Ntf3 (neurotrophin 3) - Rat Genome Database

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Gene: Ntf3 (neurotrophin 3) Mus musculus
Symbol: Ntf3
Name: neurotrophin 3
RGD ID: 732369
Description: Predicted to enable nerve growth factor binding activity; nerve growth factor receptor binding activity; and receptor ligand activity. Acts upstream of or within several processes, including nervous system development; neuromuscular synaptic transmission; and positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study atrial heart septal defect 1 and tetralogy of Fallot. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI316846; AI835689; HDNF; nerve growth factor 2; neurotrophic factor; neurotrophin-3; NGF-2; NT; NT-; Nt3; Ntf-; Ntf-3
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396126,078,375 - 126,143,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,078,375 - 126,143,873 (-)EnsemblGRCm39 Ensembl
GRCm386126,101,412 - 126,166,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,101,412 - 126,166,910 (-)EnsemblGRCm38mm10GRCm38
MGSCv376126,051,430 - 126,116,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366126,067,031 - 126,130,540 (-)NCBIMGSCv36mm8
Celera6127,765,447 - 127,832,752 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map660.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,7-dihydropurine-6-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-aminonicotinamide  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
androgen antagonist  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
cyclophosphamide  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (ISO)
Dimaprit  (ISO)
dopamine  (ISO)
endosulfan  (ISO)
famotidine  (ISO)
formaldehyde  (EXP)
furan  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
imetit  (ISO)
indole-3-methanol  (ISO)
isoprenaline  (EXP)
ketamine  (ISO)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
LY294002  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (ISO)
mepyramine  (ISO)
mercaptopurine  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
purine-6-thiol  (ISO)
scopolamine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
Thioperamide  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimethyltin  (EXP)
triprolidine  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
wortmannin  (EXP)
XL147  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrioventricular valve morphology  (IAGP)
abnormal atrium myocardial trabeculae morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cranial ganglia morphology  (IAGP)
abnormal cutaneous/subcutaneous mechanoreceptor morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal eating behavior  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal food intake  (IAGP)
abnormal gait  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle size  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart valve morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal limb posture  (IAGP)
abnormal Merkel's receptor morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal muscle spindle morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal nervous system tract morphology  (IAGP)
abnormal noradrenaline level  (IAGP)
abnormal posture  (IAGP)
abnormal proprioceptive neuron morphology  (IAGP)
abnormal pulmonary vein morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal sensory capabilities/reflexes/nociception  (IAGP)
abnormal sensory ganglion morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal sensory neuron morphology  (IAGP)
abnormal sinus venosus morphology  (IAGP)
abnormal somatic nervous system morphology  (IAGP)
abnormal stellate ganglion morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal suckling reflex  (IAGP)
abnormal vestibular ganglion morphology  (IAGP)
abnormal vestibulocochlear ganglion morphology  (IAGP)
abnormal vision  (IAGP)
absent golgi tendon organ  (IAGP)
absent muscle spindles  (IAGP)
absent proprioceptive neurons  (IAGP)
aneurysm  (IAGP)
anomalous pulmonary venous connection  (IAGP)
ataxia  (IAGP)
athetotic walking movements  (IAGP)
atrium myocardium hypoplasia  (IAGP)
cardiac hypertrophy  (IAGP)
cochlear ganglion hypoplasia  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CNS synapse formation  (IAGP)
decreased heart rate  (IAGP)
decreased locomotor activity  (IAGP)
decreased motor neuron number  (IAGP)
decreased muscle spindle number  (IAGP)
decreased neuron number  (IAGP)
decreased sensory neuron number  (IAGP)
decreased spinal cord size  (IAGP)
decreased survivor rate  (IAGP)
dilated heart atrium  (IAGP)
dilated heart right ventricle  (IAGP)
dilated pulmonary artery  (IAGP)
dystonia  (IAGP)
enlarged heart  (IAGP)
female infertility  (IAGP)
heart right ventricle outflow tract stenosis  (IAGP)
hunched posture  (IAGP)
impaired limb coordination  (IAGP)
increased heart right ventricle size  (IAGP)
limb grasping  (IAGP)
muscle spasm  (IAGP)
muscular atrophy  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ostium secundum atrial septal defect  (IAGP)
overriding aortic valve  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosus  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature closure of the ductus arteriosus  (IAGP)
pulmonary alveolar hemorrhage  (IAGP)
pulmonary edema  (IAGP)
pulmonary valve stenosis  (IAGP)
sinus venosus hypoplasia  (IAGP)
small cochlear ganglion  (IAGP)
small dorsal root ganglion  (IAGP)
small geniculate ganglion  (IAGP)
small L4 dorsal root ganglion  (IAGP)
small L5 dorsal root ganglion  (IAGP)
small mesencephalic trigeminal nucleus  (IAGP)
small nodose ganglion  (IAGP)
small petrosal ganglion  (IAGP)
small superior cervical ganglion  (IAGP)
small trigeminal ganglion  (IAGP)
thick aortic valve cusps  (IAGP)
thick mitral valve cusps  (IAGP)
thick pulmonary valve cusps  (IAGP)
vascular smooth muscle hypotrophy  (IAGP)

References - curated
# Reference Title Reference Citation
1. Increased neurotrophin production in a Penicillium chrysogenum-induced allergic asthma model in mice. Chung YJ, etal., J Toxicol Environ Health A. 2007 Jun;70(12):1020-6.
2. Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression. Dagnell C, etal., Respir Res. 2010 Nov 8;11:156.
3. A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells. ElShamy WM and Ernfors P, Neuron 1996 May;16(5):963-72.
4. Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease. Groneberg DA, etal., Biol Chem. 2005 Jan;386(1):53-9.
5. Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus. Hochhaus F, etal., BMC Pediatr 2001;1(1):2. Epub 2001 Aug 24.
6. Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese. Kunugi H, etal., Neurosci Lett 1998 Jan 23;241(1):65-7.
7. MGDs mouse GO annotations MGD data from the GO Consortium
9. Chronic exposure to ethanol alters neurotrophin content in the basal forebrain-cortex system in the mature rat: effects on autocrine-paracrine mechanisms. Miller MW and Mooney SM, J Neurobiol. 2004 Sep 15;60(4):490-8. doi: 10.1002/neu.20059.
10. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Mitsui T, etal., Exp Neurol. 2005 Aug;194(2):410-31.
11. The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics. Noga O, etal., Clin Exp Allergy. 2001 Dec;31(12):1906-12.
12. Environmental enrichment alters neurotrophin levels after fetal alcohol exposure in rats. Parks EA, etal., Alcohol Clin Exp Res. 2008 Oct;32(10):1741-51. doi: 10.1111/j.1530-0277.2008.00759.x. Epub 2008 Jul 24.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. Ricci A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):186-94.
18. Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus. Risbud RM, etal., Brain Res. 2011 Nov 18;1424:53-9. doi: 10.1016/j.brainres.2011.09.039. Epub 2011 Sep 24.
19. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Silva-Peña D, etal., Addict Biol. 2019 Sep;24(5):1019-1033. doi: 10.1111/adb.12668. Epub 2018 Sep 12.
20. Alterations in neurotrophin and neurotrophin receptor gene expression patterns in the rat central nervous system following perinatal Borna disease virus infection. Zocher M, etal., J Neurovirol. 2000 Dec;6(6):462-77.
Additional References at PubMed
PMID:925010   PMID:1645620   PMID:1688327   PMID:1889807   PMID:1967980   PMID:2206535   PMID:2314473   PMID:7514502   PMID:7566642   PMID:7601910   PMID:7605630   PMID:7712171  
PMID:7841657   PMID:7896277   PMID:7952296   PMID:7957235   PMID:7991545   PMID:8050368   PMID:8050673   PMID:8083730   PMID:8113808   PMID:8117293   PMID:8163724   PMID:8187631  
PMID:8208292   PMID:8318738   PMID:8625800   PMID:8642077   PMID:8645564   PMID:8707832   PMID:8756286   PMID:8764654   PMID:8789944   PMID:8809809   PMID:8841198   PMID:8861722  
PMID:8875319   PMID:8889548   PMID:8922422   PMID:8982156   PMID:8989769   PMID:9118804   PMID:9141083   PMID:9169087   PMID:9184113   PMID:9214629   PMID:9217002   PMID:9236232  
PMID:9331334   PMID:9331344   PMID:9348335   PMID:9364058   PMID:9405689   PMID:9547240   PMID:9579688   PMID:9591544   PMID:9640332   PMID:9699730   PMID:9736028   PMID:9736654  
PMID:9786980   PMID:9856457   PMID:9880597   PMID:9920667   PMID:10188952   PMID:10195193   PMID:10207144   PMID:10217270   PMID:10334567   PMID:10349636   PMID:10357900   PMID:10384880  
PMID:10412058   PMID:10464095   PMID:10491653   PMID:10492008   PMID:10507553   PMID:10549663   PMID:10626843   PMID:10631167   PMID:10677035   PMID:10681461   PMID:10712646   PMID:10756065  
PMID:10822262   PMID:10842362   PMID:10888742   PMID:10934262   PMID:10985348   PMID:11015591   PMID:11042159   PMID:11076861   PMID:11113302   PMID:11152640   PMID:11217851   PMID:11241389  
PMID:11331378   PMID:11356021   PMID:11466433   PMID:11487640   PMID:11526474   PMID:11553291   PMID:11684666   PMID:11794730   PMID:11810635   PMID:11848682   PMID:11891988   PMID:11978828  
PMID:12117822   PMID:12122447   PMID:12141445   PMID:12151540   PMID:12175867   PMID:12194821   PMID:12194867   PMID:12441052   PMID:12466851   PMID:12477932   PMID:12485622   PMID:12606390  
PMID:12620975   PMID:12741988   PMID:12774239   PMID:12810600   PMID:12815759   PMID:12917366   PMID:12941481   PMID:14614961   PMID:14625444   PMID:14648839   PMID:14681479   PMID:14697654  
PMID:14715936   PMID:14973275   PMID:14991566   PMID:15014133   PMID:15044550   PMID:15067320   PMID:15081586   PMID:15126035   PMID:15140017   PMID:15147765   PMID:15260993   PMID:15342740  
PMID:15376326   PMID:15465029   PMID:15470130   PMID:15489334   PMID:15496676   PMID:15497153   PMID:15550985   PMID:15708491   PMID:15817220   PMID:15837802   PMID:15844198   PMID:15869506  
PMID:15950786   PMID:16101019   PMID:16141072   PMID:16141073   PMID:16142215   PMID:16183241   PMID:16193506   PMID:16217617   PMID:16315017   PMID:16516892   PMID:16537572   PMID:16602821  
PMID:16630588   PMID:16673387   PMID:16705139   PMID:16953113   PMID:17013886   PMID:17015430   PMID:17049175   PMID:17081696   PMID:17101855   PMID:17206617   PMID:17218417   PMID:17329422  
PMID:17409232   PMID:17442747   PMID:17466268   PMID:17488777   PMID:17897394   PMID:18080292   PMID:18162309   PMID:18287559   PMID:18305247   PMID:18438927   PMID:18511043   PMID:18579678  
PMID:18657279   PMID:18703118   PMID:18752272   PMID:18925574   PMID:19173033   PMID:19291307   PMID:19342646   PMID:19350645   PMID:19369542   PMID:19409883   PMID:19610111   PMID:19692592  
PMID:19755105   PMID:19778585   PMID:19838179   PMID:19915564   PMID:19936227   PMID:20092553   PMID:20109530   PMID:20178830   PMID:20188708   PMID:20308569   PMID:20360537   PMID:20387078  
PMID:20565848   PMID:20626560   PMID:20975932   PMID:21146598   PMID:21165786   PMID:21261755   PMID:21267068   PMID:21527636   PMID:21529369   PMID:21787840   PMID:21873635   PMID:21880927  
PMID:22031887   PMID:22292060   PMID:22318233   PMID:22487415   PMID:22627288   PMID:22682244   PMID:22871470   PMID:22906231   PMID:23029089   PMID:23224557   PMID:23261763   PMID:23300470  
PMID:23416450   PMID:23426664   PMID:23522042   PMID:23525041   PMID:23614607   PMID:23671637   PMID:23733189   PMID:23954828   PMID:24068045   PMID:24190235   PMID:24224958   PMID:24288162  
PMID:24454677   PMID:24718611   PMID:24923991   PMID:24952961   PMID:24978398   PMID:25043422   PMID:25085976   PMID:25270201   PMID:25329343   PMID:25359972   PMID:25525881   PMID:25852547  
PMID:26371510   PMID:26671461   PMID:26758845   PMID:27076431   PMID:27434667   PMID:27720999   PMID:28461220   PMID:28588446   PMID:28706241   PMID:29031500   PMID:29453932   PMID:29523879  
PMID:29549646   PMID:29615468   PMID:30071216   PMID:30594389   PMID:31515492   PMID:31653916   PMID:31850343   PMID:31862889   PMID:32708917   PMID:33655887   PMID:34321664   PMID:34321999  
