Prdx3 (peroxiredoxin 3) - Rat Genome Database

Name: Prdx3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Prdx3 (peroxiredoxin 3) Mus musculus

Analyze

Symbol:

Prdx3

Name:

peroxiredoxin 3

RGD ID:

732403

MGI Page

MGI

Description:

Enables identical protein binding activity. Acts upstream of or within several processes, including maternal placenta development; myeloid cell differentiation; and response to lipopolysaccharide. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Orthologous to human PRDX3 (peroxiredoxin 3).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

A; anti-oxidant protein 1; antioxidant protein; AOP-1; Aop1; AW822249; D0Toh; D0Tohi1; Ef2; Ef2l; Mer; Mer5; mitochondrial thioredoxin dependent peroxide reductase; mitochondrial Trx dependent peroxide reductase; perioredoxin-3; peroxiredoxin III; Prx III; Prx3; SP; SP22; TDXM; thioredoxin-dependent peroxide reductase, mitochondrial; thioredoxin-dependent peroxiredoxin 3

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRDX3 (peroxiredoxin 3)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Prdx3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prdx3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PRDX3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRDX3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prdx3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRDX3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PRDX3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prdx3 (peroxiredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Prdx3 (peroxiredoxin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PRDX3 (peroxiredoxin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	prdx3 (peroxiredoxin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	TSA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	TSA2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector)
Caenorhabditis elegans (roundworm):	prdx-3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Prx3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	prdx3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Gm11905 Gm17907 Gm17926 Gm2448

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	60,852,504 - 60,862,976 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	60,852,489 - 60,862,994 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	60,864,066 - 60,874,538 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	60,864,051 - 60,874,556 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	60,939,969 - 60,950,441 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	60,918,750 - 60,929,177 (-)	NCBI		MGSCv36	mm8
Celera	19	63,076,194 - 63,086,472 (-)	NCBI		Celera
Cytogenetic Map	19	D3	NCBI
cM Map	19	56.52	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive cerebellar ataxia (ISO)

Autosomal Recessive Spinocerebellar Ataxia 32 (ISO)

CORNEAL DYSTROPHY, PUNCTIFORM AND POLYCHROMATIC PRE-DESCEMET (ISO)

COVID-19 (ISO)

diffuse large B-cell lymphoma (ISO)

Disease Progression (ISO)

genetic disease (ISO)

glucose intolerance (ISO)

Insulin Resistance (ISO)

motor neuron disease (ISO)

non-alcoholic fatty liver disease (ISO)

osteoporosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(1->4)-beta-D-glucan (EXP)

(S)-nicotine (EXP)

1,1'-azobis(N,N-dimethylformamide) (ISO)

1,2-dimethylhydrazine (EXP)

1,4-phenylenediamine (EXP)

1-chloro-2,4-dinitrobenzene (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3-dihydroxybenzoic acid (EXP)

2,4-diaminotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

2-butoxyethanol (EXP)

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine (ISO)

3,4-dihydrocoumarin (EXP)

3-chloropropane-1,2-diol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

aminoglutethimide (ISO)

amiodarone (EXP)

ammonium chloride (ISO)

antimycin A (ISO)

arsenite(3-) (EXP,ISO)

arsenous acid (ISO)

auranofin (EXP,ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

butyric acid (ISO)

cadmium dichloride (ISO)

cadmium sulfide (ISO)

carbon nanotube (EXP)

Carnosol (EXP)

chloropicrin (ISO)

chromium(6+) (EXP,ISO)

clobetasol (EXP)

clofibrate (ISO)

copper(II) chloride (EXP)

copper(II) sulfate (ISO)

crystal violet (ISO)

cyclosporin A (ISO)

deguelin (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

diquat (EXP)

dopamine (ISO)

doxorubicin (EXP)

endosulfan (ISO)

enzyme inhibitor (ISO)

ethanol (EXP)

eugenol (ISO)

famotidine (ISO)

flavonoids (ISO)

flutamide (ISO)

fluvastatin (ISO)

folic acid (EXP)

folpet (EXP)

fulvestrant (ISO)

furan (ISO)

gentamycin (EXP,ISO)

geraniol (ISO)

herbicide (EXP)

hexadecanoic acid (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

inulin (EXP)

ivermectin (ISO)

kanamycin A (EXP)

ketoconazole (ISO)

L-ascorbic acid (ISO)

lipopolysaccharide (ISO)

maneb (EXP)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

metoprolol (ISO)

miconazole (ISO)

minocycline (EXP)

N-acetyl-beta-D-glucosamine (ISO)

