Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) - Rat Genome Database

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Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11) Mus musculus
Symbol: Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
RGD ID: 731747
Description: Enables cell adhesion molecule binding activity; non-membrane spanning protein tyrosine phosphatase activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of ossification. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Predicted to be located in several cellular components, including cell junction; plasma membrane raft; and stress fiber. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study several diseases, including Noonan syndrome 1; Noonan syndrome with multiple lentigines; hepatocellular adenoma; idiopathic scoliosis; and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700084A17Rik; AW536184; protein-tyrosine phosphatase SYP; PTP; PTP1D; PTP2C; S; SAP-2; Sh; SH-P; SH-PTP2; SH-PTP3; SH2 domain-containing protein tyrosine phosphatase-2; SHP; SHP-2; Shp2; Syp; tyrosine-protein phosphatase non-receptor type 11
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395121,268,596 - 121,329,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,268,596 - 121,329,460 (-)EnsemblGRCm39 Ensembl
GRCm385121,130,533 - 121,191,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,130,533 - 121,191,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,580,542 - 121,641,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,391,158 - 121,451,946 (-)NCBIMGSCv36mm8
Celera5118,220,712 - 118,281,623 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
anogenital venereal wart  (ISO)
aortic valve stenosis  (IMP)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial heart septal defect 1  (ISO)
atrophic gastritis  (ISO)
autism spectrum disorder  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Brain Neoplasms  (ISO)
Cafe-au-Lait Spots  (ISO)
cancer  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Abnormalities  (ISO)
Carotid Artery Injuries  (ISO)
cervical cancer  (ISO)
chondroma  (ISO)
chronic lymphocytic leukemia  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniosynostosis  (ISO)
Developmental Disabilities  (ISO)
dilated cardiomyopathy  (IAGP,IMP,ISO)
disease of metabolism  (IAGP)
Dwarfism  (ISO)
embryonal rhabdomyosarcoma  (ISO)
Experimental Leukemia  (ISO)
Failure to Thrive  (ISO)
Fetal Growth Retardation  (ISO)
Funnel Chest  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Haemophilus Infections  (IEP,IMP)
Helicobacter Infections  (ISO)
hemorrhagic disease  (ISO)
hepatocellular adenoma  (IAGP)
hereditary multiple exostoses  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary spastic paraplegia  (ISO)
high grade glioma  (ISO)
Hydrops Fetalis  (ISO)
hypertrophic cardiomyopathy  (IMP,ISO)
idiopathic scoliosis  (IAGP)
influenza  (IEP)
intellectual disability  (ISO)
juvenile myelomonocytic leukemia  (IAGP,ISO)
learning disability  (ISO)
leukemia  (ISO)
lung adenocarcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
metachondromatosis  (ISO)
microcephaly  (ISO)
multiple myeloma  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
neuroblastoma  (ISO)
Neurodevelopmental Disorders  (ISO)
neurofibroma  (ISO)
neurofibromatosis-Noonan syndrome  (ISO)
Noonan Like Syndrome  (ISO)
Noonan syndrome  (IMP,ISO)
Noonan syndrome 1  (IAGP,ISO)
Noonan syndrome 3  (ISO)
Noonan syndrome with multiple lentigines  (IAGP,IMP,ISO)
Noonan syndrome with multiple lentigines 1  (ISO)
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic Leukemia  (ISO)
Ollier disease  (ISO)
Osteochondroma  (ISO)
Paraproteinemias  (ISO)
patent ductus arteriosus  (ISO)
patent foramen ovale  (ISO)
plasma cell neoplasm  (ISO)
ptosis  (ISO)
RASopathy  (ISO)
Right Ventricular Hypertrophy  (ISO)
scoliosis  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Pneumonia  (IEP,IMP)
stomach cancer  (ISO)
strabismus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
tetralogy of Fallot  (ISO)
thrombocytopenia  (ISO)
tricuspid valve insufficiency  (ISO)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
Werner syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dichlorobenzene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
Brodifacoum  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
Calpeptin  (EXP)
capillarisin  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chondroitin sulfate  (ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxazosin  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
IC-87114  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
lipopolysaccharide  (EXP)
LY294002  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
succimer  (ISO)
tipifarnib  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trimethyltin  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
atrioventricular canal development  (ISO)
axonogenesis  (IMP)
Bergmann glial cell differentiation  (IGI,IMP)
brain development  (ISO)
cellular response to angiotensin  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cerebellar cortex formation  (IGI,IMP)
dephosphorylation  (IEA)
DNA damage checkpoint signaling  (IMP)
ephrin receptor signaling pathway  (ISO)
epidermal growth factor receptor signaling pathway  (IGI)
ERBB signaling pathway  (ISO)
face morphogenesis  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
genitalia development  (ISO)
glucose homeostasis  (IMP)
heart development  (ISO)
homeostasis of number of cells within a tissue  (IGI,IMP)
hormone metabolic process  (IMP)
hormone-mediated signaling pathway  (IDA)
inner ear development  (ISO)
integrin-mediated signaling pathway  (IMP)
intestinal epithelial cell migration  (IMP)
lipid metabolic process  (IMP)
megakaryocyte development  (IMP)
microvillus organization  (IMP)
multicellular organism growth  (IMP)
multicellular organismal reproductive process  (IMP)
negative regulation of cell adhesion mediated by integrin  (IMP)
negative regulation of chondrocyte differentiation  (IMP)
negative regulation of cortisol secretion  (IMP)
negative regulation of growth hormone secretion  (IMP)
negative regulation of hormone secretion  (IMP)
negative regulation of insulin secretion  (IMP)
negative regulation of type I interferon production  (ISO)
neurotrophin TRK receptor signaling pathway  (IMP)
organ growth  (IMP)
platelet formation  (IGI)
platelet-derived growth factor receptor signaling pathway  (IGI)
positive regulation of ERK1 and ERK2 cascade  (IGI,ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of hormone secretion  (IMP)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of interferon-beta production  (IMP)
positive regulation of interleukin-6 production  (IGI)
positive regulation of mitotic cell cycle  (IGI)
positive regulation of ossification  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of signal transduction  (IMP)
positive regulation of tumor necrosis factor production  (IGI)
protein dephosphorylation  (ISO)
regulation of cell adhesion mediated by integrin  (ISO)
regulation of MAPK cascade  (IMP)
regulation of protein export from nucleus  (IMP)
regulation of protein-containing complex assembly  (ISO)
signal transduction  (IMP)
smooth muscle cell proliferation  (ISO)
triglyceride metabolic process  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal axial mesoderm morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal axon fasciculation  (IAGP)
abnormal blastocyst morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow cell number  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal carbohydrate metabolism  (IAGP)
abnormal cardiac epithelial to mesenchymal transition  (IAGP)
abnormal cell death  (IAGP)
abnormal chest morphology  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium size  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal epididymal fat pad morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal facial morphology  (IAGP)
abnormal fat cell differentiation  (IAGP)
abnormal gait  (IAGP)
abnormal gastrulation  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair growth  (IAGP)
abnormal heart development  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart septum morphology  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hippocampus neuron morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal lacrimal gland development  (IAGP)
abnormal leukopoiesis  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver parenchyma morphology  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal lung development  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber calcium currents  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nasal cartilage morphology  (IAGP)
abnormal nasopharynx morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal reproductive system morphology  (IAGP)
abnormal retina inner nuclear layer morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal Schwann cell physiology  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal Sertoli cell barrier function  (IAGP)
abnormal Sertoli cell barrier morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal spine curvature  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal trophectoderm morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal vertebral epiphyseal plate morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
absent craniofacial bones  (IAGP)
absent lacrimal glands  (IAGP)
absent mandible  (IAGP)
absent nasal capsule  (IAGP)
absent Schwann cell precursors  (IAGP)
anemia  (IAGP)
