Rest (RE1-silencing transcription factor) - Rat Genome Database

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Gene: Rest (RE1-silencing transcription factor) Mus musculus
Analyze
Symbol: Rest
Name: RE1-silencing transcription factor
RGD ID: 732239
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including auditory receptor cell stereocilium organization; regulation of gene expression; and regulation of neuron differentiation. Acts upstream of or within hematopoietic progenitor cell differentiation; negative regulation of neurogenesis; and regulation of gene expression. Located in cytosol and nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 27; gingival fibromatosis 5; and nephroblastoma. Orthologous to human REST (RE1 silencing transcription factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610008J04Rik; AA407358; D14Mgi1; MGC150099; N; neural-restrictive silencer factor; NRSF; REST/NRSF; REST4
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,413,273 - 77,434,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,413,338 - 77,434,279 (+)EnsemblGRCm39 Ensembl
GRCm38577,265,494 - 77,286,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,265,491 - 77,286,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,694,519 - 77,712,722 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,342,716 - 78,357,759 (+)NCBIMGSCv36mm8
Celera574,535,211 - 74,550,959 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
5-fluorouracil  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromochloroacetic acid  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
fenamidone  (EXP)
folic acid  (ISO)
FR900359  (ISO)
galactose  (EXP)
gentamycin  (ISO)
Gentiopicrin  (EXP)
kainic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sparteine  (ISO)
succimer  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
auditory receptor cell stereocilium organization  (IMP)
cardiac muscle cell myoblast differentiation  (IDA)
cellular response to electrical stimulus  (ISO,ISS)
cellular response to glucocorticoid stimulus  (ISO,ISS)
cellular response to stress  (IDA)
cellular response to xenobiotic stimulus  (ISO,ISS)
chromatin remodeling  (ISO,ISS)
detection of mechanical stimulus involved in sensory perception of sound  (IMP)
hematopoietic progenitor cell differentiation  (IMP)
modification of synaptic structure  (ISO,ISS)
negative regulation by host of viral transcription  (ISO,ISS)
negative regulation of aldosterone biosynthetic process  (ISO,ISS)
negative regulation of amniotic stem cell differentiation  (ISO,ISS)
negative regulation of calcium ion-dependent exocytosis  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of cortisol biosynthetic process  (ISO,ISS)
negative regulation of dense core granule biogenesis  (ISO,ISS)
negative regulation of DNA-templated transcription  (IBA,IDA,IMP,ISO)
negative regulation of gene expression  (IDA,IMP,ISO,ISS)
negative regulation of insulin secretion  (ISO,ISS)
negative regulation of mesenchymal stem cell differentiation  (ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of neurogenesis  (IGI)
negative regulation of neuron differentiation  (IBA,IDA,IMP,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
nervous system process  (ISO,ISS)
neuromuscular process controlling balance  (IMP)
neuron differentiation  (ISO)
neuronal stem cell population maintenance  (IMP)
obsolete positive regulation of cysteine-type endopeptidase activity  (ISO,ISS)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IDA,IMP)
positive regulation of neuron differentiation  (IMP)
positive regulation of programmed cell death  (ISO,ISS)
positive regulation of stem cell population maintenance  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IBA)
regulation of alternative mRNA splicing, via spliceosome  (IMP)
regulation of DNA-templated transcription  (ISO,ISS)
regulation of gene expression  (IDA)
regulation of osteoblast differentiation  (IMP)
response to ethanol  (ISO)
response to hypoxia  (ISO,ISS)
response to ischemia  (ISO,ISS)
somatic stem cell population maintenance  (IMP)

Cellular Component
chromatin  (ISO)
cytoplasm  (ISO)
cytosol  (IDA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO)
protein-containing complex  (ISO)
transcription repressor complex  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal cranial flexure morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal kinocilium morphology  (IAGP)
abnormal melanoblast morphology  (IAGP)
abnormal midbrain development  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal outer hair cell stereociliary bundle morphology  (IAGP)
abnormal retina development  (IAGP)
abnormal retina ganglion layer morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina progenitor cell morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal utricle morphology  (IAGP)
belly spot  (IAGP)
cochlear hair cell degeneration  (IAGP)
cochlear inner hair cell degeneration  (IAGP)
deafness  (IAGP)
decreased heart rate  (IEA)
decreased mean platelet volume  (IEA)
decreased neuron number  (IAGP)
decreased primordial germ cell number  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
head spot  (IAGP)
impaired balance  (IAGP)
impaired hearing  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased neuron apoptosis  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased primordial germ cell apoptosis  (IAGP)
increased retina ganglion cell number  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
premature neuronal precursor differentiation  (IAGP)
preweaning lethality, complete penetrance  (IEA)
small embryonic telencephalon  (IAGP)
thick retina ganglion layer  (IAGP)
thick retina inner plexiform layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Ballas N, etal., Cell 2005 May 20;121(4):645-57.
2. HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype. Crews FT, etal., Mol Psychiatry. 2023 Dec;28(12):5159-5172. doi: 10.1038/s41380-023-02160-6. Epub 2023 Jul 4.
3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
4. The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. Grimes JA, etal., J Biol Chem 2000 Mar 31;275(13):9461-7.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7697725   PMID:7871435   PMID:9771705   PMID:9811942   PMID:9988216   PMID:10349636   PMID:10376008   PMID:10490617   PMID:10512203   PMID:10521596   PMID:10688910   PMID:10922068  
PMID:11039732   PMID:11042159   PMID:11076861   PMID:11278361   PMID:11326268   PMID:11406295   PMID:12477932   PMID:12520002   PMID:12881722   PMID:12904583   PMID:14565956   PMID:14610273  
PMID:14633990   PMID:14645515   PMID:15193422   PMID:15240883   PMID:15322094   PMID:15340064   PMID:15489334   PMID:15528196   PMID:15741177   PMID:15755907   PMID:15782199   PMID:15840001  
PMID:16141072   PMID:16141073   PMID:16195345   PMID:16325481   PMID:16461918   PMID:16602821   PMID:16684532   PMID:17082226   PMID:17093407   PMID:17130167   PMID:17344928   PMID:17403776  
PMID:17596446   PMID:17944879   PMID:17967808   PMID:18092359   PMID:18287559   PMID:18354483   PMID:18362916   PMID:18771760   PMID:18799693   PMID:18959480   PMID:18976727   PMID:18987749  
PMID:19201947   PMID:19218269   PMID:19242417   PMID:19242418   PMID:19281761   PMID:19421833   PMID:19449303   PMID:19457133   PMID:19741146   PMID:19888342   PMID:19997604   PMID:20006971  
PMID:20085738   PMID:20211142   PMID:20346398   PMID:20351065   PMID:20395405   PMID:20398633   PMID:20412781   PMID:20457675   PMID:20503368   PMID:20811409   PMID:20823235   PMID:20969844  
PMID:21048325   PMID:21072209   PMID:21105876   PMID:21139978   PMID:21179468   PMID:21199191   PMID:21252229   PMID:21267068   PMID:21270437   PMID:21284946   PMID:21339379   PMID:21368052  
PMID:21396985   PMID:21402785   PMID:21668584   PMID:21677750   PMID:21705344   PMID:21715642   PMID:21762439   PMID:21832040   PMID:21873635   PMID:21884984   PMID:21921234   PMID:21951847  
PMID:22162260   PMID:22241837   PMID:22396653   PMID:22431737   PMID:22472570   PMID:22590451   PMID:22766071   PMID:22770845   PMID:22780989   PMID:22791895   PMID:22952733   PMID:22988430  
PMID:23022299   PMID:23029270   PMID:23055939   PMID:23145961   PMID:23242999   PMID:23250796   PMID:23754622   PMID:23928058   PMID:24029230   PMID:24149584   PMID:24194600   PMID:24291638  
PMID:24329414   PMID:24670762   PMID:24752154   PMID:24794437   PMID:24861183   PMID:24952961   PMID:25074806   PMID:25113559   PMID:25135772   PMID:25197063   PMID:25250711   PMID:25261598  
PMID:25406064   PMID:25505318   PMID:25691247   PMID:25727884   PMID:25786798   PMID:25818501   PMID:25838543   PMID:25843715   PMID:26119235   PMID:26156633   PMID:26209818   PMID:26518165  
PMID:26538656   PMID:26745185   PMID:26864965   PMID:27258257   PMID:27349310   PMID:27602517   PMID:27626380   PMID:27631609   PMID:27732941   PMID:27819263   PMID:27956497   PMID:27997532  
PMID:28049845   PMID:28256535   PMID:28285139   PMID:28378742   PMID:28391636   PMID:28489825   PMID:28524599   PMID:28786015   PMID:29024663   PMID:29670089   PMID:29748616   PMID:29795351  
PMID:29961578   PMID:30186101   PMID:30213984   PMID:30327427   PMID:30995482   PMID:31147527   PMID:31155355   PMID:31206463   PMID:31294445   PMID:31403159   PMID:31503207   PMID:31619788  
PMID:31706914   PMID:32001620   PMID:32080178   PMID:32423826   PMID:32677323   PMID:32859226   PMID:33029126   PMID:33087486   PMID:33211397   PMID:33563726   PMID:33589593   PMID:33849071  
PMID:34078664   PMID:34151974   PMID:34210779   PMID:34321999   PMID:34385258   PMID:34542211   PMID:34597683   PMID:34875852   PMID:35377797   PMID:35404272   PMID:35418568   PMID:35577801  
PMID:35638297   PMID:36125121   PMID:36130284   PMID:36229920   PMID:36230906   PMID:36265442   PMID:36282915   PMID:36497119   PMID:36758614   PMID:37170124   PMID:37481910   PMID:37919281  
PMID:38034589   PMID:38069914   PMID:38355793   PMID:38606882  


Genomics

Comparative Map Data
Rest
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,413,273 - 77,434,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,413,338 - 77,434,279 (+)EnsemblGRCm39 Ensembl
GRCm38577,265,494 - 77,286,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl577,265,491 - 77,286,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv37577,694,519 - 77,712,722 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36578,342,716 - 78,357,759 (+)NCBIMGSCv36mm8
