Socs1 (suppressor of cytokine signaling 1) - Rat Genome Database

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Gene: Socs1 (suppressor of cytokine signaling 1) Mus musculus
Symbol: Socs1
Name: suppressor of cytokine signaling 1
RGD ID: 732457
Description: Enables kinase inhibitor activity. Involved in negative regulation of CD8-positive, alpha-beta T cell differentiation and positive regulation of CD4-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including adipose tissue; genitourinary system; gut; hemolymphoid system gland; and nervous system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cis; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; JA; JAB; JAK-binding protein; JAK2-binding protein; SOC; SOCS-1; SS; SSI-1; STAT-induced STAT inhibitor 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391610,601,672 - 10,603,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,600,104 - 10,603,400 (-)EnsemblGRCm39 Ensembl
GRCm381610,783,808 - 10,785,536 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,782,240 - 10,785,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv371610,783,901 - 10,785,629 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,697,386 - 10,699,114 (-)NCBIMGSCv36mm8
Celera1611,411,246 - 11,412,974 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
alcoholic hepatitis  (ISO)
allergic contact dermatitis  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Breast Neoplasms  (ISO)
Charcot-Marie-Tooth disease type 1C  (ISO)
colitis  (IGI)
colon cancer  (IMP)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (IGI)
diabetes mellitus  (IDA)
Diabetic Nephropathies  (ISO)
ductal carcinoma in situ  (ISO)
Dysbiosis  (IMP)
Endotoxemia  (IEP)
esophageal cancer  (ISO)
esophagus squamous cell carcinoma  (IDA,ISO)
Experimental Autoimmune Uveitis  (IDA)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Familial Autoinflammatory Syndrome, with or without Immunodeficiency  (ISO)
fatty liver disease  (IMP)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypertriglyceridemia  (IMP)
Immuno-Hemolytic Anemia  (ISO)
Insulin Resistance  (IMP)
Intestinal Reperfusion Injury  (ISO)
invasive ductal carcinoma  (ISO)
Landau-Kleffner syndrome  (ISO)
laryngeal carcinoma  (ISO)
liver cirrhosis  (IMP)
liver disease  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (IMP)
MHC class II deficiency  (ISO)
myocardial infarction  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
ovarian carcinoma  (ISO)
prostate cancer  (ISO)
Reperfusion Injury  (ISO)
rheumatic heart disease  (ISO)
Sepsis  (ISO)
systemic lupus erythematosus  (IMP,ISO)
toxic shock syndrome  (IMP)
transient cerebral ischemia  (ISO)
urinary bladder cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxy-TEMPO  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antigen  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
carmustine  (ISO)
CGP 52608  (ISO)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
hexadecanoic acid  (ISO)
isotretinoin  (ISO)
L-methionine  (EXP)
lead nitrate  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
lomustine  (ISO)
manganese(II) chloride  (ISO)
muramyl dipeptide  (EXP)
nickel atom  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phosphane  (ISO)
poly(I:C)  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (ISO)
pyridaben  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
sulpiride  (ISO)
T-2 toxin  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
torcetrapib  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to amino acid stimulus  (IDA)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to thyrotropin-releasing hormone  (ISO)
cellular response to type II interferon  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cytokine-mediated signaling pathway  (IDA,IMP)
fat cell differentiation  (IMP)
intracellular signal transduction  (IEA)
macrophage differentiation  (ISO)
negative regulation of CD8-positive, alpha-beta T cell differentiation  (IMP)
negative regulation of hepatic stellate cell proliferation  (ISO)
negative regulation of insulin receptor signaling pathway  (IDA)
negative regulation of receptor signaling pathway via JAK-STAT  (IMP,ISO)
negative regulation of signal transduction  (IEA)
negative regulation of tyrosine phosphorylation of STAT protein  (IDA,ISO)
phosphatidylinositol phosphate biosynthetic process  (IBA)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (IMP)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
receptor signaling pathway via JAK-STAT  (IDA)
regulation of activation of Janus kinase activity  (IMP)
regulation of cytokine production  (IMP)
regulation of protein phosphorylation  (IDA)
regulation of receptor signaling pathway via JAK-STAT  (IMP)
regulation of tyrosine phosphorylation of STAT protein  (IMP)
response to cytokine  (ISO)
response to erythropoietin  (ISO)
response to estradiol  (ISO)