PMID:34508100   PMID:34599305   PMID:36765071   PMID:37253090  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396126,078,375 - 126,143,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,078,375 - 126,143,873 (-)EnsemblGRCm39 Ensembl
GRCm386126,101,412 - 126,166,772 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,101,412 - 126,166,910 (-)EnsemblGRCm38mm10GRCm38
MGSCv376126,051,430 - 126,116,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366126,067,031 - 126,130,540 (-)NCBIMGSCv36mm8
Celera6127,765,447 - 127,832,752 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map660.45NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38125,430,332 - 5,495,299 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl125,432,108 - 5,521,536 (+)EnsemblGRCh38hg38GRCh38
GRCh37125,541,274 - 5,604,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,411,541 - 5,474,726 (+)NCBINCBI36Build 36hg18NCBI36
Build 34125,473,526 - 5,474,725NCBI
Celera127,162,184 - 7,225,194 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef125,455,606 - 5,458,036 (+)NCBIHuRef
CHM1_1125,540,527 - 5,604,287 (+)NCBICHM1_1
T2T-CHM13v2.0125,437,400 - 5,502,089 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84160,601,161 - 160,670,623 (-)NCBIGRCr8
mRatBN7.24158,914,984 - 158,984,453 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4158,914,957 - 158,984,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4165,144,795 - 165,214,257 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04160,927,698 - 160,997,163 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04159,561,745 - 159,631,144 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04158,636,883 - 158,705,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4158,636,884 - 158,705,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04225,638,801 - 225,707,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,435,781 - 162,506,961 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14162,680,717 - 162,751,897 (-)NCBI
Celera4147,640,921 - 147,710,546 (-)NCBICelera
Cytogenetic Map4q42NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554133,207,123 - 3,273,491 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554133,207,669 - 3,273,371 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21010,982,176 - 11,046,479 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,978,933 - 11,043,237 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,551,734 - 5,615,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1125,470,093 - 5,534,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl125,530,508 - 5,533,989 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12739,383,017 - 39,454,613 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2739,383,152 - 39,454,601 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha277,231,693 - 7,233,370 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02739,739,752 - 39,811,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2739,739,747 - 39,811,226 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12739,608,720 - 39,679,940 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02739,650,338 - 39,721,747 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,639,885 - 6,711,187 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945103,495,858 - 103,555,782 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367092,163,334 - 2,223,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367092,163,510 - 2,223,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl565,052,519 - 65,123,788 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1565,052,608 - 65,122,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2567,204,186 - 67,204,959 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1115,477,208 - 5,542,404 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660632,690,949 - 2,765,784 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248602,416,503 - 2,479,225 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248602,416,448 - 2,479,216 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ntf3
2123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:328
Count of miRNA genes:133
Interacting mature miRNAs:151
Transcripts:ENSMUST00000050484, ENSMUST00000112244
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386126,101,532 - 126,101,732UniSTSGRCm38
MGSCv376126,051,550 - 126,051,750UniSTSGRCm37
Celera6127,765,567 - 127,765,767UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386126,101,490 - 126,101,573UniSTSGRCm38
