Tff1 (trefoil factor 1) - Rat Genome Database

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Gene: Tff1 (trefoil factor 1) Mus musculus
Analyze
Symbol: Tff1
Name: trefoil factor 1
RGD ID: 732017
MGI Page MGI
Description: Predicted to enable growth factor activity. Acts upstream of or within cell differentiation and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; ear; nervous system; reproductive system; and skeleton. Used to study stomach cancer. Orthologous to human TFF1 (trefoil factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bce; Bcei; P; PS2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,380,369 - 31,384,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,380,369 - 31,384,251 (-)EnsemblGRCm39 Ensembl
GRCm381731,161,395 - 31,165,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,161,395 - 31,165,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv371731,298,341 - 31,301,998 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,888,408 - 30,892,034 (-)NCBIMGSCv36mm8
Celera1732,078,643 - 32,082,300 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2-acetamidofluorene  (EXP)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
3-phenoxybenzoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-nonylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
adenine  (ISO)
afimoxifene  (ISO)
alpha-mangostin  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphotericin B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
benzyl benzoate  (ISO)
Benzyl salicylate  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
biphenyl-4-ol  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
capecitabine  (ISO)
captafol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
chrysin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyprodinil  (ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzacamene  (ISO)
equilin  (ISO)
equol  (ISO)
estriol  (ISO)
estrone  (ISO)
ethylparaben  (ISO)
exemestane  (ISO)
fenvalerate  (ISO)
flumethrin  (ISO)
Flumetralin  (ISO)
flutolanil  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
Goe 6976  (ISO)
Heptachlor epoxide  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
ICI-164384  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
Isobavachin  (ISO)
isoprothiolane  (ISO)
isorhamnetin  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
linuron  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
melatonin  (ISO)
menadione  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
molibresib  (ISO)
Moxestrol  (ISO)
N-nitrosodiethylamine  (ISO)
nandrolone  (ISO)
naphthalene  (EXP)
nilotinib  (EXP)
Nonylphenol  (ISO)
Norethynodrel  (ISO)
ospemifene  (ISO)
oxazepam  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
permethrin  (ISO)
phenothrin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
pyrimethanil  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rosuvastatin calcium  (EXP)
rottlerin  (ISO)
royal jelly  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sophoraflavanone B  (ISO)
spironolactone  (ISO)
stilbene-4,4'-diol  (ISO)
SU6656  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (EXP,ISO)
tetraphene  (EXP,ISO)
tetrathiomolybdate(2-)  (ISO)
titanium dioxide  (EXP)
toxaphene  (ISO)
trans-stilbene-4,4'-diol  (ISO)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Searching QTL by gene expression: analysis of diabesity. Brown AC, etal., BMC Genet 2005 Mar 10;6(1):12.
2. Differential RNA expression of the pS2 gene in the human benign and malignant prostatic tissue. Colombel M, etal., J Urol. 1999 Sep;162(3 Pt 1):927-30.
3. Cytosolic levels of TFF1/pS2 in breast cancer: Their relationship with clinical-pathological parameters and their prognostic significance. Corte MD, etal., Breast Cancer Res Treat. 2006 Mar;96(1):63-72. Epub 2005 Nov 3.
4. Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection. Esposito R, etal., Front Cell Infect Microbiol. 2017 Oct 9;7:434. doi: 10.3389/fcimb.2017.00434. eCollection 2017.
5. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, etal., Nature 2002 Dec 5;420(6915):586-90.
6. cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis. Itoh H, etal., Biochem J 1996 Sep 15;318 ( Pt 3):939-44.
7. Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach. Kang B, etal., J Gastroenterol Hepatol. 2001 Nov;16(11):1222-7.
8. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
9. Expression of pS2 protein in endometrial carcinomas: correlation with clinicopathologic features and sex steroid receptor status. Koshiyama M, etal., Int J Cancer. 1997 Jun 20;74(3):237-44.
10. Tumor-associated neoexpression of the pS2 peptide and MUC5AC mucin in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. Kunze E, etal., Histol Histopathol. 2008 May;23(5):539-48.
11. Expression of pS2 protein in transitional cell bladder tumours. Lipponen PK and Eskelinen MJ, J Pathol. 1994 Aug;173(4):327-32.
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Human chromosome 21 gene expression atlas in the mouse. Reymond A, etal., Nature 2002 Dec 5;420(6915):582-6.
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Estrogen receptor alpha and beta, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast. Rody A, etal., Oncol Rep. 2004 Oct;12(4):695-9.
20. Changes in expression of estrogen receptors alpha and beta in relation to progesterone receptor and pS2 status in normal and malignant endometrium. Saegusa M and Okayasu I, Jpn J Cancer Res. 2000 May;91(5):510-8.
21. Up-regulation of pS2 expression during the development of adenocarcinomas but not squamous cell carcinomas of the uterine cervix, independently of expression of c-jun or oestrogen and progesterone receptors. Saegusa M, etal., J Pathol. 2000 Apr;190(5):554-63.
22. pS2 and PAI-1 in ovarian cancer: correlation to pathohistological parameters. Speiser P, etal., Anticancer Res. 1997 Jan-Feb;17(1B):679-83.
23. Spatio-temporal expression of trefoil peptide following severe gastric ulceration in the rat implicates it in late-stage repair processes. Ulaganathan M, etal., J Gastroenterol Hepatol. 2001 May;16(5):506-12.
24. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Vestergaard EM, etal., Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):807-12.
25. Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer. Walker G, etal., Gynecol Oncol. 2007 Sep;106(3):461-8. Epub 2007 Jul 10.
Additional References at PubMed
PMID:8314841   PMID:8824193   PMID:10219910   PMID:10349636   PMID:10350130   PMID:10611155   PMID:11042159   PMID:11076861   PMID:11290420   PMID:11707078   PMID:12219085   PMID:12477932  
PMID:12768581   PMID:12810622   PMID:14681479   PMID:15361486   PMID:16049341   PMID:16133145   PMID:16141072   PMID:16141073   PMID:16374579   PMID:16602821   PMID:16990615   PMID:17196193  
PMID:17522155   PMID:18558092   PMID:19040570   PMID:20036835   PMID:21111741   PMID:21358676   PMID:21490402   PMID:21677750   PMID:21873635   PMID:22034055   PMID:22682244   PMID:24721909  
PMID:25107557   PMID:25324506   PMID:25725142   PMID:25980439   PMID:26372254   PMID:26974160   PMID:27522676   PMID:27731922   PMID:27832633   PMID:28281307   PMID:29453320   PMID:29809170  
PMID:29985646   PMID:30333090   PMID:30671113   PMID:30973865   PMID:31235784   PMID:31292446   PMID:31668390   PMID:31733149   PMID:31963721   PMID:32685004   PMID:33649537   PMID:35114215  
PMID:35279702   PMID:35332699   PMID:35588797   PMID:35677533   PMID:37628863   PMID:38355793   PMID:38872370   PMID:38905124   PMID:39197918  


Genomics

Comparative Map Data
Tff1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,380,369 - 31,384,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,380,369 - 31,384,251 (-)EnsemblGRCm39 Ensembl
GRCm381731,161,395 - 31,165,060 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,161,395 - 31,165,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv371731,298,341 - 31,301,998 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361730,888,408 - 30,892,034 (-)NCBIMGSCv36mm8
Celera1732,078,643 - 32,082,300 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.8NCBI
TFF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382142,362,282 - 42,366,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2142,362,282 - 42,366,535 (-)EnsemblGRCh38hg38GRCh38
GRCh372143,782,391 - 43,786,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,655,460 - 42,659,713 (-)NCBINCBI36Build 36hg18NCBI36
Build 342142,655,459 - 42,659,713NCBI
Celera2128,931,367 - 28,935,619 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,199,645 - 29,203,896 (-)NCBIHuRef
CHM1_12143,342,564 - 43,346,817 (-)NCBICHM1_1
T2T-CHM13v2.02140,751,729 - 40,755,982 (-)NCBIT2T-CHM13v2.0
Tff1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8209,237,095 - 9,240,956 (-)NCBIGRCr8
mRatBN7.2209,235,736 - 9,239,597 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,235,736 - 9,239,597 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx209,930,565 - 9,934,421 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0209,291,735 - 9,295,591 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0209,766,849 - 9,770,721 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0209,892,124 - 9,895,984 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl209,892,124 - 9,895,984 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,071,835 - 12,075,695 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4209,526,674 - 9,530,534 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1209,526,900 - 9,530,761 (-)NCBI
Celera2010,760,042 - 10,763,903 (-)NCBICelera
Cytogenetic Map20p12NCBI
Tff1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540739,363,693 - 39,365,724 (+)NCBIChiLan1.0ChiLan1.0
TFF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22238,417,954 - 38,422,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12133,270,372 - 33,274,614 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,669,323 - 28,673,556 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,988,039 - 41,992,270 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,988,039 - 41,992,270 (-)Ensemblpanpan1.1panPan2
TFF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,681,478 - 36,684,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,681,357 - 36,695,665 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,832,379 - 35,835,472 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,197,946 - 36,201,048 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,197,825 - 36,201,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,090,916 - 36,094,013 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,071,100 - 36,074,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,566,194 - 36,569,306 (-)NCBIUU_Cfam_GSD_1.0
TFF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,687,560 - 205,691,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,687,558 - 205,691,512 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,090,047 - 216,093,946 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,239,101 - 86,244,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl286,239,105 - 86,243,795 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605414,199,648 - 14,204,451 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tff1
159 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:151
Interacting mature miRNAs:158
Transcripts:ENSMUST00000024831
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
11038694Pas19_mpulmonary adenoma susceptibility 19 (mouse)172971116434754437Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse

Markers in Region
Tff1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS
cM Map1717.0UniSTS
Tff1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A3.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000024831   ⟹   ENSMUSP00000024831
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1731,380,369 - 31,384,251 (-)Ensembl
GRCm38.p6 Ensembl1731,161,395 - 31,165,277 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235870   ⟹   ENSMUSP00000157776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1731,380,372 - 31,383,976 (-)Ensembl
GRCm38.p6 Ensembl1731,161,398 - 31,165,002 (-)Ensembl
RefSeq Acc Id: NM_009362   ⟹   NP_033388
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391731,380,370 - 31,384,027 (-)NCBI
GRCm381731,161,396 - 31,165,053 (-)NCBI
MGSCv371731,298,341 - 31,301,998 (-)RGD
Celera1732,078,643 - 32,082,300 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006524030   ⟹   XP_006524093
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391731,380,369 - 31,384,034 (-)NCBI
GRCm381731,161,395 - 31,165,060 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033388   ⟸   NM_009362
- Peptide Label: precursor
- UniProtKB: Q3TVE6 (UniProtKB/Swiss-Prot),   Q08423 (UniProtKB/Swiss-Prot),   Q149Y8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006524093   ⟸   XM_006524030
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000157776   ⟸   ENSMUST00000235870
Ensembl Acc Id: ENSMUSP00000024831   ⟸   ENSMUST00000024831
Protein Domains
P-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q08423-F1-model_v2 AlphaFold Q08423 1-87 view protein structure

Promoters
RGD ID:13675462
Promoter ID:EPDNEW_M21879
Type:multiple initiation site
Name:Tff1_1
Description:Mus musculus trefoil factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381731,165,049 - 31,165,109EPDNEW
RGD ID:6828777
Promoter ID:MM_KWN:22985
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_009362
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361731,302,041 - 31,302,541 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88135 AgrOrtholog
Ensembl Genes ENSMUSG00000024032 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000024831 ENTREZGENE
  ENSMUST00000024831.8 UniProtKB/Swiss-Prot
  ENSMUST00000235870.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P_trefoil_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_trefoil_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88135 ENTREZGENE
NCBI Gene 21784 ENTREZGENE
PANTHER PTHR13826 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TREFOIL FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trefoil UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tff1 PhenoGen
PRINTS PTREFOIL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_TREFOIL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_TREFOIL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57492 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9V9_MOUSE UniProtKB/TrEMBL
  Q08423 ENTREZGENE
  Q149Y8 ENTREZGENE, UniProtKB/TrEMBL
  Q3TVE6 ENTREZGENE
  TFF1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TVE6 UniProtKB/Swiss-Prot