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF74853 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6P5PC97 ENTREZGENE
  A0A8C6IBX6 ENTREZGENE
  A0A8C6N4L5 ENTREZGENE
  D3YUF7_MOUSE UniProtKB/TrEMBL
  LMNA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CTL2_MOUSE UniProtKB/TrEMBL
  Q9DC21 ENTREZGENE
UniProt Secondary B3RH23 UniProtKB/Swiss-Prot
  B3RH24 UniProtKB/Swiss-Prot
  P11516 UniProtKB/Swiss-Prot
  P97859 UniProtKB/Swiss-Prot
  Q3TIH0 UniProtKB/Swiss-Prot
  Q3TTS8 UniProtKB/Swiss-Prot
  Q3U733 UniProtKB/Swiss-Prot
  Q3U7I5 UniProtKB/Swiss-Prot
  Q3UCA0 UniProtKB/Swiss-Prot
  Q3UCJ8 UniProtKB/Swiss-Prot
  Q3UCU3 UniProtKB/Swiss-Prot
  Q91WF2 UniProtKB/Swiss-Prot
  Q9DC21 UniProtKB/Swiss-Prot