MGSCv376126,051,508 - 126,051,591UniSTSGRCm37
Celera6127,765,525 - 127,765,608UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386126,148,758 - 126,148,879UniSTSGRCm38
MGSCv376126,098,776 - 126,098,897UniSTSGRCm37
Celera6127,814,774 - 127,814,887UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.0UniSTS
Whitehead Genetic649.2UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386126,101,448 - 126,102,471UniSTSGRCm38
MGSCv376126,051,466 - 126,052,489UniSTSGRCm37
Celera6127,765,483 - 127,766,506UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386126,101,399 - 126,101,550UniSTSGRCm38
MGSCv376126,051,417 - 126,051,568UniSTSGRCm37
Celera6127,765,434 - 127,765,585UniSTS
Cytogenetic Map6F3UniSTS
cM Map661.0UniSTS



RefSeq Acc Id: ENSMUST00000050484   ⟹   ENSMUSP00000052302
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6126,078,375 - 126,143,873 (-)Ensembl
GRCm38.p6 Ensembl6126,101,412 - 126,166,910 (-)Ensembl
RefSeq Acc Id: ENSMUST00000112244   ⟹   ENSMUSP00000107863
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6126,078,375 - 126,143,678 (-)Ensembl
GRCm38.p6 Ensembl6126,101,412 - 126,166,715 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204542   ⟹   ENSMUSP00000144828
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6126,078,375 - 126,141,923 (-)Ensembl
GRCm38.p6 Ensembl6126,101,412 - 126,164,960 (-)Ensembl
RefSeq Acc Id: NM_001164034   ⟹   NP_001157506
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm396126,078,375 - 126,143,703 (-)NCBI
GRCm386126,101,412 - 126,166,744 (-)NCBI
MGSCv376126,051,430 - 126,116,762 (-)RGD
Celera6127,765,447 - 127,832,752 (-)RGD
RefSeq Acc Id: NM_001164035   ⟹   NP_001157507
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm396126,078,375 - 126,141,919 (-)NCBI
GRCm386126,101,412 - 126,164,960 (-)NCBI
MGSCv376126,051,430 - 126,116,762 (-)RGD
Celera6127,765,447 - 127,832,752 (-)RGD
RefSeq Acc Id: NM_001410128   ⟹   NP_001397057
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm396126,078,375 - 126,140,862 (-)NCBI
RefSeq Acc Id: NM_001410129   ⟹   NP_001397058
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm396126,078,375 - 126,143,703 (-)NCBI
RefSeq Acc Id: NM_008742   ⟹   NP_032768
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm396126,078,375 - 126,143,703 (-)NCBI
GRCm386126,101,412 - 126,166,744 (-)NCBI
MGSCv376126,051,430 - 126,116,762 (-)RGD
Celera6127,765,447 - 127,832,752 (-)RGD
RefSeq Acc Id: NP_032768   ⟸   NM_008742
- Peptide Label: isoform b preproprotein
- UniProtKB: P20181 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001157506   ⟸   NM_001164034
- Peptide Label: isoform a
- UniProtKB: Q3V1A4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157507   ⟸   NM_001164035
- Peptide Label: isoform a
- UniProtKB: Q3V1A4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000107863   ⟸   ENSMUST00000112244
RefSeq Acc Id: ENSMUSP00000144828   ⟸   ENSMUST00000204542
RefSeq Acc Id: ENSMUSP00000052302   ⟸   ENSMUST00000050484
RefSeq Acc Id: NP_001397058   ⟸   NM_001410129
- Peptide Label: isoform c
RefSeq Acc Id: NP_001397057   ⟸   NM_001410128
- Peptide Label: isoform b preproprotein
- UniProtKB: P20181 (UniProtKB/Swiss-Prot)
Protein Domains
Nerve growth factor-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20181-F1-model_v2 AlphaFold P20181 1-258 view protein structure

RGD ID:6891080
Promoter ID:EPDNEW_M8991
Type:multiple initiation site
Description:Mus musculus neurotrophin 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8992  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm386126,164,956 - 126,165,016EPDNEW
RGD ID:6891082
Promoter ID:EPDNEW_M8992
Type:multiple initiation site
Description:Mus musculus neurotrophin 3 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8991  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm386126,166,740 - 126,166,800EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97380 AgrOrtholog
Ensembl Genes ENSMUSG00000049107 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050484 ENTREZGENE
  ENSMUST00000050484.9 UniProtKB/Swiss-Prot
  ENSMUST00000112244.8 UniProtKB/TrEMBL
  ENSMUST00000204542.3 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrophin-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTF3_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11589:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTF3_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ntf3 PhenoGen
PIRSF NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL