Itgam (integrin alpha M) - Rat Genome Database

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Gene: Itgam (integrin alpha M) Mus musculus
Analyze
Symbol: Itgam
Name: integrin alpha M
RGD ID: 732433
MGI Page MGI
Description: Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; complement-mediated synapse pruning; and endocytosis. Acts upstream of or within several processes, including activated T cell proliferation; microglia development; and neutrophil chemotaxis. Located in external side of plasma membrane and nucleus. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; renal interstitium; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis; persistent fetal circulation syndrome; and pre-eclampsia. Orthologous to human ITGAM (integrin subunit alpha M).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD11 antigen-like family member B; Cd11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR; CR-3 alpha chain; CR3; CR3A; F730045J24Rik; integrin alpha-M; leukocyte adhesion receptor MO1; Ly-4; Ly-40; Mac-; Mac-1; Mac-1 alpha; Mac-1a; MAC1; macrophage antigen alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,661,812 - 127,717,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,661,812 - 127,717,663 (+)EnsemblGRCm39 Ensembl
GRCm387128,062,640 - 128,118,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,062,640 - 128,118,491 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,206,154 - 135,262,005 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,853,854 - 127,908,772 (+)NCBIMGSCv36mm8
Celera7127,897,978 - 127,954,099 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,5-hexanedione  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-mercaptopropanoic acid  (EXP)
3-methyladenine  (ISO)
3-phenoxybenzoic acid  (ISO)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP,ISO)
agathisflavone  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (ISO)
alternariol  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
Antimony trioxide  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
asperentin  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
auranofin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bupivacaine  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP,ISO)
carnosic acid  (EXP,ISO)
chlordecone  (EXP)
chloroprene  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (EXP)
cisplatin  (EXP,ISO)
clonidine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclizine  (EXP)
cypermethrin  (ISO)
DAPT  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP)
dimemorfan  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epalrestat  (EXP)
Erythropoietin  (EXP)
estrone  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
ethylenediaminetetraacetic acid  (ISO)
everolimus  (ISO)
excitatory amino acid agonist  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
fluoxetine  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (EXP)
Fulvic acid  (ISO)
gallic acid  (EXP)
gefitinib  (ISO)
genistein  (EXP)
Ginkgoic acid  (ISO)
ginsenoside Rb1  (ISO)
glutathione  (ISO)
glyburide  (ISO)
GW 4064  (EXP)
halothane  (EXP)
heparin  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
kainic acid  (EXP)
KT 5720  (ISO)
L-methionine  (EXP)
lactacystin  (ISO)
lead nitrate  (EXP)
leukotriene B4  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
low-density lipoprotein  (ISO)
LY294002  (EXP,ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mannitol  (EXP)
mechlorethamine  (ISO)
memantine  (ISO)
methamphetamine  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methyllycaconitine  (EXP)
midazolam  (ISO)
minocycline  (EXP)
ML-7  (EXP)
Morphine-3-glucuronide  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (ISO)
Oleacein  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pinostrobin  (ISO)
pitavastatin  (ISO)
PJ34  (ISO)
plaunotol  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
poly(I:C)  (ISO)
poly(styrene)  (ISO)
progesterone  (ISO)
pyrithiamine  (ISO)
pyrithione  (ISO)
quartz  (ISO)
quercetin  (ISO)
reparixin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rolipram  (ISO)
rotenone  (ISO)
rutin  (ISO)
ryanodine  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
senecionine  (EXP)
serotonin  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium stibogluconate  (ISO)
Soman  (ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulfoxaflor  (ISO)
T-2 toxin  (EXP)
tacrine  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
Tanshinone I  (ISO)
tepoxalin  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
TMC-120A  (EXP)
tributylstannane  (EXP,ISO)
trichostatin A  (ISO)
trimethyltin  (EXP,ISO)
Triptolide  (EXP)
triptonide  (EXP)
tungsten  (EXP)
tunicamycin  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin D  (ISO)
xestospongin C  (ISO)
Y-27632  (ISO)
zileuton  (EXP)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues. Atcha H, etal., Front Immunol. 2021 Sep 22;12:689397. doi: 10.3389/fimmu.2021.689397. eCollection 2021.
2. Identification of miR-210-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction, and its potential role in the pregnancy complications. Awamleh Z and Han VKM, Pregnancy Hypertens. 2020 Jan;19:159-168. doi: 10.1016/j.preghy.2020.01.002. Epub 2020 Jan 14.
3. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Barouch FC, etal., Invest Ophthalmol Vis Sci. 2000 Apr;41(5):1153-8.
4. Perioperative platelet and monocyte activation in patients with critical limb ischemia. Burdess A, etal., J Vasc Surg. 2010 Sep;52(3):697-703. doi: 10.1016/j.jvs.2010.04.024.
5. Preventing the infiltration of leukocytes by monoclonal antibody blocks the development of progressive ischemia in rat burns. Choi M, etal., Plast Reconstr Surg. 1995 Oct;96(5):1177-85; discussion 1186-7.
6. Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain. Chopp M, etal., J Cereb Blood Flow Metab. 1996 Jul;16(4):578-84. doi: 10.1097/00004647-199607000-00007.
7. Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Chopp M, etal., Stroke. 1994 Apr;25(4):869-75; discussion 875-6. doi: 10.1161/01.str.25.4.869.
8. Antibodies against Mac-1 attenuate neutrophil accumulation after traumatic brain injury in rats. Clark RS, etal., J Neurotrauma. 1996 Jun;13(6):333-41. doi: 10.1089/neu.1996.13.333.
9. Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein. Czerwińska ME, etal., Food Chem. 2014 Jun 15;153:1-8. doi: 10.1016/j.foodchem.2013.12.019. Epub 2013 Dec 11.
10. Differential Plasma Protein Regulation and Statin Effects in Human Immunodeficiency Virus (HIV)-Infected and Non-HIV-Infected Patients Utilizing a Proteomics Approach. deFilippi C, etal., J Infect Dis. 2020 Aug 17;222(6):929-939. doi: 10.1093/infdis/jiaa196.
11. Validation of the circulating monocyte being representative of the cholesterol-loaded macrophage: biomediator activity. Devaraj S and Jialal I, Arch Pathol Lab Med. 2008 Sep;132(9):1432-5. doi: 10.5858/2008-132-1432-VOTCMB.
12. Global ischemia-induced modifications in the expression of AMPA receptors and inflammation in rat brain. Dos-Anjos S, etal., Brain Res. 2009 Sep 1;1287:20-7. doi: 10.1016/j.brainres.2009.06.065. Epub 2009 Jun 27.
13. Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL--monocyte interactions. Eisenhardt SU, etal., Atherosclerosis. 2012 Oct;224(2):384-93. doi: 10.1016/j.atherosclerosis.2012.07.039. Epub 2012 Aug 10.
14. Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Gao D, etal., Free Radic Biol Med. 2012 Aug 15;53(4):796-806. doi: 10.1016/j.freeradbiomed.2012.05.026. Epub 2012 May 26.
15. The effect of midazolam on neutrophil mitogen-activated protein kinase. Ghori K, etal., Eur J Anaesthesiol. 2010 Jun;27(6):562-5. doi: 10.1097/EJA.0b013e3283328442.
16. The effect of clonidine, an alpha-2 adrenergic receptor agonist, on inflammatory response and postischemic endothelium function during early reperfusion in healthy volunteers. Gourdin M, etal., J Cardiovasc Pharmacol. 2012 Dec;60(6):553-60. doi: 10.1097/FJC.0b013e31827303fa.
17. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Hirahashi J, etal., Circulation. 2009 Sep 29;120(13):1255-65. Epub 2009 Sep 14.
18. Fasting glucose level modulates cell surface expression of CD11b and CD66b in granulocytes and monocytes of patients with type 2 diabetes. Horvath P, etal., J Investig Med. 2013 Aug;61(6):972-7. doi: 10.2310/JIM.0b013e3182961517.
19. Determinants of platelet conjugate formation with polymorphonuclear leukocytes or monocytes in whole blood. Izzi B, etal., Thromb Haemost. 2007 Dec;98(6):1276-84.
20. Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver. Jaeschke H, etal., Hepatology. 1993 May;17(5):915-23.
21. Increased BBB Permeability Enhances Activation of Microglia and Exacerbates Loss of Dendritic Spines After Transient Global Cerebral Ischemia. Ju F, etal., Front Cell Neurosci. 2018 Aug 3;12:236. doi: 10.3389/fncel.2018.00236. eCollection 2018.
22. Mac-1 (CD11b/CD18) and intercellular adhesion molecule-1 in ischemia-reperfusion injury of rat liver. Kobayashi A, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G577-85. doi: 10.1152/ajpgi.2001.281.2.G577.
23. Translocator protein localises to CD11b+ macrophages in atherosclerosis. Kopecky C, etal., Atherosclerosis. 2019 May;284:153-159. doi: 10.1016/j.atherosclerosis.2019.03.011. Epub 2019 Mar 18.
24. Persistent behavioral impairments and neuroinflammation following global ischemia in the rat. Langdon KD, etal., Eur J Neurosci. 2008 Dec;28(11):2310-8. doi: 10.1111/j.1460-9568.2008.06513.x. Epub 2008 Nov 3.
25. Store-operated calcium channel inhibition attenuates neutrophil function and postshock acute lung injury. Lee C, etal., J Trauma. 2005 Jul;59(1):56-63; discussion 63. doi: 10.1097/01.ta.0000171456.54921.fe.
26. The pattern of inflammation in rat sepsis due to enterotoxin-producing Staphylococcus aureus: a comparison with ischemia-reperfusion injury. Lin RY, etal., J Med. 1996;27(5-6):303-17.
27. Organ-specific innate immune responses in a mouse model of invasive candidiasis. Lionakis MS, etal., J Innate Immun. 2011;3(2):180-99. doi: 10.1159/000321157. Epub 2010 Nov 9.
28. Lower prevalence of circulating invariant natural killer T (iNKT) cells in patients with acute myocardial infarction undergoing primary coronary stenting. Liu LL, etal., Int Immunopharmacol. 2011 Apr;11(4):480-4. doi: 10.1016/j.intimp.2010.12.019. Epub 2011 Jan 14.
29. Signature of subclinical femoral artery atherosclerosis in peripheral blood mononuclear cells. Llorente-Cortés V, etal., Eur J Clin Invest. 2014 Jun;44(6):539-48. doi: 10.1111/eci.12267.
30. Dysfunction of complement receptors CR3 (CD11b/18) and CR4 (CD11c/18) in pre-eclampsia: a genetic and functional study. Lokki AI, etal., BJOG. 2021 Jul;128(8):1282-1291. doi: 10.1111/1471-0528.16660. Epub 2021 Mar 14.
31. Age, gender and disease-related platelet and neutrophil activation ex vivo in whole blood samples from patients with Behçet's disease. Macey M, etal., Rheumatology (Oxford). 2011 Oct;50(10):1849-59. doi: 10.1093/rheumatology/ker177. Epub 2011 Jun 29.
32. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Maiguel D, etal., Sci Signal. 2011 Sep 6;4(189):ra57. doi: 10.1126/scisignal.2001811.
33. A Genetic Model of Constitutively Active Integrin CD11b/CD18. Martinez L, etal., J Immunol. 2020 Nov 1;205(9):2545-2553. doi: 10.4049/jimmunol.1901402. Epub 2020 Sep 16.
34. Down regulation of CD11b and CD18 expression in children with hypercholesterolemia: a preliminary report. Martino F, etal., Nutr Metab Cardiovasc Dis. 2009 Feb;19(2):105-9. doi: 10.1016/j.numecd.2008.05.001. Epub 2008 Aug 3.
35. Neutrophil surface expression of CD11b and CD62L in diabetic microangiopathy. Mastej K and Adamiec R, Acta Diabetol. 2008 Sep;45(3):183-90. doi: 10.1007/s00592-008-0040-0. Epub 2008 May 22.
36. Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation. Mauler M, etal., Circulation. 2019 Feb 12;139(7):918-931. doi: 10.1161/CIRCULATIONAHA.118.033942.
37. Primed polymorphonuclear leukocytes constitute a possible link between inflammation and oxidative stress in hyperlipidemic patients. Mazor R, etal., Atherosclerosis. 2008 Apr;197(2):937-43. doi: 10.1016/j.atherosclerosis.2007.08.014. Epub 2007 Sep 17.
38. MGDs mouse GO annotations MGD data from the GO Consortium
39. MGD IEA MGD IEA
40. Roles of beta 2 integrins of rat neutrophils in complement- and oxygen radical-mediated acute inflammatory injury. Mulligan MS, etal., J Immunol. 1992 Mar 15;148(6):1847-57.
41. Circulating platelet and neutrophil activation correlates with the clinical course of unstable angina. Murasaki S, etal., Heart Vessels. 2007 Nov;22(6):376-82. doi: 10.1007/s00380-007-0999-4. Epub 2007 Nov 26.
42. High-density lipoprotein reduces the human monocyte inflammatory response. Murphy AJ, etal., Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2071-7. doi: 10.1161/ATVBAHA.108.168690. Epub 2008 Jul 10.
43. Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation. Niyonzima N, etal., J Immunol. 2015 Jul 1;195(1):257-64. doi: 10.4049/jimmunol.1403044. Epub 2015 May 29.
44. Neutrophil and monocyte toll-like receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in preterm infants. O'Hare FM, etal., Pediatr Res. 2015 Jul;78(1):82-90. doi: 10.1038/pr.2015.66. Epub 2015 Mar 31.
45. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
46. Monocyte-platelet aggregates and CD11b expression as markers for thrombogenicity in atrial fibrillation. Pfluecke C, etal., Clin Res Cardiol. 2016 Apr;105(4):314-22. doi: 10.1007/s00392-015-0922-4. Epub 2015 Sep 28.
47. Atrial fibrillation is associated with high levels of monocyte-platelet-aggregates and increased CD11b expression in patients with aortic stenosis. Pfluecke C, etal., Thromb Haemost. 2016 May 2;115(5):993-1000. doi: 10.1160/TH15-06-0477. Epub 2016 Jan 14.
48. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
49. Mouse MP Annotation Import Pipeline RGD automated import pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. Exaggerated neutrophil-mediated reperfusion injury after ischemic stroke in a rodent model of type 2 diabetes. Ritter L, etal., Microcirculation. 2011 Oct;18(7):552-61. doi: 10.1111/j.1549-8719.2011.00115.x.
53. Hemodynamic resuscitation with arginine vasopressin reduces lung injury after brain death in the transplant donor. Rostron AJ, etal., Transplantation. 2008 Feb 27;85(4):597-606. doi: 10.1097/TP.0b013e31816398dd.
54. Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats. Ryang YM, etal., BMC Neurosci. 2011 Nov 14;12:113. doi: 10.1186/1471-2202-12-113.
55. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Sanchez E, etal., Ann Rheum Dis. 2011 Jun 30.
56. Modulatory effect of 17β-estradiol on myeloid cell infiltration into the male rat brain after ischemic stroke. Scheld M, etal., J Steroid Biochem Mol Biol. 2020 Sep;202:105667. doi: 10.1016/j.jsbmb.2020.105667. Epub 2020 May 11.
57. Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis. Scholtes VP, etal., Clin Sci (Lond). 2011 Sep;121(5):205-14. doi: 10.1042/CS20100601.
58. Role of beta 2 integrins and ICAM-1 in lung injury following ischemia-reperfusion of rat hind limbs. Seekamp A, etal., Am J Pathol. 1993 Aug;143(2):464-72.
59. Is Iba-1 protein expression a sensitive marker for microglia activation in experimental diabetic retinopathy? Shi FJ, etal., Int J Ophthalmol. 2021 Feb 18;14(2):200-208. doi: 10.18240/ijo.2021.02.04. eCollection 2021.
60. Ischemic limb preconditioning downregulates systemic inflammatory activation. Szabó A, etal., J Orthop Res. 2009 Jul;27(7):897-902. doi: 10.1002/jor.20829.
61. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
62. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Tanga FY, etal., Neurochem Int 2004 Jul-Aug;45(2-3):397-407.
63. Reduction of atrial fibrillation burden by pulmonary vein isolation leads to a decrease of CD11b expression on inflammatory cells. Tarnowski D, etal., Europace. 2018 Mar 1;20(3):459-465. doi: 10.1093/europace/euw383.
64. Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats. Tian DS, etal., J Neurochem. 2009 Jun;109(6):1658-67. doi: 10.1111/j.1471-4159.2009.06077.x. Epub 2009 Mar 30.
65. δ-Opioid receptor activation rescues the functional TrkB receptor and protects the brain from ischemia-reperfusion injury in the rat. Tian X, etal., PLoS One. 2013 Jul 2;8(7):e69252. doi: 10.1371/journal.pone.0069252. Print 2013.
66. Neutrophil-derived reactive oxygen species can modulate neutrophil adhesion to endothelial cells in preeclampsia. Tsukimori K, etal., Am J Hypertens. 2008 May;21(5):587-91. doi: 10.1038/ajh.2007.87. Epub 2008 Mar 6.
67. RNA-seq based transcriptome analysis of the protective effect of compound longmaining decoction on acute myocardial infarction. Wang C, etal., J Pharm Biomed Anal. 2018 Sep 5;158:339-345. doi: 10.1016/j.jpba.2018.06.016. Epub 2018 Jun 18.
68. Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia. Wang J, etal., Int J Mol Med. 2013 Jan;31(1):172-8. doi: 10.3892/ijmm.2012.1179. Epub 2012 Nov 13.
69. Frequent mutation of hypoxia-related genes in persistent pulmonary hypertension of the newborn. Wang M, etal., Respir Res. 2020 Feb 13;21(1):53. doi: 10.1186/s12931-020-1314-5.
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Additional References at PubMed
PMID:89034   PMID:1431091   PMID:1794058   PMID:2185332   PMID:2942940   PMID:3044779   PMID:3887182   PMID:6193226   PMID:7561687   PMID:8043862   PMID:8552190   PMID:8557754  
PMID:8562500   PMID:8600941   PMID:8690467   PMID:8769481   PMID:8777716   PMID:8788039   PMID:8986723   PMID:9077544   PMID:9207125   PMID:9324354   PMID:9341771   PMID:9382884  
PMID:9421166   PMID:9574561   PMID:9862668   PMID:9880401   PMID:10213866   PMID:10330002   PMID:10349636   PMID:10358184   PMID:10477568   PMID:10510082   PMID:10528208   PMID:10648399  
PMID:10675355   PMID:10848813   PMID:10884286   PMID:10946287   PMID:11005868   PMID:11042159   PMID:11076861   PMID:11078603   PMID:11123339   PMID:11217851   PMID:11237803   PMID:11290613  
PMID:11390487   PMID:11438667   PMID:11509326   PMID:11756189   PMID:11869678   PMID:11889125   PMID:11896209   PMID:11937272   PMID:12008927   PMID:12070044   PMID:12077272   PMID:12121661  
PMID:12163569   PMID:12234260   PMID:12244179   PMID:12244198   PMID:12356581   PMID:12466851   PMID:12477932   PMID:12480135   PMID:12480703   PMID:12515728   PMID:12526796   PMID:12529407  
PMID:12618141   PMID:12736263   PMID:12941957   PMID:14609575   PMID:14610273   PMID:14634125   PMID:14691482   PMID:14695221   PMID:15067069   PMID:15069085   PMID:15100152   PMID:15138196  
PMID:15170225   PMID:15210787   PMID:15229332   PMID:15231500   PMID:15238702   PMID:15277234   PMID:15284858   PMID:15308480   PMID:15488763   PMID:15585870   PMID:15585877   PMID:15749905  
PMID:15774618   PMID:15795238   PMID:15831844   PMID:15838804   PMID:15845452   PMID:15899409   PMID:15914564   PMID:16002427   PMID:16042992   PMID:16051744   PMID:16084683   PMID:16093349  
PMID:16141072   PMID:16141073   PMID:16177324   PMID:16179370   PMID:16234355   PMID:16239568   PMID:16272284   PMID:16288049   PMID:16301658   PMID:16362884   PMID:16374427   PMID:16374778  
PMID:16455964   PMID:16551637   PMID:16585587   PMID:16601674   PMID:16611225   PMID:16616573   PMID:16670311   PMID:16751103   PMID:16751412   PMID:16857989   PMID:16872848   PMID:16951367  
PMID:16973387   PMID:16980969   PMID:17056703   PMID:17071583   PMID:17095622   PMID:17116736   PMID:17148436   PMID:17151265   PMID:17173040   PMID:17197441   PMID:17372166   PMID:17475855  
PMID:17562817   PMID:17600340   PMID:17641014   PMID:17650101   PMID:17654704   PMID:17675497   PMID:17682126   PMID:17699657   PMID:17827392   PMID:17932565   PMID:18097035   PMID:18180310  
PMID:18197144   PMID:18216258   PMID:18250481   PMID:18292524   PMID:18297135   PMID:18375763   PMID:18378617   PMID:18424751   PMID:18430230   PMID:18503031   PMID:18509085   PMID:18516037  
PMID:18521186   PMID:18524992   PMID:18555697   PMID:18566428   PMID:18579745   PMID:18590811   PMID:18614760   PMID:18615637   PMID:18625913   PMID:18685038   PMID:18694897   PMID:18701460  
PMID:18710404   PMID:18713972   PMID:18768871   PMID:18775427   PMID:18787004   PMID:18809908   PMID:18818407   PMID:18946352   PMID:18979509   PMID:18981141   PMID:19004989   PMID:19015308  
PMID:19043561   PMID:19052854   PMID:19098321   PMID:19109196   PMID:19155216   PMID:19234143   PMID:19305412   PMID:19342649   PMID:19346498   PMID:19373938   PMID:19384874   PMID:19411110  
PMID:19415696   PMID:19428111   PMID:19451235   PMID:19454663   PMID:19454683   PMID:19494278   PMID:19542426   PMID:19542466   PMID:19620298   PMID:19653277   PMID:19666536   PMID:19710459  
PMID:19723499   PMID:19738028   PMID:19752396   PMID:19752566   PMID:19762711   PMID:19797068   PMID:19797524   PMID:19821527   PMID:19837977   PMID:19880499   PMID:19917697   PMID:19933856  
PMID:19941314   PMID:20069263   PMID:20091776   PMID:20154263   PMID:20164416   PMID:20186338   PMID:20196788   PMID:20199584   PMID:20228271   PMID:20299515   PMID:20303366   PMID:20360401  
PMID:20404134   PMID:20404138   PMID:20458145   PMID:20478304   PMID:20578039   PMID:20639876   PMID:20647008   PMID:20652350   PMID:20660734   PMID:20675592   PMID:20679227   PMID:20884890  
PMID:20889973   PMID:20930145   PMID:20947763   PMID:20955701   PMID:21037096   PMID:21044955   PMID:21076838   PMID:21134968   PMID:21148798   PMID:21169400   PMID:21170045   PMID:21181199  
PMID:21184649   PMID:21224394   PMID:21232086   PMID:21245270   PMID:21248133   PMID:21252155   PMID:21267068   PMID:21268007   PMID:21273385   PMID:21282509   PMID:21308778   PMID:21394214  
PMID:21403131   PMID:21411641   PMID:21419118   PMID:21422184   PMID:21460207   PMID:21469133   PMID:21519141   PMID:21531981   PMID:21625453   PMID:21676865   PMID:21795599   PMID:21873635  
PMID:21949025   PMID:21969013   PMID:21998326   PMID:22065991   PMID:22116828   PMID:22177564   PMID:22197822   PMID:22232682   PMID:22268142   PMID:22327225   PMID:22354871   PMID:22381526  
PMID:22387002   PMID:22438044   PMID:22442442   PMID:22487809   PMID:22491252   PMID:22511631   PMID:22535677   PMID:22551553   PMID:22632727   PMID:22646472   PMID:22677420   PMID:22677557  
PMID:22728064   PMID:22751466   PMID:22753134   PMID:22776089   PMID:22786774   PMID:22822029   PMID:22882618   PMID:22893614   PMID:22895712   PMID:22915101   PMID:22932798   PMID:22933624  
PMID:22962327   PMID:23001562   PMID:23018463   PMID:23034169   PMID:23060546   PMID:23121975   PMID:23184931   PMID:23209319   PMID:23219511   PMID:23310953   PMID:23315163   PMID:23343834  
PMID:23349620   PMID:23352232   PMID:23357382   PMID:23374103   PMID:23380685   PMID:23389444   PMID:23420014   PMID:23460364   PMID:23460613   PMID:23470120   PMID:23499552   PMID:23525041  
PMID:23543768   PMID:23550035   PMID:23585567   PMID:23595732   PMID:23601687   PMID:23632327   PMID:23708969   PMID:23720274   PMID:23751821   PMID:23785403   PMID:23844828   PMID:24029230  
PMID:24120921   PMID:24205223   PMID:24259506   PMID:24343652   PMID:24362892   PMID:24423728   PMID:24474777   PMID:24509082   PMID:24558493   PMID:24576991   PMID:24631344   PMID:24632830  
PMID:24642468   PMID:24652469   PMID:24810636   PMID:24943219   PMID:24952961   PMID:24983320   PMID:25075642   PMID:25092872   PMID:25108426   PMID:25108427   PMID:25114116   PMID:25116953  
PMID:25261488   PMID:25269085   PMID:25271254   PMID:25281714   PMID:25359083   PMID:25421226   PMID:25477463   PMID:25565310   PMID:25675510   PMID:25825709   PMID:25889536   PMID:25902531  
PMID:25972253   PMID:26021804   PMID:26104914   PMID:26160172   PMID:26174764   PMID:26192732   PMID:26207521   PMID:26333171   PMID:26353940   PMID:26416905   PMID:26422753   PMID:26438362  
PMID:26453753   PMID:26489654   PMID:26500348   PMID:26526388   PMID:26582821   PMID:26612263   PMID:26628365   PMID:26634935   PMID:26647393   PMID:26669445   PMID:26758845   PMID:26758846  
PMID:26877097   PMID:26921287   PMID:26924054   PMID:27188843   PMID:27234908   PMID:27315778   PMID:27349342   PMID:27371534   PMID:27379516   PMID:27393574   PMID:27412481   PMID:27464987  
PMID:27653694   PMID:27717807   PMID:27853810   PMID:27974454   PMID:28183849   PMID:28191643   PMID:28228282   PMID:28237965   PMID:28263189   PMID:28298456   PMID:28329690   PMID:28334989  
PMID:28370678   PMID:28404615   PMID:28423181   PMID:28424516   PMID:28555620   PMID:28570266   PMID:28570273   PMID:28634350   PMID:28661042   PMID:28809397   PMID:28854362   PMID:28857285  
PMID:28872671   PMID:28873200   PMID:28961278   PMID:28978491   PMID:29141155   PMID:29154191   PMID:29282280   PMID:29343555   PMID:29400702   PMID:29459405   PMID:29476115   PMID:29483282  
PMID:29540475   PMID:29581545   PMID:29596938   PMID:29618478   PMID:29798841   PMID:29941548   PMID:30166337   PMID:30185824   PMID:30252950   PMID:30333137   PMID:30337485   PMID:30455459  
PMID:30568188   PMID:30571485   PMID:30647151   PMID:30712924   PMID:30737131   PMID:30778357   PMID:30869196   PMID:30936549   PMID:30992366   PMID:31063937   PMID:31065682   PMID:31085833  
PMID:31201093   PMID:31209071   PMID:31209379   PMID:31270275   PMID:31383641   PMID:31395659   PMID:31415243   PMID:31505254   PMID:31519887   PMID:31594855   PMID:31594856   PMID:31594939  
PMID:31626642   PMID:31641985   PMID:31673770   PMID:31695671   PMID:31723045   PMID:31827187   PMID:31852826   PMID:31924792   PMID:31980640   PMID:32052258   PMID:32134742   PMID:32252487  
PMID:32341550   PMID:32375810   PMID:32393780   PMID:32532837   PMID:32693110   PMID:33046245   PMID:33153107   PMID:33239388   PMID:33351105   PMID:33392201   PMID:33799879   PMID:33888560  
PMID:34007995   PMID:34010642   PMID:34144215   PMID:34323105   PMID:34338598   PMID:34417332   PMID:34470858   PMID:34589086   PMID:34746147   PMID:34884889   PMID:34910922   PMID:34961984  
PMID:34971392   PMID:35277420   PMID:35481836   PMID:35609421   PMID:35634296   PMID:35838047   PMID:35849045   PMID:36103834   PMID:36155052   PMID:36210579   PMID:36377602   PMID:36768434  
PMID:36804009   PMID:36822392   PMID:36868231   PMID:36882066   PMID:36922518   PMID:37059107   PMID:37116235   PMID:37145604   PMID:37195185   PMID:37268807   PMID:37298730   PMID:37306457  
PMID:37669937   PMID:37819761   PMID:38018994   PMID:38054922   PMID:38077339   PMID:38205640   PMID:38296117  


Genomics

Comparative Map Data
Itgam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,661,812 - 127,717,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,661,812 - 127,717,663 (+)EnsemblGRCm39 Ensembl
GRCm387128,062,640 - 128,118,491 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,062,640 - 128,118,491 (+)EnsemblGRCm38mm10GRCm38