aneuploidy  (IAGP)
aortic valve regurgitation  (IAGP)
aortic valve stenosis  (IAGP)
arrest of spermatogenesis  (IAGP)
arrested B cell differentiation  (IAGP)
atelectasis  (IAGP)
atrial septal defect  (IAGP)
atrioventricular septal defect  (IAGP)
azoospermia  (IAGP)
broad snout  (IAGP)
cachexia  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
caudal body truncation  (IAGP)
chromosomal instability  (IAGP)
common truncal valve  (IAGP)
congestive heart failure  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral density  (IAGP)
decreased brown adipose tissue amount  (IAGP)
decreased cardiac cell glucose uptake  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiac neural crest cell number  (IAGP)
decreased cardiac stroke volume  (IAGP)
decreased cardiomyocyte apoptosis  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating adiponectin level  (IAGP)
decreased circulating alanine transaminase level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased circulating triiodothyronine level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased cranium height  (IAGP)
decreased cranium length  (IAGP)
decreased enteric neural crest cell number  (IAGP)
decreased exploration in new environment  (IAGP)
decreased fetal size  (IAGP)
decreased granulocyte monocyte progenitor cell number  (IAGP)
decreased hair follicle number  (IAGP)
decreased heart left ventricle posterior wall thickness  (IAGP)
decreased heart rate  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased litter size  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased male germ cell number  (IAGP)
decreased motor neuron number  (IAGP)
decreased muscle cell glucose uptake  (IAGP)
decreased nerve conduction velocity  (IAGP)
decreased Schwann cell number  (IAGP)
decreased Schwann cell precursor number  (IAGP)
decreased sensory neuron number  (IAGP)
decreased skeletal muscle fiber number  (IAGP)
decreased skeletal muscle fiber size  (IAGP)
decreased skeletal muscle triglyceride level  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased testis weight  (IAGP)
decreased total body fat amount  (IAGP)
decreased trophectoderm cell proliferation  (IAGP)
decreased ventricle muscle contractility  (IAGP)
decreased white fat cell number  (IAGP)
depressed nasal bridge  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
disorganized embryonic tissue  (IAGP)
double outlet right ventricle  (IAGP)
dry skin  (IAGP)
ectopic cartilage  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality at implantation, incomplete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enhanced lipolysis  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged mitral valve  (IAGP)
enlarged myocardial fiber  (IAGP)
enlarged semilunar valve  (IAGP)
enlarged spleen  (IAGP)
epidermal atrophy  (IAGP)
exostosis  (IAGP)
extramedullary hematopoiesis  (IAGP)
eyelids open at birth  (IAGP)
failure of initiation of embryo turning  (IAGP)
flaky skin  (IAGP)
flattened snout  (IAGP)
focal hepatic necrosis  (IAGP)
heart left ventricle hypertrophy  (IAGP)
heart valve hyperplasia  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
hepatic steatosis  (IAGP)
hydrops fetalis  (IAGP)
hyperglycemia  (IAGP)
hypermyelination  (IAGP)
hypersecretion of corticosterone  (IAGP)
hypoglycemia  (IAGP)
impaired cranial neural crest cell differentiation  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired embryo implantation  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
incomplete somite formation  (IAGP)
increased acute inflammation  (IAGP)
increased acute lymphoblastic leukemia incidence  (IAGP)
increased acute promyelocytic leukemia incidence  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased atrioventricular cushion size  (IAGP)
increased B cell derived lymphoma incidence  (IAGP)
increased body length  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased cardiac muscle triglyceride level  (IAGP)
increased cell proliferation  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating growth hormone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased energy expenditure  (IAGP)
increased fat cell size  (IAGP)
increased glycerol level  (IAGP)
increased granulocyte number  (IAGP)
increased heart ventricle size  (IAGP)
increased heart weight  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hepatocyte proliferation  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inner canthal distance  (IAGP)
increased insulin sensitivity  (IAGP)
increased lean body mass  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased left ventricle systolic pressure  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased Leydig cell number  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver glycogen level  (IAGP)
increased liver triglyceride level  (IAGP)
