Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Mus musculus
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Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 732272
MGI Page MGI
Description: Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including generation of neurons; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and positive regulation of podosome assembly. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI849689; c-Jun N-terminal kinase 1; JNK; JNK1; JNK1 beta1 protein kinase; MAP kinase 8; MAPK 8; mitogen activated protein kinase 8; Prk; Prkm8; protein kinase mitogen-activated 8; SAPK1; stress-activated protein kinase JNK1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,099,855 - 33,169,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,099,855 - 33,169,115 (-)EnsemblGRCm39 Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,377,898 - 33,447,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBIMGSCv36mm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IDA)
Acute Liver Failure  (ISO)
Acute Otitis Media  (IEP)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
Arenaviridae infectious disease  (IMP)
atopic dermatitis  (ISO)
bacterial pneumonia  (IMP)
brain ischemia  (ISO)
candidiasis  (IMP)
Cardiomegaly  (IEP)
chronic mucocutaneous candidiasis  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal adenoma  (ISO)
Contrast-Induced Nephropathy  (ISO)
dengue disease  (IEP)
endometriosis  (ISO)
Endotoxemia  (ISO)
extrahepatic cholestasis  (ISO)
Helicobacter Infections  (ISO)
hepatitis  (IMP)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
Infectious Ectromelia  (IMP)
influenza A  (IMP)
Intestinal Neoplasms  (IDA,IEP)
Kuhnt-Junius degeneration  (IMP)
Liver Reperfusion Injury  (ISO)
megacolon  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplastic Cell Transformation  (ISO)
Oxygen-Induced Retinopathy  (IMP)
pancreatic adenocarcinoma  (ISO)
pancreatic ductal adenocarcinoma  (IEP,IMP)
Parkinsonism  (ISO)
pre-malignant neoplasm  (ISO)
Pseudomonas Infections  (IMP)
rectal benign neoplasm  (ISO)
Reperfusion Injury  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
steatotic liver disease  (IMP)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (EXP)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-matairesinol  (EXP)
(1->4)-beta-D-glucan  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R)-salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-Dinitropyrene  (EXP)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (EXP,ISO)
17beta-estradiol  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-trans,6-trans-farnesyl diphosphate  (EXP)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylleucyl-leucyl-norleucinal  (EXP)
Aciculatin  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP)
ADP  (ISO)
afimoxifene  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (EXP)
all-trans-retinoic acid  (EXP)
alpha-Chaconine  (EXP)
alpha-D-galactose  (ISO)
alpha-mangostin  (ISO)
alvocidib  (ISO)
amidotrizoic acid  (ISO)
amiloride  (EXP)
amino acid  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
Anemoside B4  (EXP)
anethole  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (EXP)
Antimony trioxide  (EXP,ISO)
ANTIMYCIN  (EXP)
Apicularen A  (EXP)
apigenin  (ISO)
apocynin  (EXP,ISO)
apremilast  (ISO)
arachidonic acid  (ISO)
Arctiin  (EXP)
arecoline  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
asiatic acid  (EXP)
astaxanthin  (EXP)
atrazine  (ISO)
atropine  (ISO)
aureusidin  (ISO)
Azaspiracid  (EXP)
bafilomycin A1  (EXP)
baicalein  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (ISO)
betulin  (ISO)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bleomycin A2  (EXP)
bortezomib  (ISO)
bosutinib  (ISO)
bufalin  (ISO)
bupropion  (ISO)
butanal  (ISO)
butein  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
Calcimycin  (ISO)
calcipotriol  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
cantharidic acid  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (EXP)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (EXP)
Carnosol  (EXP)
celecoxib  (EXP,ISO)
chalcone  (EXP)
chenodeoxycholic acid  (EXP)
chlordecone  (EXP)
chlorogenic acid  (ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholate  (EXP)
choline  (EXP)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP,ISO)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
diltiazem  (ISO)
dimethylarsinic acid  (EXP,ISO)
Dinitramine  (EXP)
dinophysistoxin 1  (ISO)
dioscin  (ISO)
diosmetin  (EXP)
dioxygen  (ISO)
diphenhydramine  (ISO)
dipyridamole  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
edaravone  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (ISO)
emetine  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
erastin  (EXP)
eriocitrin  (ISO)
eriodictyol  (EXP)
esculetin  (ISO)
estragole  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl pyruvate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (ISO)
farnesyl diphosphate  (EXP)
febuxostat  (ISO)
fenvalerate  (ISO)
ferroheme b  (EXP)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
flubendazole  (ISO)
flufenoxuron  (EXP)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fomepizole  (EXP)
formononetin  (ISO)
formoterol fumarate  (ISO)
fructose  (ISO)
fucoxanthin  (EXP)
Fulvic acid  (ISO)
furan  (EXP)
galactose  (ISO)
galangin  (ISO)
gallic acid  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane </