Adcy3 (adenylate cyclase 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Adcy3 (adenylate cyclase 3) Mus musculus
Analyze
Symbol: Adcy3
Name: adenylate cyclase 3
RGD ID: 732500
MGI Page MGI
Description: Enables adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and olfactory learning. Acts upstream of or within sensory perception of smell. Located in ciliary membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study major depressive disorder. Orthologous to human ADCY3 (adenylate cyclase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A; AC; AC-III; AC3; ACIII; adenylate cyclase type 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3; ATP pyrophosphate-lyase 3; mKIAA0511
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,183,397 - 4,263,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,183,103 - 4,263,525 (+)EnsemblGRCm39 Ensembl
GRCm38124,133,116 - 4,213,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,133,103 - 4,213,525 (+)EnsemblGRCm38mm10GRCm38
MGSCv37124,133,397 - 4,213,524 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36124,134,076 - 4,214,096 (+)NCBIMGSCv36mm8
Celera124,061,963 - 4,140,655 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
disulfiram  (ISO)
divanadium pentaoxide  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
Licarin A  (EXP)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (ISO)
Octicizer  (EXP)
ozone  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
rotenone  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
thiram  (ISO)
toluene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
undecane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal circadian sleep/wake cycle  (IAGP)
abnormal CNS synaptic transmission  (IAGP)
abnormal dendrite arborization pattern  (IAGP)
abnormal depression-related behavior  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal hippocampus CA1 region morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal long-term spatial reference memory  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal non-rapid eye movement sleep pattern  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal olfaction  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal olfactory nerve morphology  (IAGP)
abnormal olfactory neuron innervation pattern  (IAGP)
abnormal olfactory system physiology  (IAGP)
abnormal response to new environment  (IAGP)
abnormal social investigation  (IAGP)
anosmia  (IAGP)
asthenozoospermia  (IAGP)
behavioral despair  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased brown fat cell size  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating renin level  (IAGP)
decreased dentate gyrus size  (IAGP)
decreased grooming behavior  (IAGP)
decreased hippocampus volume  (IAGP)
decreased lean body mass  (IEA)
decreased litter size  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased renal glomerular filtration rate  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased total body fat amount  (IAGP)
decreased urine osmolality  (IAGP)
decreased urine potassium level  (IAGP)
decreased urine sodium level  (IAGP)
decreased white fat cell size  (IAGP)
hyperactivity  (IAGP)
hypoactivity  (IAGP)
impaired fertilization  (IAGP)
impaired olfaction  (IAGP)
impaired spatial learning  (IAGP)
impaired sperm capacitation  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating creatinine level  (IAGP)
increased frequency of paradoxical sleep  (IAGP)
increased hematocrit  (IEA)
increased hemoglobin content  (IEA)
increased oxygen consumption  (IAGP)
increased total body fat amount  (IEA)
no abnormal phenotype detected  (IEA)
obese  (IAGP)
polyphagia  (IAGP)
polyuria  (IAGP)
postnatal lethality, complete penetrance  (IEA)
postnatal lethality, incomplete penetrance  (IAGP)
premature acrosome reaction  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
reduced female fertility  (IAGP)
reduced long-term potentiation  (IAGP)
reduced male fertility  (IAGP)
small hippocampus  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Bakalyar HA and Reed RR, Science 1990 Dec 7;250(4986):1403-6.
2. An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. Ceolotto G, etal., Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
3. Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Horner K, etal., Dev Biol 2003 Jun 15;258(2):385-96.
4. Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats. Liao J, etal., Mol Med Rep. 2014 Sep;10(3):1225-30. doi: 10.3892/mmr.2014.2352. Epub 2014 Jun 25.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
15. Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis. Seed Ahmed M, etal., Islets. 2012 Sep-Oct;4(5):343-8. doi: 10.4161/isl.22283. Epub 2012 Sep 1.
16. α-Cedrene protects rodents from high-fat diet-induced adiposity via adenylyl cyclase 3. Tong T, etal., Int J Obes (Lond). 2019 Jan;43(1):202-216. doi: 10.1038/s41366-018-0176-0. Epub 2018 Dec 19.
Additional References at PubMed
PMID:7766992   PMID:8889548   PMID:11055432   PMID:11544199   PMID:12122055   PMID:12477932   PMID:12613887   PMID:12665798   PMID:14610273   PMID:14681479   PMID:15065125   PMID:15261832  
PMID:15611992   PMID:15705663   PMID:15782199   PMID:16193510   PMID:16291925   PMID:16615126   PMID:16837584   PMID:17123745   PMID:17215378   PMID:17229090   PMID:17350283   PMID:17462990  
PMID:17521568   PMID:17537788   PMID:17567809   PMID:17581954   PMID:17804638   PMID:18728187   PMID:19098904   PMID:19174512   PMID:19279158   PMID:19750222   PMID:20056751   PMID:20110327  
PMID:20573694   PMID:20692344   PMID:20723208   PMID:20940229   PMID:21067603   PMID:21147989   PMID:21150908   PMID:21267068   PMID:21490195   PMID:21525298   PMID:21677750   PMID:21767396  
PMID:21873635   PMID:22020803   PMID:22179047   PMID:22442076   PMID:22952279   PMID:22985540   PMID:23077041   PMID:23136416   PMID:23240083   PMID:23300826   PMID:23332756   PMID:23392690  
PMID:23447624   PMID:23817016   PMID:23870122   PMID:23894536   PMID:23926254   PMID:24034253   PMID:24120133   PMID:24384391   PMID:24431204   PMID:24797473   PMID:24797530   PMID:25114218  
PMID:25131634   PMID:25133425   PMID:25329148   PMID:25352170   PMID:25417106   PMID:25437545   PMID:25501893   PMID:25550517   PMID:25747587   PMID:25807252   PMID:26023097   PMID:26067252  
PMID:26071364   PMID:26365258   PMID:26446231   PMID:26633363   PMID:26868444   PMID:26942602   PMID:27578798   PMID:27678003   PMID:27864010   PMID:28053034   PMID:28122017   PMID:28154160  
PMID:28154525   PMID:28167615   PMID:29078327   PMID:30133325   PMID:30366013   PMID:30668728   PMID:30692915   PMID:30799240   PMID:30814930   PMID:31758234   PMID:32023491   PMID:32098917  
PMID:32458389   PMID:32677323   PMID:32702291   PMID:32735823   PMID:32986815   PMID:33188191   PMID:33470495   PMID:33643860   PMID:33938449   PMID:34321999   PMID:34411897   PMID:34783461  
PMID:34914639   PMID:34953349   PMID:35025664   PMID:35470378   PMID:35549308   PMID:35653384   PMID:35754726   PMID:38187761   PMID:38355793   PMID:38684889   PMID:38719753   PMID:39050703  


Genomics

Comparative Map Data
Adcy3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,183,397 - 4,263,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,183,103 - 4,263,525 (+)EnsemblGRCm39 Ensembl
GRCm38124,133,116 - 4,213,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,133,103 - 4,213,525 (+)EnsemblGRCm38mm10GRCm38
MGSCv37124,133,397 - 4,213,524 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36124,134,076 - 4,214,096 (+)NCBIMGSCv36mm8
Celera124,061,963 - 4,140,655 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
ADCY3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,819,169 - 24,920,237 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,819,169 - 24,920,237 (-)EnsemblGRCh38hg38GRCh38
GRCh37225,042,038 - 25,143,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,895,542 - 24,995,559 (-)NCBINCBI36Build 36hg18NCBI36
Build 34224,953,691 - 25,053,654NCBI
Celera224,882,356 - 24,982,363 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,779,864 - 24,880,170 (-)NCBIHuRef
CHM1_1224,971,569 - 25,071,569 (-)NCBICHM1_1
T2T-CHM13v2.0224,853,918 - 24,954,979 (-)NCBIT2T-CHM13v2.0
Adcy3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,819,602 - 32,923,174 (+)NCBIGRCr8
mRatBN7.2627,100,089 - 27,203,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,124,828 - 27,203,686 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,417,094 - 27,495,948 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,732,977 - 27,811,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,210,479 - 27,289,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,570,941 - 28,648,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,571,351 - 28,650,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,378,060 - 38,454,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4627,118,325 - 27,202,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1627,121,352 - 27,205,228 (+)NCBI
Celera626,598,414 - 26,676,272 (+)NCBICelera
Cytogenetic Map6q14NCBI
Adcy3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,929,092 - 7,026,758 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554696,933,208 - 7,026,179 (-)NCBIChiLan1.0ChiLan1.0
ADCY3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,605,337 - 101,706,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,609,330 - 101,710,392 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,812,729 - 24,913,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,908,108 - 25,009,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,908,108 - 25,009,163 (-)Ensemblpanpan1.1panPan2