response to lipopolysaccharide  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal CD8-positive, alpha beta T cell morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal follicular B cell morphology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal interleukin level  (IAGP)
abnormal lactation  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal lymph node B cell domain morphology  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mature B cell morphology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal pulmonary alveolus wall morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
absent spleen germinal center  (IAGP)
absent thymus corticomedullary boundary  (IAGP)
blepharitis  (IAGP)
conjunctivitis  (IAGP)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased effector memory T-helper cell number  (IAGP)
decreased eosinophil cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to Togaviridae infection induced morbidity/mortality  (IAGP)
decreased thymocyte number  (IAGP)
dermatitis  (IAGP)
enlarged liver  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged thymus medulla  (IAGP)
extramedullary hematopoiesis  (IAGP)
glomerulonephritis  (IAGP)
heart inflammation  (IAGP)
hepatic necrosis  (IAGP)
hepatic steatosis  (IAGP)
increased activated T cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased hepatoma incidence  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased inflammatory response  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased NK T cell number  (IAGP)
increased regulatory T cell number  (IAGP)
increased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
increased spleen red pulp amount  (IAGP)
increased susceptibility to injury  (IAGP)
intestinal inflammation  (IAGP)
liver degeneration  (IAGP)
liver inflammation  (IAGP)
lymph node hyperplasia  (IAGP)
mammary gland alveolar hyperplasia  (IAGP)
myocarditis  (IAGP)
myositis  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas inflammation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
salivary gland inflammation  (IAGP)
skin inflammation  (IAGP)
small thymus  (IAGP)
thick epidermis  (IAGP)
thrombocytopenia  (IAGP)
thymus atrophy  (IAGP)
thymus cortex atrophy  (IAGP)
thymus hyperplasia  (IAGP)

References - curated
# Reference Title Reference Citation
1. Lack of prognostic significance of SOCS-1 expression in colorectal adenocarcinomas. Ayyildiz T, etal., Asian Pac J Cancer Prev. 2014;15(19):8469-74. doi: 10.7314/apjcp.2014.15.19.8469.
2. Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. Bagnyukova TV, etal., Cell Cycle. 2008 Oct;7(20):3202-10. doi: 10.4161/cc.7.20.6816. Epub 2008 Oct 18.
3. Inhibition of miR‑155‑5p attenuates the valvular damage induced by rheumatic heart disease. Chen A, etal., Int J Mol Med. 2020 Feb;45(2):429-440. doi: 10.3892/ijmm.2019.4420. Epub 2019 Dec 6.
4. SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. Chen CY, etal., Genes Chromosomes Cancer. 2003 Jul;37(3):300-5. doi: 10.1002/gcc.10222.
5. Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction. Chong MM, etal., J Immunol. 2004 May 1;172(9):5714-21. doi: 10.4049/jimmunol.172.9.5714.
6. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-3p targets SOCS1 to facilitate progression of esophageal cancer. Deng Y, etal., Life Sci. 2021 Aug 1;278:119491. doi: 10.1016/j.lfs.2021.119491. Epub 2021 Apr 13.
7. Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Friedrich MG, etal., Eur J Cancer. 2005 Nov;41(17):2769-78. Epub 2005 Oct 19.
8. [DNA methylation on urinalysis and as a prognostic marker in urothelial cancer of the bladder]. Friedrich MG, etal., Urologe A. 2007 Jul;46(7):761-8.
9. Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice. Gendo Y, etal., Inflamm Intest Dis. 2019 Feb;3(3):145-154. doi: 10.1159/000495462. Epub 2019 Jan 10.
10. Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity. Hanada T, etal., Immunity. 2003 Sep;19(3):437-50. doi: 10.1016/s1074-7613(03)00240-1.
11. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. Hanada T, etal., J Exp Med. 2006 Jun 12;203(6):1391-7. doi: 10.1084/jem.20060436. Epub 2006 May 22.
12. Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation. Hashimoto M, etal., Cancer Sci. 2009 Apr;100(4):730-6. doi: 10.1111/j.1349-7006.2009.01098.x.
13. Twenty proteins containing a C-terminal SOCS box form five structural classes. Hilton DJ, etal., Proc Natl Acad Sci U S A 1998 Jan 6;95(1):114-9.
14. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
15. Attenuation of leptin and insulin signaling by SOCS proteins. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
16. Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley. Hussain S, etal., J Recept Signal Transduct Res. 2011 Apr;31(2):147-56. doi: 10.3109/10799893.2011.553836.
17. MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Jiang S, etal., Cancer Res. 2010 Apr 15;70(8):3119-27. doi: 10.1158/0008-5472.CAN-09-4250. Epub 2010 Mar 30.
18. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
19. Promoter methylation and expression of SOCS-1 affect clinical outcome and epithelial-mesenchymal transition in colorectal cancer. Kang XC, etal., Biomed Pharmacother. 2016 May;80:23-29. doi: 10.1016/j.biopha.2016.02.011. Epub 2016 Mar 14.
20. LncRNA MAGI2-AS3 Upregulates Cytokine Signaling 1 by Sponging miR-155 in Non-Small Cell Lung Cancer. Li F, etal., Cancer Biother Radiopharm. 2020 Feb;35(1):72-76. doi: 10.1089/cbr.2019.2898. Epub 2020 Jan 7.
21. microRNA-155 Modulates Hepatic Stellate Cell Proliferation, Apoptosis, and Cell Cycle Progression in Rats With Alcoholic Hepatitis via the MAPK Signaling Pathway Through Targeting SOCS1. Liu D, etal., Front Pharmacol. 2020 Apr 7;11:270. doi: 10.3389/fphar.2020.00270. eCollection 2020.
22. Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma. Liu L, etal., Gene Ther. 2013 Jan;20(1):84-92. doi: 10.1038/gt.2012.4. Epub 2012 Feb 9.
23. Ischemic Preconditioning-Induced SOCS-1 Protects Rat Intestinal Ischemia Reperfusion Injury via Degradation of TRAF6. Liu SZ, etal., Dig Dis Sci. 2017 Jan;62(1):105-114. doi: 10.1007/s10620-016-4277-0. Epub 2016 Aug 18.
24. Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis. Mafanda EK, etal., Cytokine. 2019 Dec;124:154501. doi: 10.1016/j.cyto.2018.07.032. Epub 2018 Aug 8.
25. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
26. MGDs mouse GO annotations MGD data from the GO Consortium
28. Alteration in erythropoietin-induced cardioprotective signaling by postinfarct ventricular remodeling. Miki T, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):68-75. Epub 2005 Dec 23.
29. Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma. Miyoshi H, etal., J Gastroenterol. 2004 Jun;39(6):563-9. doi: 10.1007/s00535-003-1343-0.
30. In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Nicol AF, etal., Exp Mol Pathol. 2006 Aug;81(1):42-7.
31. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
32. Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis. Okochi O, etal., Clin Cancer Res. 2003 Nov 1;9(14):5295-8.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
36. Mouse MP Annotation Import Pipeline RGD automated import pipeline
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Sequence analysis of the conserved protamine gene cluster shows that it contains a fourth expressed gene. Schluter G, etal., Mol Reprod Dev 1996 Jan;43(1):1-6.
39. Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Starr R, etal., Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14395-9.
40. The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential biomarker for the aggressive tumor phenotype in laryngeal carcinoma. Starska K, etal., Folia Histochem Cytobiol. 2009 Jan;47(3):401-10. doi: 10.2478/v10042-009-0075-2.
41. Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. Sugase T, etal., Int J Cancer. 2017 Jun 1;140(11):2608-2621. doi: 10.1002/ijc.30666. Epub 2017 Mar 10.
42. Long noncoding RNA CASC2 suppresses esophageal squamous cell carcinoma progression by increasing SOCS1 expression. Sun K and Zhang G, Cell Biosci. 2019 Nov 9;9:90. doi: 10.1186/s13578-019-0353-4. eCollection 2019.
43. Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Sutherland KD, etal., Oncogene. 2004 Oct 7;23(46):7726-33.
44. Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer. Suzuki M, etal., Cancer Lett. 2006 Oct 28;242(2):222-30. Epub 2006 Feb 3.
45. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Ueki K, etal., Mol Cell Biol. 2004 Jun;24(12):5434-46.
46. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Ueki K, etal., Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7. Epub 2004 Jul 6.
47. Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling. Wang Z, etal., Biochem Biophys Res Commun. 2000 Oct 14;277(1):20-6.
48. Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. Worschech A, etal., Cancer Res. 2008 Apr 1;68(7):2436-46.
49. Effect of SOCS1 on diabetic renal injury through regulating TLR signaling pathway. Wu XY, etal., Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):8068-8074. doi: 10.26355/eurrev_201909_19023.
50. Inhibition of MicroRNA-221 Alleviates Neuropathic Pain Through Targeting Suppressor of Cytokine Signaling 1. Xia L, etal., J Mol Neurosci. 2016 Jul;59(3):411-20. doi: 10.1007/s12031-016-0748-1. Epub 2016 Apr 8.
