Nbn (nibrin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Nbn (nibrin) Mus musculus
Analyze
Symbol: Nbn
Name: nibrin
RGD ID: 732723
MGI Page MGI
Description: Enables chromatin-protein adaptor activity and damaged DNA binding activity. Involved in DNA metabolic process and blastocyst growth. Acts upstream of or within intracellular signal transduction; neuroblast proliferation; and neuromuscular process controlling balance. Located in PML body; chromosome, telomeric region; and replication fork. Part of Mre11 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Nijmegen breakage syndrome and T-cell acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; rectum cancer; and reproductive organ cancer (multiple). Orthologous to human NBN (nibrin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell cycle regulatory protein p95; Nb; Nbs1; nijmegen breakage syndrome protein 1 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39415,955,388 - 15,992,589 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl415,957,925 - 15,992,589 (+)EnsemblGRCm39 Ensembl
GRCm38415,957,587 - 15,992,589 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl415,957,925 - 15,992,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv37415,885,114 - 15,919,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36415,885,115 - 15,919,736 (+)NCBIMGSCv36mm8
Celera415,761,229 - 15,795,887 (+)NCBICelera
Cytogenetic Map4A2NCBI
cM Map46.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzene  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
delphinidin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fenofibrate  (ISO)
finasteride  (ISO)
folic acid  (EXP)
FR900359  (ISO)
gedunin  (ISO)
genistein  (ISO)
glafenine  (ISO)
hexadecanoic acid  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
methylmercury chloride  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
Nonidet P-40  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (EXP)
pentamidine  (ISO)
perfluorohexanesulfonic acid  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blastocyst growth  (IMP)
DNA damage checkpoint signaling  (ISO)
DNA damage response  (IEA)
DNA double-strand break processing  (ISO,NAS)
DNA duplex unwinding  (IBA,ISO)
DNA repair  (IEA)
DNA strand resection involved in replication fork processing  (ISO,NAS)
double-strand break repair  (ISO)
double-strand break repair via alternative nonhomologous end joining  (IDA,ISO)
double-strand break repair via homologous recombination  (IBA,ISO)
homologous recombination  (NAS)
in utero embryonic development  (IMP)
intrinsic apoptotic signaling pathway  (IMP)
isotype switching  (IDA)
meiotic cell cycle  (IEA)
mitotic G2 DNA damage checkpoint signaling  (IBA,IMP,ISO)
mitotic G2/M transition checkpoint  (NAS)
negative regulation of neuron differentiation  (ISO)
negative regulation of telomere capping  (ISO)
negative regulation of viral entry into host cell  (ISO)
neuroblast proliferation  (IMP)
neuromuscular process controlling balance  (IMP)
positive regulation of cell population proliferation  (ISO)
positive regulation of kinase activity  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of telomere maintenance  (ISO)
protection from non-homologous end joining at telomere  (IDA,ISO)
protein localization to site of double-strand break  (ISO)
R-loop processing  (ISO)
regulation of fibroblast proliferation  (ISO)
response to xenobiotic stimulus  (ISO)
t-circle formation  (ISO)
telomere maintenance  (ISO)
telomere maintenance in response to DNA damage  (IDA,ISO)
telomere maintenance via telomere trimming  (ISO)
telomeric 3' overhang formation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal bone marrow development  (IAGP)
abnormal brain development  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal gait  (IAGP)
abnormal inner cell mass apoptosis  (IAGP)
abnormal involuntary movement  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal reflex  (IAGP)
abnormal T cell morphology  (IAGP)
abnormal trophectoderm morphology  (IAGP)
absent cerebellar foliation  (IAGP)
absent embryonic epiblast  (IAGP)
absent extraembryonic ectoderm  (IAGP)
absent inner cell mass proliferation  (IAGP)
absent mature B cells  (IAGP)
absent oocytes  (IAGP)
absent ovarian follicles  (IAGP)
absent proamniotic cavity  (IAGP)
akinesia  (IAGP)
anemia  (IAGP)
ataxia  (IAGP)
chromosomal instability  (IAGP)
chromosome breakage  (IAGP)
decreased apoptosis  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased brain weight  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased cellular sensitivity to ionizing radiation  (IAGP)
decreased embryo size  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased inner cell mass proliferation  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased myeloid cell number  (IAGP)
decreased oocyte number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased T cell number  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor latency  (IAGP)
disorganized embryonic tissue  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
female infertility  (IAGP)
impaired balance  (IAGP)
impaired hematopoiesis  (IAGP)
increased apoptosis  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cellular sensitivity to gamma-irradiation  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased gonad tumor incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased histiocytic sarcoma incidence  (IAGP)
increased incidence of tumors by ionizing radiation induction  (IAGP)
increased leiomyosarcoma incidence  (IAGP)
increased Leydig cell tumor incidence  (IAGP)
increased liver adenocarcinoma incidence  (IAGP)
increased liver adenoma incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased mortality induced by gamma-irradiation  (IAGP)
increased pro-B cell number  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased rhabdomyosarcoma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased stereotypic behavior  (IAGP)
increased T cell acute lymphoblastic leukemia incidence  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased teratoma incidence  (IAGP)
increased thyroid adenoma incidence  (IAGP)
increased tumor incidence  (IAGP)
inner cell mass degeneration  (IAGP)
microcephaly  (IAGP)
ovary degeneration  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
small cerebellum  (IAGP)
small ovary  (IAGP)
thrombocytosis  (IAGP)
thymus hypoplasia  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
2. Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays. Chatterjee M, etal., Cancer Res. 2006 Jan 15;66(2):1181-90.
