Fgfr1 (fibroblast growth factor receptor 1) - Rat Genome Database

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Gene: Fgfr1 (fibroblast growth factor receptor 1) Mus musculus
Symbol: Fgfr1
Name: fibroblast growth factor receptor 1
RGD ID: 732291
Description: Enables SH2 domain binding activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor activity. Involved in several processes, including cementum mineralization; diphosphate metabolic process; and forebrain development. Acts upstream of or within several processes, including ear development; positive regulation of cell population proliferation; and regulation of animal organ morphogenesis. Located in plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Pfeiffer syndrome; atopic dermatitis; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW208770; basic fibroblast growth factor receptor 1; bFGF-R-1; c-fgr; Ea; Eask; FGFR; Fgfr-; Fgfr-1; FGFR-I; FLG; Flt-; Flt-2; Fr; Fr1; Hs; Hspy; MFR; proto-oncogene c-Fgr
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39826,008,808 - 26,067,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,003,670 - 26,065,734 (+)EnsemblGRCm39 Ensembl
GRCm38825,518,759 - 25,575,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,513,654 - 25,575,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,629,244 - 26,686,186 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,997,826 - 27,039,466 (+)NCBIMGSCv36mm8
Celera826,986,822 - 27,044,074 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acrocephalosyndactylia  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute myeloid leukemia  (ISO)
Acute Otitis Media  (IEP)
Alzheimer's disease  (ISO)
amenorrhea  (ISO)
atypical chronic myeloid leukemia  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
cerebellar hypoplasia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Congenital Foot Deformities  (ISO)
Craniofacial Abnormalities  (IMP,ISO)
craniosynostosis  (IMP,ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Delayed Puberty  (ISO)
demyelinating disease  (IEP)
depressive disorder  (ISO)
disease of cellular proliferation  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
Experimental Arthritis  (IMP)
Experimental Leukemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
Femoral Fractures  (ISO)
fibrolamellar carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
heart valve disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 54  (ISO)
high grade glioma  (ISO)
holoprosencephaly  (ISO)
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip/Palate  (ISO)
Hypoglossal Nerve Injuries  (ISO)
hypogonadism  (ISO)
hypogonadotropic hypogonadism  (ISO)
hypogonadotropic hypogonadism 2 with or without anosmia  (ISO)
hypogonadotropic hypogonadism 7 with or without anosmia  (ISO)
Hypogonadotropic Hypogonadism and Anosmia, Autosomal Dominant  (ISO)
infertility  (ISO)
Jackson-Weiss syndrome  (ISO)
Kallmann syndrome  (ISO)
Klinefelter syndrome  (ISO)
limb ischemia  (ISO)
Liver Metastasis  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
Martsolf syndrome 1  (ISO)
medulloblastoma  (ISO)
mesangial proliferative glomerulonephritis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP)
mouth disease  (ISO)
myeloid leukemia  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (IEP)
Neointima  (ISO)
Neoplasm Metastasis  (IMP)
neuroblastoma  (ISO)
Nonsyndromic Trigonocephaly  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (IMP)
osteoglophonic dysplasia  (ISO)
otitis media  (IAGP)
paraplegia  (ISO)
Penetrating Head Injuries  (ISO)
Pfeiffer syndrome  (IAGP,ISO)
pilomyxoid astrocytoma  (ISO)
prostate adenocarcinoma  (IDA,IEP)
prostate cancer  (ISO)
prostate carcinoma in situ  (IDA)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
retinal detachment  (ISO)
rosette-forming glioneuronal tumor  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
squamous cell carcinoma  (ISO)
Stargardt Disease 3  (IEP)
steatotic liver disease  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
Trigonocephaly 1  (ISO)
Tympanic Membrane Perforation  (ISO)
type 2 diabetes mellitus  (IMP)
umbilical hernia  (IMP)
vascular dementia  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
AP20187  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (EXP,ISO)
clothianidin  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (EXP)
coumestrol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dimethylarsinous acid  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
ethanol  (EXP,ISO)
ethyl trans-caffeate  (ISO)
fenamidone  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-tocopherol  (ISO)
heparan sulfate  (EXP,ISO)
heparin  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (EXP)
isotretinoin  (ISO)
kainic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
lenalidomide  (ISO)
malathion  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
orantinib  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraoxon  (ISO)
PD-166866  (ISO)
PD173074  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
peroxynitrous acid  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
pomalidomide  (ISO)
ponatinib  (ISO)
resveratrol  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tocopherol  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triptonide  (EXP)
urea  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IGI)
auditory receptor cell development  (IMP)
blood vessel morphogenesis  (IMP)
brain development  (IMP)
branching involved in salivary gland morphogenesis  (IMP)
calcium ion homeostasis  (IGI)
cardiac muscle cell proliferation  (IGI)
