Lmna (lamin A) - Rat Genome Database

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Gene: Lmna (lamin A) Mus musculus
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Symbol: Lmna
Name: lamin A
RGD ID: 732791
MGI Page MGI
Description: A structural constituent of cytoskeleton. Involved in several processes, including establishment or maintenance of microtubule cytoskeleton polarity; negative regulation of cardiac muscle hypertrophy in response to stress; and protein localization to nucleus. Acts upstream of or within several processes, including negative regulation of apoptotic signaling pathway; protein import into nucleus; and ventricular cardiac muscle cell development. Located in lamin filament and nuclear membrane. Is active in nuclear lamina. Is expressed in several structures, including embryo mesenchyme; epithelium; heart; hemolymphoid system; and musculature. Used to study several diseases, including Charcot-Marie-Tooth disease type 2B1; achalasia; dilated cardiomyopathy 1A; muscular dystrophy (multiple); and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Dhe; lamin A/C; lamin C; lamin-A/C; prelamin-A/C
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)EnsemblGRCm39 Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBIMGSCv36mm8
Celera388,521,102 - 88,543,289 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
achalasia  (IAGP)
aortic valve disease 2  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
arteriosclerosis  (ISO)
atrioventricular block  (ISO)
autosomal dominant distal hereditary motor neuronopathy  (ISO)
autosomal dominant Emery-Dreifuss muscular dystrophy 2  (IMP,ISO)
autosomal recessive Emery-Dreifuss muscular dystrophy 3  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
autosomal recessive nonsyndromic deafness 4  (ISO)
Cardiac Arrhythmias  (IAGP)
Cardiac Conduction Disease with or without Dilated Cardiomyopathy  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
cerebrovascular disease  (ISO)
Charcot-Marie-Tooth disease  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
Charcot-Marie-Tooth disease type 2B1  (IAGP,ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Microtia  (ISO)
congenital muscular dystrophy  (ISO)
congenital muscular dystrophy due to LMNA mutation  (IAGP,ISO)
Craniofacial Abnormalities  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (IAGP,ISO)
dilated cardiomyopathy 1A  (IAGP,ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome  (ISO)
disease of metabolism  (ISO)
Dwarfism  (ISO)
Emery-Dreifuss muscular dystrophy  (IAGP,ISO)
familial hypertrophic cardiomyopathy  (ISO)
familial partial lipodystrophy  (ISO)
familial partial lipodystrophy type 2  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Heart-Hand Syndrome, Slovenian Type  (ISO)
hereditary neuropathy with liability to pressure palsies  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Hypercholesterolemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
immunodeficiency 42  (ISO)
Insulin Resistance  (ISO)
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans  (ISO)
Laminopathies  (ISO)
left ventricular noncompaction  (ISO)
limb-girdle muscular dystrophy  (ISO)
lipoatrophic diabetes mellitus  (ISO)
lipodystrophy  (ISO)
localized scleroderma  (ISO)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
mandibuloacral dysplasia  (ISO)
mandibuloacral dysplasia type A lipodystrophy  (ISO)
maturity-onset diabetes of the young  (ISO)
Metabolic Syndrome  (ISO)
MHC class II deficiency  (ISO)
muscular dystrophy  (ISO)
neuromuscular disease  (ISO)
neuropathy  (ISO)
Noonan syndrome 8  (ISO)
otitis media  (IAGP)
parathyroid carcinoma  (ISO)
Paroxysmal Ventricular Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
polycystic ovary syndrome  (ISO)
polyneuropathy  (ISO)
progeria  (IAGP,IMP,ISO)
Progeria Syndrome, Childhood-Onset  (ISO)
restrictive dermopathy  (ISO)
restrictive dermopathy 2  (ISO)
severe congenital neutropenia 3  (ISO)
severe congenital neutropenia 5  (ISO)
sick sinus syndrome  (ISO)
Sinoatrial Block  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,5-hexanedione  (ISO)
2,6-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brodifacoum  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chelerythrine  (ISO)
chloromethylisothiazolinone  (ISO)
chromium(6+)  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (EXP)
genistein  (ISO)
gentamycin  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
isoflavones  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lonafarnib  (ISO)
lopinavir  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
microcystin RR  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
suramin  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta smooth muscle morphology  (IAGP)
abnormal aorta tunica adventitia morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal auditory bulla morphology  (IAGP)
