Nlgn2 (neuroligin 2) - Rat Genome Database

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Gene: Nlgn2 (neuroligin 2) Mus musculus
Analyze
Symbol: Nlgn2
Name: neuroligin 2
RGD ID: 732706
MGI Page MGI
Description: Enables cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of signal transduction; and synapse organization. Acts upstream of or within several processes, including protein localization to cell surface; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in synapse. Is active in several cellular components, including dopaminergic synapse; glycinergic synapse; and postsynaptic specialization membrane. Is expressed in brain; brainstem; cerebral cortex; and hippocampus. Used to study schizophrenia. Orthologous to human NLGN2 (neuroligin 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC67386; N; neuroligin-2; NL; NL2; NLG2; ortholog of human and rat neuroligin 2 NLGN2; RP23-422L16.24
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,713,949 - 69,728,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,713,948 - 69,728,610 (-)EnsemblGRCm39 Ensembl
GRCm381169,823,123 - 69,837,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,823,122 - 69,837,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,636,625 - 69,648,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,639,318 - 69,651,044 (-)NCBIMGSCv36mm8
Celera1177,384,083 - 77,395,807 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
gephyrin clustering involved in postsynaptic density assembly  (IDA,IGI,IMP)
inhibitory synapse assembly  (IDA)
insulin metabolic process  (IEA,ISO)
jump response  (ISO,ISS)
locomotory exploration behavior  (IMP)
modulation of chemical synaptic transmission  (IGI)
neuromuscular process controlling balance  (IMP)
neuron cell-cell adhesion  (ISO,ISS)
neurotransmitter-gated ion channel clustering  (IDA,IGI,IMP)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of dendritic spine development  (IEA,ISO)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of inhibitory postsynaptic potential  (IMP,ISO)
positive regulation of insulin secretion  (IEA,ISO)
positive regulation of protein localization to synapse  (ISO)
positive regulation of synapse assembly  (ISO,ISS)
positive regulation of synaptic transmission, GABAergic  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of synaptic vesicle clustering  (IDA)
positive regulation of t-SNARE clustering  (IEA,ISO)
postsynaptic density protein 95 clustering  (IDA)
postsynaptic membrane assembly  (IDA)
postsynaptic specialization assembly  (IDA,IMP)
presynapse assembly  (IDA)
presynaptic membrane assembly  (IDA,IMP,ISO)
protein localization to cell surface  (IDA,IMP)
protein localization to synapse  (IDA)
regulation of AMPA receptor activity  (IMP)
regulation of presynapse assembly  (IEA,ISO)
regulation of respiratory gaseous exchange by nervous system process  (IGI)
sensory perception of pain  (IMP)
social behavior  (ISO,ISS)
synapse assembly  (ISO,ISS)
synapse organization  (ISO,ISS)
synaptic transmission, GABAergic  (IDA,IGI,IMP)
terminal button organization  (ISO,ISS)
thigmotaxis  (ISO,ISS)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Unexpected association of the "inhibitory" neuroligin 2 with excitatory PSD95 in neuropathic pain. Dolique T, etal., Pain. 2013 Nov;154(11):2529-46. doi: 10.1016/j.pain.2013.07.035. Epub 2013 Jul 25.
2. Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult. Jackson J, etal., PLoS One. 2012;7(4):e35557. doi: 10.1371/journal.pone.0035557. Epub 2012 Apr 23.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function. Suckow AT, etal., J Biol Chem. 2012 Jun 8;287(24):19816-26. doi: 10.1074/jbc.M111.280537. Epub 2012 Apr 23.
9. Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy. Zelano J, etal., J Comp Neurol. 2007 Jul 10;503(2):308-18.
Additional References at PubMed
PMID:8889548   PMID:9647694   PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15368895   PMID:15540461  
PMID:15620359   PMID:15681343   PMID:16141072   PMID:16141073   PMID:16186258   PMID:16602821   PMID:16701208   PMID:16982420   PMID:17114649   PMID:17582332   PMID:17897391   PMID:18227507  
PMID:18250328   PMID:18550748   PMID:18723687   PMID:18799693   PMID:18854036   PMID:19016888   PMID:19553444   PMID:19755106   PMID:19816407   PMID:19859968   PMID:19889999   PMID:20471353  
PMID:20530218   PMID:21282647   PMID:21424692   PMID:21864334   PMID:21873635   PMID:22671294   PMID:22764252   PMID:22768092   PMID:22820233   PMID:22915109   PMID:22960622   PMID:23172145  
PMID:23226954   PMID:23358245   PMID:23493706   PMID:23663753   PMID:23751499   PMID:23776533   PMID:24039767   PMID:24613359   PMID:25020278   PMID:25042347   PMID:25082542   PMID:25190809  
PMID:25297980   PMID:25765754   PMID:25824299   PMID:26142252   PMID:26291161   PMID:26403076   PMID:26793096   PMID:26882036   PMID:27035941   PMID:27217145   PMID:27473321   PMID:27507650  
PMID:27581450   PMID:27912058   PMID:28607166   PMID:28643105   PMID:28671696   PMID:28864826   PMID:28939043   PMID:29100073   PMID:29107521   PMID:29111324   PMID:29120426   PMID:29278843  
PMID:29339486   PMID:29709479   PMID:29724786   PMID:29742426   PMID:29859117   PMID:30056576   PMID:30231918   PMID:30573727   PMID:30605713   PMID:30871858   PMID:30878196   PMID:30998708  
PMID:31910261   PMID:31953212   PMID:32027825   PMID:32325033   PMID:32581705   PMID:32719346   PMID:32973045   PMID:33471287   PMID:33960026   PMID:34616037   PMID:34848499   PMID:34919427  
PMID:36604605   PMID:36709408   PMID:37865312   PMID:38570872   PMID:38657049   PMID:39307290  


Genomics

Comparative Map Data
Nlgn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,713,949 - 69,728,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,713,948 - 69,728,610 (-)EnsemblGRCm39 Ensembl
GRCm381169,823,123 - 69,837,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,823,122 - 69,837,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,636,625 - 69,648,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,639,318 - 69,651,044 (-)NCBIMGSCv36mm8
Celera1177,384,083 - 77,395,807 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.89NCBI
NLGN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,404,653 - 7,419,860 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,404,874 - 7,419,860 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,311,164 - 7,323,179 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,252,226 - 7,263,903 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,252,225 - 7,263,903NCBI
Celera177,337,380 - 7,349,064 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,205,598 - 7,217,206 (+)NCBIHuRef
CHM1_1177,320,590 - 7,332,275 (+)NCBICHM1_1
T2T-CHM13v2.0177,308,683 - 7,323,908 (+)NCBIT2T-CHM13v2.0
Nlgn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,042,175 - 55,056,578 (-)NCBIGRCr8
mRatBN7.21054,544,461 - 54,557,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,544,588 - 54,558,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,206,968 - 59,220,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,695,535 - 58,708,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,203,207 - 54,216,624 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,431,586 - 56,444,847 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,431,573 - 56,444,847 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,176,705 - 56,189,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,646,081 - 56,678,060 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,659,705 - 56,691,680 (-)NCBI
Celera1053,698,870 - 53,712,041 (-)NCBICelera
Cytogenetic Map10q24NCBI
Nlgn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,504,974 - 9,520,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,504,974 - 9,520,059 (-)NCBIChiLan1.0ChiLan1.0
NLGN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,001,795 - 15,016,817 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,967,475 - 16,982,617 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,438,853 - 7,454,014 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,425,927 - 7,438,504 (+)NCBIpanpan1.1PanPan1.1panPan2
NLGN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,338,602 - 32,351,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,340,335 - 32,352,412 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,476,574 - 32,491,676 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,444,141 - 32,459,248 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,446,860 - 32,457,104 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,409,378 - 32,424,482 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,368,131 - 32,383,214 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,545,377 - 32,560,482 (+)NCBIUU_Cfam_GSD_1.0
Nlgn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,218,152 - 47,230,462 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595692,334 - 704,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595692,340 - 704,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLGN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,781,510 - 6,796,304 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,784,642 - 6,794,419 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,612,269 - 14,627,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nlgn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,022,717 - 10,034,624 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,019,307 - 10,034,624 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nlgn2
511 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2810
Count of miRNA genes:633
Interacting mature miRNAs:835
Transcripts:ENSMUST00000056484, ENSMUST00000108634, ENSMUST00000139893, ENSMUST00000140477
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000056484   ⟹   ENSMUSP00000053097
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,713,948 - 69,725,675 (-)Ensembl
GRCm38.p6 Ensembl1169,823,122 - 69,834,849 (-)Ensembl
Ensembl Acc Id: ENSMUST00000108634   ⟹   ENSMUSP00000104274
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,713,948 - 69,728,610 (-)Ensembl
GRCm38.p6 Ensembl1169,823,122 - 69,837,784 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139893   ⟹   ENSMUSP00000120428
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,718,565 - 69,725,085 (-)Ensembl
GRCm38.p6 Ensembl1169,827,739 - 69,834,259 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140477
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1169,718,870 - 69,719,385 (-)Ensembl
GRCm38.p6 Ensembl1169,828,044 - 69,828,559 (-)Ensembl
RefSeq Acc Id: NM_001364137   ⟹   NP_001351066
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,713,949 - 69,728,610 (-)NCBI
GRCm381169,823,123 - 69,837,784 (-)NCBI
Sequence:
RefSeq Acc Id: NM_198862   ⟹   NP_942562
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,713,949 - 69,725,675 (-)NCBI
GRCm381169,823,123 - 69,834,849 (-)NCBI
MGSCv371169,636,625 - 69,648,351 (-)RGD
Celera1177,384,083 - 77,395,807 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532902   ⟹   XP_006532965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,713,949 - 69,728,119 (-)NCBI
GRCm381169,823,123 - 69,837,134 (-)NCBI
Sequence:
RefSeq Acc Id: NP_942562   ⟸   NM_198862
- Peptide Label: precursor
- UniProtKB: Q5F288 (UniProtKB/Swiss-Prot),   Q69ZK9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532965   ⟸   XM_006532902
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001351066   ⟸   NM_001364137
- Peptide Label: precursor
- UniProtKB: Q69ZK9 (UniProtKB/Swiss-Prot),   Q5F288 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000120428   ⟸   ENSMUST00000139893
Ensembl Acc Id: ENSMUSP00000053097   ⟸   ENSMUST00000056484
Ensembl Acc Id: ENSMUSP00000104274   ⟸   ENSMUST00000108634
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q69ZK9-F1-model_v2 AlphaFold Q69ZK9 1-836 view protein structure

Promoters
RGD ID:6821430
Promoter ID:MM_KWN:8125
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000077461
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,642,761 - 69,643,261 (-)MPROMDB
RGD ID:6821431
Promoter ID:MM_KWN:8126
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:ENSMUST00000056484,   ENSMUST00000094069,   OTTMUST00000077460
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,647,261 - 69,647,761 (-)MPROMDB
RGD ID:6821434
Promoter ID:MM_KWN:8127
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung,   MEF_B4
Transcripts:ENSMUST00000108634
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,650,926 - 69,652,012 (-)MPROMDB
RGD ID:8675228
Promoter ID:EPDNEW_M15645
Type:initiation region
Name:Nlgn2_1
Description:Mus musculus neuroligin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,837,743 - 69,837,803EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2681835 AgrOrtholog
Ensembl Genes ENSMUSG00000051790 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056484 ENTREZGENE
  ENSMUST00000056484.10 UniProtKB/Swiss-Prot
  ENSMUST00000108634 ENTREZGENE
  ENSMUST00000108634.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  CarbesteraseB UniProtKB/Swiss-Prot
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot
  Neuroligin/BSAL UniProtKB/Swiss-Prot
  Nlgn UniProtKB/Swiss-Prot
KEGG Report mmu:216856 UniProtKB/Swiss-Prot
MGD MGI:2681835 ENTREZGENE
NCBI Gene 216856 ENTREZGENE
PANTHER NEUROLIGIN UniProtKB/Swiss-Prot
Pfam COesterase UniProtKB/Swiss-Prot
PhenoGen Nlgn2 PhenoGen
PRINTS NEUROLIGIN UniProtKB/Swiss-Prot
PROSITE CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt F6VE93_MOUSE UniProtKB/TrEMBL
  NLGN2_MOUSE UniProtKB/Swiss-Prot
  Q3UVR7_MOUSE UniProtKB/TrEMBL
  Q5F288 ENTREZGENE
  Q69ZK9 ENTREZGENE
  Q6PHN2_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q5F288 UniProtKB/Swiss-Prot