N-acetyl-D-glucosamine (ISO)

N-acetyl-L-cysteine (ISO)

N-methyl-4-phenylpyridinium (ISO)

nefazodone (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

nicotine (EXP)

nimesulide (ISO)

nitrofen (ISO)

oxaliplatin (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

peptidoglycan (ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenobarbital (EXP,ISO)

picloram (EXP)

potassium dichromate (ISO)

propiconazole (EXP)

pyrogallol (EXP)

quercetin (EXP,ISO)

rotenone (EXP,ISO)

senecionine (EXP)

sodium arsenite (ISO)

sodium fluoride (EXP)

sodium nitrate (EXP)

streptozocin (EXP,ISO)

sulfasalazine (EXP)

sulforaphane (ISO)

T-2 toxin (ISO)

tamoxifen (EXP,ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thiostrepton (ISO)

topotecan (ISO)

trichlopyr (EXP)

trichloroethene (ISO)

tunicamycin (ISO)

urethane (EXP)

vinclozolin (ISO)

vorinostat (ISO)

zinc oxide (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell redox homeostasis (IBA)

cellular response to oxidative stress (ISO)

cellular response to reactive oxygen species (ISO)

hydrogen peroxide catabolic process (IBA,ISO)

maternal placenta development (IMP)

mitochondrion organization (ISO)

myeloid cell differentiation (IMP)

negative regulation of apoptotic process (ISO)

negative regulation of kinase activity (ISO)

negative regulation of neuron apoptotic process (ISO)

peptidyl-cysteine oxidation (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of NF-kappaB transcription factor activity (ISO)

regulation of mitochondrial membrane potential (ISO)

response to hydrogen peroxide (ISO)

response to lipopolysaccharide (IMP)

response to oxidative stress (IBA,IMP,ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IBA,ISO)

early endosome (ISO)

endosome (IEA)

intracellular membrane-bounded organelle (ISO)

mitochondrion (HDA,IBA,ISO)

myelin sheath (HDA)

nucleoplasm (ISO)

plasma membrane (ISO)

protein-containing complex (ISO)

Molecular Function

antioxidant activity (IEA)

cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ISO)

identical protein binding (IPI,ISO)

oxidoreductase activity (IEA)

peroxidase activity (IEA)

peroxiredoxin activity (IEA)

protein binding (ISO)

protein kinase binding (ISO)

thioredoxin peroxidase activity (IBA,ISO)

thioredoxin-dependent peroxiredoxin activity (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cell physiology (IAGP)

abnormal circulating protein level (IAGP)

abnormal epididymal fat pad morphology (IAGP)

abnormal lipid metabolism (IAGP)

abnormal mitochondrial physiology (IAGP)

abnormal redox activity (IAGP)

abnormal renal fat pad morphology (IAGP)

abnormal white adipose tissue physiology (IAGP)

abnormal white fat cell differentation (IAGP)

decreased adiponectin level (IAGP)

decreased body weight (IAGP)

decreased circulating adiponectin level (IAGP)

decreased circulating triglyceride level (IAGP)

decreased fatty acid oxidation (IAGP)

impaired glucose tolerance (IAGP)

increased body fat mass (IAGP)

increased body weight (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating insulin level (IAGP)

increased fasting circulating glucose level (IAGP)

increased white adipose tissue amount (IAGP)

increased white fat cell size (IAGP)

insulin resistance (IAGP)

lung inflammation (IAGP)

oxidative stress (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat.	Kotoh J, etal., J Vet Med Sci. 2016 Aug 11.
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2210385	PMID:2583515	PMID:7733872	PMID:7751935	PMID:8344960	PMID:8360158	PMID:8496166	PMID:8884266	PMID:9070923	PMID:9636075	PMID:10349636	PMID:10501973
PMID:10548725	PMID:10632718	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11591653	PMID:11973313	PMID:12011429	PMID:12477932	PMID:12861054	PMID:14610273	PMID:14681479
PMID:15489334	PMID:15858817	PMID:16141072	PMID:16141073	PMID:17316558	PMID:17609286	PMID:17634366	PMID:17967808	PMID:18077825	PMID:18426799	PMID:18544346	PMID:18614015
PMID:19086807	PMID:19155266	PMID:19230834	PMID:20716930	PMID:20807727	PMID:20929858	PMID:21267068	PMID:21278135	PMID:21586322	PMID:21873635	PMID:21902452	PMID:22490042
PMID:22681886	PMID:23461683	PMID:23626763	PMID:25224038	PMID:25737280	PMID:25975898	PMID:26199344	PMID:26797130	PMID:27037278	PMID:27106802	PMID:27113764	PMID:27689697
PMID:27998725	PMID:28202400	PMID:28378742	PMID:28432216	PMID:28986255	PMID:30097850	PMID:30333137	PMID:30529270	PMID:30550785	PMID:31781336	PMID:32325033	PMID:34054813
PMID:35248828	PMID:35779442	PMID:36293380

Genomics

Comparative Map Data

Prdx3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	60,852,504 - 60,862,976 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	60,852,489 - 60,862,994 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	60,864,066 - 60,874,538 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	60,864,051 - 60,874,556 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	60,939,969 - 60,950,441 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	60,918,750 - 60,929,177 (-)	NCBI		MGSCv36	mm8
Celera	19	63,076,194 - 63,086,472 (-)	NCBI		Celera
Cytogenetic Map	19	D3	NCBI
cM Map	19	56.52	NCBI

PRDX3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	119,167,720 - 119,178,812 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	119,167,720 - 119,178,812 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	120,927,232 - 120,938,324 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	120,917,205 - 120,928,335 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	120,917,204 - 120,928,335	NCBI
Celera	10	114,656,794 - 114,667,924 (-)	NCBI		Celera
Cytogenetic Map	10	q26.11	NCBI
HuRef	10	114,556,779 - 114,567,810 (-)	NCBI		HuRef
CHM1_1	10	121,211,591 - 121,222,754 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	120,063,136 - 120,074,228 (-)	NCBI		T2T-CHM13v2.0

Prdx3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	260,001,642 - 260,014,064 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	260,001,637 - 260,014,111 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	268,208,324 - 268,220,730 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	274,914,350 - 274,926,756 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	267,568,638 - 267,581,056 (-)	NCBI	Rnor_WKY
Rnor_6.0	1	282,238,774 - 282,251,193 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	282,238,773 - 282,251,257 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	289,577,325 - 289,589,744 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	267,468,371 - 267,481,273 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	267,679,456 - 267,692,358 (-)	NCBI
Celera	1	255,642,701 - 255,655,171 (-)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

Prdx3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	23,638,765 - 23,652,191 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	23,640,775 - 23,651,738 (-)	NCBI	ChiLan1.0	ChiLan1.0

PRDX3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	131,031,795 - 131,042,978 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	115,738,346 - 115,749,482 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	119,162,714 - 119,173,845 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	119,162,714 - 119,173,845 (-)	Ensembl	panpan1.1		panPan2

PRDX3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	29,395,593 - 29,403,745 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	29,395,581 - 29,403,745 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	29,537,872 - 29,546,025 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	29,926,539 - 29,934,692 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	29,926,543 - 29,934,703 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	29,480,901 - 29,489,053 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	29,500,899 - 29,509,052 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	29,694,965 - 29,703,117 (-)	NCBI		UU_Cfam_GSD_1.0

Prdx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	16,954,513 - 16,963,828 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	8,597,388 - 8,606,780 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936486	8,597,479 - 8,606,727 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRDX3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	129,079,051 - 129,090,830 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	129,079,050 - 129,090,790 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	140,603,648 - 140,614,864 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRDX3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	111,957,865 - 111,968,514 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	111,955,952 - 111,968,475 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	73,230,005 - 73,240,570 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prdx3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624737	27,625,120 - 27,635,221 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Prdx3
352 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	172
Count of miRNA genes:	134
Interacting mature miRNAs:	151
Transcripts:	ENSMUST00000025961
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
13506250	Renmq1_m	renal mercury accumulation QTL 1 (mouse)					19	27385594	61385705	Mouse
4141138	Femwf11_m	femur work to failure 11 (mouse)			Not determined			28140348	61420004	Mouse
1300683	Fembm7_m	femoral bone morphometry 7 (mouse)			Not determined		19	30141224	61420004	Mouse
1301942	Pas13_m	pulmonary adenoma susceptibility 13 (mouse)			Not determined		19	30141231	61420004	Mouse
1301410	Cd8mts6_m	CD8 memory T cell subset 6 (mouse)			Not determined		19	30141231	61420004	Mouse
1300856	Nobq2_m	New Zealand obese QTL 2 (mouse)			Not determined		19	30897880	61420004	Mouse
1301741	Lith2_m	lithogenic gene 2 (mouse)			Not determined		19	32992158	61420004	Mouse
1301639	Stnn_m	striatal neuron number (mouse)			Not determined		19	33951952	61420004	Mouse
4141019	Tgq29_m	triglyceride QTL 29 (mouse)			Not determined			34596786	61420004	Mouse
1302170	Tanidd1_m	tally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)			Not determined		19	36752597	61420004	Mouse
4141650	Chldq9_m	cholesterol and HDL QTL 9 (mouse)			Not determined		19	37882982	61420004	Mouse
1301466	T2dm2_m	type 2 diabetes mellitus 2 (mouse)			Not determined		19	38376050	61420004	Mouse
1302104	Lfp1_m	long free running period 1 (mouse)			Not determined		19	39184064	61420004	Mouse
10043896	Bw21_m	body weight QTL 21 (mouse)			Not determined		19	39596066	61420004	Mouse
1300585	Pgia12_m	proteoglycan induced arthritis 12 (mouse)			Not determined		19	42586859	61420004	Mouse

