Slc15a3 (solute carrier family 15, member 3) - Rat Genome Database

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Gene: Slc15a3 (solute carrier family 15, member 3) Mus musculus
Analyze
Symbol: Slc15a3
Name: solute carrier family 15, member 3
RGD ID: 731836
MGI Page MGI
Description: Enables peptidoglycan transmembrane transporter activity. Involved in peptidoglycan transport and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Located in endosome membrane and lysosomal membrane. Is expressed in several structures, including brain; gut; hemolymphoid system; liver lobe; and testis. Orthologous to human SLC15A3 (solute carrier family 15 member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP inducible gene 1; cAMP-inducible gene 1 protein; Ci; cI-; cI-1; Ci1; peptide transporter 3; peptide/histidine transporter 2; solute carrier family 15 member 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,819,908 - 10,835,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,817,091 - 10,836,726 (+)EnsemblGRCm39 Ensembl
GRCm381910,842,544 - 10,857,915 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,839,727 - 10,859,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,917,034 - 10,932,405 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,909,589 - 10,924,948 (+)NCBIMGSCv36mm8
Celera1911,535,605 - 11,550,983 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP)
Cuprizon  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
genistein  (EXP)
gentamycin  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indole-3-methanol  (ISO)
lipopolysaccharide  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
oxaliplatin  (ISO)
oxycodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
pravastatin  (EXP,ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
Soman  (ISO)
streptozocin  (ISO)
succimer  (EXP)
tamoxifen  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11004510   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:24194600   PMID:24695226   PMID:27553280   PMID:27626380   PMID:32325033   PMID:35349343   PMID:38355793   PMID:38374230  


Genomics

Comparative Map Data
Slc15a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,819,908 - 10,835,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,817,091 - 10,836,726 (+)EnsemblGRCm39 Ensembl
GRCm381910,842,544 - 10,857,915 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,839,727 - 10,859,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,917,034 - 10,932,405 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,909,589 - 10,924,948 (+)NCBIMGSCv36mm8
Celera1911,535,605 - 11,550,983 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.23NCBI
SLC15A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,937,084 - 60,952,176 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,937,060 - 60,952,653 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,704,556 - 60,719,648 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,461,134 - 60,475,833 (-)NCBINCBI36Build 36hg18NCBI36
Build 341160,461,135 - 60,475,833NCBI
Celera1158,065,442 - 58,080,124 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1157,050,724 - 57,065,416 (-)NCBIHuRef
CHM1_11160,570,855 - 60,585,488 (-)NCBICHM1_1
T2T-CHM13v2.01160,888,231 - 60,903,306 (-)NCBIT2T-CHM13v2.0
Slc15a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,906,836 - 216,932,046 (+)NCBIGRCr8
mRatBN7.21207,492,365 - 207,507,158 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,492,365 - 207,507,157 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,867,205 - 215,881,996 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,927,770 - 222,942,588 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,621,593 - 215,636,384 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,896,387 - 226,912,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,897,625 - 226,912,708 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,963,402 - 233,978,193 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,341,322 - 213,356,103 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,499,751 - 213,514,532 (+)NCBI
Celera1204,984,950 - 204,999,742 (+)NCBICelera
Cytogenetic Map1q43NCBI
Slc15a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,574,840 - 5,582,307 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,574,686 - 5,582,992 (-)NCBIChiLan1.0ChiLan1.0
SLC15A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,106,337 - 62,121,515 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,150,381 - 63,165,578 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,200,278 - 56,215,451 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,640,834 - 59,655,144 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,640,970 - 59,655,535 (-)Ensemblpanpan1.1panPan2
SLC15A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,354,987 - 55,363,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1853,928,148 - 53,936,956 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,403,606 - 56,412,382 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11855,460,980 - 55,469,748 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01855,082,563 - 55,091,327 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01855,963,727 - 55,972,508 (+)NCBIUU_Cfam_GSD_1.0
Slc15a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,871,196 - 11,883,099 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365811,984,344 - 1,996,924 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365811,985,062 - 1,996,924 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC15A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,800,503 - 10,814,389 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,799,927 - 10,814,363 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,352,005 - 10,366,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC15A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,896,612 - 12,910,740 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,895,982 - 12,912,214 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,264,616 - 110,279,317 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc15a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624926294,376 - 303,248 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624926294,263 - 303,326 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc15a3
439 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:711
Count of miRNA genes:406
Interacting mature miRNAs:467
Transcripts:ENSMUST00000025646, ENSMUST00000131010, ENSMUST00000138263, ENSMUST00000138380
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
01.MMHAP6FRA7.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381910,852,190 - 10,852,267UniSTSGRCm38
MGSCv371910,926,680 - 10,926,757UniSTSGRCm37
Celera1911,545,250 - 11,545,327UniSTS
Cytogenetic Map19BUniSTS
Whitehead_YAC19 UniSTS
R74613  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381910,858,488 - 10,858,642UniSTSGRCm38
MGSCv371910,932,978 - 10,933,132UniSTSGRCm37
Celera1911,551,556 - 11,551,710UniSTS
Cytogenetic Map19BUniSTS
Cytogenetic Map19AUniSTS
Whitehead_YAC19 UniSTS
RH125077  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381910,858,399 - 10,858,514UniSTSGRCm38
MGSCv371910,932,889 - 10,933,004UniSTSGRCm37
Celera1911,551,467 - 11,551,582UniSTS
Cytogenetic Map19BUniSTS
Cytogenetic Map19AUniSTS
RH141151  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381910,857,228 - 10,857,728UniSTSGRCm38
MGSCv371910,931,718 - 10,932,218UniSTSGRCm37
Celera1911,550,296 - 11,550,796UniSTS
Cytogenetic Map19BUniSTS
Slc15a3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
cM Map197.23UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025646   ⟹   ENSMUSP00000025646
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1910,819,908 - 10,835,279 (+)Ensembl
GRCm38.p6 Ensembl1910,842,544 - 10,857,915 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131010
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1910,819,914 - 10,820,835 (+)Ensembl
GRCm38.p6 Ensembl1910,842,550 - 10,843,471 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138263
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1910,820,259 - 10,836,726 (+)Ensembl
GRCm38.p6 Ensembl1910,842,895 - 10,859,362 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138380
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1910,817,091 - 10,820,711 (+)Ensembl
GRCm38.p6 Ensembl1910,839,727 - 10,843,347 (+)Ensembl
RefSeq Acc Id: NM_023044   ⟹   NP_075531
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391910,819,908 - 10,835,279 (+)NCBI
GRCm381910,842,544 - 10,857,915 (+)ENTREZGENE
MGSCv371910,917,034 - 10,932,405 (+)RGD
Celera1911,535,605 - 11,550,983 (+)RGD
cM Map19 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_075531 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD24570 (Get FASTA)   NCBI Sequence Viewer  
  AAH51940 (Get FASTA)   NCBI Sequence Viewer  
  BAC34816 (Get FASTA)   NCBI Sequence Viewer  
  EDL41383 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000025646
  ENSMUSP00000025646.3
GenBank Protein Q8BPX9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_075531   ⟸   NM_023044
- UniProtKB: Q9WU80 (UniProtKB/Swiss-Prot),   Q8BPX9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025646   ⟸   ENSMUST00000025646

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BPX9-F1-model_v2 AlphaFold Q8BPX9 1-578 view protein structure

Promoters
RGD ID:13678934
Promoter ID:EPDNEW_M23616
Type:initiation region
Name:Slc15a3_1
Description:Mus musculus solute carrier family 15, member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23617  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381910,842,539 - 10,842,599EPDNEW
RGD ID:13678936
Promoter ID:EPDNEW_M23617
Type:initiation region
Name:Slc15a3_2
Description:Mus musculus solute carrier family 15, member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23616  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381910,842,767 - 10,842,827EPDNEW
RGD ID:6829955
Promoter ID:MM_KWN:26400
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000070029,   OTTMUST00000086500,   UC008GRB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361910,916,276 - 10,917,712 (+)MPROMDB
RGD ID:6848732
Promoter ID:MM_TRO:4997
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:MTR008723.19.392.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361910,931,926 - 10,932,426 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929691 AgrOrtholog
Ensembl Genes ENSMUSG00000024737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025646 ENTREZGENE
  ENSMUST00000025646.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MFS_trans_sf UniProtKB/Swiss-Prot
  POT_fam UniProtKB/Swiss-Prot
  PTR2_symporter_CS UniProtKB/Swiss-Prot
KEGG Report mmu:65221 UniProtKB/Swiss-Prot
MGD MGI:1929691 ENTREZGENE
NCBI Gene 65221 ENTREZGENE
PANTHER PTHR11654 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 15 MEMBER 3 UniProtKB/Swiss-Prot
Pfam PTR2 UniProtKB/Swiss-Prot
PhenoGen Slc15a3 PhenoGen
PROSITE PTR2_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt Q8BPX9 ENTREZGENE
  Q9WU80 ENTREZGENE
  S15A3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q9WU80 UniProtKB/Swiss-Prot