Msh2 (mutS homolog 2) - Rat Genome Database

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Gene: Msh2 (mutS homolog 2) Mus musculus
Analyze
Symbol: Msh2
Name: mutS homolog 2
RGD ID: 732746
MGI Page MGI
Description: Enables ATP hydrolysis activity and DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in positive regulation of isotype switching to IgA isotypes and positive regulation of isotype switching to IgG isotypes. Acts upstream of or within several processes, including DNA metabolic process; determination of adult lifespan; and intracellular signal transduction. Located in nucleus. Part of MutSalpha complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and tail dorsal root ganglion. Used to study Lynch syndrome and colorectal cancer. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI788990; DNA mismatch repair protein Msh2; mutS protein homolog 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,979,960 - 88,031,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,979,758 - 88,031,141 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381787,672,532 - 87,723,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,672,330 - 87,723,713 (+)Ensemblmm10GRCm38
MGSCv371788,071,897 - 88,123,053 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361787,580,883 - 87,632,039 (+)NCBIMGSCv36mm8
Celera1792,079,522 - 92,130,140 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
ascending colon cancer  (ISO)
ataxia telangiectasia  (ISO)
bile duct cancer  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
colitis  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colon Diverticulum  (ISO)
Colonic Polyps  (ISO)
colorectal adenocarcinoma  (IMP)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Ependymomas  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Seizures  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
glioblastoma  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 2  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
high grade glioma  (ISO)
Huntington's disease  (IMP)
Hydatidiform Mole  (ISO)
Hydatidiform Mole, Invasive  (ISO)
laryngeal squamous cell carcinoma  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (IAGP,ISO)
Lynch syndrome 1  (ISO)
mismatch repair cancer syndrome  (ISO)
Mismatch Repair Cancer Syndrome 1  (ISO)
Mismatch Repair Cancer Syndrome 2  (ISO)
Muir-Torre syndrome  (ISO)
Neoplasm Metastasis  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian cyst  (ISO)
Ovarian Neoplasms  (ISO)
Pitt-Hopkins-like syndrome 2  (ISO)
prostate cancer  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
rhabdomyosarcoma  (ISO)
sarcoma  (ISO)
sigmoid colon cancer  (ISO)
sigmoid neoplasm  (ISO)
stomach cancer  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urogenital Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
uterine corpus cancer  (ISO)
Vulvar Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrobenzenesulfonic acid  (EXP)
2,4-dinitrotoluene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (EXP,ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
carboplatin  (ISO)
carmustine  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
Dimethyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
erastin  (ISO)
escitalopram  (ISO)
floxuridine  (ISO)
folic acid  (EXP)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (EXP)
indirubin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
mechlorethamine  (EXP)
menadione  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nitrates  (EXP)
olaparib  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
pergolide  (ISO)
phenobarbital  (ISO)
PhIP  (EXP,ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
pyrimidines  (EXP,ISO)
quercetin  (ISO)
resveratrol  (EXP)
riddelliine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sterigmatocystin  (ISO)
succimer  (EXP)
sunitinib  (ISO)
temozolomide  (EXP,ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
tioguanine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
MutSalpha complex  (IBA,IDA,IEA,ISO)
MutSbeta complex  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IC,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell cycle  (IAGP)
abnormal cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal mismatch repair  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal somatic hypermutation frequency  (IAGP)
abnormal tumor morphology  (IAGP)
anemia  (IAGP)
colon polyps  (IAGP)
decreased enterocyte apoptosis  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG3 level  (IAGP)
decreased mature B cell number  (IAGP)
decreased survivor rate  (IAGP)
increased brain tumor incidence  (IAGP)
increased cellular sensitivity to ultraviolet irradiation  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased incidence of tumors by UV-induction  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lymphoblastic lymphoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary gland tumor incidence  (IAGP)
increased mortality induced by ionizing radiation  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pheochromocytoma incidence  (IAGP)
increased pituitary adenohypophysis tumor incidence  (IAGP)
increased pituitary melanotroph tumor incidence  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased small intestine adenocarcinoma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased thyroid C-cell carcinoma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
increased uterus tumor incidence  (IAGP)
intestinal obstruction  (IAGP)
intestine polyps  (IAGP)
neuronal intranuclear inclusions  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. Bai YQ, etal., Int J Cancer. 1999 Aug 12;82(4):512-5.
2. Mismatch repair genes in renal cortical neoplasms. Baiyee D and Banner B, Hum Pathol. 2006 Feb;37(2):185-9. Epub 2005 Dec 15.
3. Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain. Belloni M, etal., Neuroscience. 1999;94(4):1323-31.
4. Expression of the mismatch repair protein hMSH2 in carcinoma in situ and invasive cancer of the breast. Bock N, etal., Anticancer Res. 2000 Jan-Feb;20(1A):119-24.
5. Analysis of MSH2 Loss of Heterozygosity, Expression, and IVS10+12G>A Polymorphism in Sporadic Colon Cancer. Cacev T, etal., Anticancer Res. 2018 May;38(5):2841-2848. doi: 10.21873/anticanres.12529.
6. Apurinic/apyrimidinic endonuclease 1, the sensitive marker for DNA deterioration in dextran sulfate sodium-induced acute colitis. Chang IY, etal., Redox Rep. 2013;18(5):165-73. doi: 10.1179/1351000213Y.0000000056. Epub 2013 Jul 23.
7. Mismatch repair gene promoter methylation and expression in hydatidiform moles. Chen H, etal., Arch Gynecol Obstet. 2005 Jun;272(1):35-9. Epub 2004 Aug 28.
8. Polymorphisms in hMSH2 and hMLH1 and response to platinum-based chemotherapy in advanced non-small-cell lung cancer patients. Cheng H, etal., Acta Biochim Biophys Sin (Shanghai). 2010 May 15;42(5):311-7. doi: 10.1093/abbs/gmq023.
9. The expression of mismatched repair genes and their correlation with clinicopathological parameters and response to neo-adjuvant chemotherapy in breast cancer. Chintamani, etal., Int Semin Surg Oncol. 2007 Feb 14;4:5.
10. Immunohistochemical expression of DNA mismatch repair (MMR) system proteins (hMLH1, hMSH2) in cervical preinvasive and invasive lesions. Ciavattini A, etal., Pathol Res Pract. 2005;201(1):21-5.
11. 1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice. Colussi C, etal., J Natl Cancer Inst. 2001 Oct 17;93(20):1534-40. doi: 10.1093/jnci/93.20.1534.
12. An intronic germline transition in the HNPCC gene hMSH2 is associated with sporadic colorectal cancer. Goessl C, etal., Eur J Cancer. 1997 Oct;33(11):1869-74. doi: 10.1016/s0959-8049(97)00219-0.
13. Reduced expression of mutS homolog 2 and mutL homolog 1 affects overall survival in laryngeal squamous cell carcinoma patients: Investigation into a potential cause. Gong HL, etal., Oncol Rep. 2013 Sep;30(3):1371-9. doi: 10.3892/or.2013.2559. Epub 2013 Jun 20.
14. Cyclical change of hMSH2 protein expression in normal endometrium during the menstrual cycle and its overexpression in endometrial hyperplasia and sporadic endometrial carcinoma. Hamid AA, etal., Cancer. 2002 Feb 15;94(4):997-1005.
15. Overexpression of MutL homolog 1 and MutS homolog 2 proteins have reversed prognostic implications for stage I-II colon cancer patients. Huang SC, etal., Biomed J. 2017 Feb;40(1):39-48. doi: 10.1016/j.bj.2017.01.004. Epub 2017 Mar 14.
16. DNA mismatch repair defects: role in colorectal carcinogenesis. Jacob S and Praz F, Biochimie. 2002 Jan;84(1):27-47.
17. Expression of MSH2 and MSH6 on a tissue microarray in patients with osteosarcoma. Jentzsch T, etal., Anticancer Res. 2014 Dec;34(12):6961-72.
18. Urinary Tract Cancer in Lynch Syndrome; Increased Risk in Carriers of MSH2 Mutations. Joost P, etal., Urology. 2015 Dec;86(6):1212-7. doi: 10.1016/j.urology.2015.08.018. Epub 2015 Sep 15.
19. Polymorphisms in the hMSH2 gene and the risk of primary lung cancer. Jung CY, etal., Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):762-8.
20. MutS homologue 2 and the long-term benefit of adjuvant chemotherapy in lung cancer. Kamal NS, etal., Clin Cancer Res. 2010 Feb 15;16(4):1206-15. doi: 10.1158/1078-0432.CCR-09-2204. Epub 2010 Feb 9.
21. Expression of DNA mismatch repair gene MSH2 in cytological material from lung cancer patients. Kanellis G, etal., Diagn Cytopathol. 2006 Jul;34(7):463-6. doi: 10.1002/dc.20473.
22. Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis. Karihtala P, etal., Eur J Cancer. 2006 Oct;42(15):2653-9. Epub 2006 Sep 22.
23. Immunohistochemistry of proteins for DNA mismatch repair in correlation to prognostic factors of mammarian cancer. Koster F, etal., Oncol Rep. 2007 May;17(5):1223-7.
24. Immunohistochemical detection of hMLH1 and hMSH2 proteins in vulvar carcinoma. Kwasniewska A, etal., Int J Mol Med. 2005 Jun;15(6):955-61.
25. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
26. [Relationship between combined multigene detection and response to chemotherapy and prognosis in epithelial ovarian carcinomas]. Li L, etal., Zhonghua Fu Chan Ke Za Zhi. 2007 Sep;42(9):600-4.
27. Aberrant methylation of different DNA repair genes demonstrates distinct prognostic value for esophageal cancer. Ling ZQ, etal., Dig Dis Sci. 2011 Oct;56(10):2992-3004. doi: 10.1007/s10620-011-1774-z. Epub 2011 Jun 15.
28. MSH2 promoter hypermethylation in circulating tumor DNA is a valuable predictor of disease-free survival for patients with esophageal squamous cell carcinoma. Ling ZQ, etal., Eur J Surg Oncol. 2012 Apr;38(4):326-32. doi: 10.1016/j.ejso.2012.01.008. Epub 2012 Jan 23.
29. Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients. Liu JY, etal., Chin J Cancer. 2017 Jan 16;36(1):12. doi: 10.1186/s40880-016-0175-2.
30. Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer. Lu KH, etal., J Clin Oncol. 2007 Nov 20;25(33):5158-64. Epub 2007 Oct 9.
31. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
32. New founding mutation in MSH2 associated with hereditary nonpolyposis colorectal cancer syndrome on the Island of Tenerife. Medina-Arana V, etal., Cancer Lett. 2006 Dec 8;244(2):268-73. doi: 10.1016/j.canlet.2005.12.033. Epub 2006 Feb 24.
33. MGDs mouse GO annotations MGD data from the GO Consortium
34. MGD IEA MGD IEA
35. Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract. Mongiat-Artus P, etal., Oncogene. 2006 Mar 30;25(14):2113-8.
36. Prognostic value of microsatellite instability determined by immunohistochemical staining of hMSH2 and hMSH6 in urothelial carcinoma of the bladder. Mylona E, etal., APMIS. 2008 Jan;116(1):59-65.
37. Screening for urinary tract cancer with urine cytology in Lynch syndrome and familial colorectal cancer. Myrhoj T, etal., Fam Cancer. 2008 Apr 4;.
38. Loss of MSH2 protein expression is a risk factor in early stage cervical cancer. Nijhuis ER, etal., J Clin Pathol. 2007 Jul;60(7):824-30.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. Polymorphisms of the DNA mismatch repair gene HMSH2 in breast cancer occurence and progression. Poplawski T, etal., Breast Cancer Res Treat. 2005 Dec;94(3):199-204.
42. Tissue microarray analysis of hMSH2 expression predicts outcome in men with prostate cancer. Prtilo A, etal., J Urol. 2005 Nov;174(5):1814-8; discussion 1818.
