Kcnq1 (potassium voltage-gated channel, subfamily Q, member 1) - Rat Genome Database

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Gene: Kcnq1 (potassium voltage-gated channel, subfamily Q, member 1) Mus musculus
Analyze
Symbol: Kcnq1
Name: potassium voltage-gated channel, subfamily Q, member 1
RGD ID: 731777
MGI Page MGI
Description: Enables voltage-gated potassium channel activity. Involved in several processes, including inner ear development; metal ion transport; and regulation of heart contraction. Acts upstream of or within digestive system process and membrane repolarization during ventricular cardiac muscle cell action potential. Located in apical plasma membrane and lumenal side of membrane. Part of voltage-gated potassium channel complex. Is active in several cellular components, including basolateral part of cell; ciliary base; and neuronal cell body. Is expressed in several structures, including alimentary system; extraembryonic component; heart; hemolymphoid system gland; and reproductive system. Used to study Jervell-Lange Nielsen syndrome and long QT syndrome 1. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and type 2 diabetes mellitus. Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW559127; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Kcn; Kcna9; KQT-like 1; KVLQ; KVLQT1; potassium voltage-gated channel subfamily KQT member 1; voltage-gated potassium channel subunit Kv7.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,660,614 - 142,980,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,660,099 - 142,980,779 (+)EnsemblGRCm39 Ensembl
GRCm387143,106,877 - 143,427,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,106,362 - 143,427,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv377150,293,159 - 150,612,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,916,644 - 143,236,432 (+)NCBIMGSCv36mm8
Celera7142,862,859 - 143,182,707 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-ropivacaine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-(hydroxymethyl)cytosine  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
aprindine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
atenolol  (ISO)
atrazine  (ISO)
barium chloride  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bupivacaine  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
Chromanol 293B  (EXP,ISO)
clofibrate  (EXP)
daunorubicin  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
folic acid  (EXP)
fulvestrant  (ISO)
glycidol  (ISO)
isoprenaline  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
mepivacaine  (ISO)
methapyrilene  (ISO)
mitoxantrone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (EXP)
ozone  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
potassium atom  (EXP,ISO)
propranolol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
Terfenadine  (ISO)
testosterone  (ISO)
trazodone  (ISO)
tributylstannane  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IBA)
adrenergic receptor signaling pathway  (IMP)
atrial cardiac muscle cell action potential  (ISO)
auditory receptor cell development  (IMP)
cardiac conduction  (IMP)
cardiac muscle contraction  (IMP,ISO)
cellular response to cAMP  (ISO)
cellular response to epinephrine stimulus  (IMP)
cellular response to xenobiotic stimulus  (ISO)
chloride ion homeostasis  (IMP)
cochlea development  (IMP)
corticosterone secretion  (IMP)
detection of mechanical stimulus involved in sensory perception of sound  (IMP)
digestive system process  (IMP)
erythrocyte differentiation  (IMP)
gastric acid secretion  (IMP)
gastrin-induced gastric acid secretion  (IMP)
glucose metabolic process  (IMP)
heart development  (IMP)
inner ear development  (IMP)
inner ear morphogenesis  (IMP)
intestinal absorption  (ISO)
intracellular chloride ion homeostasis  (IDA,IMP)
iodide transport  (IMP)
male gonad development  (ISO)
membrane repolarization  (IMP)
membrane repolarization during action potential  (IMP,ISO)
membrane repolarization during atrial cardiac muscle cell action potential  (ISO)
membrane repolarization during cardiac muscle cell action potential  (ISO)
membrane repolarization during ventricular cardiac muscle cell action potential  (IBA,IMP,ISO)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of voltage-gated potassium channel activity  (ISO)
non-motile cilium assembly  (IDA,IMP)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of potassium ion transmembrane transport  (ISO)
potassium ion export across plasma membrane  (IBA,ISO)
potassium ion homeostasis  (IMP)
potassium ion import across plasma membrane  (IMP)
potassium ion transmembrane transport  (IDA,IMP,ISO)
potassium ion transport  (ISO)