MGSCv377135,206,154 - 135,262,005 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,853,854 - 127,908,772 (+)NCBIMGSCv36mm8
Celera7127,897,978 - 127,954,099 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.93NCBI
ITGAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,259,975 - 31,332,877 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,259,967 - 31,332,892 (+)EnsemblGRCh38hg38GRCh38
GRCh371631,271,296 - 31,344,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,178,789 - 31,251,714 (+)NCBINCBI36Build 36hg18NCBI36
Build 341631,178,811 - 31,251,691NCBI
Celera1628,953,869 - 29,026,766 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,832,071 - 28,904,704 (+)NCBIHuRef
CHM1_11632,589,199 - 32,661,884 (+)NCBICHM1_1
T2T-CHM13v2.01631,647,380 - 31,720,298 (+)NCBIT2T-CHM13v2.0
Itgam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,089,496 - 192,139,947 (+)NCBIGRCr8
mRatBN7.21182,659,047 - 182,709,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,659,000 - 182,709,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,009,691 - 191,059,554 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,195,778 - 198,245,649 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,866,175 - 190,916,092 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,495,312 - 199,545,738 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,495,298 - 199,623,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,522,794 - 206,573,619 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,334,413 - 187,385,583 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,484,293 - 187,535,464 (+)NCBI
Celera1180,308,890 - 180,355,319 (+)NCBICelera
Cytogenetic Map1q37NCBI
Itgam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,116,834 - 8,260,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554938,116,886 - 8,160,806 (+)NCBIChiLan1.0ChiLan1.0
ITGAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,467,770 - 34,540,427 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,269,199 - 39,341,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,634,476 - 23,707,147 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,630,983 - 31,702,406 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,630,146 - 31,702,406 (+)Ensemblpanpan1.1panPan2
ITGAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,944,062 - 16,996,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,808,971 - 16,996,286 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,516,000 - 18,571,559 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,068,771 - 17,127,224 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,069,907 - 17,127,159 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,871,848 - 16,927,654 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,791,010 - 16,846,822 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,102,490 - 17,158,038 (-)NCBIUU_Cfam_GSD_1.0
Itgam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,528,028 - 125,576,877 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,461,307 - 8,508,524 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365438,460,526 - 8,508,524 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,957,162 - 28,042,697 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,957,324 - 28,042,691 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,400,356 - 1,493,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,318,499 - 14,367,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,316,505 - 14,367,841 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgam
1830 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2203
Count of miRNA genes:680
Interacting mature miRNAs:846
Transcripts:ENSMUST00000064821, ENSMUST00000098015, ENSMUST00000106240, ENSMUST00000106242, ENSMUST00000119696, ENSMUST00000120355, ENSMUST00000126475, ENSMUST00000134694, ENSMUST00000156593
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse

Markers in Region
Itgam  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387128,117,409 - 128,117,624UniSTSGRCm38
MGSCv377135,260,923 - 135,261,138UniSTSGRCm37
Celera7127,953,005 - 127,953,220UniSTS
Cytogenetic Map7F4UniSTS
cM MapUN UniSTS
cM Map7 UniSTS
PMC27130P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387128,148,762 - 128,149,129UniSTSGRCm38
MGSCv377135,292,276 - 135,292,643UniSTSGRCm37
Celera7127,982,421 - 127,982,788UniSTS
Cytogenetic Map7F4UniSTS
Cytogenetic Map7F3UniSTS
Itgam  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387128,115,825 - 128,117,341UniSTSGRCm38
MGSCv377135,259,339 - 135,260,855UniSTSGRCm37
Celera7127,951,421 - 127,952,937UniSTS
Cytogenetic Map7F4UniSTS
Itgam  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001082960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS104356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF101557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000064821   ⟹   ENSMUSP00000068468
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,661,812 - 127,717,663 (+)Ensembl
GRCm38.p6 Ensembl7128,062,640 - 128,118,491 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106240   ⟹   ENSMUSP00000101847
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,661,855 - 127,716,703 (+)Ensembl
GRCm38.p6 Ensembl7128,062,683 - 128,117,531 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106242   ⟹   ENSMUSP00000101849
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,661,841 - 127,717,662 (+)Ensembl
GRCm38.p6 Ensembl7128,062,669 - 128,118,490 (+)Ensembl
RefSeq Acc Id: ENSMUST00000119696
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,661,900 - 127,669,787 (+)Ensembl
GRCm38.p6 Ensembl7128,062,728 - 128,070,615 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120355   ⟹   ENSMUSP00000113957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,661,851 - 127,716,262 (+)Ensembl
GRCm38.p6 Ensembl7128,062,679 - 128,117,090 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156593   ⟹   ENSMUSP00000121676
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,661,915 - 127,670,029 (+)Ensembl
GRCm38.p6 Ensembl7128,062,743 - 128,070,857 (+)Ensembl
RefSeq Acc Id: NM_001082960   ⟹   NP_001076429
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,661,812 - 127,717,663 (+)NCBI
GRCm387128,062,640 - 128,118,491 (+)NCBI
MGSCv377135,206,154 - 135,262,005 (+)RGD
Celera7127,897,978 - 127,954,099 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008401   ⟹   NP_032427
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,661,812 - 127,717,663 (+)NCBI
GRCm387128,062,640 - 128,118,491 (+)NCBI
MGSCv377135,206,154 - 135,262,005 (+)RGD
Celera7127,897,978 - 127,954,099 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001076429   ⟸   NM_001082960
- Peptide Label: isoform 1 precursor
- UniProtKB: G5E8F1 (UniProtKB/TrEMBL),   Q3TD86 (UniProtKB/TrEMBL),   Q3U4I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_032427   ⟸   NM_008401
- Peptide Label: isoform 2 precursor
- UniProtKB: E9Q604 (UniProtKB/TrEMBL),   Q3TD86 (UniProtKB/TrEMBL),   Q3U4I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000101847   ⟸   ENSMUST00000106240
RefSeq Acc Id: ENSMUSP00000101849   ⟸   ENSMUST00000106242
RefSeq Acc Id: ENSMUSP00000113957   ⟸   ENSMUST00000120355
RefSeq Acc Id: ENSMUSP00000068468   ⟸   ENSMUST00000064821
RefSeq Acc Id: ENSMUSP00000121676   ⟸   ENSMUST00000156593
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05555-F1-model_v2 AlphaFold P05555 1-1153 view protein structure

Promoters
RGD ID:8665745
Promoter ID:EPDNEW_M10903
Type:initiation region
Name:Itgam_1
Description:Mus musculus integrin alpha M , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387128,062,711 - 128,062,771EPDNEW
RGD ID:6841370
Promoter ID:MM_KWN:52849
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:ENSMUST00000106240,   ENSMUST00000119696,   NM_001082960,   NM_008401,   OTTMUST00000076534,   OTTMUST00000076535,   OTTMUST00000076538,   UC009JXW.1,   UC009JXX.1,   UC009JYA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367135,206,131 - 135,206,631 (+)MPROMDB
RGD ID:6841366
Promoter ID:MM_KWN:52850
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000076536
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367135,214,061 - 135,214,561 (+)MPROMDB
RGD ID:6841368
Promoter ID:MM_KWN:52851
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000076539
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367135,259,221 - 135,260,057 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96607 AgrOrtholog
Ensembl Genes ENSMUSG00000030786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064821 ENTREZGENE
  ENSMUST00000064821.14 UniProtKB/TrEMBL
  ENSMUST00000106240.9 UniProtKB/TrEMBL
  ENSMUST00000106242 ENTREZGENE
  ENSMUST00000106242.10 UniProtKB/TrEMBL
  ENSMUST00000120355.8 UniProtKB/TrEMBL
  ENSMUST00000156593.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ITGAX-like_Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16409 UniProtKB/TrEMBL
MGD MGI:96607 ENTREZGENE
NCBI Gene 16409 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN ALPHA-M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ITGAX-like_Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itgam PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J1B4_MOUSE UniProtKB/TrEMBL
  D6RJ73_MOUSE UniProtKB/TrEMBL
  E9Q5K8_MOUSE UniProtKB/TrEMBL
  E9Q604 ENTREZGENE, UniProtKB/TrEMBL
  G5E8F1 ENTREZGENE, UniProtKB/TrEMBL
  ITAM_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TD86 ENTREZGENE, UniProtKB/TrEMBL
  Q3U4I5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8CA73 UniProtKB/Swiss-Prot