cell maturation  (IMP)
cell population proliferation  (IGI)
cell projection assembly  (IDA,IMP)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to histamine  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cementum mineralization  (IDA,IMP)
central nervous system neuron development  (ISO)
chondrocyte differentiation  (IGI)
diphosphate metabolic process  (IDA,IMP)
ear development  (IMP)
embryonic limb morphogenesis  (IMP)
epithelial to mesenchymal transition  (ISO)
female pregnancy  (ISO)
fibroblast growth factor receptor signaling pathway  (IGI,ISO)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  (IMP)
gene expression  (IDA,IMP)
generation of neurons  (IMP)
in utero embryonic development  (IGI)
inner ear morphogenesis  (IMP)
lung development  (IGI,IMP)
lung-associated mesenchyme development  (IGI)
mesenchymal cell differentiation  (IGI)
mesenchymal cell proliferation  (IGI,IMP)
midbrain development  (IGI,IMP)
middle ear morphogenesis  (IMP)
motogenic signaling involved in postnatal olfactory bulb interneuron migration  (ISO)
negative regulation of fibroblast growth factor production  (IGI)
negative regulation of gene expression  (IGI,IMP)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
neuron projection development  (IGI,ISO)
orbitofrontal cortex development  (IMP)
organ induction  (IMP)
outer ear morphogenesis  (IMP)
paraxial mesoderm development  (IGI)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cardiac muscle cell proliferation  (IGI,ISO)
positive regulation of cell cycle  (IMP)
positive regulation of cell differentiation  (IBA)
positive regulation of cell population proliferation  (IDA,IGI,IMP,ISO,TAS)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of hepatic stellate cell activation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (IGI)
positive regulation of mesenchymal cell proliferation  (IGI,IMP,ISO)
positive regulation of mitotic cell cycle DNA replication  (IDA)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (IGI,ISO)
positive regulation of parathyroid hormone secretion  (IGI)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of stem cell proliferation  (IGI,IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
postnatal olfactory bulb interneuron migration  (ISO)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IDA)
regulation of cell population proliferation  (ISO)
regulation of epithelial cell proliferation  (IMP)
regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IMP)
regulation of gene expression  (IMP)
regulation of lateral mesodermal cell fate specification  (IGI)
regulation of phosphate transport  (IGI)
regulation of phosphorus metabolic process  (IGI)
regulation of postsynaptic density assembly  (IDA,IMP)
regulation of stem cell proliferation  (ISO)
response to ischemia  (ISO)
response to nutrient levels  (ISO)
response to sodium phosphate  (IDA,IGI)
salivary gland morphogenesis  (IMP)
sensory perception of sound  (IMP)
stem cell differentiation  (IGI)
stem cell population maintenance  (ISO)
stem cell proliferation  (IGI,IMP)
tangential migration from the subventricular zone to the olfactory bulb  (ISO)
ureteric bud development  (IGI)
vasculogenesis involved in coronary vascular morphogenesis  (TAS)
ventricular zone neuroblast division  (IMP)
vitamin D3 metabolic process  (IGI)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alisphenoid bone morphology  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal auditory bulla morphology  (IAGP)
abnormal axial skeleton morphology  (IAGP)
abnormal axon guidance  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal blastocyst morphology  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum vermis morphology  (IAGP)
abnormal cervical axis morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear hair cell development  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear nerve compound action potential  (IAGP)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal dorsal telencephalic commissure morphology  (IAGP)
abnormal ear physiology  (IAGP)
abnormal ear position  (IEA)
abnormal ear shape  (IAGP)
abnormal egg cylinder morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo size  (IEA)
abnormal embryonic autopod plate morphology  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal forelimb bud morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal forelimb stylopod morphology  (IAGP)
abnormal forelimb zeugopod morphology  (IAGP)
abnormal frontal lobe morphology  (IAGP)
abnormal gait  (IAGP)
abnormal gastrulation  (IAGP)
abnormal gastrulation movements  (IAGP)
abnormal hair cycle  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal head fold morphology  (IAGP)
abnormal head mesenchyme morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal hippocampal commissure morphology  (IAGP)
abnormal hyoid bone lesser horn morphology  (IAGP)
abnormal incudostapedial joint morphology  (IAGP)
abnormal incus body morphology  (IAGP)
abnormal incus long process morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal incus short process morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal lateral plate mesoderm morphology  (IAGP)
abnormal limb development  (IAGP)
abnormal limb morphology  (IAGP)
abnormal locus ceruleus morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mast cell morphology  (IAGP)
abnormal maxillary-premaxillary suture morphology  (IAGP)
