Pzp (PZP, alpha-2-macroglobulin like) - Rat Genome Database

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Gene: Pzp (PZP, alpha-2-macroglobulin like) Mus musculus
Analyze
No known orthologs.
Symbol: Pzp
Name: PZP, alpha-2-macroglobulin like
RGD ID: 731856
MGI Page MGI
Description: Enables endopeptidase inhibitor activity. Acts upstream of or within embryo implantation. Located in collagen-containing extracellular matrix. Is expressed in liver and liver lobe.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A1m; A2m; AI893533; alpha 1 macroglobulin; alpha-2-M; alpha-2-macroglobulin; MAM
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,460,530 - 128,503,683 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,460,530 - 128,503,683 (-)EnsemblGRCm39 Ensembl
GRCm386128,483,567 - 128,526,720 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,483,567 - 128,526,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv376128,433,585 - 128,476,738 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366128,449,186 - 128,492,314 (-)NCBIMGSCv36mm8
Celera6130,160,377 - 130,203,323 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1280217   PMID:1374478   PMID:1379499   PMID:5559967   PMID:7508936   PMID:7514554   PMID:7524394   PMID:7528166   PMID:7542371   PMID:7544347   PMID:7595098   PMID:7686585  
PMID:8798151   PMID:8798779   PMID:9027502   PMID:9169139   PMID:9177771   PMID:9398738   PMID:10487856   PMID:10860661   PMID:12069948   PMID:12114513   PMID:12477932   PMID:14580373  
PMID:15355875   PMID:15489334   PMID:16944957   PMID:17296600   PMID:17330941   PMID:19423573   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22159717   PMID:24457600   PMID:28071719  
PMID:30814992   PMID:36051914  


Genomics

Variants

.
Variants in Pzp
1679 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:115
Interacting mature miRNAs:121
Transcripts:ENSMUST00000032510, ENSMUST00000112132, ENSMUST00000143664
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125269523149588044Mouse
4141611Btts_mbitterness tasting (mouse)Not determined6125333609134096586Mouse
10412134Cmv4_mcytomegalovirus resistance 4 (mouse)Not determined6127815180136022150Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
4141151Ath38_matherosclerosis 38 (mouse)Not determined128495857136293176Mouse

Markers in Region
AI893533  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386128,485,575 - 128,485,655UniSTSGRCm38
MGSCv376128,435,593 - 128,435,673UniSTSGRCm37
Celera6130,162,109 - 130,162,189UniSTS
Cytogenetic Map6F1-G3UniSTS
Whitehead/MRC_RH61315.01UniSTS
D6Mit61  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386128,518,894 - 128,519,025UniSTSGRCm38
MGSCv376128,468,912 - 128,469,043UniSTSGRCm37
Celera6130,195,518 - 130,195,663UniSTS
Cytogenetic Map6F1-G3UniSTS
cM Map662.3UniSTS
Whitehead Genetic651.4UniSTS
Whitehead_YAC6 UniSTS
A2m  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera6130,202,532 - 130,202,801UniSTS
Cytogenetic Map6F1-G3UniSTS
cM Map662.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000112132   ⟹   ENSMUSP00000107760
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6128,460,530 - 128,503,683 (-)Ensembl
GRCm38.p6 Ensembl6128,483,567 - 128,526,720 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143664   ⟹   ENSMUSP00000120114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6128,498,094 - 128,503,666 (-)Ensembl
GRCm38.p6 Ensembl6128,521,131 - 128,526,703 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203753
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6128,470,311 - 128,472,186 (-)Ensembl
GRCm38.p6 Ensembl6128,493,348 - 128,495,223 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204291
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6128,462,527 - 128,464,818 (-)Ensembl
GRCm38.p6 Ensembl6128,485,564 - 128,487,855 (-)Ensembl
RefSeq Acc Id: NM_007376   ⟹   NP_031402
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396128,460,530 - 128,503,683 (-)NCBI
GRCm386128,483,567 - 128,526,720 (-)NCBI
MGSCv376128,433,585 - 128,476,738 (-)RGD
Celera6130,160,377 - 130,203,323 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031402   ⟸   NM_007376
- Peptide Label: precursor
- UniProtKB: Q6PEM2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000120114   ⟸   ENSMUST00000143664
RefSeq Acc Id: ENSMUSP00000107760   ⟸   ENSMUST00000112132
Protein Domains
Macroglobulin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61838-F1-model_v2 AlphaFold Q61838 1-1495 view protein structure

Promoters
RGD ID:6848027
Promoter ID:MM_ACW:42830
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:PZP.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366128,440,959 - 128,441,459 (-)MPROMDB
RGD ID:6848026
Promoter ID:MM_ACW:42831
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:PZP.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366128,443,651 - 128,445,552 (-)MPROMDB
RGD ID:6848028
Promoter ID:MM_ACW:42832
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:PZP.ESEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366128,453,251 - 128,453,751 (-)MPROMDB
RGD ID:6839812
Promoter ID:MM_KWN:47798
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver
Transcripts:ENSMUST00000032510,   NM_007376,   OTTMUST00000052791
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366128,476,451 - 128,476,951 (-)MPROMDB
RGD ID:6891146
Promoter ID:EPDNEW_M9024
Type:initiation region
Name:Pzp_1
Description:Mus musculus PZP, alpha-2-macroglobulin like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386128,526,712 - 128,526,772EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87854 AgrOrtholog
Ensembl Genes ENSMUSG00000030359 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000107760 ENTREZGENE
  ENSMUSP00000107760.2 UniProtKB/Swiss-Prot
  ENSMUSP00000120114.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000112132 ENTREZGENE
  ENSMUST00000112132.8 UniProtKB/Swiss-Prot
  ENSMUST00000143664.2 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
  2.20.130.20 UniProtKB/Swiss-Prot
  2.60.120.1540 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.1930 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1940 UniProtKB/Swiss-Prot
  2.60.40.690 UniProtKB/Swiss-Prot
  6.20.50.160 UniProtKB/Swiss-Prot
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot
  A2M_N_BRD UniProtKB/Swiss-Prot
  A2M_TED UniProtKB/Swiss-Prot
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MacrogloblnA2_CS UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
MGD MGI:87854 ENTREZGENE
NCBI Gene 11287 ENTREZGENE
PANTHER MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PREGNANCY ZONE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot
PhenoGen Pzp PhenoGen
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot
  SSF49410 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt D3YUI3_MOUSE UniProtKB/TrEMBL
  PZP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PEM2 ENTREZGENE
UniProt Secondary E9QPW0 UniProtKB/Swiss-Prot
  Q60628 UniProtKB/Swiss-Prot
  Q6PEM2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-04 Pzp  PZP, alpha-2-macroglobulin like    pregnancy zone protein  Symbol and/or name change 5135510 APPROVED