43. [Expression and significance of hMSH2 protein in laryngeal squamous cell carcinoma]. Ren Y, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Sep;27(18):986-8.
44. Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer. Rey JM, etal., Cancer Genet Cytogenet. 2004 Dec;155(2):149-51.
45. Mouse MP Annotation Import Pipeline RGD automated import pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer. Skeldon SC, etal., Eur Urol. 2013 Feb;63(2):379-85. doi: 10.1016/j.eururo.2012.07.047. Epub 2012 Aug 2.
49. Mismatch repair gene polymorphisms and association with lung cancer development. Slováková P, etal., Adv Exp Med Biol. 2015;833:15-22. doi: 10.1007/5584_2014_83.
50. Promoter methylation status of MGMT, hMSH2, and hMLH1 and its relationship to corresponding protein expression and TP53 mutations in human esophageal squamous cell carcinoma. Su Y, etal., Med Oncol. 2014 Feb;31(2):784. doi: 10.1007/s12032-013-0784-4. Epub 2013 Dec 24.
51. Germline truncating mutations in both MSH2 and BRCA2 in a single kindred. Thiffault I, etal., Br J Cancer. 2004 Jan 26;90(2):483-91.
52. Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence. Velasco A, etal., Cancer Biol Ther. 2004 Nov;3(11):1152-8; discussion 1159-61. Epub 2004 Nov 9.
53. Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum. Wheeler VC, etal., Hum Mol Genet. 2003 Feb 1;12(3):273-81.
54. DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer. Wu XY, etal., J Biochem. 2020 Aug 1;168(2):151-157. doi: 10.1093/jb/mvaa034.
55. Comparative study of mutations in SNP loci of K-RAS, hMLH1 and hMSH2 genes in neoplastic intestinal polyps and colorectal cancer. Yan ZH, etal., World J Gastroenterol. 2014 Dec 28;20(48):18338-45. doi: 10.3748/wjg.v20.i48.18338.
Additional References at PubMed
PMID:7550317   PMID:7628020   PMID:7713503   PMID:7838728   PMID:8252616   PMID:8261515   PMID:8492116   PMID:8575305   PMID:8674041   PMID:8706033   PMID:8751373   PMID:8812455  
PMID:9116269   PMID:9157971   PMID:9244348   PMID:9288110   PMID:9425892   PMID:9443401   PMID:9607915   PMID:9607916   PMID:9697842   PMID:9697843   PMID:9823302   PMID:9927509  
PMID:10097137   PMID:10349636   PMID:10369687   PMID:10430621   PMID:10501974   PMID:10545954   PMID:10581038   PMID:10602475   PMID:10662804   PMID:10720738   PMID:10747038   PMID:10809667  
PMID:10837019   PMID:10866310   PMID:10874005   PMID:10992298   PMID:11042159   PMID:11046134   PMID:11076861   PMID:11133819   PMID:11156379   PMID:11217851   PMID:11223406   PMID:11283247  
PMID:11429706   PMID:11507063   PMID:11555625   PMID:11585736   PMID:11593414   PMID:11828012   PMID:11890935   PMID:11929830   PMID:12185594   PMID:12195036   PMID:12214270   PMID:12234974  
PMID:12244177   PMID:12466851   PMID:12477932   PMID:12489114   PMID:12520002   PMID:12531017   PMID:12531020   PMID:12531021   PMID:12584170   PMID:12606123   PMID:12612914   PMID:12687013  
PMID:12725522   PMID:12727820   PMID:12743174   PMID:12904583   PMID:12967659   PMID:14563316   PMID:14568978   PMID:14576827   PMID:14592986   PMID:14610273   PMID:14701736   PMID:14712231  
PMID:14744764   PMID:15044851   PMID:15126346   PMID:15135636   PMID:15166087   PMID:15489334   PMID:15494304   PMID:15496421   PMID:15533840   PMID:15700306   PMID:15753043   PMID:15778432  
PMID:15782199   PMID:15805259   PMID:15888344   PMID:15955838   PMID:16141072   PMID:16141073   PMID:16240453   PMID:16260499   PMID:16314305   PMID:16331258   PMID:16381012   PMID:16407970  
PMID:16437133   PMID:16713580   PMID:16728433   PMID:16805809   PMID:16894013   PMID:17090531   PMID:17113727   PMID:17142234   PMID:17190840   PMID:17218062   PMID:17297472   PMID:17331550  
PMID:17761884   PMID:17912366   PMID:17947680   PMID:17967808   PMID:18273020   PMID:18461468   PMID:18799693   PMID:18832169   PMID:18986375   PMID:19435918   PMID:19436705   PMID:19553545  
