Ptger4 (prostaglandin E receptor 4 (subtype EP4)) - Rat Genome Database

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Gene: Ptger4 (prostaglandin E receptor 4 (subtype EP4)) Mus musculus
Analyze
Symbol: Ptger4
Name: prostaglandin E receptor 4 (subtype EP4)
RGD ID: 732089
MGI Page MGI
Description: Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; cellular response to mechanical stimulus; and regulation of cytokine production. Acts upstream of or within several processes, including regulation of ossification; response to lipopolysaccharide; and response to nematode. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; heart valve; and skin. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EP; EP4; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (EP4 subtype); prostaglandin E receptor EP4 subtype; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; Ptger; Ptgerep4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,262,880 - 5,273,668 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,236,142 - 5,273,668 (-)EnsemblGRCm39 Ensembl
GRCm38155,233,399 - 5,244,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,206,661 - 5,244,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,183,404 - 5,193,831 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,181,080 - 5,191,046 (-)NCBIMGSCv36mm8
Celera155,082,719 - 5,093,146 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
8-epi-prostaglandin E2  (EXP)
acetamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alternariol  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
bellidifolin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Botulinum toxin type A  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
captan  (EXP)
carbon nanotube  (EXP)
celecoxib  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cryptotanshinone  (ISO)
cyclophosphamide  (ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enzalutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
glucose  (ISO)
hydrazine  (EXP)
iron dichloride  (ISO)
isoliquiritigenin  (ISO)
kenpaullone  (ISO)
ketorolac  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
Nonylphenol  (ISO)
NS-398  (EXP,ISO)
ochratoxin A  (ISO)
Ono-AE1-329  (EXP)
oxidopamine  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
pristane  (EXP)
progesterone  (ISO)
prostaglandin E2  (EXP,ISO)
puromycin  (EXP)
Rebamipide  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium hydrogensulfite  (ISO)
sodium sulfite  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vincristine  (ISO)
vinyl carbamate  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,TAS)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
bone development  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to prostaglandin E stimulus  (IBA,ISO)
chemokinesis  (ISO)
ductus arteriosus closure  (ISO)
ERK1 and ERK2 cascade  (ISO)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
immune response  (ISO)
inflammatory response  (IBA)
JNK cascade  (ISO)
maternal process involved in parturition  (ISO)
negative regulation of cytokine production  (IMP)
negative regulation of ductus arteriosus closure  (ISO)
negative regulation of endothelin production  (ISO)
negative regulation of eosinophil extravasation  (ISO)
negative regulation of hydrogen peroxide metabolic process  (ISO)
negative regulation of inflammatory response  (IBA,IGI,IMP,ISO)
negative regulation of integrin activation  (ISO)
negative regulation of interleukin-1 alpha production  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of peptide secretion  (ISO)
negative regulation of small intestine smooth muscle contraction  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of antral ovarian follicle growth  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of calcitonin secretion  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokinesis  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cytokine production  (IDA)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of inflammatory response  (IDA)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of protein modification process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of substance P secretion  (ISO)
positive regulation of substance P secretion, neurotransmission  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of urine volume  (ISO)
positive regulation of wound healing  (ISO)
regulation of circadian sleep/wake cycle, wakefulness  (ISO)
regulation of ossification  (IMP)
regulation of stress fiber assembly  (IDA)
response to amino acid  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (IMP)
response to mechanical stimulus  (ISO)
response to nematode  (IMP)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to prostaglandin E  (ISO)
response to salt  (ISO)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
T-helper cell differentiation  (IDA)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal calcium ion homeostasis  (IAGP)
abnormal capillary morphology  (IAGP)
abnormal cardiac muscle tissue morphology  (IAGP)
abnormal circulating interleukin-6 level  (IAGP)
abnormal circulating serum amyloid protein level  (IAGP)
abnormal cytokine level  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal Langerhans cell physiology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal prostaglandin level  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal vascular regression  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased heart left ventricle posterior wall thickness  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased pulmonary vascular resistance  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to type IV hypersensitivity reaction  (IAGP)
decreased T cell proliferation  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
dilated pulmonary artery  (IAGP)
heart inflammation  (IAGP)
increased heart weight  (IAGP)
increased lung weight  (IAGP)
left-to-right shunt  (IAGP)
lethargy  (IAGP)
liver vascular congestion  (IAGP)
lung hemorrhage  (IAGP)
lymphangiectasis  (IAGP)
macrovesicular hepatic steatosis  (IAGP)
microvesicular hepatic steatosis  (IAGP)
neonatal lethality  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
patent ductus arteriosus  (IAGP)
perinatal lethality  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preneoplasia  (IAGP)
pulmonary alveolar hemorrhage  (IAGP)
pulmonary edema  (IAGP)
pulmonary vascular congestion  (IAGP)
rheumatoid arthritis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Cameron KO, etal., Bioorg Med Chem Lett. 2006 Apr 1;16(7):1799-802. Epub 2006 Jan 26.
2. A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Chen Q, etal., Br J Pharmacol. 2010 May;160(2):292-310. doi: 10.1111/j.1476-5381.2010.00647.x.
3. Expression of prostaglandin E2 receptor subtypes, EP2 and EP4, in the rat hippocampus after cerebral ischemia and ischemic tolerance. Choi JS, etal., Cell Tissue Res. 2006 May;324(2):203-11. Epub 2006 Jan 26.
4. Intravesical immune suppression by liposomal tacrolimus in cyclophosphamide-induced inflammatory cystitis. Chuang YC, etal., Neurourol Urodyn. 2011 Mar;30(3):421-7. doi: 10.1002/nau.20981. Epub 2010 Sep 21.
5. Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human. Cipollone F, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1925-31. Epub 2005 Jul 14.
6. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbe nzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. Clark P, etal., J Pharmacol Exp Ther. 2008 May;325(2):425-34. doi: 10.1124/jpet.107.134510. Epub 2008 Feb 20.
7. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Evans DM, etal., Nat Genet. 2011 Jul 10;43(8):761-7. doi: 10.1038/ng.873.
8. Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice. Hamaguchi K, etal., Neuropharmacology. 2012 Mar;62(4):1841-7. Epub 2011 Dec 16.
9. Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. Hoshino T, etal., J Neurochem. 2012 Mar;120(5):795-805. doi: 10.1111/j.1471-4159.2011.07567.x. Epub 2012 Jan 23.
10. Comparison of prostaglandin E2 receptor subtype 4 agonist and sulfasalazine in mouse colitis prevention and treatment. Jiang GL, etal., J Pharmacol Exp Ther. 2010 Dec;335(3):546-52. Epub 2010 Sep 10.
11. 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors. Kunikata T, etal., Dig Dis Sci. 2002 Apr;47(4):894-904.
12. Up-regulation of prostaglandin E receptor EP2 and EP4 subtypes in rat synovial tissues with adjuvant arthritis. Kurihara Y, etal., Clin Exp Immunol. 2001 Feb;123(2):323-30.
13. Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients. Latiano A, etal., PLoS One. 2011;6(7):e22688. Epub 2011 Jul 27.
14. A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. Li JH, etal., J Clin Invest. 2009 Oct;119(10):3115-26. doi: 10.1172/JCI39680.
15. Signaling via the prostaglandin E(2) receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia. Liang X, etal., J Clin Invest. 2011 Nov;121(11):4362-71. doi: 10.1172/JCI46279. Epub 2011 Oct 3.
16. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. The anti-inflammatory mechanism of prostaglandin e2 receptor 4 activation in rat experimental autoimmune myocarditis. Ngoc PB, etal., J Cardiovasc Pharmacol. 2011 Mar;57(3):365-72.
20. Expression of the EP4 prostaglandin E2 receptor subtype with rat dextran sodium sulphate colitis: colitis suppression by a selective agonist, ONO-AE1-329. Nitta M, etal., Scand J Immunol 2002 Jul;56(1):66-75.
21. Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. Oka T, etal., J Comp Neurol. 2000 Dec 4;428(1):20-32.
22. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
23. Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis. Okumura T, etal., J Pharm Pharmacol. 2008 Jun;60(6):723-30. doi: 10.1211/jpp.60.6.0007.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. A prostaglandin E2 receptor subtype EP4 agonist attenuates cardiovascular depression in endotoxin shock by inhibiting inflammatory cytokines and nitric oxide production. Sakamoto A, etal., Shock. 2004 Jul;22(1):76-81.
28. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Segi E, etal., Biochem Biophys Res Commun. 1998 May 8;246(1):7-12.
29. Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. Sennlaub F, etal., Circulation. 2003 Jul 15;108(2):198-204. Epub 2003 Jun 23.
30. Role of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study. St-Jacques B and Ma W, J Neurochem. 2011 Sep;118(5):841-54. doi: 10.1111/j.1471-4159.2011.07230.x. Epub 2011 Mar 28.
31. Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure. Vukicevic S, etal., Kidney Int. 2006 Sep;70(6):1099-106. Epub 2006 Jul 26.
32. Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation. Yokoyama U, etal., PLoS One. 2012;7(5):e36724. Epub 2012 May 3.
33. Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Yoshida K, etal., Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4580-5. Epub 2002 Mar 26.
Additional References at PubMed
PMID:2788176   PMID:4704351   PMID:7758593   PMID:7910583   PMID:8385118   PMID:8939885   PMID:9116135   PMID:9124591   PMID:9337410   PMID:9348184   PMID:9363893   PMID:9521872  
PMID:9751056   PMID:10349636   PMID:10508233   PMID:10593166   PMID:10749873   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11238561   PMID:11301049   PMID:11533709  
PMID:11602631   PMID:11782353   PMID:11792579   PMID:11867175   PMID:11927615   PMID:12208866   PMID:12477932   PMID:12618422   PMID:12637575   PMID:12642666   PMID:12740571   PMID:12841871  
PMID:14623055   PMID:14632179   PMID:14665434   PMID:15075356   PMID:15113745   PMID:15123663   PMID:15240726   PMID:15265935   PMID:15336550   PMID:15336573   PMID:15354288   PMID:15372104  
PMID:15619666   PMID:15806106   PMID:15808664   PMID:15834134   PMID:15834430   PMID:15869929   PMID:15958566   PMID:15976003   PMID:15983244   PMID:16108069   PMID:16141072   PMID:16141073  
PMID:16237060   PMID:16247016   PMID:16303601   PMID:16446378   PMID:16537572   PMID:16598377   PMID:16602821   PMID:16830205   PMID:16954344   PMID:16964442   PMID:16966370   PMID:16997129  
PMID:17003499   PMID:17018624   PMID:17065565   PMID:17075575   PMID:17080198   PMID:17175225   PMID:17401137   PMID:17585336   PMID:17673547   PMID:17681894   PMID:17890674   PMID:17965409  
PMID:18180401   PMID:18250418   PMID:18258202   PMID:18270204   PMID:18287559   PMID:18762248   PMID:18787774   PMID:18792778   PMID:19041765   PMID:19075289   PMID:19098906   PMID:19273625  
PMID:19303430   PMID:19344793   PMID:19407341   PMID:19419302   PMID:19465928   PMID:19570035   PMID:19628768   PMID:19671668   PMID:19966781   PMID:20008274   PMID:20083684   PMID:20110411  
PMID:20219142   PMID:20483760   PMID:20566843   PMID:20671216   PMID:20736236   PMID:21088251   PMID:21267068   PMID:21311040   PMID:21444662   PMID:21460251   PMID:21693121   PMID:21710489  
PMID:21835766   PMID:21873635   PMID:21876756   PMID:22159280   PMID:22227567   PMID:22300734   PMID:22306906   PMID:22342504   PMID:22442093   PMID:22513820   PMID:22522619   PMID:22573380  
PMID:22595380   PMID:22615395   PMID:22641101   PMID:22732652   PMID:22993066   PMID:23041537   PMID:23237743   PMID:23315170   PMID:23317035   PMID:23485965   PMID:23624557   PMID:23639875  
PMID:23817085   PMID:23936109   PMID:24146253   PMID:24281828   PMID:24342806   PMID:24355567   PMID:24560715   PMID:24760848   PMID:24923772   PMID:25054560   PMID:25122504   PMID:25510249  
PMID:25532785   PMID:25776075   PMID:25799228   PMID:26051593   PMID:26100911   PMID:26122137   PMID:26189370   PMID:26271253   PMID:26308623   PMID:26312751   PMID:26378024   PMID:26410627  
PMID:26439841   PMID:26475855   PMID:26485285   PMID:26639895   PMID:26690700   PMID:27032908   PMID:27245461   PMID:27351842   PMID:27711210   PMID:27797821   PMID:27815317   PMID:27827823  
PMID:28341741   PMID:28465762   PMID:28533326   PMID:28572443   PMID:28607093   PMID:28819185   PMID:28844837   PMID:29522761   PMID:29599139   PMID:29890224   PMID:29935220   PMID:30166566  
PMID:30320390   PMID:30397349   PMID:30562059   PMID:30619314   PMID:30787297   PMID:30948641   PMID:31015404   PMID:31432142   PMID:31645712   PMID:31688905   PMID:31755615   PMID:32142358  
PMID:32267917   PMID:32322056   PMID:32484881   PMID:32640908   PMID:32641583   PMID:32722929   PMID:33053354   PMID:33275302   PMID:33647796   PMID:34239062   PMID:35037469   PMID:35260536  
PMID:35379745   PMID:35499079   PMID:35675777   PMID:36172956   PMID:36749647   PMID:37315536   PMID:37451271   PMID:37566109   PMID:38658748   PMID:38856684  


Genomics

Comparative Map Data
Ptger4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,262,880 - 5,273,668 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl155,236,142 - 5,273,668 (-)EnsemblGRCm39 Ensembl
GRCm38155,233,399 - 5,244,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,206,661 - 5,244,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,183,404 - 5,193,831 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36155,181,080 - 5,191,046 (-)NCBIMGSCv36mm8
Celera155,082,719 - 5,093,146 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.99NCBI
PTGER4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38540,679,915 - 40,746,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl540,679,915 - 40,693,735 (+)EnsemblGRCh38hg38GRCh38
GRCh37540,680,017 - 40,693,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,715,789 - 40,729,594 (+)NCBINCBI36Build 36hg18NCBI36
Build 34540,715,788 - 40,729,592NCBI
Celera540,568,598 - 40,582,403 (+)NCBICelera
Cytogenetic Map5p13.1NCBI
HuRef540,632,020 - 40,645,825 (+)NCBIHuRef
CHM1_1540,681,992 - 40,695,797 (+)NCBICHM1_1
T2T-CHM13v2.0540,936,331 - 41,003,197 (+)NCBIT2T-CHM13v2.0
Ptger4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8256,061,699 - 56,074,594 (-)NCBIGRCr8
mRatBN7.2254,330,563 - 54,347,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl254,335,424 - 54,346,670 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx261,442,386 - 61,453,021 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0259,501,061 - 59,511,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0254,511,378 - 54,522,007 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0254,951,625 - 54,966,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,952,821 - 54,963,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,974,390 - 73,987,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,423,280 - 54,433,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1254,351,507 - 54,362,753 (-)NCBI
Celera249,982,896 - 49,993,523 (-)NCBICelera
Cytogenetic Map2q16NCBI
Ptger4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542624,997,811 - 25,010,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542624,997,811 - 25,010,822 (+)NCBIChiLan1.0ChiLan1.0
PTGER4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2469,643,990 - 69,657,266 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1567,797,598 - 67,810,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0569,686,906 - 69,700,739 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1574,731,470 - 74,745,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,731,470 - 74,745,148 (-)Ensemblpanpan1.1panPan2
PTGER4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,663,362 - 68,676,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,663,364 - 68,676,358 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,339,460 - 68,352,693 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0469,169,559 - 69,182,795 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl469,169,566 - 69,182,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1468,929,030 - 68,942,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0469,042,114 - 69,055,368 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0469,581,192 - 69,594,491 (-)NCBIUU_Cfam_GSD_1.0
Ptger4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,454,672 - 229,468,133 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365181,903,725 - 1,916,746 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365181,903,636 - 1,916,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,670,862 - 25,686,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,670,832 - 25,686,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTGER4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,440,697 - 39,453,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl439,440,276 - 39,454,004 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607129,862,058 - 29,876,121 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptger4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475914,244,899 - 14,258,445 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475914,243,887 - 14,259,090 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptger4
126 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1360
Count of miRNA genes:473
Interacting mature miRNAs:554
Transcripts:ENSMUST00000047379, ENSMUST00000120563, ENSMUST00000133966
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300594Eae2_msusceptibility to experimental allergic encephalomyelitis 2 (mouse)Not determined15131218736Mouse
1301136Pgia8_mproteoglycan induced arthritis 8 (mouse)Not determined15324016724388176Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357459Nhdlq7_mnon-HDL QTL 7 (mouse)Not determined15120489829Mouse
1300953Bdt5_mbone density traits 5 (mouse)Not determined15120489829Mouse
5491193Mobq4_mmultigenic obesity QTL 4 (mouse)Not determined15120489829Mouse
1301023Sluc24_msusceptibility to lung cancer 24 (mouse)Not determined15120489829Mouse
1301662Faq8_mfluctuating asymmetry QTL 8 (mouse)Not determined15120489829Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
4141358Ath22_matherosclerosis 22 (mouse)Not determined346465237464652Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4141446Ffaq4_mfree fatty acid QTL 4 (mouse)Not determined127101390Mouse
1302121Cliff_mcliff drop aversion (mouse)Not determined15120489829Mouse
4141541Tglq3_mtriglyceride QTL 3 (mouse)Not determined15120489829Mouse
11062069Bpq31_mblood pressure QTL 31 (mouse)15126273195Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse

Markers in Region
RH127164  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38155,237,319 - 5,237,566UniSTSGRCm38
MGSCv37155,187,319 - 5,187,566UniSTSGRCm37
Celera155,086,634 - 5,086,881UniSTS
Cytogenetic Map15A1UniSTS
cM Map156.4UniSTS
Whitehead/MRC_RH1015.43UniSTS
Ptger4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38155,234,387 - 5,234,819UniSTSGRCm38
MGSCv37155,184,387 - 5,184,819UniSTSGRCm37
Celera155,083,702 - 5,084,134UniSTS
Cytogenetic Map15A1UniSTS
cM Map156.4UniSTS
SHGC-64757  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38155,242,606 - 5,242,779UniSTSGRCm38
MGSCv37155,192,606 - 5,192,779UniSTSGRCm37
Celera155,091,921 - 5,092,094UniSTS
Cytogenetic Map15A1UniSTS
cM Map156.4UniSTS


Expression


Sequence


Ensembl Acc Id: ENSMUST00000047379   ⟹   ENSMUSP00000048736
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,262,880 - 5,273,668 (-)Ensembl
GRCm38.p6 Ensembl155,233,399 - 5,244,187 (-)Ensembl
Ensembl Acc Id: ENSMUST00000120563   ⟹   ENSMUSP00000112858
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,262,880 - 5,273,653 (-)Ensembl
GRCm38.p6 Ensembl155,233,399 - 5,244,172 (-)Ensembl
Ensembl Acc Id: ENSMUST00000133966
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl155,236,142 - 5,272,191 (-)Ensembl
GRCm38.p6 Ensembl155,206,661 - 5,242,710 (-)Ensembl
RefSeq Acc Id: NM_001136079   ⟹   NP_001129551
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39155,262,880 - 5,273,668 (-)NCBI
GRCm38155,233,399 - 5,244,187 (-)NCBI
MGSCv37155,183,404 - 5,193,831 (-)RGD
Celera155,082,714 - 5,093,503 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008965   ⟹   NP_032991
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39155,262,880 - 5,273,668 (-)NCBI
GRCm38155,233,399 - 5,244,187 (-)NCBI
MGSCv37155,183,404 - 5,193,831 (-)RGD
Celera155,082,714 - 5,093,503 (-)NCBI
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032991   ⟸   NM_008965
- Peptide Label: isoform 2
- UniProtKB: P32240 (UniProtKB/Swiss-Prot),   Q3UM94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001129551   ⟸   NM_001136079
- Peptide Label: isoform 1
- UniProtKB: Q91VE4 (UniProtKB/TrEMBL),   Q3UM94 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000048736   ⟸   ENSMUST00000047379
Ensembl Acc Id: ENSMUSP00000112858   ⟸   ENSMUST00000120563
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32240-F1-model_v2 AlphaFold P32240 1-513 view protein structure

Promoters
RGD ID:6826386
Promoter ID:MM_KWN:17940
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:OTTMUST00000069331
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36155,192,371 - 5,193,377 (-)MPROMDB
RGD ID:6826385
Promoter ID:MM_KWN:17941
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000120563,   OTTMUST00000069329
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36155,194,121 - 5,194,822 (-)MPROMDB
RGD ID:8683336
Promoter ID:EPDNEW_M19698
Type:multiple initiation site
Name:Ptger4_1
Description:Mus musculus prostaglandin E receptor 4 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38155,244,186 - 5,244,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104311 AgrOrtholog
Ensembl Genes ENSMUSG00000039942 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000047379 ENTREZGENE
  ENSMUST00000047379.15 UniProtKB/Swiss-Prot
  ENSMUST00000120563 ENTREZGENE
  ENSMUST00000120563.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prost_EP4_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostanoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_DP_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19219 UniProtKB/Swiss-Prot
MGD MGI:104311 ENTREZGENE
NCBI Gene 19219 ENTREZGENE
PANTHER PTHR11866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11866:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptger4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROSTAGLNDNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROSTANOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDEP4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P32240 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UM94 ENTREZGENE, UniProtKB/TrEMBL
  Q8BZK1_MOUSE UniProtKB/TrEMBL
  Q91VE4 ENTREZGENE, UniProtKB/TrEMBL