Nf2 (neurofibromin 2) - Rat Genome Database

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Gene: Nf2 (neurofibromin 2) Mus musculus
Analyze
Symbol: Nf2
Name: neurofibromin 2
RGD ID: 731859
MGI Page MGI
Description: Predicted to enable several functions, including actin binding activity; beta-catenin binding activity; and integrin binding activity. Involved in lens fiber cell differentiation. Acts upstream of or within several processes, including hippocampus development; negative regulation of MAPK cascade; and negative regulation of cell population proliferation. Located in several cellular components, including adherens junction; cleavage furrow; and ruffle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study coloboma; otitis media; renal cell carcinoma; and vestibular schwannomatosis. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: me; merlin; moesin-ezrin-radixin-like protein; neurofibromatosis 2; neurofibromin-2; schw; schwannomin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,715,845 - 4,799,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,715,845 - 4,799,536 (-)EnsemblGRCm39 Ensembl
GRCm38114,757,639 - 4,849,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,665,851 - 4,749,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,667,997 - 4,749,553 (-)NCBIMGSCv36mm8
Celera115,266,247 - 5,349,954 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
brain development  (IMP)
cell-cell junction organization  (IMP)
ectoderm development  (IMP)
hippocampus development  (IMP)
lens fiber cell differentiation  (IMP)
MAPK cascade  (IMP)
mesoderm formation  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IBA,IMP,ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of MAPK cascade  (IMP)
negative regulation of osteoblast proliferation  (IMP)
negative regulation of protein kinase activity  (IDA,IMP)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of Schwann cell proliferation  (IMP)
negative regulation of tyrosine phosphorylation of STAT protein  (ISO)
odontogenesis of dentin-containing tooth  (IMP)
osteoblast proliferation  (IMP)
positive regulation of cell differentiation  (IMP)
positive regulation of early endosome to late endosome transport  (IBA)
positive regulation of protein localization to early endosome  (IBA)
positive regulation of stress fiber assembly  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell cycle  (ISO)
regulation of cell population proliferation  (IMP)
regulation of cell shape  (IBA)
regulation of gliogenesis  (IBA,IMP)
regulation of hippo signaling  (IBA,ISO)
regulation of neural precursor cell proliferation  (IMP)
regulation of neurogenesis  (IMP)
regulation of organelle assembly  (IBA)
regulation of protein localization to nucleus  (IMP)
regulation of protein stability  (IMP)
regulation of stem cell proliferation  (IGI,IMP)
Schwann cell proliferation  (IMP,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal auditory brainstem response waveform shape  (IAGP)
abnormal axon morphology  (IAGP)
abnormal bile duct epithelium morphology  (IAGP)
abnormal bile duct physiology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal dorsal-ventral axis patterning  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal meninges morphology  (IAGP)
abnormal optic cup morphology  (IAGP)
abnormal optic fissure morphology  (IAGP)
abnormal osteoblast morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
absent extraembryonic ectoderm  (IAGP)
absent mesoderm  (IAGP)
bile duct hyperplasia  (IAGP)
bile duct proliferation  (IAGP)
cataract  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
cleft upper lip  (IAGP)
coloboma  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased survivor rate  (IAGP)
delayed tooth eruption  (IAGP)
disorganized extraembryonic tissue  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged dorsal root ganglion  (IAGP)
enlarged liver  (IAGP)
failure of eyelid fusion  (IAGP)
failure of tooth eruption  (IAGP)
failure to gastrulate  (IAGP)
head bobbing  (IAGP)
head tilt  (IAGP)
head tossing  (IAGP)
hydrocephaly  (IAGP)
impaired coordination  (IAGP)
impaired righting response  (IAGP)
impaired swimming  (IAGP)
increased carcinoma incidence  (IAGP)
increased extremity angiosarcoma incidence  (IAGP)
increased fibroadenoma incidence  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased hamartoma incidence  (IAGP)
increased hepatobiliary system tumor incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased leiomyosarcoma incidence  (IAGP)
increased leukemia incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased malignant tumor incidence  (IAGP)
increased meningioma incidence  (IAGP)
increased mesothelioma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased nervous system tumor incidence  (IAGP)
increased neurofibroma incidence  (IAGP)
increased neurofibrosarcoma incidence  (IAGP)
increased odontoma incidence  (IAGP)
increased odontosarcoma incidence  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased osteoma incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased renal carcinoma incidence  (IAGP)
increased rhabdomyosarcoma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased Schwann cell number  (IAGP)
increased Schwannoma incidence  (IAGP)
increased skeletal tumor incidence  (IAGP)
increased susceptibility to otitis media  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased thyroid tumor incidence  (IAGP)
increased tumor incidence  (IAGP)
increased uterus leiomyoma incidence  (IAGP)
infertility  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
osseous metaplasia  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
pleural effusion  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
retina pigment epithelium hyperplasia  (IAGP)
sensorineural hearing loss  (IAGP)
small ectoplacental cone  (IAGP)
trunk curl  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A mouse model recapitulating molecular features of human mesothelioma. Altomare DA, etal., Cancer Res. 2005 Sep 15;65(18):8090-5. doi: 10.1158/0008-5472.CAN-05-2312.
2. Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice. Badhai J, etal., J Exp Med. 2020 Jun 1;217(6). pii: 151644. doi: 10.1084/jem.20191257.
3. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Bueno R, etal., Nat Genet. 2016 Apr;48(4):407-16. doi: 10.1038/ng.3520. Epub 2016 Feb 29.
4. A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. Caltabiano R, etal., Childs Nerv Syst. 2017 Jun;33(6):933-940. doi: 10.1007/s00381-017-3340-2. Epub 2017 Apr 1.
5. Loss of NF2/Merlin expression in advanced sporadic colorectal cancer. Cačev T, etal., Cell Oncol (Dordr). 2014 Feb;37(1):69-77. doi: 10.1007/s13402-013-0164-2. Epub 2013 Dec 10.
6. Merlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells. Cocciadiferro L, etal., J Steroid Biochem Mol Biol. 2017 Sep;172:222-230. doi: 10.1016/j.jsbmb.2016.05.023. Epub 2016 Jun 8.
7. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout. Doi Y, etal., J Biol Chem 1999 Jan 22;274(4):2315-21.
8. Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor. Fukasawa T, etal., Jpn J Cancer Res. 2000 Dec;91(12):1241-9. doi: 10.1111/j.1349-7006.2000.tb00910.x.
9. [Expression of Merlin protein in non-small cell lung carcinoma and the clinical significance]. Hu J, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jun;36(6):565-9. doi: 10.3969/j.issn.1672-7347.2011.06.015.
10. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
11. p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis. Laine H, etal., J Neurosci. 2007 Feb 7;27(6):1434-44.
12. Targeted next-generation sequencing for differential diagnosis of neurofibromatosis type 2, schwannomatosis, and meningiomatosis. Louvrier C, etal., Neuro Oncol. 2018 Jun 18;20(7):917-929. doi: 10.1093/neuonc/noy009.
13. A splicing variant of Merlin promotes metastasis in hepatocellular carcinoma. Luo ZL, etal., Nat Commun. 2015 Oct 7;6:8457. doi: 10.1038/ncomms9457.
14. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
15. Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma. Meerang M, etal., Mol Oncol. 2016 Oct;10(8):1255-65. doi: 10.1016/j.molonc.2016.06.005. Epub 2016 Jun 25.
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Morris ZS and McClatchey AI, Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9767-72. Epub 2009 Jun 1.
19. Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. Mérel P, etal., Genes Chromosomes Cancer. 1995 Jul;13(3):211-6. doi: 10.1002/gcc.2870130311.
20. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Molecular genetics of meningiomas. Ragel BT and Jensen RL, Neurosurg Focus. 2005 Nov 15;19(5):E9.
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma. Singhi AD, etal., Mod Pathol. 2016 Jan;29(1):14-24. doi: 10.1038/modpathol.2015.121. Epub 2015 Oct 23.
27. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Wang Q, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jan;37(1):115-7.
28. Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas. Wu H, etal., Neuroscience. 2010 Sep 29;170(1):149-55. doi: 10.1016/j.neuroscience.2010.06.051. Epub 2010 Jul 1.
29. Molecular alterations of the NF2 gene in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Zhang N, etal., Oncol Rep. 2017 Dec;38(6):3650-3658. doi: 10.3892/or.2017.6055. Epub 2017 Oct 24.
Additional References at PubMed
PMID:7506121   PMID:7913580   PMID:7981675   PMID:7983158   PMID:8012352   PMID:8088840   PMID:8162023   PMID:8547603   PMID:8889548   PMID:8889551   PMID:8930405   PMID:8982467  
PMID:9171370   PMID:9553042   PMID:9563848   PMID:9631655   PMID:9661659   PMID:9662407   PMID:9917000   PMID:10215625   PMID:10349636   PMID:10887156   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11544199   PMID:11756419   PMID:11782491   PMID:12000789   PMID:12082543   PMID:12130630   PMID:12203111   PMID:12386807   PMID:12477932   PMID:12558984   PMID:12695331  
PMID:12802287   PMID:12904583   PMID:14580336   PMID:14610273   PMID:14681479   PMID:14691545   PMID:15133494   PMID:15221010   PMID:15467741   PMID:15659388   PMID:15699051   PMID:15782199  
PMID:15797715   PMID:15913605   PMID:16141072   PMID:16141073   PMID:16319530   PMID:16405865   PMID:16602821   PMID:16885985   PMID:16894610   PMID:16953231   PMID:17015433   PMID:17210637  
PMID:17272307   PMID:17360635   PMID:17924978   PMID:18086884   PMID:18328429   PMID:18486129   PMID:18632626   PMID:18682243   PMID:18799693   PMID:18923024   PMID:19029950   PMID:19103750  
PMID:19451225   PMID:19451229   PMID:19654444   PMID:19884346   PMID:19910496   PMID:20154721   PMID:20156804   PMID:20181838   PMID:20643348   PMID:20668201   PMID:20675406   PMID:21074722  
PMID:21182951   PMID:21242963   PMID:21267068   PMID:21281820   PMID:21402777   PMID:21481793   PMID:21677750   PMID:21873635   PMID:21878678   PMID:22482125   PMID:23045274   PMID:23045281  
PMID:23249734   PMID:23455610   PMID:23563179   PMID:23644383   PMID:23791728   PMID:23863479   PMID:24003254   PMID:24012335   PMID:24014231   PMID:24166499   PMID:24309211   PMID:24401838  
PMID:24581491   PMID:24706749   PMID:24817309   PMID:24906150   PMID:24912773   PMID:25026211   PMID:25113746   PMID:25336744   PMID:25433207   PMID:26057084   PMID:26109051   PMID:26258444  
PMID:26359368   PMID:26371508   PMID:26418719   PMID:26483553   PMID:26496610   PMID:26549232   PMID:26554010   PMID:26935421   PMID:26985001   PMID:27358050   PMID:27402866   PMID:27467574  
PMID:27480037   PMID:27568557   PMID:27818180   PMID:28087714   PMID:28137778   PMID:28195124   PMID:28824165   PMID:28947533   PMID:28972170   PMID:29107558   PMID:29249622   PMID:29408605  
PMID:29416648   PMID:29507420   PMID:29712669   PMID:30118662   PMID:30401838   PMID:30651296   PMID:31015291   PMID:31040226   PMID:31062247   PMID:31151962   PMID:31165301   PMID:32098917  
PMID:32325033   PMID:32451369   PMID:32525563   PMID:32554809   PMID:32960816   PMID:33075808   PMID:33331896   PMID:33410252   PMID:33414453   PMID:34075397   PMID:34264955   PMID:34321999  
PMID:34389715   PMID:34433060   PMID:35429439   PMID:35955749   PMID:36355620   PMID:36806881   PMID:37174657   PMID:38102738  


Genomics

Comparative Map Data
Nf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,715,845 - 4,799,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,715,845 - 4,799,536 (-)EnsemblGRCm39 Ensembl
GRCm38114,757,639 - 4,849,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,665,851 - 4,749,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,667,997 - 4,749,553 (-)NCBIMGSCv36mm8
Celera115,266,247 - 5,349,954 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.0NCBI
NF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,603,556 - 29,698,600 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,603,553 - 29,698,598 (+)EnsemblGRCh38hg38GRCh38
GRCh372229,999,545 - 30,094,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,329,565 - 28,424,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 342228,324,118 - 28,419,137NCBI
Celera2213,799,281 - 13,894,313 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2212,962,966 - 13,057,866 (+)NCBIHuRef
CHM1_12229,958,840 - 30,053,867 (+)NCBICHM1_1
T2T-CHM13v2.02230,066,918 - 30,161,963 (+)NCBIT2T-CHM13v2.0
Nf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,850,894 - 83,934,263 (-)NCBIGRCr8
mRatBN7.21479,627,399 - 79,710,709 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,627,399 - 79,710,667 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,057,988 - 84,141,291 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,298,058 - 85,381,369 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,747,732 - 81,831,027 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,996,905 - 85,088,547 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,996,905 - 85,088,523 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,673,149 - 85,766,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,415,142 - 85,508,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,436,559 - 85,527,546 (-)NCBI
Celera1478,532,232 - 78,615,355 (-)NCBICelera
Cytogenetic Map14q21NCBI
Nf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,862,347 - 3,951,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,862,804 - 3,950,669 (+)NCBIChiLan1.0ChiLan1.0
NF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,576,173 - 39,669,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,277,420 - 42,371,228 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,648,022 - 10,738,167 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,454,119 - 28,544,013 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,454,119 - 28,544,013 (+)Ensemblpanpan1.1panPan2
NF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,816,869 - 22,896,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,816,551 - 22,894,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,688,278 - 22,767,181 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,190,481 - 23,269,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,190,429 - 23,269,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,900,555 - 22,979,936 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,163,349 - 23,242,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,223,162 - 23,302,265 (+)NCBIUU_Cfam_GSD_1.0
Nf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,250,596 - 112,334,448 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,536,141 - 3,623,821 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,536,212 - 3,622,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,653,900 - 46,731,999 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,653,869 - 46,726,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,688,078 - 49,760,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,474,479 - 12,572,144 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,474,468 - 12,572,250 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,569,107 - 113,665,600 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,923,834 - 6,011,939 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,923,827 - 6,011,276 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nf2
2451 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2605
Count of miRNA genes:853
Interacting mature miRNAs:1145
Transcripts:ENSMUST00000053079, ENSMUST00000056290, ENSMUST00000093374, ENSMUST00000109908, ENSMUST00000109910, ENSMUST00000124878, ENSMUST00000137926, ENSMUST00000141342, ENSMUST00000152656, ENSMUST00000155600, ENSMUST00000164190, ENSMUST00000167480, ENSMUST00000172305
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
RH94846  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,782,194 - 4,782,346UniSTSGRCm38
MGSCv37114,682,197 - 4,682,349UniSTSGRCm37
Celera115,282,609 - 5,282,761UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.25UniSTS
43.MMHAP85FLG4.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,806,503 - 4,806,675UniSTSGRCm38
MGSCv37114,706,506 - 4,706,678UniSTSGRCm37
Celera115,306,933 - 5,307,105UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.25UniSTS
Whitehead_YAC11 UniSTS
GDB:373416  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,784,444 - 4,784,561UniSTSGRCm38
MGSCv37114,684,447 - 4,684,564UniSTSGRCm37
Celera115,284,859 - 5,284,976UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.25UniSTS
GDB:373421  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,782,195 - 4,782,336UniSTSGRCm38
MGSCv37114,682,198 - 4,682,339UniSTSGRCm37
Celera115,282,610 - 5,282,751UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.25UniSTS
Nf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37114,689,668 - 4,689,885UniSTSGRCm37
Celera115,290,072 - 5,290,289UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.25UniSTS
cM Map110.25UniSTS
D11Mcg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,767,852 - 4,768,136UniSTSGRCm38
MGSCv37114,667,855 - 4,668,139UniSTSGRCm37
Celera115,268,250 - 5,268,544UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.25UniSTS
Nf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,789,665 - 4,789,882UniSTSGRCm38
MGSCv37114,689,668 - 4,689,885UniSTSGRCm37
Celera115,290,072 - 5,290,289UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.25UniSTS
Nf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001252250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001252251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001252252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001252253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011243669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB839081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM951158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ745455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX638106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY144572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY271441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB519415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD561250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK346889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN526793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN715904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV654856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY442315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L22987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L22988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L22989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X75759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000053079   ⟹   ENSMUSP00000055033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,722,334 - 4,799,365 (-)Ensembl
GRCm38.p6 Ensembl114,772,334 - 4,849,365 (-)Ensembl
Ensembl Acc Id: ENSMUST00000056290   ⟹   ENSMUSP00000055061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,717,665 - 4,798,985 (-)Ensembl
GRCm38.p6 Ensembl114,767,665 - 4,848,985 (-)Ensembl
Ensembl Acc Id: ENSMUST00000093374   ⟹   ENSMUSP00000091066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,729,814 - 4,770,396 (-)Ensembl
GRCm38.p6 Ensembl114,779,814 - 4,820,396 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109908
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,731,937 - 4,783,133 (-)Ensembl
GRCm38.p6 Ensembl114,781,937 - 4,833,133 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109910   ⟹   ENSMUSP00000105536
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,715,845 - 4,799,536 (-)Ensembl
GRCm38.p6 Ensembl114,765,845 - 4,849,536 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124878   ⟹   ENSMUSP00000132184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,749,861 - 4,770,396 (-)Ensembl
GRCm38.p6 Ensembl114,799,861 - 4,820,396 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137926   ⟹   ENSMUSP00000116505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,744,480 - 4,768,547 (-)Ensembl
GRCm38.p6 Ensembl114,794,480 - 4,818,547 (-)Ensembl
Ensembl Acc Id: ENSMUST00000141342
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,717,953 - 4,735,107 (-)Ensembl
GRCm38.p6 Ensembl114,767,953 - 4,785,107 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152656   ⟹   ENSMUSP00000128494
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,734,436 - 4,766,165 (-)Ensembl
GRCm38.p6 Ensembl114,784,436 - 4,816,165 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,744,431 - 4,765,240 (-)Ensembl
GRCm38.p6 Ensembl114,794,431 - 4,815,240 (-)Ensembl
Ensembl Acc Id: ENSMUST00000164190   ⟹   ENSMUSP00000129388
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,741,201 - 4,799,194 (-)Ensembl
GRCm38.p6 Ensembl114,791,201 - 4,849,194 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167480
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,768,505 - 4,774,921 (-)Ensembl
GRCm38.p6 Ensembl114,818,505 - 4,824,921 (-)Ensembl
Ensembl Acc Id: ENSMUST00000172305   ⟹   ENSMUSP00000130263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,779,843 - 4,799,125 (-)Ensembl
GRCm38.p6 Ensembl114,829,843 - 4,849,125 (-)Ensembl
RefSeq Acc Id: NM_001252250   ⟹   NP_001239179
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,715,845 - 4,799,544 (-)NCBI
GRCm38114,765,845 - 4,849,544 (-)NCBI
Celera115,266,244 - 5,349,971 (-)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001252251   ⟹   NP_001239180
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,722,334 - 4,799,544 (-)NCBI
GRCm38114,772,334 - 4,849,544 (-)NCBI
Celera115,266,244 - 5,349,971 (-)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001252252   ⟹   NP_001239181
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,715,845 - 4,799,544 (-)NCBI
GRCm38114,765,845 - 4,849,544 (-)NCBI
Celera115,266,244 - 5,349,971 (-)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001252253   ⟹   NP_001239182
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,732,105 - 4,783,135 (-)NCBI
GRCm38114,782,105 - 4,833,135 (-)NCBI
Celera115,266,244 - 5,349,971 (-)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001361675   ⟹   NP_001348604