increased lymphoblastic lymphoma incidence  (IAGP)
increased lymphocyte cell number  (IAGP)
increased male germ cell apoptosis  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased skeletal muscle triglyceride level  (IAGP)
increased spleen weight  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased white adipose tissue amount  (IAGP)
inner cell mass degeneration  (IAGP)
insulin resistance  (IAGP)
intermingled spleen red and white pulp  (IAGP)
intestinal hypoperistalsis  (IAGP)
kinked neural tube  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver fibrosis  (IAGP)
liver hyperplasia  (IAGP)
liver inflammation  (IAGP)
lordosis  (IAGP)
male infertility  (IAGP)
microcephaly  (IAGP)
micrognathia  (IAGP)
myeloid hyperplasia  (IAGP)
myocardium hypertrophy  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
ocular hypertelorism  (IAGP)
open neural tube  (IAGP)
optic nerve atrophy  (IAGP)
pectus carinatum  (IAGP)
pectus excavatum  (IAGP)
pericardial effusion  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosus  (IAGP)
polyploidy  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged QT interval  (IAGP)
prolonged RR interval  (IAGP)
prolonged ST segment  (IAGP)
reduced female fertility  (IAGP)
retina degeneration  (IAGP)
retina ganglion cell degeneration  (IAGP)
retina outer nuclear layer degeneration  (IAGP)
scoliosis  (IAGP)
seminiferous tubule degeneration  (IAGP)
short femur  (IAGP)
short tibia  (IAGP)
slow postnatal weight gain  (IAGP)
small cranium  (IAGP)
small ears  (IAGP)
small liver  (IAGP)
small seminiferous tubules  (IAGP)
small snout  (IAGP)
small testis  (IAGP)
thick aortic valve  (IAGP)
thick interventricular septum  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thick pulmonary valve  (IAGP)
thick ventricular wall  (IAGP)
thin epidermis  (IAGP)
thin myocardium  (IAGP)
thin myocardium compact layer  (IAGP)
thin retina ganglion layer  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina inner plexiform layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thin retina outer plexiform layer  (IAGP)
thin skin  (IAGP)
ventricular septal defect  (IAGP)
waved hair  (IAGP)
weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. Purification, identification and subcellular distribution of three predominant protein-tyrosine phosphatase enzymes in skeletal muscle tissue. Ahmad F and Goldstein BJ, Biochim Biophys Acta. 1995 Apr 5;1248(1):57-69.
2. An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta. Arena S, etal., Mol Endocrinol. 2007 Jan;21(1):229-46. Epub 2006 Oct 4.
3. Met, metastasis, motility and more. Birchmeier C, etal., Nat Rev Mol Cell Biol. 2003 Dec;4(12):915-25.
4. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Chen B, etal., Nat Genet 2000 Mar;24(3):296-9.
5. Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection. Chitranshi N, etal., Mol Ther. 2019 Feb 6;27(2):424-441. doi: 10.1016/j.ymthe.2018.09.019. Epub 2018 Oct 4.
6. Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature. De Rocca Serra-Nedelec A, etal., Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4257-62. doi: 10.1073/pnas.1119803109. Epub 2012 Feb 27.
7. Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene. Digilio MC, etal., Am J Hum Genet. 2002 Aug;71(2):389-94. Epub 2002 Jun 7.
8. The Met tyrosine kinase receptor in development and cancer. Gentile A, etal., Cancer Metastasis Rev. 2008 Mar;27(1):85-94.
9. A common variant in the PTPN11 gene contributes to the risk of tetralogy of Fallot. Goodship JA, etal., Circ Cardiovasc Genet. 2012 Jun;5(3):287-92. doi: 10.1161/CIRCGENETICS.111.962035. Epub 2012 Apr 13.
10. Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy. Goto Y, etal., Int J Med Sci. 2006 Nov 1;4(1):1-6. doi: 10.7150/ijms.4.1.
11. Associations between a PTPN11 polymorphism and gastric atrophy--opposite in Uzbekistan to that in Japan. Hamajima N, etal., Asian Pac J Cancer Prev. 2008 Apr-Jun;9(2):217-20.
12. Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese. Hishida A, etal., BMC Gastroenterol. 2009 Jul 9;9:51. doi: 10.1186/1471-230X-9-51.
13. Noonan-like syndrome mutations in PTPN11 in patients diagnosed with cherubism. Jafarov T, etal., Clin Genet. 2005 Aug;68(2):190-1.
14. Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population. Jiang J, etal., BMC Gastroenterol. 2012 Jul 12;12:89. doi: 10.1186/1471-230X-12-89.
15. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
16. PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience. Keren B, etal., J Med Genet. 2004 Nov;41(11):e117.
17. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
18. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Kontaridis MI, etal., Circulation. 2008 Mar 18;117(11):1423-35. doi: 10.1161/CIRCULATIONAHA.107.728865. Epub 2008 Mar 3.
19. PTPN11 mutations in LEOPARD syndrome. Legius E, etal., J Med Genet. 2002 Aug;39(8):571-4.
20. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. Marin TM, etal., J Clin Invest. 2011 Mar;121(3):1026-43. doi: 10.1172/JCI44972. Epub 2011 Feb 21.
21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
24. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
25. Peroxisome proliferator-activated receptor-gamma agonist improves skeletal muscle insulin signaling in the pregestational intrauterine growth-restricted rat offspring. Oak S, etal., Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E514-24. doi: 10.1152/ajpendo.00008.2009. Epub 2009 Jun 2.
26. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection. Ouyang W, etal., Cell Prolif. 2020 Jan;53(1):e12721. doi: 10.1111/cpr.12721. Epub 2019 Nov 29.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. Mouse MP Annotation Import Pipeline RGD automated import pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Clinical and molecular analysis of 30 patients with multiple lentigines LEOPARD syndrome. Sarkozy A, etal., J Med Genet. 2004 May;41(5):e68.
35. The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. Schramm C, etal., Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H231-43. doi: 10.1152/ajpheart.00665.2011. Epub 2011 Nov 4.
36. Role of SRC homology 2-containing tyrosine phosphatase 2 on proliferation of rat smooth muscle cells. Seki N, etal., Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1081-5. doi: 10.1161/
37. Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene. Sobreira NL, etal., PLoS Genet. 2010 Jun 17;6(6):e1000991. doi: 10.1371/journal.pgen.1000991.
38. Significance of SHP-1 and SHP-2 expression in human papillomavirus infected Condyloma acuminatum and cervical cancer. Tao XH, etal., Pathol Oncol Res. 2008 Dec;14(4):365-71. doi: 10.1007/s12253-008-9065-5. Epub 2008 Jun 10.
39. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Tartaglia M, etal., Am J Hum Genet. 2002 Jun;70(6):1555-63. Epub 2002 May 1.
40. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Tartaglia M, etal., Nat Genet. 2003 Jun;34(2):148-50.
41. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Valentino L and Pierre J, Biochem Pharmacol. 2006 Mar 14;71(6):713-21. Epub 2006 Jan 19.
42. Leptin signaling and obesity: cardiovascular consequences. Yang R and Barouch LA, Circ Res. 2007 Sep 14;101(6):545-59.
43. Shp2 Deficiency Impairs the Inflammatory Response Against Haemophilus influenzae by Regulating Macrophage Polarization. Zhao L, etal., J Infect Dis. 2016 Aug 15;214(4):625-33. doi: 10.1093/infdis/jiw205. Epub 2016 May 24.
44. Chemotherapy Effectiveness and Prognosis of Gastric Cancer Influenced by PTPN11 Polymorphisms. Zhuo C, etal., Cell Physiol Biochem. 2016;39(4):1537-52. doi: 10.1159/000447856. Epub 2016 Sep 12.
Additional References at PubMed
PMID:7521735   PMID:7522233   PMID:7523381   PMID:7681217   PMID:8096088   PMID:8183548   PMID:8479755   PMID:8505282   PMID:8530013   PMID:8620532   PMID:8702915   PMID:8810330  
PMID:8875997   PMID:8889548   PMID:8955893   PMID:8959326   PMID:9062191   PMID:9070220   PMID:9110989   PMID:9171349   PMID:9271425   PMID:9299490   PMID:9393882   PMID:9422771  
PMID:9507023   PMID:9670943   PMID:9742124   PMID:9867848   PMID:9973385   PMID:10026201   PMID:10097116   PMID:10349636   PMID:10411909   PMID:10512203   PMID:10521483   PMID:10742110  
PMID:10862698   PMID:10896938   PMID:10922068   PMID:10995764   PMID:11023980   PMID:11042159   PMID:11076861   PMID:11159516   PMID:11432792   PMID:11533026   PMID:11684012   PMID:11739737  