Markers in Region

AW822249

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	19	60,864,162 - 60,864,443	UniSTS	GRCm38
MGSCv37	19	60,940,065 - 60,940,346	UniSTS	GRCm37
Celera	19	63,076,290 - 63,076,558	UniSTS
Cytogenetic Map	19	D3	UniSTS
cM Map	19	50.0	UniSTS
Whitehead/MRC_RH	19	654.83	UniSTS

M28723

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	19	60,864,441 - 60,864,539	UniSTS	GRCm38
MGSCv37	19	60,940,344 - 60,940,442	UniSTS	GRCm37
Celera	19	63,076,556 - 63,076,654	UniSTS
Cytogenetic Map	19	D3	UniSTS
cM Map	19	50.0	UniSTS
Whitehead/MRC_RH	19	660.24	UniSTS

Prdx3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	19	60,864,273 - 60,864,409	UniSTS	GRCm38
MGSCv37	19	60,940,176 - 60,940,312	UniSTS	GRCm37
Celera	19	63,076,388 - 63,076,524	UniSTS
Cytogenetic Map	19	D3	UniSTS
cM Map	19	50.0	UniSTS

Prdx3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	19	D3	UniSTS
cM Map	19	50.0	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_007452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC102432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF333976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH009229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK002448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BB372344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC005626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY318475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M28723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M28725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000025961 ⟹ ENSMUSP00000025961

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	19	60,852,489 - 60,862,994 (-)	Ensembl
GRCm38.p6 Ensembl	19	60,864,051 - 60,874,556 (-)	Ensembl

RefSeq Acc Id:

NM_007452 ⟹ NP_031478

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	19	60,852,504 - 60,862,976 (-)	NCBI
GRCm38	19	60,864,066 - 60,874,538 (-)	ENTREZGENE
MGSCv37	19	60,939,969 - 60,950,441 (-)	RGD
Celera	19	63,076,194 - 63,086,472 (-)	RGD
cM Map	19		ENTREZGENE

Sequence:

show sequence

AGAAGCACACCCGGCGTGCTCCGGCTACTCCTCGGTATCTCCGCCTATCGTGCCTCTTGCGTGC
TCTGAAGATGGCGGCAGCTGCGGGAAGGTTGCTCTGGTCCTCGGTTGCTCGTCATGCAAGTGCT
ATTTCCCGGAGTATTTCTGCCTCAACAGTTCTTAGGCCTGTTGCTTCTAGAAGAACCTGTTTGA
CAGACATACTGTGGTCTGCCTCTGCCCAAGGAAAGTCAGCCTTTAGCACCAGTTCCTCTTTCCA
CACCCCTGCTGTCACCCAGCACGCGCCCTATTTTAAAGGTACTGCTGTTGTCAATGGAGAGTTC
AAAGAGCTGAGTCTCGACGACTTTAAGGGAAAATACTTGGTGCTTTTCTTCTACCCTTTGGATT
TCACATTTGTGTGTCCTACAGAAATTGTTGCTTTCAGTGACAAAGCCAATGAATTTCATGATGT
AAACTGTGAAGTAGTTGCAGTTTCAGTGGATTCCCACTTCAGTCATCTTGCCTGGATCAACACA
CCAAGAAAGAATGGTGGTTTGGGCCACATGAACATCACACTGTTGTCGGATATAACTAAGCAGA
TATCCCGAGACTACGGAGTGCTGTTGGAAAGTGCTGGCATTGCACTCAGAGGTCTCTTCATTAT
TGACCCTAATGGTGTCGTCAAGCACCTGAGTGTCAACGACCTTCCGGTGGGCCGCAGTGTGGAA
GAAACACTCCGTTTGGTAAAGGCGTTCCAGTTTGTGGAGACCCATGGAGAAGTCTGCCCAGCCA
ACTGGACACCAGAGTCCCCTACGATCAAGCCAAGTCCAACAGCTTCCAAAGAGTACTTTGAGAA
GGTCCATCAGTAGGCCATCCTATGTCTGCAATTACCTGAAGCTTTTCAGGCCAAAAAAGAGCCC
CAGCTGGAATCCTTCCAATGCCTTGAAGATTATTTATAGAATGGCAAAACCTCATTATGTTTGT
GTTTATAAGTACTGCTCCACAGGCTTTGTAATTTTAAGACAGGTTCAGGCTCTCTAAAGGTGGC
TAGCTGCTTCCATAGCTGCTCTTACTAGGGACTTCTTGATGGCTAACCAATTCTCCCCGAGTGC
TTGGCCCCCATTTCTTGGATCATGTCCTTAGAGGGTAAGCATTCTTTCCCTTAGCCTGCCCTGA
ACCTTGGTCTACAGTGAAGTAGCACATAGTGCCAGTACTTGGTGAAATGAAGTAGCACATAGCA
CCAGCACTTAATGGAAGCTTCTGATCAAGGTCCTAAAATTTCCTCTTGAATTTTTGTGAATTAT
GCTGAATTTCCCTTTTTTTTTTTTTTAAATTGTAGTCATTAACTCACAGTGTCCTTGTGTGTTC
TGAGGTATTGAAGAGGTATAATCATGAAGGACTATGTCTAATCCATAAGTCATTTTCTTCAAGA
GCTGGATATATAGAATAAAAATAAACATTAAAATATT

hide sequence

Protein Sequences


Protein RefSeqs	NP_031478	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA39524	(Get FASTA)	NCBI Sequence Viewer
	AAA39525	(Get FASTA)	NCBI Sequence Viewer
	AAF63705	(Get FASTA)	NCBI Sequence Viewer
	AAH05626	(Get FASTA)	NCBI Sequence Viewer
	AAM74564	(Get FASTA)	NCBI Sequence Viewer
	BAB22108	(Get FASTA)	NCBI Sequence Viewer
	EDL01849	(Get FASTA)	NCBI Sequence Viewer
	P20108	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_031478 ⟸ NM_007452
- Peptide Label:	precursor
- UniProtKB:	P20108 (UniProtKB/Swiss-Prot), A0A8C6I8S9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAAAGRLLWSSVARHASAISRSISASTVLRPVASRRTCLTDILWSASAQGKSAFSTSSSFHTP AVTQHAPYFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNC EVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDITKQISRDYGVLLESAGIALRGLFIIDP NGVVKHLSVNDLPVGRSVEETLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVH Q hide sequence

RefSeq Acc Id:

ENSMUSP00000025961 ⟸ ENSMUST00000025961

Protein Domains

Thioredoxin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P20108-F1-model_v2	AlphaFold	P20108	1-257	view protein structure

Promoters

RGD ID:

13679922

Promoter ID:

EPDNEW_M24109

Type:

initiation region

Name:

Prdx3_1

Description:

Mus musculus peroxiredoxin 3 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	19	60,874,480 - 60,874,540	EPDNEW

RGD ID:

6830329

Promoter ID:

MM_KWN:27485

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000050247

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	19	60,950,114 - 60,950,614 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:88034	AgrOrtholog
Ensembl Genes	ENSMUSG00000024997	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000025961	ENTREZGENE
	ENSMUSP00000025961.7	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000025961	ENTREZGENE
	ENSMUST00000025961.7	UniProtKB/Swiss-Prot
Gene3D-CATH	Glutaredoxin	UniProtKB/Swiss-Prot
InterPro	AhpC/TSA	UniProtKB/Swiss-Prot
	Peroxiredoxin_C	UniProtKB/Swiss-Prot
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot
	Thioredoxin_domain	UniProtKB/Swiss-Prot
KEGG Report	mmu:11757	UniProtKB/Swiss-Prot
MGD	MGI:88034	ENTREZGENE
NCBI Gene	11757	ENTREZGENE
PANTHER	THIOREDOXIN PEROXIDASE	UniProtKB/Swiss-Prot
	THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL	UniProtKB/Swiss-Prot
Pfam	1-cysPrx_C	UniProtKB/Swiss-Prot
	AhpC-TSA	UniProtKB/Swiss-Prot
PhenoGen	Prdx3	PhenoGen
PROSITE	THIOREDOXIN_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot
UniProt	A0A8C6I8S9	ENTREZGENE
	P20108	ENTREZGENE, UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Mammalian Phenotype

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