PMID:19596785   PMID:19765110   PMID:19805137   PMID:19837692   PMID:19901081   PMID:19931261   PMID:20154148   PMID:20362541   PMID:20567595   PMID:20705648   PMID:20812239   PMID:20923998  
PMID:20940147   PMID:21151102   PMID:21242524   PMID:21267068   PMID:21285353   PMID:21436383   PMID:21551128   PMID:21589869   PMID:21677750   PMID:21788338   PMID:21804017   PMID:21865299  
PMID:21873635   PMID:22083510   PMID:22289650   PMID:22447450   PMID:22465156   PMID:22560297   PMID:22768095   PMID:22810206   PMID:22970194   PMID:23071719   PMID:23140944   PMID:23603115  
PMID:23741483   PMID:23772033   PMID:23920106   PMID:23935891   PMID:23984319   PMID:24013230   PMID:24038355   PMID:24097111   PMID:24130133   PMID:24205214   PMID:24244021   PMID:24258150  
PMID:24391453   PMID:24457600   PMID:24882211   PMID:24966277   PMID:25036629   PMID:25088490   PMID:25122144   PMID:25726753   PMID:25773971   PMID:26022687   PMID:26267846   PMID:26327213  
PMID:26343801   PMID:26365490   PMID:26385350   PMID:27261510   PMID:27476972   PMID:27873144   PMID:27886214   PMID:27941880   PMID:28039326   PMID:28378742   PMID:28522752   PMID:28767666  
PMID:28775312   PMID:29669924   PMID:30946744   PMID:31077711   PMID:31126976   PMID:31165767   PMID:31757865   PMID:32109374   PMID:32286276   PMID:32362315   PMID:33230847   PMID:34003775  
PMID:34111601   PMID:34224739   PMID:34255829   PMID:34298973   PMID:34380768   PMID:34543445   PMID:34819670   PMID:35688320   PMID:36114006   PMID:36603026   PMID:36715327   PMID:37012289  
PMID:37395714   PMID:37642881   PMID:37709863   PMID:37746286   PMID:38636522   PMID:38893159   PMID:39938516   PMID:39946195  


Genomics

Comparative Map Data
Msh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,979,960 - 88,031,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,979,758 - 88,031,141 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381787,672,532 - 87,723,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,672,330 - 87,723,713 (+)Ensemblmm10GRCm38
MGSCv371788,071,897 - 88,123,053 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361787,580,883 - 87,632,039 (+)NCBIMGSCv36mm8
Celera1792,079,522 - 92,130,140 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
MSH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,403,067 - 47,709,830 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,403,067 - 47,663,146 (+)Ensemblhg38GRCh38
GRCh37247,630,206 - 47,936,969 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,483,767 - 47,563,864 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34247,541,913 - 47,622,011NCBI
Celera247,469,014 - 47,549,030 (+)NCBICelera
Cytogenetic Map2p21-p16.3NCBI
HuRef247,367,170 - 47,445,840 (+)NCBIHuRef
CHM1_1247,560,266 - 47,640,762 (+)NCBICHM1_1
T2T-CHM13v2.0247,408,101 - 47,714,827 (+)NCBIT2T-CHM13v2.0
Msh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,567,368 - 12,626,534 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl612,567,368 - 12,626,503 (-)EnsemblGRCr8
mRatBN7.266,813,793 - 6,872,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,813,795 - 6,872,938 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx67,095,880 - 7,155,017 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,405,284 - 7,464,421 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,932,416 - 6,991,551 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,215,951 - 11,274,916 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,215,963 - 11,274,932 (-)Ensemblrn6Rnor6.0
Rnor_5.0621,198,374 - 21,256,838 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4611,199,906 - 11,258,350 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera66,571,260 - 6,630,220 (-)NCBICelera
RGSC_v3.1611,199,905 - 11,258,350 (+)NCBI
Cytogenetic Map6q12NCBI
Msh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544114,187,805 - 14,247,698 (+)Ensembl
ChiLan1.0NW_00495544114,188,315 - 14,247,608 (+)NCBIChiLan1.0ChiLan1.0
MSH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,853,510 - 78,981,234 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A78,857,477 - 78,985,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,524,468 - 47,602,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,447,207 - 48,525,638 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,447,207 - 48,554,461 (+)EnsemblpanPan2panpan1.1
MSH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,517,448 - 49,594,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,517,369 - 49,594,210 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1049,372,675 - 49,449,176 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01050,390,734 - 50,467,292 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,390,727 - 50,467,285 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,098,560 - 50,174,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,386,621 - 50,461,201 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,572,222 - 50,649,102 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Msh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,515,476 - 33,584,710 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,944,007 - 5,013,356 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,943,987 - 5,013,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl393,081,219 - 93,163,585 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1393,082,958 - 93,163,556 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2399,052,166 - 99,101,600 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2399,274,469 - 99,306,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11459,730,101 - 59,802,857 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1459,729,789 - 59,802,819 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604552,045,654 - 52,118,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473828,780,614 - 28,861,704 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473828,780,596 - 28,861,523 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Msh2
1647 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1469
Count of miRNA genes:722
Interacting mature miRNAs:886
Transcripts:ENSMUST00000024967, ENSMUST00000172596, ENSMUST00000172855, ENSMUST00000173097, ENSMUST00000174240, ENSMUST00000174703
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
14697708Stsl5_mSalmonella typhimurium susceptibility locus 5 (mouse)178080742991407428Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse

Markers in Region
BB296288  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,723,560 - 87,723,644UniSTSGRCm38
MGSCv371788,122,900 - 88,122,984UniSTSGRCm37
Celera1792,129,987 - 92,130,071UniSTS
Cytogenetic Map17E4UniSTS
cM Map1745.9UniSTS
Whitehead/MRC_RH171092.27UniSTS
AI788990  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,723,443 - 87,723,569UniSTSGRCm38
MGSCv371788,122,783 - 88,122,909UniSTSGRCm37
Celera1792,129,868 - 92,129,996UniSTS
Cytogenetic Map17E4UniSTS
cM Map1745.9UniSTS
Whitehead/MRC_RH171095.6UniSTS
PMC102144P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,717,493 - 87,717,666UniSTSGRCm38
MGSCv371788,116,833 - 88,117,006UniSTSGRCm37
Celera1792,123,938 - 92,124,111UniSTS
Cytogenetic Map17E4UniSTS
cM Map1745.9UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000024967   ⟹   ENSMUSP00000024967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,979,758 - 88,031,141 (+)Ensembl
GRCm38.p6 Ensembl1787,672,330 - 87,723,713 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172596
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,996,370 - 88,004,131 (+)Ensembl
GRCm38.p6 Ensembl1787,688,942 - 87,696,703 (+)Ensembl
Ensembl Acc Id: ENSMUST00000172855   ⟹   ENSMUSP00000133650
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,980,037 - 87,992,994 (+)Ensembl
GRCm38.p6 Ensembl1787,672,609 - 87,685,566 (+)Ensembl
Ensembl Acc Id: ENSMUST00000173097
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,979,989 - 88,016,836 (+)Ensembl
GRCm38.p6 Ensembl1787,672,561 - 87,709,408 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,979,968 - 87,987,120 (+)Ensembl
GRCm38.p6 Ensembl1787,672,540 - 87,679,692 (+)Ensembl
Ensembl Acc Id: ENSMUST00000174703   ⟹   ENSMUSP00000133488
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1788,003,969 - 88,025,106 (+)Ensembl
GRCm38.p6 Ensembl1787,696,541 - 87,717,678 (+)Ensembl
RefSeq Acc Id: NM_008628   ⟹   NP_032654
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391787,979,960 - 88,031,141 (+)NCBI
GRCm381787,672,532 - 87,723,713 (+)NCBI
MGSCv371788,071,897 - 88,123,053 (+)RGD
Celera1792,079,522 - 92,130,140 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032654   ⟸   NM_008628
- UniProtKB: P43247 (UniProtKB/Swiss-Prot),   Q3TZI5 (UniProtKB/TrEMBL),   Q80V79 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000133650   ⟸   ENSMUST00000172855
Ensembl Acc Id: ENSMUSP00000133488   ⟸   ENSMUST00000174703
Ensembl Acc Id: ENSMUSP00000024967   ⟸   ENSMUST00000024967
Protein Domains
DNA mismatch repair protein MutS connector   DNA mismatch repair protein MutS-like N-terminal   DNA mismatch repair proteins mutS family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43247-F1-model_v2 AlphaFold P43247 1-935 view protein structure

Promoters
RGD ID:13676960
Promoter ID:EPDNEW_M22629
Type:initiation region
Name:Msh2_1
Description:Mus musculus mutS homolog 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381787,672,532 - 87,672,592EPDNEW
RGD ID:6828384
Promoter ID:MM_KWN:24406
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008628,   UC008DUZ.1,   UC008DVA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361788,071,539 - 88,072,039 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101816 AgrOrtholog
Ensembl Genes ENSMUSG00000024151 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024967 ENTREZGENE
  ENSMUST00000024967.14 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1420.10 UniProtKB/Swiss-Prot
  3.30.420.110 UniProtKB/Swiss-Prot
  3.40.1170.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro DNA_mismatch_repair_Msh2 UniProtKB/Swiss-Prot
  DNA_mismatch_repair_MutS-lik_N UniProtKB/Swiss-Prot
  DNA_mismatch_repair_MutS_C UniProtKB/Swiss-Prot
  DNA_mismatch_repair_MutS_clamp UniProtKB/Swiss-Prot
  DNA_mismatch_repair_MutS_core UniProtKB/Swiss-Prot
  DNA_mismatch_repair_MutS_N UniProtKB/Swiss-Prot
  DNA_mismatch_repair_MutS_sf UniProtKB/Swiss-Prot
  DNA_mmatch_repair_MutS_con_dom UniProtKB/Swiss-Prot
  Msh2 UniProtKB/Swiss-Prot
  MutS_con_dom_sf UniProtKB/Swiss-Prot
  MutS_family UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:17685 UniProtKB/Swiss-Prot
MGD MGI:101816 ENTREZGENE
NCBI Gene 17685 ENTREZGENE
PANTHER PTHR11361 UniProtKB/Swiss-Prot
  PTHR11361:SF35 UniProtKB/Swiss-Prot
Pfam MutS_I UniProtKB/Swiss-Prot
  MutS_II UniProtKB/Swiss-Prot
  MutS_III UniProtKB/Swiss-Prot
  MutS_IV UniProtKB/Swiss-Prot
  MutS_V UniProtKB/Swiss-Prot
PharmGKB MSH2 RGD
PhenoGen Msh2 PhenoGen
PIRSF MSH2 UniProtKB/Swiss-Prot
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/Swiss-Prot
SMART MUTSac UniProtKB/Swiss-Prot
  MUTSd UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48334 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF53150 UniProtKB/Swiss-Prot
UniProt G3UWZ8_MOUSE UniProtKB/TrEMBL
  G3UXD8_MOUSE UniProtKB/TrEMBL
  MSH2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TZI5 ENTREZGENE, UniProtKB/TrEMBL
  Q80V79 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Msh2  mutS homolog 2    mutS homolog 2 (E. coli)  Symbol and/or name change 5135510 APPROVED