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,715,845 - 4,799,544 (-)NCBI
GRCm38114,765,845 - 4,849,544 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001361676   ⟹   NP_001348605
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,715,845 - 4,799,544 (-)NCBI
GRCm38114,765,845 - 4,849,544 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001361677   ⟹   NP_001348606
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,715,845 - 4,799,544 (-)NCBI
GRCm38114,765,845 - 4,849,544 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010898   ⟹   NP_035028
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,715,845 - 4,799,544 (-)NCBI
GRCm38114,765,845 - 4,849,544 (-)NCBI
MGSCv37114,665,851 - 4,749,530 (-)RGD
Celera115,266,244 - 5,349,971 (-)ENTREZGENE
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514570   ⟹   XP_006514633
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,729,814 - 4,799,544 (-)NCBI
GRCm38114,779,814 - 4,849,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243669   ⟹   XP_011241971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,716,340 - 4,799,544 (-)NCBI
GRCm38114,768,065 - 4,849,544 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245645   ⟹   XP_030101505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,716,340 - 4,799,536 (-)NCBI
GRCm38114,765,848 - 4,849,516 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156401   ⟹   XP_036012294
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,716,340 - 4,799,540 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156402   ⟹   XP_036012295
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,716,340 - 4,758,718 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001239179 (Get FASTA)   NCBI Sequence Viewer  
  NP_001239180 (Get FASTA)   NCBI Sequence Viewer  
  NP_001239181 (Get FASTA)   NCBI Sequence Viewer  
  NP_001239182 (Get FASTA)   NCBI Sequence Viewer  
  NP_001348604 (Get FASTA)   NCBI Sequence Viewer  
  NP_001348605 (Get FASTA)   NCBI Sequence Viewer  
  NP_001348606 (Get FASTA)   NCBI Sequence Viewer  
  NP_035028 (Get FASTA)   NCBI Sequence Viewer  
  XP_006514633 (Get FASTA)   NCBI Sequence Viewer  
  XP_011241971 (Get FASTA)   NCBI Sequence Viewer  
  XP_030101505 (Get FASTA)   NCBI Sequence Viewer  
  XP_036012294 (Get FASTA)   NCBI Sequence Viewer  
  XP_036012295 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA39807 (Get FASTA)   NCBI Sequence Viewer  
  AAA39808 (Get FASTA)   NCBI Sequence Viewer  
  AAA57150 (Get FASTA)   NCBI Sequence Viewer  
  AAA57151 (Get FASTA)   NCBI Sequence Viewer  
  AAA63648 (Get FASTA)   NCBI Sequence Viewer  
  AAH05442 (Get FASTA)   NCBI Sequence Viewer  
  BAB30698 (Get FASTA)   NCBI Sequence Viewer  
  BAC32567 (Get FASTA)   NCBI Sequence Viewer  
  BAE39732 (Get FASTA)   NCBI Sequence Viewer  
  CAA52737 (Get FASTA)   NCBI Sequence Viewer  
  CAA53386 (Get FASTA)   NCBI Sequence Viewer  
  EDL40492 (Get FASTA)   NCBI Sequence Viewer  
  EDL40493 (Get FASTA)   NCBI Sequence Viewer  
  EDL40494 (Get FASTA)   NCBI Sequence Viewer  
  EDL40495 (Get FASTA)   NCBI Sequence Viewer  
  EDL40496 (Get FASTA)   NCBI Sequence Viewer  
  EDL40497 (Get FASTA)   NCBI Sequence Viewer  
  EDL40498 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000055033
  ENSMUSP00000055033.7
  ENSMUSP00000055061
  ENSMUSP00000055061.7
  ENSMUSP00000091066
  ENSMUSP00000091066.5
  ENSMUSP00000105536
  ENSMUSP00000105536.3
  ENSMUSP00000116505.3
  ENSMUSP00000128494.2
  ENSMUSP00000129388.2
  ENSMUSP00000130263.2
  ENSMUSP00000132184.2
GenBank Protein P46662 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035028   ⟸   NM_010898
- Peptide Label: isoform 2
- UniProtKB: Q8BR03 (UniProtKB/Swiss-Prot),   P46662 (UniProtKB/Swiss-Prot),   Q9D3K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239179   ⟸   NM_001252250
- Peptide Label: isoform 1
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239181   ⟸   NM_001252252
- Peptide Label: isoform 3
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239180   ⟸   NM_001252251
- Peptide Label: isoform 1
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001239182   ⟸   NM_001252253
- Peptide Label: isoform 4
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514633   ⟸   XM_006514570
- Peptide Label: isoform X1
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241971   ⟸   XM_011243669
- Peptide Label: isoform X1
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001348604   ⟸   NM_001361675
- Peptide Label: isoform 5