51. The inhibitory effect of Gualou Guizhi Decoction on post-ischemic neuroinflammation via miR-155 in MCAO rats. Yang J, etal., Ann Palliat Med. 2021 Feb;10(2):1370-1379. doi: 10.21037/apm-20-518. Epub 2020 Oct 16.
52. Suppressor of cytokine signaling 1 (SOCS1) mitigates anterior uveitis and confers protection against ocular HSV-1 infection. Yu CR, etal., Inflammation. 2015 Apr;38(2):555-65. doi: 10.1007/s10753-014-9962-6.
Additional References at PubMed
PMID:9202125   PMID:9202126   PMID:9202127   PMID:9344848   PMID:9789053   PMID:9844915   PMID:9861011   PMID:9869640   PMID:9889194   PMID:10022833   PMID:10051596   PMID:10064597  
PMID:10349636   PMID:10360382   PMID:10374907   PMID:10490099   PMID:10490100   PMID:10490101   PMID:10500304   PMID:10534114   PMID:10679190   PMID:10679268   PMID:10764816   PMID:10792035  
PMID:10867663   PMID:10908669   PMID:11042159   PMID:11076861   PMID:11208867   PMID:11217851   PMID:11371356   PMID:11384984   PMID:11445538   PMID:11522790   PMID:11576226   PMID:11591796  
PMID:11606785   PMID:11782537   PMID:11854514   PMID:11870615   PMID:11907070   PMID:11919579   PMID:12023971   PMID:12032139   PMID:12163497   PMID:12193701   PMID:12221108   PMID:12228220  
PMID:12242343   PMID:12391216   PMID:12396724   PMID:12407025   PMID:12433365   PMID:12433373   PMID:12477932   PMID:12517953   PMID:12639998   PMID:12665516   PMID:12682261   PMID:12705851  
PMID:12907450   PMID:12911518   PMID:12917417   PMID:12928391   PMID:14522994   PMID:14578288   PMID:14625101   PMID:14690596   PMID:14694187   PMID:14713198   PMID:14733929   PMID:14734616  
PMID:14764533   PMID:15100267   PMID:15173123   PMID:15197228   PMID:15232610   PMID:15240659   PMID:15256287   PMID:15304214   PMID:15304476   PMID:15331415   PMID:15452126   PMID:15456882  
PMID:15491990   PMID:15491991   PMID:15522878   PMID:15545275   PMID:15558048   PMID:15596523   PMID:15601820   PMID:15707970   PMID:15728516   PMID:15778397   PMID:15880051   PMID:15899915  
PMID:15924143   PMID:15983045   PMID:16033816   PMID:16083990   PMID:16091384   PMID:16116187   PMID:16120757   PMID:16127460   PMID:16141072   PMID:16141073   PMID:16216888   PMID:16239531  
PMID:16287972   PMID:16311601   PMID:16357940   PMID:16390939   PMID:16407264   PMID:16415872   PMID:16424215   PMID:16472593   PMID:16473883   PMID:16547238   PMID:16571771   PMID:16687505  
PMID:16816922   PMID:16920712   PMID:16988256   PMID:17045460   PMID:17093501   PMID:17114459   PMID:17126530   PMID:17198696   PMID:17364147   PMID:17404264   PMID:17404288   PMID:17579030  
PMID:17945083   PMID:18068850   PMID:18083102   PMID:18321577   PMID:18322180   PMID:18322213   PMID:18325991   PMID:18354218   PMID:18378198   PMID:18381351   PMID:18393318   PMID:18471922  
PMID:18524780   PMID:18606672   PMID:18713987   PMID:18725457   PMID:18754879   PMID:18776134   PMID:18929539   PMID:18971287   PMID:19144316   PMID:19164812   PMID:19222642   PMID:19287004  
PMID:19296467   PMID:19299500   PMID:19309352   PMID:19385048   PMID:19403057   PMID:19414010   PMID:19482358   PMID:19542368   PMID:19564419   PMID:19592492   PMID:19607861   PMID:19617348  
PMID:19620279   PMID:19622834   PMID:19734231   PMID:19763396   PMID:19933379   PMID:20005840   PMID:20067833   PMID:20118929   PMID:20299783   PMID:20372794   PMID:20406299   PMID:20519645  
PMID:20548288   PMID:20596075   PMID:20622265   PMID:20645407   PMID:20850013   PMID:20854017   PMID:20934424   PMID:20937844   PMID:21130166   PMID:21206089   PMID:21258009   PMID:21294722  
PMID:21304519   PMID:21393632   PMID:21537342   PMID:21604070   PMID:21606371   PMID:21622562   PMID:21628332   PMID:21646388   PMID:21703184   PMID:21757742   PMID:21764457   PMID:21778271  
PMID:21788442   PMID:21795592   PMID:21873521   PMID:21873635   PMID:21893603   PMID:21899704   PMID:22043967   PMID:22230748   PMID:22427680   PMID:22517899   PMID:22546503   PMID:22547696  
PMID:22634176   PMID:22771905   PMID:22792286   PMID:22798678   PMID:23091595   PMID:23300554   PMID:23443260   PMID:23545584   PMID:23583238   PMID:23643168   PMID:23667107   PMID:23831231  
PMID:23990909   PMID:23994402   PMID:24037089   PMID:24140964   PMID:24194600   PMID:24210661   PMID:24275663   PMID:24391501   PMID:24557021   PMID:24778118   PMID:24880459   PMID:24956148  
PMID:24966052   PMID:25057888   PMID:25253351   PMID:25381480   PMID:25500584   PMID:25604439   PMID:25611689   PMID:25645925   PMID:25728680   PMID:25847945   PMID:25850028   PMID:25959978  
