Clcn4 (chloride channel, voltage-sensitive 4) - Rat Genome Database

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Gene: Clcn4 (chloride channel, voltage-sensitive 4) Mus musculus
Analyze
Symbol: Clcn4
Name: chloride channel, voltage-sensitive 4
RGD ID: 732620
MGI Page MGI
Description: Predicted to enable antiporter activity and voltage-gated chloride channel activity. Involved in non-motile cilium assembly. Is active in ciliary base. Is expressed in cortical plate; early conceptus; heart; heart ventricle; and oocyte. Human ortholog(s) of this gene implicated in Raynaud-Claes syndrome. Orthologous to human CLCN4 (chloride voltage-gated channel 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chloride channel 4-2; chloride channel protein 4; chloride transporter ClC-4; clC-4; Clc4-; Clc4-2; Clcn4-2; H(+)/Cl(-) exchange transporter 4; MGC117899; voltage-gated chloride channel ClC-4A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3977,285,308 - 7,303,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl77,285,308 - 7,303,850 (-)EnsemblGRCm39 Ensembl
GRCm3877,282,309 - 7,300,916 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl77,282,309 - 7,300,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv3777,235,027 - 7,252,222 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3676,887,494 - 6,902,833 (-)NCBIMGSCv36mm8
MGSCv3676,634,944 - 6,651,482 (-)NCBIMGSCv36mm8
Cytogenetic Map7A1NCBI
cM Map74.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (EXP)
dexamethasone  (ISO)
diquat  (EXP)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
ethylbenzene  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fonofos  (ISO)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
L-ethionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
omeprazole  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7670496   PMID:7670497   PMID:8889548   PMID:9144225   PMID:9256467   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12819125   PMID:15033168   PMID:15782199  
PMID:16129671   PMID:16141072   PMID:16141073   PMID:16985003   PMID:18799693   PMID:19339555   PMID:20351103   PMID:21267068   PMID:21282478   PMID:21677750   PMID:21873635   PMID:23115349  
PMID:25798587   PMID:26546361   PMID:32118314   PMID:32325033   PMID:34321999  


Genomics

Comparative Map Data
Clcn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3977,285,308 - 7,303,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl77,285,308 - 7,303,850 (-)EnsemblGRCm39 Ensembl
GRCm3877,282,309 - 7,300,916 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl77,282,309 - 7,300,851 (-)EnsemblGRCm38mm10GRCm38
MGSCv3777,235,027 - 7,252,222 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3676,887,494 - 6,902,833 (-)NCBIMGSCv36mm8
MGSCv3676,634,944 - 6,651,482 (-)NCBIMGSCv36mm8
Cytogenetic Map7A1NCBI
cM Map74.23NCBI
CLCN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X10,156,975 - 10,237,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX10,156,975 - 10,237,660 (+)EnsemblGRCh38hg38GRCh38
GRCh37X10,125,015 - 10,205,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X10,084,985 - 10,165,700 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X9,934,772 - 10,013,256NCBI
CeleraX14,296,240 - 14,376,955 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX7,954,825 - 8,038,622 (+)NCBIHuRef
CHM1_1X10,155,417 - 10,236,107 (+)NCBICHM1_1
T2T-CHM13v2.0X9,739,532 - 9,820,250 (+)NCBIT2T-CHM13v2.0
Clcn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X27,290,769 - 27,356,967 (+)NCBIGRCr8
mRatBN7.2X23,729,194 - 23,795,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX23,729,338 - 23,793,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX24,703,884 - 24,767,782 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X28,124,882 - 28,188,779 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X24,377,222 - 24,441,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X25,016,177 - 25,082,563 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX25,016,401 - 25,080,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X25,427,399 - 25,493,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X44,355,648 - 44,419,524 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X44,436,114 - 44,471,196 (+)NCBI
CeleraX24,157,917 - 24,221,792 (+)NCBICelera
Cytogenetic MapXq13NCBI
Clcn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555442,922,338 - 3,000,112 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555442,922,338 - 2,999,979 (-)NCBIChiLan1.0ChiLan1.0
CLCN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X11,958,252 - 12,039,812 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X11,962,836 - 12,043,479 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X2,787,185 - 2,867,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X10,040,067 - 10,120,991 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX10,040,067 - 10,120,991 (+)Ensemblpanpan1.1panPan2
CLCN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X6,853,184 - 6,921,478 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX6,854,728 - 6,917,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX6,809,155 - 6,878,437 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X6,799,857 - 6,868,917 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX6,799,854 - 6,868,914 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X6,790,241 - 6,854,866 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X6,825,444 - 6,894,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X6,815,874 - 6,884,896 (+)NCBIUU_Cfam_GSD_1.0
Clcn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X142,869 - 215,738 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936470142,832 - 212,154 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936470142,862 - 214,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX6,939,387 - 7,019,738 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X6,939,637 - 7,019,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X7,339,448 - 7,419,589 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X8,611,443 - 8,692,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX8,611,485 - 8,693,192 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605610,305,321 - 10,386,398 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clcn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248824,080,525 - 4,148,628 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248824,080,525 - 4,148,749 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clcn4
647 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:473
Count of miRNA genes:374
Interacting mature miRNAs:399
Transcripts:ENSMUST00000000619
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25394569Skmw57_mskeletal muscle weight 57, gastroc (mouse)7458046916687861Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse

Markers in Region
STS-AA018252  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3877,295,027 - 7,295,153UniSTSGRCm38
MGSCv3777,247,738 - 7,247,864UniSTSGRCm37
Cytogenetic Map7A1UniSTS
cM Map74.0UniSTS
Clcn4-1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3877,283,750 - 7,284,177UniSTSGRCm38
MGSCv3777,236,461 - 7,236,888UniSTSGRCm37
Cytogenetic Map7A1UniSTS
Cytogenetic MapXF3-F4UniSTS
cM MapX74.0UniSTS
cM Map74.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001302386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_126157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_178086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_178087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030242051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_391040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC149056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ176890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU610450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY035169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY790669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ186662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z49916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000000619   ⟹   ENSMUSP00000000619
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,285,308 - 7,302,532 (-)Ensembl
GRCm38.p6 Ensembl77,282,309 - 7,299,533 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209916   ⟹   ENSMUSP00000147449
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,298,063 - 7,301,770 (-)Ensembl
GRCm38.p6 Ensembl77,295,064 - 7,298,771 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210061   ⟹   ENSMUSP00000148174
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,287,054 - 7,301,805 (-)Ensembl
GRCm38.p6 Ensembl77,284,055 - 7,298,806 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210362   ⟹   ENSMUSP00000147627
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,297,018 - 7,299,843 (-)Ensembl
GRCm38.p6 Ensembl77,294,019 - 7,296,844 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210444
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,287,061 - 7,301,768 (-)Ensembl
GRCm38.p6 Ensembl77,284,062 - 7,298,769 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210594   ⟹   ENSMUSP00000147562
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,287,101 - 7,302,261 (-)Ensembl
GRCm38.p6 Ensembl77,284,102 - 7,299,262 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210809
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,301,000 - 7,303,850 (-)Ensembl
GRCm38.p6 Ensembl77,298,001 - 7,300,851 (-)Ensembl
RefSeq Acc Id: ENSMUST00000210989
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,301,000 - 7,302,556 (-)Ensembl
GRCm38.p6 Ensembl77,298,001 - 7,299,557 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211551
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,297,542 - 7,301,745 (-)Ensembl
GRCm38.p6 Ensembl77,294,543 - 7,298,746 (-)Ensembl
RefSeq Acc Id: ENSMUST00000211574   ⟹   ENSMUSP00000148061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl77,294,314 - 7,301,797 (-)Ensembl
GRCm38.p6 Ensembl77,291,315 - 7,298,798 (-)Ensembl
RefSeq Acc Id: NM_001302386   ⟹   NP_001289315
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
GRCm3877,282,309 - 7,298,836 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302387   ⟹   NP_001289316
