Mbl1 (mannose-binding lectin (protein A) 1) - Rat Genome Database

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Gene: Mbl1 (mannose-binding lectin (protein A) 1) Mus musculus
Analyze
Symbol: Mbl1
Name: mannose-binding lectin (protein A) 1
RGD ID: 732763
MGI Page MGI
Description: Predicted to enable several functions, including D-mannose binding activity; calcium-dependent carbohydrate binding activity; and phosphatidylinositol-4-phosphate binding activity. Acts upstream of or within defense response to other organism and positive regulation of phagocytosis. Located in extracellular space. Orthologous to human MBL1P (mannose binding lectin 1, pseudogene).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mannan-binding protein; mannose binding lectin (A); mannose binding lectin, serum (A); mannose-binding protein A; MBL; MBL-A; MBP; MBP-A; ra-reactive factor polysaccharide-binding component p28B; raRF p28B; S-MBP
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,873,413 - 40,885,861 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,873,415 - 40,881,558 (+)EnsemblGRCm39 Ensembl
GRCm381441,151,456 - 41,163,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,151,458 - 41,159,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv371441,964,745 - 41,972,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361440,060,169 - 40,067,672 (+)NCBIMGSCv36mm8
Celera1437,311,454 - 37,318,966 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Resistance of MBL gene-knockout mice to experimental systemic aspergillosis. Clemons KV, etal., Immunol Lett. 2010 Feb 16;128(2):105-7. doi: 10.1016/j.imlet.2009.12.021. Epub 2010 Jan 12.
2. The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury. de Vries B, etal., Am J Pathol. 2004 Nov;165(5):1677-88.
3. Protection from inflammatory disease in insulin resistance: the role of mannan-binding lectin. Fernandez-Real JM, etal., Diabetologia. 2006 Oct;49(10):2402-11. Epub 2006 Aug 29.
4. Mannan-binding lectin modulates the response to HSV-2 infection. Gadjeva M, etal., Clin Exp Immunol. 2004 Nov;138(2):304-11.
5. The mannose-binding lectin pathway is a significant contributor to reperfusion injury in the type 2 diabetic heart. La Bonte LR, etal., Diab Vasc Dis Res. 2009 Jul;6(3):172-80.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Involvement of mannose-binding lectin in the pathogenesis of Kawasaki disease-like murine vasculitis. Nakamura A, etal., Clin Immunol. 2014 Jul;153(1):64-72. doi: 10.1016/j.clim.2014.03.019. Epub 2014 Apr 8.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes. Usui H, etal., Gene 2000 May 2;248(1-2):127-35.
15. Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. Walsh MC, etal., J Immunol. 2005 Jul 1;175(1):541-6.
16. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. Zhang M, etal., J Immunol. 2006 Oct 1;177(7):4727-34.
Additional References at PubMed
PMID:1637828   PMID:1712818   PMID:7499852   PMID:7766991   PMID:7894166   PMID:8961631   PMID:9417917   PMID:9828146   PMID:10047541   PMID:10349636   PMID:10423401   PMID:10679100  
PMID:11021254   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11309157   PMID:12270724   PMID:12417723   PMID:12471128   PMID:12477932   PMID:14761934   PMID:15148336   PMID:15489334  
PMID:15735014   PMID:15749852   PMID:15879138   PMID:15882434   PMID:16141072   PMID:16141073   PMID:16299314   PMID:16424207   PMID:16602821   PMID:17114482   PMID:17363917   PMID:17404294  
PMID:17473913   PMID:17475881   PMID:17485663   PMID:17681821   PMID:17785849   PMID:18180310   PMID:18183030   PMID:18493734   PMID:18501966   PMID:18672286   PMID:19112490   PMID:19149778  
PMID:19380618   PMID:19476514   PMID:19749170   PMID:19843088   PMID:20140243   PMID:20305659   PMID:20375621   PMID:20399528   PMID:20585009   PMID:20810984   PMID:21208161   PMID:21257205  
PMID:21835783   PMID:21873635   PMID:21943708   PMID:22079428   PMID:22156595   PMID:22457620   PMID:22566568   PMID:22645604   PMID:22792067   PMID:22879370   PMID:23032324   PMID:23139754  
PMID:23350935   PMID:23427256   PMID:23478320   PMID:23936347   PMID:24167262   PMID:24676774   PMID:24743949   PMID:25008177   PMID:25419660   PMID:25482922   PMID:26442658   PMID:26631482  
PMID:27106289   PMID:27262512   PMID:27733776   PMID:28700732   PMID:28819174   PMID:29497373   PMID:30351498   PMID:30354247   PMID:30573546   PMID:30706943   PMID:30723261   PMID:30967639  
PMID:31175160   PMID:31260126   PMID:31578522   PMID:31869396   PMID:33927296   PMID:34031614   PMID:34547288   PMID:35021101   PMID:35195918   PMID:35643350   PMID:38280374  