PMID:11832424   PMID:11895767   PMID:11970986   PMID:11997521   PMID:12024020   PMID:12181353   PMID:12219085   PMID:12270932   PMID:12477932   PMID:12482708   PMID:12520002   PMID:12522270  
PMID:12582165   PMID:12594211   PMID:12611902   PMID:12615921   PMID:12791646   PMID:12796776   PMID:12808090   PMID:12893283   PMID:12904583   PMID:12913007   PMID:12923167   PMID:12937170  
PMID:12955078   PMID:12971893   PMID:12974390   PMID:14514016   PMID:14522994   PMID:14534538   PMID:14610044   PMID:14610273   PMID:14967142   PMID:14967925   PMID:15062102   PMID:15169898  
PMID:15215307   PMID:15273746   PMID:15477348   PMID:15489334   PMID:15520383   PMID:15548697   PMID:15563458   PMID:15568026   PMID:15569927   PMID:15574420   PMID:15611085   PMID:15650750  
PMID:15677447   PMID:15699129   PMID:15710330   PMID:15723811   PMID:15737732   PMID:15741177   PMID:15761018   PMID:15840001   PMID:15870281   PMID:15950607   PMID:16055440   PMID:16141072  
PMID:16141073   PMID:16179375   PMID:16239343   PMID:16260787   PMID:16272304   PMID:16284184   PMID:16371368   PMID:16442778   PMID:16461457   PMID:16516835   PMID:16602821   PMID:16702225  
PMID:16731527   PMID:16738330   PMID:16837792   PMID:16873377   PMID:16885344   PMID:16939816   PMID:16959766   PMID:16963136   PMID:17015617   PMID:17056523   PMID:17082620   PMID:17095659  
PMID:17157040   PMID:17213291   PMID:17229738   PMID:17239631   PMID:17330819   PMID:17369354   PMID:17440960   PMID:17442246   PMID:17487421   PMID:17605785   PMID:17646384   PMID:17804806  
PMID:17881575   PMID:17954568   PMID:17961593   PMID:17962719   PMID:17971444   PMID:18077586   PMID:18223690   PMID:18246201   PMID:18368066   PMID:18378677   PMID:18403587   PMID:18450421  
PMID:18640765   PMID:18799693   PMID:18827006   PMID:19001090   PMID:19008228   PMID:19017799   PMID:19036852   PMID:19179468   PMID:19251646   PMID:19261604   PMID:19275884   PMID:19287004  
PMID:19290061   PMID:19380737   PMID:19393645   PMID:19433062   PMID:19509418   PMID:19528235   PMID:19541608   PMID:19542364   PMID:19587381   PMID:19635473   PMID:19637226   PMID:19679834  
PMID:19698715   PMID:19727691   PMID:19786542   PMID:19805360   PMID:19887591   PMID:19948503   PMID:20160350   PMID:20215346   PMID:20237281   PMID:20400923   PMID:20417562   PMID:20421975  
PMID:20435932   PMID:20472558   PMID:20526344   PMID:20648636   PMID:20651068   PMID:20682772   PMID:20697350   PMID:20723025   PMID:20734316   PMID:20841350   PMID:20846526   PMID:20884876  
PMID:21056449   PMID:21068439   PMID:21297004   PMID:21353259   PMID:21364532   PMID:21393858   PMID:21398220   PMID:21450902   PMID:21531714   PMID:21575863   PMID:21576358   PMID:21636860  
PMID:21677750   PMID:21725048   PMID:21803945   PMID:21804557   PMID:21873635   PMID:21884940   PMID:21903867   PMID:21930766   PMID:22015719   PMID:22362894   PMID:22389718   PMID:22431513  
PMID:22522491   PMID:22566685   PMID:22576369   PMID:22619361   PMID:22641383   PMID:22660330   PMID:22759635   PMID:22806893   PMID:22890240   PMID:22891281   PMID:22942432   PMID:23027125  
PMID:23057634   PMID:23103841   PMID:23112346   PMID:23129808   PMID:23236157   PMID:23269672   PMID:23321074   PMID:23349485   PMID:23374343   PMID:23382182   PMID:23452850   PMID:23509158  
PMID:23530062   PMID:23675459   PMID:23720040   PMID:23863940   PMID:23873233   PMID:23884424   PMID:23929766   PMID:23937658   PMID:24030516   PMID:24035415   PMID:24052308   PMID:24077964  
PMID:24088816   PMID:24123360   PMID:24204042   PMID:24216759   PMID:24284065   PMID:24372081   PMID:24431450   PMID:24439672   PMID:24472646   PMID:24493648   PMID:24550486   PMID:24553178  
PMID:24586749   PMID:24590274   PMID:24599474   PMID:24618081   PMID:24675817   PMID:24706815   PMID:24733849   PMID:24858400   PMID:24865967   PMID:24875294   PMID:24933319   PMID:24981838  