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
GRCm3877,282,309 - 7,299,557 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001357102   ⟹   NP_001344031
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
GRCm3877,282,309 - 7,299,557 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001357103   ⟹   NP_001344032
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
GRCm3877,282,309 - 7,299,557 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001357104   ⟹   NP_001344033
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
GRCm3877,282,309 - 7,299,557 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001412259   ⟹   NP_001399188
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,303,837 (-)NCBI
RefSeq Acc Id: NM_001412260   ⟹   NP_001399189
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,303,837 (-)NCBI
RefSeq Acc Id: NM_001412261   ⟹   NP_001399190
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
RefSeq Acc Id: NM_001412262   ⟹   NP_001399191
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
RefSeq Acc Id: NM_001412263   ⟹   NP_001399192
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,303,837 (-)NCBI
RefSeq Acc Id: NM_001412264   ⟹   NP_001399193
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
RefSeq Acc Id: NM_001412265   ⟹   NP_001399194
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,303,837 (-)NCBI
RefSeq Acc Id: NM_001412266   ⟹   NP_001399195
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
RefSeq Acc Id: NM_011334   ⟹   NP_035464
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
GRCm3877,282,309 - 7,299,557 (-)NCBI
MGSCv3777,235,027 - 7,252,222 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_126156
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,300,995 - 7,302,476 (-)NCBI
GRCm3877,298,001 - 7,299,557 (-)NCBI
Sequence:
RefSeq Acc Id: NR_126157
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,300,995 - 7,303,837 (-)NCBI
GRCm3877,298,001 - 7,300,851 (-)NCBI
Sequence:
RefSeq Acc Id: NR_178086
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,476 (-)NCBI
RefSeq Acc Id: NR_178087
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,303,837 (-)NCBI
RefSeq Acc Id: XM_030242049   ⟹   XP_030097909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,816 (-)NCBI
GRCm3877,282,309 - 7,299,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030242051   ⟹   XP_030097911
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,816 (-)NCBI
GRCm3877,282,309 - 7,299,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152617   ⟹   XP_036008510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,303,759 (-)NCBI
Sequence:
RefSeq Acc Id: XR_391040
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3977,285,308 - 7,302,816 (-)NCBI
GRCm3877,282,309 - 7,299,971 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001289315 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289316 (Get FASTA)   NCBI Sequence Viewer  
  NP_001344031 (Get FASTA)   NCBI Sequence Viewer  
  NP_001344032 (Get FASTA)   NCBI Sequence Viewer  
  NP_001344033 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399188 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399189 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399190 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399191 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399192 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399193 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399194 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399195 (Get FASTA)   NCBI Sequence Viewer  
  NP_035464 (Get FASTA)   NCBI Sequence Viewer  
  XP_030097909 (Get FASTA)   NCBI Sequence Viewer  
  XP_030097911 (Get FASTA)   NCBI Sequence Viewer  
  XP_036008510 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI10669 (Get FASTA)   NCBI Sequence Viewer  
  ABA28317 (Get FASTA)   NCBI Sequence Viewer  
  BAC29192 (Get FASTA)   NCBI Sequence Viewer  
  BAC34428 (Get FASTA)   NCBI Sequence Viewer  
  CAA90150 (Get FASTA)   NCBI Sequence Viewer  
  EDL01087 (Get FASTA)   NCBI Sequence Viewer  
  EDL01088 (Get FASTA)   NCBI Sequence Viewer  
  EDL01089 (Get FASTA)   NCBI Sequence Viewer  
  EDL01090 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000000619
  ENSMUSP00000000619.7
  ENSMUSP00000147449.2
  ENSMUSP00000147562
  ENSMUSP00000147562.2
  ENSMUSP00000147627.2
  ENSMUSP00000148061.2
  ENSMUSP00000148174
  ENSMUSP00000148174.2
GenBank Protein Q61418 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035464   ⟸   NM_011334
- Peptide Label: isoform 1
- UniProtKB: Q2TAX6 (UniProtKB/Swiss-Prot),   Q61418 (UniProtKB/Swiss-Prot),   Q8CBL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289315   ⟸   NM_001302386
- Peptide Label: isoform 2 precursor
- UniProtKB: Q3LRV6 (UniProtKB/TrEMBL),   Q8CBL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289316   ⟸   NM_001302387
- Peptide Label: isoform 3
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL),   A0A1B0GT29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030097911   ⟸   XM_030242051
- Peptide Label: isoform X3
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL),   A0A1B0GT29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030097909   ⟸   XM_030242049
- Peptide Label: isoform X2
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344032   ⟸   NM_001357103
- Peptide Label: isoform 1
- UniProtKB: Q61418 (UniProtKB/Swiss-Prot),   Q2TAX6 (UniProtKB/Swiss-Prot),   Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344033   ⟸   NM_001357104
- Peptide Label: isoform 4
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001344031   ⟸   NM_001357102
- Peptide Label: isoform 1
- UniProtKB: Q61418 (UniProtKB/Swiss-Prot),   Q2TAX6 (UniProtKB/Swiss-Prot),   Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000000619   ⟸   ENSMUST00000000619
RefSeq Acc Id: ENSMUSP00000148061   ⟸   ENSMUST00000211574
RefSeq Acc Id: ENSMUSP00000147627   ⟸   ENSMUST00000210362
RefSeq Acc Id: ENSMUSP00000147562   ⟸   ENSMUST00000210594
RefSeq Acc Id: ENSMUSP00000148174   ⟸   ENSMUST00000210061
RefSeq Acc Id: ENSMUSP00000147449   ⟸   ENSMUST00000209916
RefSeq Acc Id: XP_036008510   ⟸   XM_036152617
- Peptide Label: isoform X1
- UniProtKB: Q61418 (UniProtKB/Swiss-Prot),   Q2TAX6 (UniProtKB/Swiss-Prot),   Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399194   ⟸   NM_001412265
- Peptide Label: isoform 4
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399189   ⟸   NM_001412260
- Peptide Label: isoform 1
- UniProtKB: Q61418 (UniProtKB/Swiss-Prot),   Q2TAX6 (UniProtKB/Swiss-Prot),   Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399192   ⟸   NM_001412263
- Peptide Label: isoform 3
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL),   A0A1B0GT29 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399188   ⟸   NM_001412259
- Peptide Label: isoform 1
- UniProtKB: Q61418 (UniProtKB/Swiss-Prot),   Q2TAX6 (UniProtKB/Swiss-Prot),   Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399193   ⟸   NM_001412264
- Peptide Label: isoform 4
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399191   ⟸   NM_001412262
- Peptide Label: isoform 5
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399190   ⟸   NM_001412261
- Peptide Label: isoform 1
- UniProtKB: Q61418 (UniProtKB/Swiss-Prot),   Q2TAX6 (UniProtKB/Swiss-Prot),   Q8CBL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399195   ⟸   NM_001412266
- Peptide Label: isoform 6 precursor
- UniProtKB: Q8CBL5 (UniProtKB/TrEMBL)
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61418-F1-model_v2 AlphaFold Q61418 1-747 view protein structure

Promoters
RGD ID:6848107
Promoter ID:MM_ACW:43418
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:CLCN4-2.GSEP07,   CLCN4-2.JSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3677,250,346 - 7,250,846 (-)MPROMDB
RGD ID:6840842
Promoter ID:MM_KWN:48610
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000007436,   NM_011334,   UC009FCP.1,   UC009FCQ.1,   UC009FCS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3677,251,411 - 7,253,047 (-)MPROMDB
RGD ID:6891804
Promoter ID:EPDNEW_M9353
Type:multiple initiation site
Name:Clcn4_2
Description:Mus musculus chloride channel, voltage-sensitive 4 , transcriptvariant 5, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9354  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3877,298,393 - 7,298,453EPDNEW
RGD ID:6891806
Promoter ID:EPDNEW_M9354
Type:multiple initiation site
Name:Clcn4_1
Description:Mus musculus chloride channel, voltage-sensitive 4 , transcriptvariant 5, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M9353  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3877,298,781 - 7,298,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104571 AgrOrtholog
Ensembl Genes ENSMUSG00000000605 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000619 ENTREZGENE
  ENSMUST00000000619.8 UniProtKB/Swiss-Prot
  ENSMUST00000209916.2 UniProtKB/TrEMBL
  ENSMUST00000210061 ENTREZGENE
  ENSMUST00000210061.2 UniProtKB/TrEMBL
  ENSMUST00000210362.2 UniProtKB/TrEMBL
  ENSMUST00000210594 ENTREZGENE
  ENSMUST00000210594.2 UniProtKB/TrEMBL
  ENSMUST00000210809 ENTREZGENE
  ENSMUST00000210989 ENTREZGENE
  ENSMUST00000211574.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.580.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1280.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12727 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104571 ENTREZGENE
NCBI Gene 12727 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45711:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clcn4 PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLCHANNEL4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GRB0_MOUSE UniProtKB/TrEMBL
  A0A1B0GRR0_MOUSE UniProtKB/TrEMBL
  A0A1B0GST3_MOUSE UniProtKB/TrEMBL
  A0A1B0GT29 ENTREZGENE, UniProtKB/TrEMBL
  CLCN4_MOUSE UniProtKB/Swiss-Prot
  Q2TAX6 ENTREZGENE
  Q3LRV6 ENTREZGENE, UniProtKB/TrEMBL
  Q61418 ENTREZGENE
  Q8BQG0_MOUSE UniProtKB/TrEMBL
  Q8CBL5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q2TAX6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-20 Clcn4  chloride channel, voltage-sensitive 4  Clcn4-2  chloride channel 4-2  Symbol and/or name change 5135510 APPROVED