abnormal medial nasal prominence morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal metanephric mesenchyme morphology  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal motor neuron morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neural crest cell morphology  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural fold morphology  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal notochordal process morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal orientation of inner hair cell stereociliary bundles  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal palatal rugae morphology  (IAGP)
abnormal palatine bone morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal pinna reflex  (IAGP)
abnormal posterior primitive streak morphology  (IAGP)
abnormal posture  (IAGP)
abnormal primitive endoderm morphology  (IAGP)
abnormal primitive streak morphology  (IAGP)
abnormal pterygoid bone morphology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal retrotympanic process morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal rostral-caudal body axis extension  (IAGP)
abnormal second pharyngeal arch morphology  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal skin adnexa morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal small intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal snout morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal somite size  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal stapes posterior crus morphology  (IAGP)
abnormal sternocostal joint morphology  (IAGP)
abnormal styloid process morphology  (IAGP)
abnormal tail development  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal thoracic vertebrae morphology  (IAGP)
abnormal tongue position  (IAGP)
abnormal tooth development  (IAGP)
abnormal trochlear nerve morphology  (IAGP)
abnormal ureteric bud elongation  (IAGP)
abnormal ureteric bud invasion  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal urethra urothelium morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal visceral yolk sac endoderm morphology  (IAGP)
abnormal visceral yolk sac mesenchyme morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal viscerocranium morphology  (IAGP)
absent cerebellum vermis  (IAGP)
absent cochlear outer hair cells  (IAGP)
absent gonial bone  (IAGP)
absent hair follicles  (IAGP)
absent incus lenticular process  (IAGP)
absent inferior colliculus  (IAGP)
absent kidney  (IAGP)
absent limb buds  (IAGP)
absent mast cells  (IAGP)
absent metanephric mesenchyme  (IAGP)
absent middle ear ossicles  (IAGP)
absent organ of Corti supporting cells  (IAGP)
absent round window  (IAGP)
absent sebaceous gland  (IAGP)
absent second pharyngeal arch  (IAGP)
absent somites  (IAGP)
absent stapes head  (IAGP)
absent telencephalon  (IAGP)
absent tympanic ring  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
acanthosis  (IAGP)
alopecia  (IAGP)
bleb  (IAGP)
broad limb buds  (IAGP)
caudal body truncation  (IAGP)
cervical vertebral transformation  (IAGP)
choanal atresia  (IAGP)
cleft palate  (IAGP)
cleft primary palate  (IAGP)
cleft secondary palate  (IAGP)
cleft upper lip  (IAGP)
complete cleft palate  (IAGP)
craniofacial asymmetry  (IAGP)
craniorachischisis  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased caudal vertebrae number  (IAGP)
decreased cochlear hair cell number  (IAGP)
decreased cochlear outer hair cell number  (IAGP)
decreased embryo size  (IAGP)
decreased endocochlear potential  (IAGP)
decreased inferior colliculus size  (IAGP)
decreased kidney cell proliferation  (IAGP)
decreased lumbar vertebrae number  (IAGP)
decreased maxillary shelf size  (IAGP)
decreased palatal shelf size  (IAGP)
decreased paraxial mesoderm size  (IAGP)
decreased renal glomerulus number  (IAGP)
decreased round window size  (IAGP)
decreased somite size  (IAGP)
decreased thoracic vertebrae number  (IAGP)
decreased tympanic ring size  (IAGP)
dermatitis  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart right ventricle  (IAGP)
dry skin  (IAGP)
ectopic ureteric bud  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
enlarged allantois  (IAGP)
enlarged heart  (IAGP)
excessive cerumen  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
facial asymmetry  (IAGP)
facial cleft  (IAGP)
failure of heart looping  (IAGP)
failure of palatal shelf elevation  (IAGP)
failure of primitive streak formation  (IAGP)
failure of somite differentiation  (IAGP)
female infertility  (IAGP)
forelimb oligodactyly  (IAGP)
fusion of atlas and occipital bones  (IAGP)
genital tubercle hypoplasia  (IAGP)
heart hypoplasia  (IAGP)
hydronephrosis  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
impaired coordination  (IAGP)
impaired skin barrier function  (IAGP)
increased axial mesoderm size  (IAGP)
increased cell death  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased heart atrium size  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased kidney apoptosis  (IAGP)
increased mast cell number  (IAGP)
increased metanephric mesenchyme apoptosis  (IAGP)
increased or absent threshold for auditory brainstem response  (IEA)
increased osteoblast cell number  (IAGP)
increased osteoblast proliferation  (IAGP)
increased respiratory quotient  (IEA)
increased rib number  (IAGP)
increased susceptibility to otitis media  (IAGP)
increased thoracic vertebrae number  (IAGP)
incus hypoplasia  (IAGP)
kinked neural tube  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
long incisors  (IAGP)
lowered ear position  (IAGP)
lumbar vertebral transformation  (IAGP)
malleus hypoplasia  (IAGP)
micrognathia  (IAGP)
middle ear ossicle hypoplasia  (IAGP)
midface hypoplasia  (IAGP)
midline facial cleft  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
oligodactyly  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistence of medial edge epithelium during palatal shelf fusion  (IAGP)
polydipsia  (IAGP)
postaxial polydactyly  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature coronal suture closure  (IAGP)
premature cranial suture closure  (IAGP)
premature maxillary-premaxillary suture closure  (IAGP)
premature metopic suture closure  (IAGP)
premature sagittal suture closure  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
progressive hair loss  (IAGP)
reduced male fertility  (IAGP)
rib bifurcation  (IAGP)
rib fusion  (IAGP)
sacral vertebral transformation  (IAGP)
second pharyngeal arch hypoplasia  (IAGP)
short mandible  (IAGP)
short nasal bone  (IAGP)
short snout  (IAGP)
short tail  (IAGP)
short tibia  (IAGP)
skin fibrosis  (IAGP)
skin inflammation  (IAGP)
small cranium  (IAGP)
small ears  (IAGP)
small frontonasal prominence  (IAGP)
small gonial bone  (IAGP)
small hair follicles  (IAGP)
small kidney  (IAGP)
small proamniotic cavity  (IAGP)
small second pharyngeal arch  (IAGP)
small ureteric bud  (IAGP)
small visceral yolk sac  (IAGP)
spina bifida  (IAGP)
stapes hypoplasia  (IAGP)
styloid process hypoplasia  (IAGP)
supernumerary teeth  (IAGP)
syndactyly  (IAGP)
thick epidermis  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
thoracic vertebral transformation  (IAGP)
tympanic ring hypoplasia  (IAGP)
vertebral transformation  (IAGP)

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Additional References at PubMed
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Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39826,008,808 - 26,067,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,003,670 - 26,065,734 (+)EnsemblGRCm39 Ensembl
GRCm38825,518,759 - 25,575,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,513,654 - 25,575,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,629,244 - 26,686,186 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36826,997,826 - 27,039,466 (+)NCBIMGSCv36mm8
Celera826,986,822 - 27,044,074 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38838,411,143 - 38,468,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl838,400,215 - 38,468,834 (-)EnsemblGRCh38hg38GRCh38
GRCh37838,268,661 - 38,326,153 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,387,813 - 38,445,509 (-)NCBINCBI36Build 36hg18NCBI36
Build 34838,389,448 - 38,445,293NCBI
Celera837,221,633 - 37,279,334 (-)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef836,802,638 - 36,860,684 (-)NCBIHuRef
CHM1_1838,470,562 - 38,528,261 (-)NCBICHM1_1
T2T-CHM13v2.0838,688,107 - 38,745,588 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81673,194,631 - 73,249,855 (-)NCBIGRCr8
mRatBN7.21666,491,930 - 66,547,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,494,042 - 66,547,350 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,773,130 - 71,812,564 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01675,179,067 - 75,218,502 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,419,796 - 70,459,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01671,265,390 - 71,319,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1671,266,248 - 71,319,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,924,716 - 70,977,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,869,974 - 70,910,045 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11670,870,238 - 70,910,310 (-)NCBI
Celera1664,402,647 - 64,442,189 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495546314,013,247 - 14,064,111 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546314,013,247 - 14,064,354 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2756,974,947 - 57,034,140 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1832,691,569 - 32,751,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0837,713,133 - 37,773,098 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1834,890,147 - 34,948,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,890,147 - 34,948,904 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11627,029,902 - 27,080,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,031,588 - 27,078,261 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,547,259 - 27,597,845 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01628,928,146 - 28,978,790 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1628,927,382 - 28,977,436 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11627,151,667 - 27,202,222 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01627,728,739 - 27,779,306 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01627,767,626 - 27,818,261 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494349,645,976 - 49,698,868 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367101,760,089 - 1,815,508 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367101,760,365 - 1,815,269 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1548,053,340 - 48,106,724 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,053,895 - 48,106,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,216,111 - 55,269,152 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1836,426,116 - 36,485,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl836,427,110 - 36,485,508 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660525,502,205 - 5,561,763 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247805,161,073 - 5,213,870 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247805,161,245 - 5,212,641 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Fgfr1
2034 total Variants