3. NBS1 is a prostate cancer susceptibility gene. Cybulski C, etal., Cancer Res. 2004 Feb 15;64(4):1215-9.
4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
5. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
6. Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. Hsu HM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2024-32.
7. Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. Jacobsen E, etal., Brain Res Mol Brain Res. 2004 Sep 10;128(1):1-7.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Naccarati A, etal., Oncotarget. 2016 Apr 26;7(17):23156-69. doi: 10.18632/oncotarget.6804.
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. I171V germline mutation in the NBS1 gene significantly increases risk of breast cancer. Roznowski K, etal., Breast Cancer Res Treat. 2008 Jul;110(2):343-8. Epub 2007 Sep 26.
18. Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer. Soderlund K, etal., Int J Radiat Oncol Biol Phys. 2007 May 1;68(1):50-8. Epub 2007 Mar 6.
19. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, etal., Hum Mol Genet 2001 Sep 1;10(18):1995-2011.
20. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Varon R, etal., Cell. 1998 May 1;93(3):467-76.
21. DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Xu Y Nat Rev Immunol. 2006 Apr;6(4):261-70.
Additional References at PubMed
PMID:10349636   PMID:10640816   PMID:10811102   PMID:10915761   PMID:11042159   PMID:11062235   PMID:11076861   PMID:11161784   PMID:11217851   PMID:11231126   PMID:11889050   PMID:11934988  
PMID:11967151   PMID:12477932   PMID:12520002   PMID:12529385   PMID:12792649   PMID:12904583   PMID:14610273   PMID:14612522   PMID:14690604   PMID:15175241   PMID:15326357   PMID:15333589  
PMID:15489334   PMID:15632067   PMID:15668383   PMID:15668392   PMID:15734743   PMID:15782199   PMID:15821748   PMID:15965469   PMID:16036916   PMID:16141072   PMID:16141073   PMID:16357220  
PMID:16400328   PMID:16790366   PMID:16797606   PMID:17082765   PMID:17291760   PMID:17429352   PMID:17485521   PMID:17562874   PMID:17967808   PMID:18156798   PMID:18171670   PMID:18287559  
PMID:18411308   PMID:18541670   PMID:18614044   PMID:18678890   PMID:18723444   PMID:18854157   PMID:18931658   PMID:19015239   PMID:19075003   PMID:19171781   PMID:19221393   PMID:19244116  
PMID:19345213   PMID:19362533   PMID:19412544   PMID:19584276   PMID:19633670   PMID:19667071   PMID:19782649   PMID:19910469   PMID:20368419   PMID:20921278   PMID:21147852   PMID:21300797  
PMID:21664921   PMID:21677273   PMID:21677750   PMID:21873635   PMID:21884979   PMID:21945094   PMID:22078264   PMID:22212482   PMID:22266795   PMID:22369660   PMID:22522401   PMID:22576691  
PMID:22670056   PMID:22869595   PMID:23219553   PMID:23444137   PMID:23934213   PMID:23935957   PMID:24120666   PMID:24272708   PMID:24388752   PMID:24793032   PMID:25768017   PMID:25771721  
PMID:26160886   PMID:26324700   PMID:26512707   PMID:26538284   PMID:26544571   PMID:27050272   PMID:27320916   PMID:27814490   PMID:28076792   PMID:28216226   PMID:28819025   PMID:29709199  
PMID:30017584   PMID:30657944   PMID:31285322   PMID:31965061   PMID:32325033   PMID:33010171   PMID:33524014   PMID:33586242   PMID:35153719   PMID:35839783   PMID:37296499   PMID:37466852  
PMID:38961290  


Genomics

Comparative Map Data
Nbn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39415,955,388 - 15,992,589 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl415,957,925 - 15,992,589 (+)EnsemblGRCm39 Ensembl
GRCm38415,957,587 - 15,992,589 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl415,957,925 - 15,992,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv37415,885,114 - 15,919,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36415,885,115 - 15,919,736 (+)NCBIMGSCv36mm8
Celera415,761,229 - 15,795,887 (+)NCBICelera
Cytogenetic Map4A2NCBI
cM Map46.66NCBI
NBN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38889,933,331 - 89,984,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl889,924,515 - 90,003,228 (-)EnsemblGRCh38hg38GRCh38
GRCh37890,945,559 - 90,996,895 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36891,014,740 - 91,066,075 (-)NCBINCBI36Build 36hg18NCBI36
Build 34891,014,888 - 91,066,072NCBI
Celera887,140,375 - 87,191,710 (-)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef886,155,741 - 86,207,078 (-)NCBIHuRef
CHM1_1890,986,489 - 91,037,825 (-)NCBICHM1_1
T2T-CHM13v2.0891,056,512 - 91,107,848 (-)NCBIT2T-CHM13v2.0
Nbn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8534,256,678 - 34,291,163 (+)NCBIGRCr8