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001348605   ⟸   NM_001361676
- Peptide Label: isoform 6
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001348606   ⟸   NM_001361677
- Peptide Label: isoform 7
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030101505   ⟸   XM_030245645
- Peptide Label: isoform X2
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000129388   ⟸   ENSMUST00000164190
Ensembl Acc Id: ENSMUSP00000132184   ⟸   ENSMUST00000124878
Ensembl Acc Id: ENSMUSP00000130263   ⟸   ENSMUST00000172305
Ensembl Acc Id: ENSMUSP00000128494   ⟸   ENSMUST00000152656
Ensembl Acc Id: ENSMUSP00000091066   ⟸   ENSMUST00000093374
Ensembl Acc Id: ENSMUSP00000055033   ⟸   ENSMUST00000053079
Ensembl Acc Id: ENSMUSP00000105536   ⟸   ENSMUST00000109910
Ensembl Acc Id: ENSMUSP00000055061   ⟸   ENSMUST00000056290
Ensembl Acc Id: ENSMUSP00000116505   ⟸   ENSMUST00000137926
RefSeq Acc Id: XP_036012294   ⟸   XM_036156401
- Peptide Label: isoform X3
- UniProtKB: Q9D3K3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036012295   ⟸   XM_036156402
- Peptide Label: isoform X4
- UniProtKB: Q3TIW4 (UniProtKB/TrEMBL)
Protein Domains
FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46662-F1-model_v2 AlphaFold P46662 1-596 view protein structure

Promoters
RGD ID:6821416
Promoter ID:MM_KWN:6254
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000053079,   ENSMUST00000093374,   ENSMUST00000109907,   OTTMUST00000011302,   UC007HVG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,749,221 - 4,749,872 (-)MPROMDB
RGD ID:8673808
Promoter ID:EPDNEW_M14935
Type:single initiation site
Name:Nf2_3
Description:Mus musculus neurofibromin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14936  EPDNEW_M14937  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,809,270 - 4,809,330EPDNEW
RGD ID:8673810
Promoter ID:EPDNEW_M14936
Type:initiation region
Name:Nf2_2
Description:Mus musculus neurofibromin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14935  EPDNEW_M14937  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,833,119 - 4,833,179EPDNEW
RGD ID:8673812
Promoter ID:EPDNEW_M14937
Type:initiation region
Name:Nf2_1
Description:Mus musculus neurofibromin 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14935  EPDNEW_M14936  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,849,455 - 4,849,515EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97307 AgrOrtholog
Ensembl Genes ENSMUSG00000009073 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000053079 ENTREZGENE
  ENSMUST00000053079.13 UniProtKB/Swiss-Prot
  ENSMUST00000056290 ENTREZGENE
  ENSMUST00000056290.13 UniProtKB/Swiss-Prot
  ENSMUST00000093374 ENTREZGENE
  ENSMUST00000093374.11 UniProtKB/TrEMBL
  ENSMUST00000109908 ENTREZGENE
  ENSMUST00000109910 ENTREZGENE
  ENSMUST00000109910.9 UniProtKB/Swiss-Prot
  ENSMUST00000124878.3 UniProtKB/TrEMBL
  ENSMUST00000137926.9 UniProtKB/TrEMBL
  ENSMUST00000152656.8 UniProtKB/TrEMBL
  ENSMUST00000164190.8 UniProtKB/TrEMBL
  ENSMUST00000172305.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.80.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.80.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.360.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ez/rad/moesin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_central UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Moesin_tail_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18016 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97307 ENTREZGENE
NCBI Gene 18016 ENTREZGENE
PANTHER MERLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERM_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nf2 PhenoGen
PIRSF ERM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS BAND41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ERMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART B41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERM_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48678 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PW99_MOUSE UniProtKB/TrEMBL
  E9Q7I0_MOUSE UniProtKB/TrEMBL
  F6X089_MOUSE UniProtKB/TrEMBL
  F7D6P2_MOUSE UniProtKB/TrEMBL
  F7DBY2_MOUSE UniProtKB/TrEMBL
  F8WJ43_MOUSE UniProtKB/TrEMBL
  MERL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TIW4 ENTREZGENE, UniProtKB/TrEMBL
  Q62207_MOUSE UniProtKB/TrEMBL
  Q8BR03 ENTREZGENE
  Q99K59_MOUSE UniProtKB/TrEMBL
  Q9D3K3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8BR03 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-21 Nf2  neurofibromin 2    neurofibromatosis 2  Symbol and/or name change 5135510 APPROVED