regulation of atrial cardiac muscle cell membrane repolarization  (ISO)
regulation of blood pressure  (IMP)
regulation of gastric acid secretion  (IMP)
regulation of heart rate  (IMP)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane potential  (ISO)
regulation of membrane repolarization  (ISO)
regulation of transporter activity  (IMP)
regulation of ventricular cardiac muscle cell membrane repolarization  (IMP,ISO)
regulation of voltage-gated sodium channel activity  (IMP)
renal absorption  (IMP)
renal sodium ion absorption  (IMP)
response to anesthetic  (ISO)
response to insulin  (IMP)
rhythmic behavior  (IMP)
sensory perception of sound  (IMP)
social behavior  (IMP)
sodium ion transport  (IDA,IMP)
stomach development  (IMP)
transmembrane transport  (IEA)
ventricular cardiac muscle cell action potential  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal basilar membrane morphology  (IAGP)
abnormal cochlea morphology  (IEA)
abnormal cochlear sensory epithelium morphology  (IAGP)
abnormal crista ampullaris morphology  (IAGP)
abnormal crista ampullaris neuroepithelium morphology  (IAGP)
abnormal gait  (IEA)
abnormal gastric chief cell morphology  (IAGP)
abnormal gastric parietal cell morphology  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal inner ear canal morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal inner ear vestibule morphology  (IAGP)
abnormal membranous labyrinth morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal mucous neck cell morphology  (IAGP)
abnormal otolith morphology  (IAGP)
abnormal P wave  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal stria vascularis morphology  (IAGP)
abnormal T wave  (IAGP)
abnormal tectorial membrane morphology  (IAGP)
abnormal utricle morphology  (IAGP)
abnormal vestibular labyrinth morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
absent cochlear hair cells  (IAGP)
absent distortion product otoacoustic emissions  (IAGP)
absent organ of Corti supporting cells  (IAGP)
absent pinna reflex  (IAGP)
absent vestibular hair cell stereocilia  (IAGP)
absent vestibular hair cells  (IAGP)
bidirectional circling  (IAGP)
cardiac hypertrophy  (IAGP)
circling  (IAGP)
cochlear ganglion degeneration  (IAGP)
cochlear inner hair cell degeneration  (IAGP)
cochlear outer hair cell degeneration  (IAGP)
collapsed Reissner membrane  (IAGP)
deafness  (IAGP)
decreased body weight  (IAGP)
detached otolithic membrane  (IAGP)
dilated gastric gland  (IAGP)
enlarged stomach  (IAGP)
head bobbing  (IAGP)
head tossing  (IAGP)
hyperactivity  (IAGP)
hypochlorhydria  (IAGP)
impaired balance  (IEA)
impaired coordination  (IAGP)
impaired righting response  (IAGP)
impaired swimming  (IAGP)
increased circulating gastrin level  (IAGP)
increased heart weight  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased QRS amplitude  (IAGP)
increased stomach mucosa thickness  (IAGP)
increased stomach pH  (IAGP)
jerky movement  (IAGP)
no abnormal phenotype detected  (IAGP)
opisthotonus  (IAGP)
organ of Corti degeneration  (IAGP)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged QT interval  (IAGP)
retropulsion  (IEA)
small scala media  (IAGP)
spinning  (IAGP)
stereotypic behavior  (IAGP)
stomach mucosa hyperplasia  (IAGP)
syndromic hearing impairment  (IAGP)
thin stria vascularis  (IAGP)
tremors  (IAGP)
utricular macular degeneration  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner. Amin AS, etal., Eur Heart J. 2012 Mar;33(6):714-23. doi: 10.1093/eurheartj/ehr473. Epub 2011 Dec 23.
2. KCNQ1 gain-of-function mutation in familial atrial fibrillation. Chen YH, etal., Science. 2003 Jan 10;299(5604):251-4.
3. Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias. Chouabe C, etal., EMBO J. 1997 Sep 1;16(17):5472-9.
4. Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score. Eze IC, etal., Environ Int. 2016 Sep;94:263-271. doi: 10.1016/j.envint.2016.04.032. Epub 2016 Jun 6.
5. WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions. Gohma H, etal., Physiol Genomics. 2006 Feb 14;24(3):198-206. Epub 2005 Dec 20.
6. Pancreatic metaplasia in the gastro-achlorhydria in WTC-dfk rat, a potassium channel Kcnq1 mutant. Kuwamura M, etal., Vet Pathol. 2008 Jul;45(4):586-91.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
15. KCNQ1/KCNE1 channels during germ-cell differentiation in the rat: expression associated with testis pathologies. Tsevi I, etal., J Cell Physiol. 2005 Feb;202(2):400-10.2: id: 27199802 Error occurred: Document retrieval error: document does notexist
16. Compound heterozygous mutations in KvLQT1 cause Jervell and Lange-Nielsen syndrome. Wang Z, etal., Mol Genet Metab. 2002 Apr;75(4):308-16.