PMID:26163372   PMID:26251957   PMID:26276821   PMID:26324446   PMID:26725321   PMID:26795246   PMID:26841929   PMID:27050510   PMID:27058411   PMID:27183599   PMID:27213690   PMID:27236107  
PMID:27583437   PMID:27626380   PMID:27721430   PMID:27798161   PMID:27843203   PMID:28079159   PMID:28182772   PMID:28215626   PMID:28258213   PMID:28550203   PMID:28608623   PMID:28679957  
PMID:28753604   PMID:28900038   PMID:28901399   PMID:29085209   PMID:29150567   PMID:29361558   PMID:29478968   PMID:29581081   PMID:29792529   PMID:29976680   PMID:30143932   PMID:30181351  
PMID:30214448   PMID:30577275   PMID:30816678   PMID:31405809   PMID:31545427   PMID:31637892   PMID:31653894   PMID:32096766   PMID:32106541   PMID:32217132   PMID:32900697   PMID:32968282  
PMID:33220174   PMID:33493533   PMID:33724556   PMID:33737712   PMID:33830082   PMID:34629023   PMID:34860579   PMID:35294601   PMID:35428280   PMID:35807375  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391610,601,672 - 10,603,400 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,600,104 - 10,603,400 (-)EnsemblGRCm39 Ensembl
GRCm381610,783,808 - 10,785,536 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,782,240 - 10,785,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv371610,783,901 - 10,785,629 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,697,386 - 10,699,114 (-)NCBIMGSCv36mm8
Celera1611,411,246 - 11,412,974 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.81NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381611,254,417 - 11,256,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1611,254,417 - 11,256,204 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,348,274 - 11,350,061 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,255,775 - 11,257,540 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,255,774 - 11,257,540NCBI
Celera1611,517,679 - 11,519,444 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,266,017 - 11,267,782 (-)NCBIHuRef
CHM1_11611,348,201 - 11,349,966 (-)NCBICHM1_1
T2T-CHM13v2.01611,290,646 - 11,292,433 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2104,882,651 - 4,884,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,882,560 - 4,884,383 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,579,226 - 9,580,917 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0109,100,342 - 9,102,033 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0104,738,623 - 4,740,314 (+)NCBIRnor_WKY
Rnor_6.0104,956,795 - 4,958,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,957,326 - 4,958,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,782,936 - 3,783,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,819,971 - 4,820,609 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,819,970 - 4,820,609 (+)NCBI
Celera103,904,246 - 3,905,811 (+)NCBICelera
Cytogenetic Map10q11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554427,321,337 - 7,323,109 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554427,321,337 - 7,323,109 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11615,578,424 - 15,580,662 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,196,432 - 10,198,205 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1631,511,003 - 31,511,995 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,509,268 - 31,511,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,893,176 - 32,894,903 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,692,882 - 31,694,609 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1631,506,103 - 31,507,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,380,389 - 31,382,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,804,768 - 31,806,494 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024409344111,469,049 - 111,470,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365309,312,965 - 9,316,165 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365309,312,965 - 9,315,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl331,881,225 - 31,884,967 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,879,143 - 31,883,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,670,021 - 32,674,785 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1510,731,866 - 10,733,745 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,732,350 - 10,732,991 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,430,111 - 19,432,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248248,444,877 - 8,446,628 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Socs1
37 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir155mmu-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19699171
Mir155mmu-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19144316
Mir155mmu-miR-155-5pMirtarbaseexternal_infoImmunoblotFunctional MTI (Weak)20937844
Mir155mmu-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22634176
Mir155mmu-miR-155-5pMirtarbaseexternal_infoELISA//Flow//Western blotFunctional MTI23091595

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:185
Interacting mature miRNAs:196
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
1357658Dice1a_mdetermination of interleukin 4 commitment 1a (mouse)Not determined16780110010957706Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
13432183Rotse3_mrotarod training saline/ethanol 3 (mouse)16991777110617771Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381610,783,999 - 10,784,106UniSTSGRCm38
MGSCv371610,784,092 - 10,784,199UniSTSGRCm37
Celera1611,411,437 - 11,411,544UniSTS
Cytogenetic Map16A1UniSTS
cM Map163.4UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381610,783,993 - 10,784,283UniSTSGRCm38
MGSCv371610,784,086 - 10,784,376UniSTSGRCm37
Celera1611,411,431 - 11,411,721UniSTS
Cytogenetic Map16A1UniSTS
cM Map163.4UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000038099   ⟹   ENSMUSP00000038121
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,600,107 - 10,603,400 (-)Ensembl
GRCm38.p6 Ensembl1610,782,243 - 10,785,536 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229866   ⟹   ENSMUSP00000155530
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1610,600,104 - 10,603,400 (-)Ensembl
GRCm38.p6 Ensembl1610,782,240 - 10,785,536 (-)Ensembl
RefSeq Acc Id: NM_001271603   ⟹   NP_001258532
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391610,601,672 - 10,603,400 (-)NCBI
GRCm381610,783,808 - 10,785,536 (-)NCBI
Celera1611,411,246 - 11,412,974 (-)NCBI
RefSeq Acc Id: NM_009896   ⟹   NP_034026
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391610,601,672 - 10,603,400 (-)NCBI
GRCm381610,783,808 - 10,785,536 (-)ENTREZGENE
MGSCv371610,783,901 - 10,785,629 (-)RGD
Celera1611,411,246 - 11,412,974 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_034026   ⟸   NM_009896
- UniProtKB: Q3U3L0 (UniProtKB/Swiss-Prot),   O35716 (UniProtKB/Swiss-Prot),   A0A8C6GQR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258532   ⟸   NM_001271603
- UniProtKB: Q3U3L0 (UniProtKB/Swiss-Prot),   O35716 (UniProtKB/Swiss-Prot),   A0A8C6GQR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000155530   ⟸   ENSMUST00000229866
RefSeq Acc Id: ENSMUSP00000038121   ⟸   ENSMUST00000038099
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35716-F1-model_v2 AlphaFold O35716 1-212 view protein structure

RGD ID:6849069
Promoter ID:MM_XEF:2740
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_2Hour,   Brain,   Lung,   MEF_B4
Transcripts:NM_001011327,   NM_001092026,   NM_001137648,   NM_001159688,   NM_145879
Mouse AssemblyChrPosition (strand)Source
MGSCv361610,784,734 - 10,785,234 (-)MPROMDB
RGD ID:8685430
Promoter ID:EPDNEW_M20745
Type:initiation region
Description:Mus musculus suppressor of cytokine signaling 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M20746  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381610,785,045 - 10,785,105EPDNEW
RGD ID:6827526
Promoter ID:MM_KWN:20089
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Mouse AssemblyChrPosition (strand)Source
MGSCv361610,785,431 - 10,786,572 (-)MPROMDB
RGD ID:8685432
Promoter ID:EPDNEW_M20746
Type:multiple initiation site
Description:Mus musculus suppressor of cytokine signaling 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M20745  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381610,785,536 - 10,785,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354910 AgrOrtholog
Ensembl Genes ENSMUSG00000038037 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000038121 ENTREZGENE
  ENSMUSP00000038121.5 UniProtKB/Swiss-Prot
  ENSMUSP00000155530.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038099 ENTREZGENE
  ENSMUST00000038099.6 UniProtKB/Swiss-Prot
  ENSMUST00000229866.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SOCS1_SH2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:12703 UniProtKB/Swiss-Prot
  PTHR10155:SF4 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PhenoGen Socs1 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SOCS1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2RT46 UniProtKB/Swiss-Prot
  O35960 UniProtKB/Swiss-Prot
  Q3U3L0 UniProtKB/Swiss-Prot