Celera574,535,211 - 74,550,959 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.61NCBI
REST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,907,900 - 56,935,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,907,876 - 56,966,808 (+)EnsemblGRCh38hg38GRCh38
GRCh37457,774,066 - 57,802,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36457,468,799 - 57,493,097 (+)NCBINCBI36Build 36hg18NCBI36
Build 34457,614,969 - 57,639,268NCBI
Celera455,279,985 - 55,307,950 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,727,986 - 53,755,535 (+)NCBIHuRef
CHM1_1457,809,465 - 57,837,418 (+)NCBICHM1_1
T2T-CHM13v2.0460,399,324 - 60,427,254 (+)NCBIT2T-CHM13v2.0
Rest
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,213,415 - 31,233,451 (-)NCBIGRCr8
mRatBN7.21430,859,109 - 30,879,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1430,862,553 - 30,894,354 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,239,986 - 31,260,061 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,548,313 - 32,568,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,032,969 - 31,053,042 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,131,985 - 33,152,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,134,511 - 33,164,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01432,925,741 - 32,951,551 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,136,046 - 33,151,142 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,136,045 - 33,151,142 (-)NCBI
Celera1430,181,687 - 30,196,879 (-)NCBICelera
Cytogenetic Map14p11NCBI
REST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2372,840,537 - 72,868,421 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,046,074 - 73,073,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0466,984,466 - 67,012,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1473,556,780 - 73,582,419 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl473,526,085 - 73,582,242 (-)Ensemblpanpan1.1panPan2
REST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11349,041,082 - 49,062,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1349,041,047 - 49,059,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,930,954 - 48,953,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,654,746 - 49,677,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,656,727 - 49,673,995 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11349,327,159 - 49,349,567 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,856,606 - 48,878,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,801,275 - 49,823,781 (+)NCBIUU_Cfam_GSD_1.0
Rest
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,258,819 - 27,303,941 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648219,018,454 - 19,040,438 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl856,035,150 - 56,215,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1856,035,182 - 56,061,140 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,440,573 - 57,466,453 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1711,749,312 - 11,776,103 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl711,749,168 - 11,773,340 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606612,388,814 - 12,415,743 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rest
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476112,464,243 - 12,495,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rest
1168 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1700
Count of miRNA genes:548
Interacting mature miRNAs:635
Transcripts:ENSMUST00000080359, ENSMUST00000113449
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse

Markers in Region
RH125678  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38577,281,197 - 77,281,347UniSTSGRCm38
MGSCv37577,710,222 - 77,710,372UniSTSGRCm37
Celera574,548,459 - 74,548,609UniSTS
Cytogenetic Map5C3.3UniSTS
Rest  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS
cM Map5 UniSTS
UniSTS:237124  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38577,281,075 - 77,281,266UniSTSGRCm38
MGSCv37577,710,100 - 77,710,291UniSTSGRCm37
Celera574,548,337 - 74,548,528UniSTS
Cytogenetic Map5C3.3UniSTS
UniSTS:237123  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38577,281,918 - 77,282,221UniSTSGRCm38
MGSCv37577,710,943 - 77,711,246UniSTSGRCm37
Celera574,549,180 - 74,549,483UniSTS
Cytogenetic Map5C3.3UniSTS