mRatBN7.2529,459,574 - 29,494,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl529,459,457 - 29,494,150 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx531,615,796 - 31,650,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0533,208,466 - 33,243,256 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0533,168,642 - 33,203,436 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0529,622,347 - 29,656,877 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl529,622,281 - 29,656,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0534,300,932 - 34,335,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4530,541,610 - 30,576,168 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1530,541,609 - 30,576,168 (+)NCBI
Celera528,665,088 - 28,699,404 (+)NCBICelera
Cytogenetic Map5q13NCBI
Nbn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554176,839,312 - 6,880,133 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554176,840,916 - 6,880,479 (-)NCBIChiLan1.0ChiLan1.0
NBN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27107,329,160 - 107,380,523 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1882,868,830 - 82,938,522 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0886,622,797 - 86,674,202 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1888,575,198 - 88,626,200 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl888,575,198 - 88,626,307 (-)Ensemblpanpan1.1panPan2
NBN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12935,416,093 - 35,477,569 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,416,093 - 35,477,563 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2935,567,773 - 35,628,935 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02935,612,774 - 35,674,851 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2935,612,774 - 35,692,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12935,604,159 - 35,665,432 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02935,624,597 - 35,685,889 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02936,059,084 - 36,120,657 (-)NCBIUU_Cfam_GSD_1.0
Nbn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530343,980,776 - 44,018,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365443,775,220 - 3,808,837 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365443,773,828 - 3,812,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NBN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl446,787,691 - 46,874,603 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1446,787,664 - 46,854,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2451,264,106 - 51,288,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NBN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1885,017,807 - 85,069,219 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl885,015,752 - 85,069,028 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603955,810,092 - 55,861,864 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nbn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247442,013,922 - 2,061,708 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247442,013,936 - 2,061,726 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nbn
1324 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:82
Interacting mature miRNAs:96
Transcripts:ENSMUST00000029879, ENSMUST00000149069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
11049579Lmr9b_mleishmaniasis resistance 9b (mouse)4120657234Mouse
11049580Lmr9a_mleishmaniasis resistance 9 (mouse)4120657234Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
1301274Lmr9_mleishmaniasis resistance 9 (mouse)Not determined4120657234Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
10412079Sm1_msusceptibility to Schistosoma mansoni infection 1 (mouse)Not determined4122955614Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse

Markers in Region
Nbn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37415,908,484 - 15,908,657UniSTSGRCm37
Celera415,784,635 - 15,784,808UniSTS
Cytogenetic Map4AUniSTS
cM Map4 UniSTS
RH126493  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38415,976,666 - 15,976,865UniSTSGRCm38
MGSCv37415,903,813 - 15,904,012UniSTSGRCm37
Celera415,779,964 - 15,780,163UniSTS
Cytogenetic Map4AUniSTS
Whitehead/MRC_RH4312.22UniSTS
Nbn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38415,981,337 - 15,981,510UniSTSGRCm38
MGSCv37415,908,484 - 15,908,657UniSTSGRCm37
Celera415,784,635 - 15,784,808UniSTS
Cytogenetic Map4AUniSTS
cM Map4 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030253594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB016988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF076687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF092840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL807737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000029879   ⟹   ENSMUSP00000029879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl415,957,925 - 15,992,589 (+)Ensembl
GRCm38.p6 Ensembl415,957,925 - 15,992,589 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149069   ⟹   ENSMUSP00000120829
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl415,957,967 - 15,981,554 (+)Ensembl
GRCm38.p6 Ensembl415,957,967 - 15,981,554 (+)Ensembl
RefSeq Acc Id: NM_013752   ⟹   NP_038780
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39415,957,967 - 15,992,589 (+)NCBI
GRCm38415,957,967 - 15,992,589 (+)NCBI
MGSCv37415,885,114 - 15,919,736 (+)RGD
Celera415,761,229 - 15,795,887 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006537970   ⟹   XP_006538033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39415,955,388 - 15,992,589 (+)NCBI
GRCm38415,957,587 - 15,992,589 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006537971   ⟹   XP_006538034
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39415,955,388 - 15,992,589 (+)NCBI
GRCm38415,957,587 - 15,992,589 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030253592   ⟹   XP_030109452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39415,955,388 - 15,991,164 (+)NCBI
GRCm38415,957,587 - 15,991,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030253593   ⟹   XP_030109453
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39415,955,388 - 15,991,166 (+)NCBI
GRCm38415,957,587 - 15,991,164 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030253594   ⟹   XP_030109454
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39415,955,388 - 15,991,166 (+)NCBI
GRCm38415,957,587 - 15,991,165 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164174   ⟹   XP_036020067
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39415,964,152 - 15,991,166 (+)NCBI
Sequence:
RefSeq Acc Id: NP_038780   ⟸   NM_013752
- UniProtKB: Q8CCY0 (UniProtKB/Swiss-Prot),   Q811I6 (UniProtKB/Swiss-Prot),   Q3UY57 (UniProtKB/Swiss-Prot),   O88981 (UniProtKB/Swiss-Prot),   Q9R1X1 (UniProtKB/Swiss-Prot),   Q9R207 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006538033   ⟸   XM_006537970
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006538034   ⟸   XM_006537971
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_030109454   ⟸   XM_030253594
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030109453   ⟸   XM_030253593
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030109452   ⟸   XM_030253592
- Peptide Label: isoform X1
Ensembl Acc Id: ENSMUSP00000029879   ⟸   ENSMUST00000029879
Ensembl Acc Id: ENSMUSP00000120829   ⟸   ENSMUST00000149069
RefSeq Acc Id: XP_036020067   ⟸   XM_036164174
- Peptide Label: isoform X2
Protein Domains
BRCT   FHA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R207-F1-model_v2 AlphaFold Q9R207 1-751 view protein structure

Promoters
RGD ID:6882878
Promoter ID:EPDNEW_M4890
Type:initiation region
Name:Nbn_1
Description:Mus musculus nibrin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38415,957,951 - 15,958,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351625 AgrOrtholog
Ensembl Genes ENSMUSG00000028224 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029879 ENTREZGENE
  ENSMUST00000029879.15 UniProtKB/Swiss-Prot
  ENSMUST00000149069.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10980 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRCT_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-repair_Nbs1_C UniProtKB/Swiss-Prot
  FHA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nibrin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nibrin_BRCT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nibrin_BRCT2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nibrin_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:27354 UniProtKB/Swiss-Prot
MGD MGI:1351625 ENTREZGENE
NCBI Gene 27354 ENTREZGENE
PANTHER NIBRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12162 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nbs1_C UniProtKB/Swiss-Prot
  NIBRIN_BRCT_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nbn PhenoGen
PIRSF Nibrin_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FHA_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nbs1_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AMG5_MOUSE UniProtKB/TrEMBL
  NBN_MOUSE UniProtKB/Swiss-Prot
  O88981 ENTREZGENE
  Q3UY57 ENTREZGENE
  Q811I6 ENTREZGENE
  Q8CCY0 ENTREZGENE
  Q9R1X1 ENTREZGENE
  Q9R207 ENTREZGENE
UniProt Secondary O88981 UniProtKB/Swiss-Prot
  Q3UY57 UniProtKB/Swiss-Prot
  Q811I6 UniProtKB/Swiss-Prot
  Q8CCY0 UniProtKB/Swiss-Prot
  Q9R1X1 UniProtKB/Swiss-Prot