Genomics

Comparative Map Data
Mbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391440,873,413 - 40,885,861 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1440,873,415 - 40,881,558 (+)EnsemblGRCm39 Ensembl
GRCm381441,151,456 - 41,163,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1441,151,458 - 41,159,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv371441,964,745 - 41,972,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361440,060,169 - 40,067,672 (+)NCBIMGSCv36mm8
Celera1437,311,454 - 37,318,966 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1422.36NCBI
MBL1P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381079,920,178 - 79,923,119 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1079,920,327 - 79,923,032 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1079,920,178 - 79,923,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371081,679,934 - 81,682,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361081,669,914 - 81,672,855 (+)NCBINCBI36Build 36hg18NCBI36
Build 341081,669,913 - 81,672,855NCBI
Celera1075,670,857 - 75,673,805 (+)NCBICelera
Cytogenetic Map10q22.3NCBI
HuRef1075,522,689 - 75,525,630 (+)NCBIHuRef
CHM1_11081,962,581 - 81,965,522 (+)NCBICHM1_1
T2T-CHM13v2.01080,789,562 - 80,792,503 (+)NCBIT2T-CHM13v2.0
Mbl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,063,232 - 17,069,271 (+)NCBIGRCr8
mRatBN7.21617,029,146 - 17,035,187 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,029,118 - 17,035,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,093,376 - 17,099,473 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,221,699 - 18,227,754 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,146,274 - 17,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01618,736,154 - 18,742,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1618,736,154 - 18,742,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,604,750 - 18,610,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,591,820 - 17,597,859 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,591,817 - 17,597,857 (+)NCBI
Celera1617,254,917 - 17,260,956 (+)NCBICelera
RH 3.4 Map16167.5RGD
Cytogenetic Map16p14NCBI

Variants

.
Variants in Mbl1
469 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:116
Interacting mature miRNAs:116
Transcripts:ENSMUST00000047095
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse


Sequence


Ensembl Acc Id: ENSMUST00000047095   ⟹   ENSMUSP00000048765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1440,873,458 - 40,880,916 (+)Ensembl
GRCm38.p6 Ensembl1441,151,501 - 41,158,959 (+)Ensembl
Ensembl Acc Id: ENSMUST00000225792   ⟹   ENSMUSP00000153147
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1440,873,415 - 40,881,558 (+)Ensembl
GRCm38.p6 Ensembl1441,151,458 - 41,159,601 (+)Ensembl
RefSeq Acc Id: NM_010775   ⟹   NP_034905
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391440,873,413 - 40,880,916 (+)NCBI
GRCm381441,151,456 - 41,158,959 (+)NCBI
MGSCv371441,964,745 - 41,972,248 (+)RGD
Celera1437,311,454 - 37,318,966 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006518669   ⟹   XP_006518732
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391440,873,589 - 40,885,861 (+)NCBI
GRCm381441,151,632 - 41,163,904 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034905   ⟸   NM_010775
- Peptide Label: precursor
- UniProtKB: Q0P6H1 (UniProtKB/Swiss-Prot),   P39039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006518732   ⟸   XM_006518669
- Peptide Label: isoform X1
- UniProtKB: Q0P6H1 (UniProtKB/Swiss-Prot),   P39039 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000048765   ⟸   ENSMUST00000047095
Ensembl Acc Id: ENSMUSP00000153147   ⟸   ENSMUST00000225792
Protein Domains
C-type lectin   Collagen-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P39039-F1-model_v2 AlphaFold P39039 1-239 view protein structure

Promoters
RGD ID:8682052
Promoter ID:EPDNEW_M19027
Type:initiation region
Name:Mbl1_1
Description:Mus musculus mannose-binding lectin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381441,151,504 - 41,151,564EPDNEW
RGD ID:6825155
Promoter ID:MM_KWN:16275
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000047095,   UC007TCQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361441,964,496 - 41,964,996 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96923 AgrOrtholog
Ensembl Genes ENSMUSG00000037780 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000047095.4 UniProtKB/TrEMBL
  ENSMUST00000225792 ENTREZGENE
  ENSMUST00000225792.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  C-type_lectin_CS UniProtKB/Swiss-Prot
  Ca-dependent_lectin UniProtKB/Swiss-Prot
  Collagen UniProtKB/Swiss-Prot
  Collectin_CTLD UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
KEGG Report mmu:17194 UniProtKB/Swiss-Prot
MGD MGI:96923 ENTREZGENE
NCBI Gene 17194 ENTREZGENE
PANTHER PTHR24024:SF35 UniProtKB/Swiss-Prot
  PULMONARY SURFACTANT-ASSOCIATED PROTEIN A UniProtKB/Swiss-Prot
Pfam Collagen UniProtKB/Swiss-Prot
  Lectin_C UniProtKB/Swiss-Prot
PhenoGen Mbl1 PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
  Triple coiled coil domain of C-type lectins UniProtKB/Swiss-Prot
UniProt A0A2C9F2B6_MOUSE UniProtKB/TrEMBL
  MBL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0P6H1 ENTREZGENE
UniProt Secondary Q0P6H1 UniProtKB/Swiss-Prot