abnormal auditory tube morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cholinergic neuron morphology  (IAGP)
abnormal chromosomal synapsis  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cornea morphology  (IEA)
abnormal coronal suture morphology  (IAGP)
abnormal cranial suture morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal cranium size  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal distortion product otoacoustic emission  (IAGP)
abnormal DNA replication  (IAGP)
abnormal double-strand DNA break repair  (IAGP)
abnormal ear morphology  (IAGP)
abnormal ear physiology  (IAGP)
abnormal enteric neuron morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermal melanocyte morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal esophageal smooth muscle morphology  (IAGP)
abnormal esophageal squamous epithelium morphology  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal female meiosis  (IAGP)
abnormal frontonasal suture morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gastrocnemius morphology  (IAGP)
abnormal hair cycle anagen phase  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hard palate morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hypaxial muscle morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal inguinal fat pad morphology  (IAGP)
abnormal interstitial cell of Cajal morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal lambdoid suture morphology  (IAGP)
abnormal meiosis  (IAGP)
abnormal middle ear development  (IAGP)
abnormal middle ear epithelium morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal mitochondrial ATP synthesis coupled electron transport  (IAGP)
abnormal mitosis  (IAGP)
abnormal mitotic spindle assembly checkpoint  (IAGP)
abnormal muscle development  (IAGP)
abnormal muscle tone  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nasopharynx morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal nuclear lamina morphology  (IAGP)
abnormal optic disk morphology  (IEA)
abnormal peritoneal macrophage morphology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal rib morphology  (IAGP)
abnormal sagittal suture morphology  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal scapula morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin morphology  (IAGP)
abnormal soleus morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tibialis anterior morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tympanic membrane morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vasodilation  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
absent subcutaneous adipose tissue  (IAGP)
alopecia  (IAGP)
aneuploidy  (IAGP)
arrest of male meiosis  (IAGP)
atherosclerotic lesions  (IAGP)
azoospermia  (IAGP)
bradykinesia  (IAGP)
calcified aorta  (IAGP)
calcified aortic arch  (IAGP)
calcified thoracic aorta  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
cardiac muscle degeneration  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
congestive heart failure  (IAGP)
cornea ulcer  (IEA)
decreased abdominal adipose tissue amount  (IAGP)
decreased body height  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone trabecula number  (IAGP)
decreased bone volume  (IAGP)
decreased capillary density  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac output  (IAGP)
decreased circulating carnitine level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating lactate level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased core body temperature  (IAGP)
decreased cranium height  (IAGP)
decreased cranium width  (IAGP)
decreased eccrine gland number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased grip strength  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased heart left ventricle weight  (IAGP)
decreased heart rate  (IAGP)
decreased heart ventricle muscle contractility  (IAGP)
decreased heart weight  (IAGP)
decreased liver glycogen level  (IAGP)
decreased locomotor activity  (IAGP)
decreased myocardial fiber number  (IAGP)
decreased myocardial fiber size  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased quadriceps weight  (IAGP)
decreased sebaceous gland number  (IAGP)
decreased skeletal muscle fiber diameter  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to bone fracture  (IAGP)
decreased total body fat amount  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased vascular endothelial cell number  (IAGP)
decreased white adipose tissue amount  (IAGP)
decreased white adipose tissue mass  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated esophagus  (IAGP)
dilated heart atrium  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
disheveled coat  (IAGP)
distended cecum  (IAGP)
duodenum polyps  (IAGP)
dystrophic muscle  (IAGP)
enhanced exercise endurance  (IAGP)
enlarged heart  (IAGP)
epidermal hyperplasia  (IAGP)