Additional References at PubMed
PMID:1971786   PMID:8900282   PMID:9467008   PMID:9584186   PMID:9618174   PMID:9799609   PMID:9922400   PMID:10036981   PMID:10349636   PMID:10369881   PMID:10691133   PMID:10903843  
PMID:10907850   PMID:10915772   PMID:10922068   PMID:11007485   PMID:11042159   PMID:11063728   PMID:11076855   PMID:11076861   PMID:11120752   PMID:11208532   PMID:11217851   PMID:11223304  
PMID:11226272   PMID:11527966   PMID:11528397   PMID:11557234   PMID:11668390   PMID:11889581   PMID:12204355   PMID:12410230   PMID:12466851   PMID:12473685   PMID:12475990   PMID:12477932  
PMID:12554682   PMID:12627233   PMID:12766260   PMID:14610273   PMID:15004216   PMID:15163367   PMID:15240882   PMID:15272004   PMID:15327781   PMID:15340049   PMID:15385447   PMID:15459184  
PMID:15489334   PMID:15498462   PMID:15516931   PMID:15516932   PMID:15640248   PMID:15707997   PMID:15859358   PMID:15891643   PMID:16141072   PMID:16141073   PMID:16314573   PMID:16463373  
PMID:16478723   PMID:16628224   PMID:16702402   PMID:16896189   PMID:16901941   PMID:16985003   PMID:17021040   PMID:17245608   PMID:17519950   PMID:17597584   PMID:17660684   PMID:17901046  
PMID:17916649   PMID:18006587   PMID:18079696   PMID:18353863   PMID:18554416   PMID:19006182   PMID:19041715   PMID:19136628   PMID:19144718   PMID:19218243   PMID:19255508   PMID:19306073  
PMID:19369585   PMID:19439080   PMID:19491250   PMID:20051516   PMID:20132415   PMID:20368164   PMID:20437101   PMID:20457925   PMID:20459838   PMID:20573698   PMID:20962273   PMID:20978783  
PMID:21233130   PMID:21267068   PMID:21354127   PMID:21426709   PMID:21426901   PMID:21859894   PMID:21873635   PMID:21925491   PMID:22219655   PMID:22549510   PMID:22808246   PMID:23028363  
PMID:23154976   PMID:23457544   PMID:23542581   PMID:23741519   PMID:23975432   PMID:24018950   PMID:24395636   PMID:24595108   PMID:25331955   PMID:25441029   PMID:25444851   PMID:25539921  
PMID:26084842   PMID:26100882   PMID:26241757   PMID:26321200   PMID:26378152   PMID:26454161   PMID:26546361   PMID:26971948   PMID:27287879   PMID:27466704   PMID:27488639   PMID:27525866  
PMID:28428215   PMID:28743749   PMID:28926866   PMID:29107558   PMID:29143340   PMID:29265344   PMID:29452158   PMID:30144972   PMID:30635621   PMID:30721152   PMID:30771304   PMID:31024170  
PMID:31162977   PMID:31243019   PMID:31550482   PMID:31570121   PMID:32127020   PMID:32212902   PMID:32492036   PMID:33500348   PMID:33964205   PMID:34112814   PMID:35372344   PMID:36343245  
PMID:37045597   PMID:37067297   PMID:37233881   PMID:37279265   PMID:37720106   PMID:38278860   PMID:38444763   PMID:38602877  


Genomics

Comparative Map Data
Kcnq1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397142,660,614 - 142,980,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7142,660,099 - 142,980,779 (+)EnsemblGRCm39 Ensembl
GRCm387143,106,877 - 143,427,050 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,106,362 - 143,427,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv377150,293,159 - 150,612,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367142,916,644 - 143,236,432 (+)NCBIMGSCv36mm8
Celera7142,862,859 - 143,182,707 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.12NCBI
KCNQ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,445,008 - 2,849,105 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,444,654 - 2,849,105 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,466,238 - 2,870,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,422,797 - 2,826,916 (+)NCBINCBI36Build 36hg18NCBI36
Build 34112,439,259 - 2,826,915NCBI
Celera112,501,049 - 2,905,069 (+)NCBICelera
Cytogenetic Map11p15.5-p15.4NCBI
HuRef112,256,184 - 2,658,673 (+)NCBIHuRef
CHM1_1112,465,155 - 2,869,215 (+)NCBICHM1_1
T2T-CHM13v2.0112,534,332 - 2,938,419 (+)NCBIT2T-CHM13v2.0
Kcnq1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81207,721,134 - 208,054,073 (+)NCBIGRCr8
mRatBN7.21198,291,711 - 198,624,683 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,291,766 - 198,624,669 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1206,670,364 - 207,003,324 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01213,756,445 - 214,089,840 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01206,430,601 - 206,763,990 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,293,087 - 216,630,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,293,087 - 216,630,339 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,154,713 - 223,490,458 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41203,383,401 - 203,803,687 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11203,536,853 - 203,957,140 (+)NCBI