Rest  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006534842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB024496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB024497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB221588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB221589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC141469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF220154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI121875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE132774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ644039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN019832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U13878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000080359   ⟹   ENSMUSP00000079231
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl577,413,338 - 77,434,279 (+)Ensembl
GRCm38.p6 Ensembl577,265,491 - 77,286,432 (+)Ensembl
Ensembl Acc Id: ENSMUST00000113449   ⟹   ENSMUSP00000109076
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl577,414,043 - 77,434,279 (+)Ensembl
GRCm38.p6 Ensembl577,266,196 - 77,286,432 (+)Ensembl
RefSeq Acc Id: NM_011263   ⟹   NP_035393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39577,413,341 - 77,431,544 (+)NCBI
GRCm38577,265,494 - 77,283,697 (+)NCBI
MGSCv37577,694,519 - 77,712,722 (+)RGD
Celera574,535,211 - 74,550,959 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534842   ⟹   XP_006534905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39577,413,787 - 77,434,279 (+)NCBI
GRCm38577,266,023 - 77,286,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036164926   ⟹   XP_036020819
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39577,413,273 - 77,428,638 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035393   ⟸   NM_011263
- UniProtKB: Q8VIG1 (UniProtKB/Swiss-Prot),   Q4VAD6 (UniProtKB/Swiss-Prot),   Q3U0W0 (UniProtKB/Swiss-Prot),   Q155C6 (UniProtKB/Swiss-Prot),   A0JNY8 (UniProtKB/Swiss-Prot),   Q9CW43 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006534905   ⟸   XM_006534842
- Peptide Label: isoform X1
- UniProtKB: Q8VIG1 (UniProtKB/Swiss-Prot),   Q4VAD6 (UniProtKB/Swiss-Prot),   Q3U0W0 (UniProtKB/Swiss-Prot),   Q155C6 (UniProtKB/Swiss-Prot),   A0JNY8 (UniProtKB/Swiss-Prot),   Q9CW43 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000109076   ⟸   ENSMUST00000113449
Ensembl Acc Id: ENSMUSP00000079231   ⟸   ENSMUST00000080359
RefSeq Acc Id: XP_036020819   ⟸   XM_036164926
- Peptide Label: isoform X2
- UniProtKB: F8V330 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIG1-F1-model_v2 AlphaFold Q8VIG1 1-1082 view protein structure

Promoters
RGD ID:6886978
Promoter ID:EPDNEW_M6940
Type:initiation region
Name:Rest_1
Description:Mus musculus RE1-silencing transcription factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6941  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38577,265,482 - 77,265,542EPDNEW
RGD ID:6886980
Promoter ID:EPDNEW_M6941
Type:initiation region
Name:Rest_2
Description:Mus musculus RE1-silencing transcription factor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6940  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38577,266,227 - 77,266,287EPDNEW
RGD ID:6838208
Promoter ID:MM_KWN:42679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung
Transcripts:ENSMUST00000113448,   ENSMUST00000113449,   OTTMUST00000050751
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36577,694,286 - 77,695,312 (+)MPROMDB
RGD ID:6838211
Promoter ID:MM_KWN:42680
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC008XWB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36577,696,111 - 77,697,312 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104897 AgrOrtholog
Ensembl Genes ENSMUSG00000029249 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000080359 ENTREZGENE
  ENSMUST00000080359.12 UniProtKB/Swiss-Prot
  ENSMUST00000113449 ENTREZGENE
  ENSMUST00000113449.2 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Zinc_finger/UBP_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19712 UniProtKB/Swiss-Prot
MGD MGI:104897 ENTREZGENE
NCBI Gene 19712 ENTREZGENE
PANTHER RE1-SILENCING TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rest PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0JNY8 ENTREZGENE
  F8V330 ENTREZGENE, UniProtKB/TrEMBL
  Q155C6 ENTREZGENE
  Q3U0W0 ENTREZGENE
  Q4VAD6 ENTREZGENE
  Q60694_MOUSE UniProtKB/TrEMBL
  Q8VIG1 ENTREZGENE
  Q9CW43 ENTREZGENE
  REST_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A0JNY8 UniProtKB/Swiss-Prot
  Q155C6 UniProtKB/Swiss-Prot
  Q3U0W0 UniProtKB/Swiss-Prot
  Q4VAD6 UniProtKB/Swiss-Prot
  Q9CW43 UniProtKB/Swiss-Prot