esophageal achalasia  (IAGP)
exophthalmos  (IAGP)
female infertility  (IAGP)
flaky skin  (IAGP)
hepatic steatosis  (IAGP)
hunched posture  (IAGP)
hyperkeratosis  (IAGP)
hypoglycemia  (IAGP)
impaired coordination  (IAGP)
impaired exercise endurance  (IAGP)
impaired glucose tolerance  (IAGP)
impaired hearing  (IAGP)
improved glucose tolerance  (IEA)
increased abdominal fat pad weight  (IAGP)
increased aorta wall thickness  (IAGP)
increased body weight  (IAGP)
increased bone trabecular spacing  (IAGP)
increased brown adipose tissue mass  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased circulating growth hormone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating ketone body level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating phosphate level  (IAGP)
increased heart atrium size  (IAGP)
increased liver triglyceride level  (IAGP)
increased middle ear goblet cell number  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased renal fat pad weight  (IAGP)
increased susceptibility to otitis media  (IAGP)
increased triglyceride level  (IAGP)
infertility  (IAGP)
insulin resistance  (IAGP)
jejunum polyps  (IAGP)
keratoconjunctivitis sicca  (IAGP)
kinked tail  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lordokyphosis  (IAGP)
male infertility  (IAGP)
malocclusion  (IAGP)
mandible hypoplasia  (IAGP)
meteorism  (IAGP)
micrognathia  (IAGP)
muscle degeneration  (IAGP)
muscle weakness  (IAGP)
muscular atrophy  (IAGP)
myocardial fiber degeneration  (IAGP)
myocardium necrosis  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypotelorism  (IAGP)
oligozoospermia  (IAGP)
orthokeratosis  (IAGP)
osteoporosis  (IAGP)
penis prolapse  (IAGP)
poor grooming  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
progressive muscle weakness  (IAGP)
prolonged P wave  (IAGP)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged RR interval  (IAGP)
prominent ears  (IAGP)
pulmonary edema  (IAGP)
pulmonary hypertension  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
rib fractures  (IAGP)
rough coat  (IAGP)
sebaceous gland hypoplasia  (IAGP)
shallow orbits  (IAGP)
short ears  (IAGP)
short maxilla  (IAGP)
short snout  (IAGP)
short tibia  (IEA)
short upper incisors  (IAGP)
sinoatrial block  (IAGP)
skeletal muscle degeneration  (IAGP)
skeletal muscle fibrosis  (IAGP)
slow postnatal weight gain  (IAGP)
small cranium  (IAGP)
small gonad  (IAGP)
small heart  (IAGP)
small lower incisors  (IAGP)
small seminiferous tubules  (IAGP)
small spleen  (IAGP)
small testis  (IAGP)
small thymus  (IAGP)
small xiphoid process  (IAGP)
sparse hair  (IAGP)
tachypnea  (IAGP)
thick epidermis  (IAGP)
thin dermal layer  (IAGP)
thin myocardium  (IAGP)
thymus atrophy  (IAGP)
tympanic membrane retraction  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
weight loss  (IAGP)
wide cranial sutures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Laminopathies and atherosclerosis. Al-Shali KZ and Hegele RA, Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1591-5. Epub 2004 Jun 17.
2. Proteomic analysis of rat aorta during atherosclerosis induced by high cholesterol diet and injection of vitamin D3. Almofti MR, etal., Clin Exp Pharmacol Physiol. 2006 Apr;33(4):305-9.
3. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Bonne G, etal., Nat Genet. 1999 Mar;21(3):285-8.
4. Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Cao H and Hegele RA, Hum Mol Genet. 2000 Jan 1;9(1):109-12.
5. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). Cao H and Hegele RA, J Hum Genet. 2003;48(5):271-4. Epub 2003 Apr 3.
6. LMNA mutations in atypical Werner's syndrome. Chen L, etal., Lancet. 2003 Aug 9;362(9382):440-5.
7. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
8. Lamin a truncation in Hutchinson-Gilford progeria. De Sandre-Giovannoli A, etal., Science. 2003 Jun 27;300(5628):2055. Epub 2003 Apr 17.
9. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. Fatkin D, etal., N Engl J Med. 1999 Dec 2;341(23):1715-24.
10. Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy. Filesi I, etal., Physiol Genomics. 2005 Oct 17;23(2):150-8. Epub 2005 Jul 26.
11. Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Fong LG, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. Epub 2004 Dec 17.
12. Clinical and functional characterization of a novel mutation in lamin a/c gene in a multigenerational family with arrhythmogenic cardiac laminopathy. Forleo C, etal., PLoS One. 2015 Apr 2;10(4):e0121723. doi: 10.1371/journal.pone.0121723. eCollection 2015.
13. Atypical progeroid syndrome due to heterozygous missense LMNA mutations. Garg A, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4971-83. doi: 10.1210/jc.2009-0472. Epub 2009 Oct 29.
14. Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. Grewal N, etal., J Thorac Cardiovasc Surg. 2014 Oct;148(4):1583-90. doi: 10.1016/j.jtcvs.2014.01.027. Epub 2014 Jan 25.
15. Elevated serum C-reactive protein and free fatty acids among nondiabetic carriers of missense mutations in the gene encoding lamin A/C (LMNA) with partial lipodystrophy. Hegele RA, etal., Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):111-6.
16. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
17. Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes. Liang H, etal., Clin Endocrinol (Oxf). 2005 Sep;63(3):317-22.
18. A novel mutation in the central rod domain of lamin A/C producing a phenotype resembling the Emery-Dreifuss muscular dystrophy phenotype. Maioli MA, etal., Muscle Nerve. 2007 Dec;36(6):828-32.
19. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. McClintock D, etal., Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2154-9. Epub 2006 Feb 6.
20. Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies. Mesa JL, etal., Diabetes. 2007 Mar;56(3):884-9.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
23. MGD IEA MGD IEA
24. A progeroid syndrome in mice is caused by defects in A-type lamins. Mounkes LC, etal., Nature 2003 May 15;423(6937):298-301.
25. Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B). Muchir A, etal., Hum Mol Genet. 2000 May 22;9(9):1453-9.
26. Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. Muchir A, etal., J Clin Invest. 2007 May;117(5):1282-93. Epub 2007 Apr 19.
27. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Long-term outcome and risk stratification in dilated cardiolaminopathies. Pasotti M, etal., J Am Coll Cardiol. 2008 Oct 7;52(15):1250-60.
30. Congenital muscular dystrophy with dropped head linked to the LMNA gene in a Brazilian cohort. Pasqualin LM, etal., Pediatr Neurol. 2014 Apr;50(4):400-6. doi: 10.1016/j.pediatrneurol.2013.11.010. Epub 2013 Nov 21.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Homozygous missense mutation in the lamin A/C gene causes autosomal recessive Hutchinson-Gilford progeria syndrome. Plasilova M, etal., J Med Genet. 2004 Aug;41(8):609-14.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Shackleton S, etal., Nat Genet. 2000 Feb;24(2):153-6.
37. Identification of novel mutations in LMNA associated with familial forms of dilated cardiomyopathy. Stallmeyer B, etal., Genet Test Mol Biomarkers. 2012 Jun;16(6):543-9. doi: 10.1089/gtmb.2011.0214. Epub 2012 Jan 6.
38. Variation in the lamin A/C gene: associations with metabolic syndrome. Steinle NI, etal., Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1708-13. Epub 2004 Jun 17.
39. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. Taylor MR, etal., J Am Coll Cardiol. 2003 Mar 5;41(5):771-80.
40. Phenotypic variability in autosomal recessive axonal Charcot-Marie-Tooth disease due to the R298C mutation in lamin A/C. Tazir M, etal., Brain 2004 Jan;127(Pt 1):154-63. Epub 2003 Nov 7.
41. Lamin A/C mutations with lipodystrophy, cardiac abnormalities, and muscular dystrophy. van der Kooi AJ, etal., Neurology. 2002 Aug 27;59(4):620-3.
42. A G613A missense in the Hutchinson's progeria lamin A/C gene causes a lone, autosomal dominant atrioventricular block. Villa F, etal., Immun Ageing. 2014 Nov 26;11(1):19. doi: 10.1186/s12979-014-0019-3. eCollection 2014.
43. Common variation in LMNA increases susceptibility to type 2 diabetes and associates with elevated fasting glycemia and estimates of body fat and height in the general population: studies of 7,495 Danish whites. Wegner L, etal., Diabetes. 2007 Mar;56(3):694-8.
44. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. Wolf CM, etal., J Mol Cell Cardiol. 2008 Feb;44(2):293-303. Epub 2007 Dec 3.