Celera1195,860,199 - 196,193,008 (+)NCBICelera
Cytogenetic Map1q42NCBI
Kcnq1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542214,212,553 - 14,544,556 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542214,212,563 - 14,544,556 (+)NCBIChiLan1.0ChiLan1.0
KCNQ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v294,855,419 - 5,260,218 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1114,067,311 - 4,472,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,469,750 - 2,874,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1112,498,001 - 2,902,198 (+)NCBIpanpan1.1PanPan1.1panPan2
KCNQ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11846,554,390 - 46,830,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1846,518,908 - 46,830,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,116,523 - 45,440,309 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,186,461 - 47,510,762 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,186,461 - 47,517,416 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11846,634,218 - 46,955,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,214,974 - 46,538,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,962,029 - 47,285,048 (+)NCBIUU_Cfam_GSD_1.0
Kcnq1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049472,763,921 - 3,051,025 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936794707,119 - 994,778 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936794707,122 - 994,206 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,675,360 - 1,989,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,675,323 - 1,989,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNQ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112,261,448 - 2,661,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12,261,845 - 2,661,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603899,462,284 - 99,862,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476715,252,950 - 15,613,562 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476715,252,961 - 15,613,373 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnq1
9060 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:362
Count of miRNA genes:298
Interacting mature miRNAs:313
Transcripts:ENSMUST00000009689
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
Kcnq1ot1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,295,068 - 143,295,440UniSTSGRCm38
MGSCv377150,451,138 - 150,451,433UniSTSGRCm37
MGSCv377150,612,516 - 150,612,632UniSTSGRCm37
MGSCv377150,459,708 - 150,460,007UniSTSGRCm37
MGSCv377150,481,154 - 150,481,453UniSTSGRCm37
MGSCv377150,480,070 - 150,480,321UniSTSGRCm37
MGSCv377150,479,939 - 150,480,050UniSTSGRCm37
Celera7143,050,740 - 143,051,112UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map7 UniSTS
RH135848  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,257,053 - 143,257,258UniSTSGRCm38
MGSCv377150,442,958 - 150,443,163UniSTSGRCm37
Celera7143,012,725 - 143,012,930UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
G36388  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,384,407 - 143,384,599UniSTSGRCm38
MGSCv377150,570,312 - 150,570,504UniSTSGRCm37
Celera7143,140,072 - 143,140,264UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
AW559127  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,426,661 - 143,426,773UniSTSGRCm38
MGSCv377150,612,566 - 150,612,678UniSTSGRCm37
Celera7143,182,326 - 143,182,438UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Whitehead/MRC_RH71446.82UniSTS
D7Mit175  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,209,639 - 143,209,745UniSTSGRCm38
MGSCv377150,395,544 - 150,395,650UniSTSGRCm37
Celera7142,965,310 - 142,965,416UniSTS
Cytogenetic Map7F5UniSTS
cM Map770.5UniSTS
Whitehead Genetic766.7UniSTS
Whitehead/MRC_RH71443.36UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377150,377,397 - 150,378,533UniSTSGRCm37
MGSCv377150,612,351 - 150,612,458UniSTSGRCm37
MGSCv377150,293,587 - 150,293,626UniSTSGRCm37
MGSCv377150,380,199 - 150,381,294UniSTSGRCm37
MGSCv377150,611,826 - 150,611,969UniSTSGRCm37
MGSCv377150,549,543 - 150,549,582UniSTSGRCm37