ADCY3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,153,732 - 19,231,943 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,154,571 - 19,232,411 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,050,504 - 19,129,367 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01719,426,953 - 19,505,567 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,426,958 - 19,505,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,163,469 - 19,242,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,172,925 - 19,251,551 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,212,943 - 19,298,018 (-)NCBIUU_Cfam_GSD_1.0
Adcy3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,506,132 - 63,589,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,250,194 - 7,335,691 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,250,194 - 7,333,433 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,876,339 - 113,982,369 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,875,005 - 113,969,053 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,107,146 - 121,199,908 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,752,786 - 82,858,727 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,753,177 - 82,859,415 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604529,309,587 - 29,414,423 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,163,354 - 7,249,190 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247387,163,189 - 7,249,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy3
2225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1533
Count of miRNA genes:502
Interacting mature miRNAs:599
Transcripts:ENSMUST00000020984, ENSMUST00000124505, ENSMUST00000127110, ENSMUST00000127756, ENSMUST00000134680, ENSMUST00000150944, ENSMUST00000152065, ENSMUST00000152792
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse

Markers in Region
Adcy3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37124,195,180 - 4,196,781UniSTSGRCm37
Celera124,122,333 - 4,123,934UniSTS
Cytogenetic Map12A-BUniSTS
cM Map12 UniSTS
AI448222  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38124,213,577 - 4,213,818UniSTSGRCm38
MGSCv37124,213,577 - 4,213,818UniSTSGRCm37
Celera124,140,708 - 4,140,949UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map12A-BUniSTS
Whitehead/MRC_RH1227.71UniSTS
D12Ertd482e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38124,213,497 - 4,213,732UniSTSGRCm38
MGSCv37124,213,497 - 4,213,732UniSTSGRCm37
Celera124,140,628 - 4,140,863UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map12A-BUniSTS
cM Map121.0UniSTS
ADCY3_1034  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38124,212,633 - 4,213,453UniSTSGRCm38
MGSCv37124,212,633 - 4,213,453UniSTSGRCm37
Celera124,139,764 - 4,140,584UniSTS
Cytogenetic Map12A-BUniSTS
Cytogenetic Map12A1.1UniSTS
MARC_7285-7286:996687727:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38124,211,542 - 4,212,137UniSTSGRCm38
MGSCv37124,211,542 - 4,212,137UniSTSGRCm37
Celera124,138,673 - 4,139,268UniSTS
Cytogenetic Map12A-BUniSTS
Cytogenetic Map12A1.1UniSTS
Adcy3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38124,195,180 - 4,196,781UniSTSGRCm38
MGSCv37124,195,180 - 4,196,781UniSTSGRCm37
Celera124,122,333 - 4,123,934UniSTS
Cytogenetic Map12A-BUniSTS
cM Map12 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001159536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001422786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF253540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF458089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ442923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF532558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT572999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020984   ⟹   ENSMUSP00000020984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,184,153 - 4,263,524 (+)Ensembl
GRCm38.p6 Ensembl124,134,153 - 4,213,524 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124505   ⟹   ENSMUSP00000122073
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,183,104 - 4,263,525 (+)Ensembl
GRCm38.p6 Ensembl124,133,104 - 4,213,525 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127110
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,253,268 - 4,256,445 (+)Ensembl
GRCm38.p6 Ensembl124,203,268 - 4,206,445 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127756   ⟹   ENSMUSP00000115406
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,183,402 - 4,263,524 (+)Ensembl
GRCm38.p6 Ensembl124,133,402 - 4,213,524 (+)Ensembl
Ensembl Acc Id: ENSMUST00000134680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,209,600 - 4,232,945 (+)Ensembl
GRCm38.p6 Ensembl124,159,600 - 4,182,945 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,244,821 - 4,246,904 (+)Ensembl
GRCm38.p6 Ensembl124,194,821 - 4,196,904 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152065   ⟹   ENSMUSP00000115644
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,183,397 - 4,263,525 (+)Ensembl
GRCm38.p6 Ensembl124,133,397 - 4,213,525 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152792
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,183,103 - 4,263,525 (+)Ensembl
GRCm38.p6 Ensembl124,133,103 - 4,213,525 (+)Ensembl
RefSeq Acc Id: NM_001159536   ⟹   NP_001153008
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,183,397 - 4,263,524 (+)NCBI
GRCm38124,133,397 - 4,213,524 (+)NCBI
MGSCv37124,133,397 - 4,213,524 (+)RGD
Celera124,061,963 - 4,140,655 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001159537   ⟹   NP_001153009
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,183,397 - 4,263,524 (+)NCBI
GRCm38124,133,397 - 4,213,524 (+)NCBI
MGSCv37124,133,397 - 4,213,524 (+)RGD
Celera124,061,963 - 4,140,655 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001422786   ⟹   NP_001409715
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,183,402 - 4,263,525 (+)NCBI
RefSeq Acc Id: NM_138305   ⟹   NP_612178
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,183,402 - 4,263,525 (+)NCBI
GRCm38124,134,153 - 4,213,524 (+)NCBI
MGSCv37124,133,397 - 4,213,524 (+)RGD
Celera124,061,963 - 4,140,655 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514934   ⟹   XP_006514997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,183,630 - 4,263,525 (+)NCBI
GRCm38124,133,630 - 4,213,352 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006514935   ⟹   XP_006514998
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,183,632 - 4,263,525 (+)NCBI
GRCm38124,133,634 - 4,213,352 (+)NCBI
Sequence:
RefSeq Acc Id: NP_612178   ⟸   NM_138305
- Peptide Label: isoform 1
- UniProtKB: B8JK57 (UniProtKB/Swiss-Prot),   Q8VHH7 (UniProtKB/Swiss-Prot),   Q6PGC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153008   ⟸   NM_001159536
- Peptide Label: isoform 2
- UniProtKB: B8JK56 (UniProtKB/TrEMBL),   Q6PGC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153009   ⟸   NM_001159537
- Peptide Label: isoform 2
- UniProtKB: B8JK56 (UniProtKB/TrEMBL),   Q6PGC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514998   ⟸   XM_006514935
- Peptide Label: isoform X1
- UniProtKB: Q8VHH7 (UniProtKB/Swiss-Prot),   B8JK57 (UniProtKB/Swiss-Prot),   Q6PGC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514997   ⟸   XM_006514934
- Peptide Label: isoform X1
- UniProtKB: Q8VHH7 (UniProtKB/Swiss-Prot),   B8JK57 (UniProtKB/Swiss-Prot),   Q6PGC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000122073   ⟸   ENSMUST00000124505
Ensembl Acc Id: ENSMUSP00000020984   ⟸   ENSMUST00000020984
Ensembl Acc Id: ENSMUSP00000115406   ⟸   ENSMUST00000127756
Ensembl Acc Id: ENSMUSP00000115644   ⟸   ENSMUST00000152065
RefSeq Acc Id: NP_001409715   ⟸   NM_001422786
- Peptide Label: isoform 1
- UniProtKB: Q8VHH7 (UniProtKB/Swiss-Prot),   B8JK57 (UniProtKB/Swiss-Prot)
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHH7-F1-model_v2 AlphaFold Q8VHH7 1-1145 view protein structure

Promoters
RGD ID:6822667
Promoter ID:MM_KWN:11072
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000020984,   NM_138305,   OTTMUST00000084969,   OTTMUST00000084970,   OTTMUST00000084971,   OTTMUST00000084972
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36124,133,024 - 4,133,524 (+)MPROMDB
RGD ID:8677832
Promoter ID:EPDNEW_M16947
Type:single initiation site
Name:Adcy3_1
Description:Mus musculus adenylate cyclase 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16948  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38124,133,402 - 4,133,462EPDNEW
RGD ID:8677834
Promoter ID:EPDNEW_M16948
Type:single initiation site
Name:Adcy3_2
Description:Mus musculus adenylate cyclase 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16947  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38124,134,226 - 4,134,286EPDNEW
RGD ID:6822666
Promoter ID:MM_KWN:11074
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000084974
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36124,194,816 - 4,195,316 (+)MPROMDB
RGD ID:6822669
Promoter ID:MM_KWN:11075
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000084975
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36124,203,216 - 4,203,716 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99675 AgrOrtholog
Ensembl Genes ENSMUSG00000020654 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020984 ENTREZGENE
  ENSMUST00000020984.9 UniProtKB/Swiss-Prot
  ENSMUST00000124505 ENTREZGENE
  ENSMUST00000124505.8 UniProtKB/TrEMBL
  ENSMUST00000127756 ENTREZGENE
  ENSMUST00000127756.8 UniProtKB/Swiss-Prot
  ENSMUST00000152065 ENTREZGENE
  ENSMUST00000152065.8 UniProtKB/TrEMBL
  ENSMUST00000152792 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:104111 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99675 ENTREZGENE
NCBI Gene Adcy3 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy3 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ADCY3_MOUSE UniProtKB/Swiss-Prot
  B8JK56 ENTREZGENE, UniProtKB/TrEMBL
  B8JK57 ENTREZGENE
  Q6PG12_MOUSE UniProtKB/TrEMBL
  Q6PGC0 ENTREZGENE, UniProtKB/TrEMBL
  Q80TY9_MOUSE UniProtKB/TrEMBL
  Q8VHH7 ENTREZGENE
  Q9JK77_MOUSE UniProtKB/TrEMBL
UniProt Secondary B8JK57 UniProtKB/Swiss-Prot