Additional References at PubMed
PMID:1959608   PMID:2583287   PMID:2680424   PMID:2719959   PMID:3046911   PMID:7680212   PMID:7781761   PMID:7916626   PMID:8032679   PMID:8187835   PMID:8889548   PMID:10349636  
PMID:10579712   PMID:10740265   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11092755   PMID:11739632   PMID:11799477   PMID:11855819   PMID:12235369   PMID:12467752   PMID:12477932  
PMID:12670476   PMID:12783988   PMID:12904583   PMID:14610273   PMID:14755333   PMID:14755334   PMID:14996939   PMID:15159393   PMID:15210943   PMID:15219855   PMID:15234001   PMID:15356259  
PMID:15367494   PMID:15489334   PMID:15548545   PMID:15703219   PMID:15782199   PMID:15972724   PMID:15980864   PMID:16014412   PMID:16079796   PMID:16115815   PMID:16141072   PMID:16141073  
PMID:16339967   PMID:16380439   PMID:16403804   PMID:16445279   PMID:16452087   PMID:16476058   PMID:16481476   PMID:16511598   PMID:16511604   PMID:16602821   PMID:16630578   PMID:16648470  
PMID:16731532   PMID:16809772   PMID:16825190   PMID:16862216   PMID:17110338   PMID:17123807   PMID:17164264   PMID:17321498   PMID:17488709   PMID:17513488   PMID:17565040   PMID:17567779  
PMID:17631533   PMID:17676639   PMID:17893180   PMID:17896003   PMID:17980036   PMID:18082640   PMID:18178963   PMID:18294630   PMID:18396346   PMID:18442998   PMID:18443001   PMID:18497856  
PMID:18524819   PMID:18606848   PMID:18664494   PMID:18757838   PMID:18769635   PMID:18799693   PMID:18808171   PMID:18809582   PMID:18836436   PMID:18847334   PMID:18849980   PMID:18927124  
PMID:18951892   PMID:19013199   PMID:19015316   PMID:19022376   PMID:19124654   PMID:19423573   PMID:19509342   PMID:19629036   PMID:19850871   PMID:19913544   PMID:19915186   PMID:19933576  
PMID:20019332   PMID:20069564   PMID:20106865   PMID:20130288   PMID:20376364   PMID:20388542   PMID:20405040   PMID:20421363   PMID:20439468   PMID:20457914   PMID:20685963   PMID:20726853  
PMID:20833363   PMID:21088111   PMID:21151901   PMID:21156181   PMID:21173262   PMID:21267068   PMID:21327075   PMID:21327095   PMID:21350821   PMID:21364987   PMID:21464947   PMID:21498514  
PMID:21547077   PMID:21565611   PMID:21575749   PMID:21677750   PMID:21701264   PMID:21750527   PMID:21818413   PMID:21831885   PMID:21873635   PMID:21875900   PMID:21884692   PMID:21902803  
PMID:21976703   PMID:21982926   PMID:22030750   PMID:22068161   PMID:22090424   PMID:22116031   PMID:22119912   PMID:22223883   PMID:22251972   PMID:22293021   PMID:22308344   PMID:22331516  
PMID:22349700   PMID:22443097   PMID:22541428   PMID:22610065   PMID:22773734   PMID:22819531   PMID:22837537   PMID:22837538   PMID:22886301   PMID:22893709   PMID:22895093   PMID:22905185  
PMID:23019125   PMID:23029315   PMID:23044536   PMID:23048029   PMID:23064282   PMID:23071752   PMID:23095062   PMID:23213392   PMID:23217256   PMID:23261543   PMID:23324457   PMID:23374351  
PMID:23382700   PMID:23418438   PMID:23427149   PMID:23430973   PMID:23444379   PMID:23451281   PMID:23455585   PMID:23535822   PMID:23575224   PMID:23631840   PMID:23644458   PMID:23650370  
PMID:23686339   PMID:23690466   PMID:23695662   PMID:23917225   PMID:23933734   PMID:23990565   PMID:23998933   PMID:24153156   PMID:24203701   PMID:24294364   PMID:24305605   PMID:24457600  
PMID:24523288   PMID:24639560   PMID:24672053   PMID:24757177   PMID:25118303   PMID:25218145   PMID:25237101   PMID:25246615   PMID:25312645   PMID:25343989   PMID:25380821   PMID:25437426  
PMID:25450615   PMID:25535984   PMID:25559185   PMID:25578479   PMID:25609380   PMID:25652409   PMID:25852735   PMID:26045045   PMID:26102067   PMID:26204409   PMID:26234751   PMID:26359759  
PMID:26436652   PMID:26496610   PMID:26510501   PMID:26553927   PMID:26644582   PMID:26900797   PMID:26999604   PMID:27131347   PMID:27221609   PMID:27270425   PMID:27287550   PMID:27498076  
PMID:27617860   PMID:27626380   PMID:27746211   PMID:27766308   PMID:27798115   PMID:27798236   PMID:27926859   PMID:27984723   PMID:28062850   PMID:28069793   PMID:28088180   PMID:28237702  
PMID:28241138   PMID:28246125   PMID:28374669   PMID:28378742   PMID:28533284   PMID:28595999   PMID:28674081   PMID:28702670   PMID:28803787   PMID:28854361   PMID:28872940   PMID:28930673  
PMID:29242553   PMID:29311549   PMID:29317431   PMID:29360543   PMID:29466729   PMID:29565969   PMID:29668927   PMID:29703891   PMID:29719249   PMID:29849091   PMID:29878125   PMID:29893868  
PMID:29923310   PMID:29982513   PMID:30053027   PMID:30157432   PMID:30199159   PMID:30257952   PMID:30282816   PMID:30283351   PMID:30284086   PMID:30342008   PMID:30457570   PMID:30550785  
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PMID:31332389   PMID:31341969   PMID:31372995   PMID:31397869   PMID:31430335   PMID:31668660   PMID:31690656   PMID:31740672   PMID:31794718   PMID:31833196   PMID:31844279   PMID:31941672  
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PMID:32540097   PMID:32554809   PMID:32581210   PMID:32698523   PMID:32805188   PMID:32807790   PMID:32815283   PMID:32817327   PMID:32875720   PMID:32968282   PMID:33049978   PMID:33388782  
PMID:33393189   PMID:33393499   PMID:33398110   PMID:33413510   PMID:33514739   PMID:33526168   PMID:33570570   PMID:33605210   PMID:33624748   PMID:33687998   PMID:33907225   PMID:33972393  
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PMID:37839992   PMID:37880237   PMID:37940872   PMID:37951507   PMID:38187761   PMID:38206094   PMID:38284866   PMID:38308845   PMID:38322613   PMID:38332517   PMID:38355793   PMID:38404031  
PMID:38538837   PMID:38648484   PMID:38877142   PMID:38917013  


Genomics

Comparative Map Data
Lmna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,388,455 - 88,413,842 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,387,454 - 88,417,263 (-)EnsemblGRCm39 Ensembl
GRCm38388,481,148 - 88,509,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,480,147 - 88,509,956 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,285,071 - 88,307,254 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,567,076 - 88,589,234 (-)NCBIMGSCv36mm8
Celera388,521,102 - 88,543,289 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.84NCBI
LMNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,082,573 - 156,140,081 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,082,572 - 156,140,081 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,052,364 - 156,109,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36Build 36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,481 - 157,505,990 (+)NCBICHM1_1
T2T-CHM13v2.01155,221,038 - 155,278,530 (+)NCBIT2T-CHM13v2.0
Lmna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,237,564 - 176,265,301 (-)NCBIGRCr8
mRatBN7.22173,939,751 - 173,960,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,939,751 - 173,960,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,083,809 - 181,104,527 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,106,174 - 179,126,892 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,706,353 - 173,727,003 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,842,884 - 187,863,552 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,842,885 - 187,863,516 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,245,237 - 207,265,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,595,724 - 180,616,354 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,545,829 - 180,566,460 (-)NCBI
Celera2167,884,341 - 167,905,010 (-)NCBICelera
Cytogenetic Map2q34NCBI
Lmna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,290,037 - 2,313,033 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,290,076 - 2,310,982 (+)NCBIChiLan1.0ChiLan1.0
LMNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,706,163 - 93,763,674 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,438,136 - 93,463,558 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,456,819 - 131,482,275 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,253,700 - 135,311,542 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,253,700 - 135,311,539 (+)Ensemblpanpan1.1panPan2
LMNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,702,491 - 41,719,870 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,508,450 - 41,746,931 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,192,089 - 41,209,467 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,569,142 - 41,586,514 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,568,716 - 41,586,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,349,981 - 41,367,355 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,403,350 - 41,420,721 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,687,512 - 41,704,901 (-)NCBIUU_Cfam_GSD_1.0
Lmna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,343,835 - 26,365,060 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,373,974 - 5,395,468 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,374,208 - 5,395,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,899,019 - 93,926,320 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,899,019 - 93,927,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,641,459 - 102,668,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4qNCBI
LMNA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,723,059 - 7,748,799 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,723,477 - 7,748,780 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,017,993 - 7,044,309 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmna
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,447,395 - 1,467,554 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,423,563 - 1,466,657 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Lmna
876 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1821
Count of miRNA genes:609
Interacting mature miRNAs:750
Transcripts:ENSMUST00000029699, ENSMUST00000036252, ENSMUST00000120377, ENSMUST00000135494, ENSMUST00000147537, ENSMUST00000149068, ENSMUST00000150496
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38717045489140094Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)