MGSCv377150,335,407 - 150,335,446UniSTSGRCm37
MGSCv377150,368,697 - 150,368,736UniSTSGRCm37
Celera7142,949,965 - 142,951,060UniSTS
Celera7143,119,303 - 143,119,342UniSTS
Celera7143,182,111 - 143,182,218UniSTS
Celera7143,181,586 - 143,181,729UniSTS
Celera7142,947,163 - 142,948,299UniSTS
Celera7142,863,287 - 142,863,326UniSTS
Celera7142,905,107 - 142,905,146UniSTS
Celera7142,938,463 - 142,938,502UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
UniSTS:235814  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,255,470 - 143,255,560UniSTSGRCm38
MGSCv377150,441,375 - 150,441,465UniSTSGRCm37
Celera7143,011,142 - 143,011,232UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
cM Map769.3UniSTS
23H6.T7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,287,955 - 143,288,079UniSTSGRCm38
MGSCv377150,473,860 - 150,473,984UniSTSGRCm37
Celera7143,043,627 - 143,043,751UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.41UniSTS
245A8.T7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,212,409 - 143,212,518UniSTSGRCm38
MGSCv377150,398,314 - 150,398,423UniSTSGRCm37
Celera7142,968,080 - 142,968,189UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.4UniSTS
Kcnq1ot1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,295,249 - 143,295,548UniSTSGRCm38
MGSCv377150,481,154 - 150,481,453UniSTSGRCm37
Celera7143,050,921 - 143,051,220UniSTS
Cytogenetic Map7F5UniSTS
Kcnq1ot1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,273,803 - 143,274,102UniSTSGRCm38
MGSCv377150,459,708 - 150,460,007UniSTSGRCm37
Celera7143,029,475 - 143,029,774UniSTS
Cytogenetic Map7F5UniSTS
Kcnq1ot1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,265,233 - 143,265,528UniSTSGRCm38
MGSCv377150,451,138 - 150,451,433UniSTSGRCm37
Celera7143,020,905 - 143,021,200UniSTS
Cytogenetic Map7F5UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,426,446 - 143,426,553UniSTSGRCm38
MGSCv377150,612,351 - 150,612,458UniSTSGRCm37
Celera7143,182,111 - 143,182,218UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,194,294 - 143,195,389UniSTSGRCm38
MGSCv377150,380,199 - 150,381,294UniSTSGRCm37
Celera7142,949,965 - 142,951,060UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,182,792 - 143,182,831UniSTSGRCm38
MGSCv377150,368,697 - 150,368,736UniSTSGRCm37
Celera7142,938,463 - 142,938,502UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,425,921 - 143,426,064UniSTSGRCm38
MGSCv377150,611,826 - 150,611,969UniSTSGRCm37
Celera7143,181,586 - 143,181,729UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,363,638 - 143,363,677UniSTSGRCm38
MGSCv377150,549,543 - 150,549,582UniSTSGRCm37
Celera7143,119,303 - 143,119,342UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,149,502 - 143,149,541UniSTSGRCm38
MGSCv377150,335,407 - 150,335,446UniSTSGRCm37
Celera7142,905,107 - 142,905,146UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,107,682 - 143,107,721UniSTSGRCm38
MGSCv377150,293,587 - 150,293,626UniSTSGRCm37
Celera7142,863,287 - 142,863,326UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
cM Map769.3UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,191,492 - 143,192,628UniSTSGRCm38
MGSCv377150,377,397 - 150,378,533UniSTSGRCm37
Celera7142,947,163 - 142,948,299UniSTS
Cytogenetic Map7F5UniSTS
Kcnq1ot1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,294,034 - 143,294,145UniSTSGRCm38
MGSCv377150,479,939 - 150,480,050UniSTSGRCm37
Celera7143,049,706 - 143,049,817UniSTS
Cytogenetic Map7F5UniSTS
Kcnq1ot1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,294,165 - 143,294,416UniSTSGRCm38
MGSCv377150,480,070 - 150,480,321UniSTSGRCm37
Celera7143,049,837 - 143,050,088UniSTS
Cytogenetic Map7F5UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Kcnq1ot1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387143,426,611 - 143,426,727UniSTSGRCm38
MGSCv377150,612,516 - 150,612,632UniSTSGRCm37
Celera7143,182,276 - 143,182,392UniSTS
Cytogenetic Map7F5UniSTS
cM Map7 UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS
Kcnq1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001412611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001412612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB079603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC012540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC015800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC023248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ251835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY331142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY644390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ425882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ425883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ425884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ425885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ425886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ425887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000009689   ⟹   ENSMUSP00000009689
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,660,991 - 142,980,779 (+)Ensembl
GRCm38.p6 Ensembl7143,107,254 - 143,427,042 (+)Ensembl
Ensembl Acc Id: ENSMUST00000185383   ⟹   ENSMUSP00000139548
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,661,288 - 142,979,862 (+)Ensembl
GRCm38.p6 Ensembl7143,107,551 - 143,426,125 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186284   ⟹   ENSMUSP00000140156
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,662,088 - 142,703,274 (+)Ensembl
GRCm38.p6 Ensembl7143,108,351 - 143,149,537 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186288   ⟹   ENSMUSP00000140779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,660,252 - 142,703,274 (+)Ensembl
GRCm38.p6 Ensembl7143,106,515 - 143,149,537 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186488   ⟹   ENSMUSP00000140673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,660,099 - 142,703,274 (+)Ensembl
GRCm38.p6 Ensembl7143,106,362 - 143,149,537 (+)Ensembl
Ensembl Acc Id: ENSMUST00000186798   ⟹   ENSMUSP00000139798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,660,482 - 142,703,274 (+)Ensembl
GRCm38.p6 Ensembl7143,106,745 - 143,149,537 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187213   ⟹   ENSMUSP00000139700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7142,662,931 - 142,703,274 (+)Ensembl
GRCm38.p6 Ensembl7143,109,194 - 143,149,537 (+)Ensembl
RefSeq Acc Id: NM_001412611   ⟹   NP_001399540
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,662,970 - 142,980,781 (+)NCBI
RefSeq Acc Id: NM_001412612   ⟹   NP_001399541
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,662,970 - 142,980,781 (+)NCBI
RefSeq Acc Id: NM_008434   ⟹   NP_032460
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,660,979 - 142,980,781 (+)NCBI
GRCm387143,107,254 - 143,427,042 (+)NCBI
MGSCv377150,293,159 - 150,612,947 (+)RGD
Celera7142,862,859 - 143,182,707 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508488   ⟹   XP_006508551
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,660,984 - 142,980,787 (+)NCBI
GRCm387143,107,247 - 143,427,050 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508489   ⟹   XP_006508552
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,660,984 - 142,979,700 (+)NCBI
GRCm387143,107,247 - 143,425,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508490   ⟹   XP_006508553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,660,833 - 142,979,862 (+)NCBI
GRCm387143,107,096 - 143,426,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508491   ⟹   XP_006508554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,660,833 - 142,815,117 (+)NCBI
GRCm387143,107,096 - 143,261,380 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006508492   ⟹   XP_006508555
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,660,614 - 142,980,787 (+)NCBI
GRCm387143,106,877 - 143,427,050 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011241982   ⟹   XP_011240284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,660,984 - 142,979,850 (+)NCBI
GRCm387143,107,247 - 143,426,113 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036152718   ⟹   XP_036008611
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397142,662,976 - 142,980,787 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001399540 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399541 (Get FASTA)   NCBI Sequence Viewer  
  NP_032460 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508551 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508552 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508553 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508554 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508555 (Get FASTA)   NCBI Sequence Viewer  
  XP_011240284 (Get FASTA)   NCBI Sequence Viewer  
  XP_036008611 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB36518 (Get FASTA)   NCBI Sequence Viewer  
  AAH45142 (Get FASTA)   NCBI Sequence Viewer  
  AAH55304 (Get FASTA)   NCBI Sequence Viewer  
  AAP93874 (Get FASTA)   NCBI Sequence Viewer  
  AAT46418 (Get FASTA)   NCBI Sequence Viewer  
  BAC15571 (Get FASTA)   NCBI Sequence Viewer  
  BAE22959 (Get FASTA)   NCBI Sequence Viewer  
  BAE32460 (Get FASTA)   NCBI Sequence Viewer  
  CAA05246 (Get FASTA)   NCBI Sequence Viewer  
  CAC27354 (Get FASTA)   NCBI Sequence Viewer  
  EDL18203 (Get FASTA)   NCBI Sequence Viewer  
  EDL18204 (Get FASTA)   NCBI Sequence Viewer  
  EDL18205 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000009689
  ENSMUSP00000009689.5
  ENSMUSP00000139548
  ENSMUSP00000139548.2
  ENSMUSP00000139700.2
  ENSMUSP00000139798.2
  ENSMUSP00000140156.2
  ENSMUSP00000140673.2
  ENSMUSP00000140779.2
GenBank Protein P97414 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032460   ⟸   NM_008434
- Peptide Label: isoform 1
- UniProtKB: Q7TPL7 (UniProtKB/Swiss-Prot),   Q7TNZ1 (UniProtKB/Swiss-Prot),   Q3U4H1 (UniProtKB/Swiss-Prot),   O88702 (UniProtKB/Swiss-Prot),   Q80VR7 (UniProtKB/Swiss-Prot),   P97414 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508555   ⟸   XM_006508492
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006508552   ⟸   XM_006508489
- Peptide Label: isoform X3
- UniProtKB: A0A087WNY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508554   ⟸   XM_006508491
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006508553   ⟸   XM_006508490
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006508551   ⟸   XM_006508488
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011240284   ⟸   XM_011241982
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSMUSP00000139798   ⟸   ENSMUST00000186798
Ensembl Acc Id: ENSMUSP00000140779   ⟸   ENSMUST00000186288
Ensembl Acc Id: ENSMUSP00000140156   ⟸   ENSMUST00000186284
Ensembl Acc Id: ENSMUSP00000140673   ⟸   ENSMUST00000186488
Ensembl Acc Id: ENSMUSP00000009689   ⟸   ENSMUST00000009689
Ensembl Acc Id: ENSMUSP00000139548   ⟸   ENSMUST00000185383
Ensembl Acc Id: ENSMUSP00000139700   ⟸   ENSMUST00000187213
RefSeq Acc Id: XP_036008611   ⟸   XM_036152718
- Peptide Label: isoform X7
RefSeq Acc Id: NP_001399540   ⟸   NM_001412611
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001399541   ⟸   NM_001412612
- Peptide Label: isoform 3
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97414-F1-model_v2 AlphaFold P97414 1-668 view protein structure

Promoters
RGD ID:8666241
Promoter ID:EPDNEW_M11152
Type:initiation region
Name:Kcnq1_1
Description:Mus musculus potassium voltage-gated channel, subfamily Q, member1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387143,107,242 - 143,107,302EPDNEW
RGD ID:6841384
Promoter ID:MM_KWN:53381
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:ENSMUST00000009689
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367150,292,861 - 150,293,361 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108083 AgrOrtholog
Ensembl Genes ENSMUSG00000009545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000009689 ENTREZGENE
  ENSMUST00000009689.11 UniProtKB/Swiss-Prot
  ENSMUST00000185383 ENTREZGENE
  ENSMUST00000185383.2 UniProtKB/TrEMBL
  ENSMUST00000186284.7 UniProtKB/TrEMBL
  ENSMUST00000186288.7 UniProtKB/TrEMBL
  ENSMUST00000186488.7 UniProtKB/TrEMBL
  ENSMUST00000186798.2 UniProtKB/TrEMBL
  ENSMUST00000187213.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCQN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16535 UniProtKB/Swiss-Prot
MGD MGI:108083 ENTREZGENE
NCBI Gene 16535 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNQ1 RGD
PhenoGen Kcnq1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ1CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WNY7 ENTREZGENE, UniProtKB/TrEMBL
  A0A087WPA8_MOUSE UniProtKB/TrEMBL
  A0A087WPJ2_MOUSE UniProtKB/TrEMBL
  A0A087WQE3_MOUSE UniProtKB/TrEMBL
  A0A087WRK7_MOUSE UniProtKB/TrEMBL
  A0A087WRU8_MOUSE UniProtKB/TrEMBL
  KCNQ1_MOUSE UniProtKB/Swiss-Prot
  O88702 ENTREZGENE
  P97414 ENTREZGENE
  Q3U4H1 ENTREZGENE
  Q3UWF6_MOUSE UniProtKB/TrEMBL
  Q7TNZ1 ENTREZGENE
  Q7TPL7 ENTREZGENE
  Q80VR7 ENTREZGENE
  Q8CJG2_MOUSE UniProtKB/TrEMBL
  Q99NF6_MOUSE UniProtKB/TrEMBL
UniProt Secondary O88702 UniProtKB/Swiss-Prot
  Q3U4H1 UniProtKB/Swiss-Prot
  Q7TNZ1 UniProtKB/Swiss-Prot
  Q7TPL7 UniProtKB/Swiss-Prot
  Q80VR7 UniProtKB/Swiss-Prot