PMID:25026279   PMID:25127857   PMID:25159185   PMID:25288766   PMID:25289670   PMID:25317600   PMID:25339680   PMID:25359717   PMID:25377219   PMID:25383899   PMID:25538234   PMID:25593124  
PMID:25650089   PMID:25713104   PMID:25736378   PMID:25915733   PMID:25919282   PMID:26100917   PMID:26265072   PMID:26365186   PMID:26416283   PMID:26456821   PMID:26460004   PMID:26617336  
PMID:26644409   PMID:26755576   PMID:27054330   PMID:27100271   PMID:27183387   PMID:27348588   PMID:27422603   PMID:27521458   PMID:27578777   PMID:27582544   PMID:27736153   PMID:27783593  
PMID:27799550   PMID:27840422   PMID:27861634   PMID:27935860   PMID:27942593   PMID:27974211   PMID:28106071   PMID:28287082   PMID:28344320   PMID:28346493   PMID:28352079   PMID:28424251  
PMID:28434868   PMID:28463680   PMID:28481957   PMID:28489004   PMID:28582432   PMID:28701303   PMID:28751523   PMID:28754897   PMID:28768764   PMID:28804122   PMID:28814604   PMID:28878211  
PMID:28975680   PMID:28983104   PMID:29025706   PMID:29028795   PMID:29046360   PMID:29141219   PMID:29217681   PMID:29255148   PMID:29257282   PMID:29360039   PMID:29360139   PMID:29464054  
PMID:29505847   PMID:29514104   PMID:29559584   PMID:29617671   PMID:29644115   PMID:29659837   PMID:29774106   PMID:29808009   PMID:29891536   PMID:30089263   PMID:30102570   PMID:30108215  
PMID:30333137   PMID:30355677   PMID:30376595   PMID:30413615   PMID:30444570   PMID:30467378   PMID:30471432   PMID:30526882   PMID:30610104   PMID:30837304   PMID:30926899   PMID:30931927  
PMID:31201283   PMID:31210146   PMID:31398269   PMID:31500245   PMID:31562133   PMID:31634485   PMID:31651330   PMID:31653968   PMID:31843886   PMID:32092146   PMID:32280997   PMID:32290105  
PMID:32325033   PMID:32335126   PMID:32350404   PMID:32437509   PMID:32499374   PMID:32546483   PMID:32584792   PMID:32697817   PMID:33045063   PMID:33165997   PMID:33446805   PMID:33601422  
PMID:33604918   PMID:33689087   PMID:33905568   PMID:33910978   PMID:34237430   PMID:34728626   PMID:34758313   PMID:35025868   PMID:35243230   PMID:35260907   PMID:35476985   PMID:35589562  
PMID:35850773   PMID:35983034   PMID:36002018   PMID:36096674   PMID:36102977   PMID:36194675   PMID:36528691   PMID:36581713   PMID:36634415   PMID:36739480   PMID:36768520   PMID:36828281  
PMID:36979407   PMID:36988860   PMID:37169572   PMID:37184079   PMID:37304233   PMID:37461040   PMID:37466473   PMID:37473759   PMID:37486591   PMID:37942607   PMID:38088801   PMID:38095642  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395121,268,596 - 121,329,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,268,596 - 121,329,460 (-)EnsemblGRCm39 Ensembl
GRCm385121,130,533 - 121,191,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,130,533 - 121,191,397 (-)EnsemblGRCm38mm10GRCm38
MGSCv375121,580,542 - 121,641,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,391,158 - 121,451,946 (-)NCBIMGSCv36mm8
Celera5118,220,712 - 118,281,623 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.72NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812112,418,947 - 112,509,918 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,418,351 - 112,509,918 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,856,751 - 112,947,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,340,919 - 111,432,100 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412111,319,255 - 111,410,436NCBI
Celera12112,483,686 - 112,574,781 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12109,868,826 - 109,960,330 (+)NCBIHuRef
CHM1_112112,825,224 - 112,916,404 (+)NCBICHM1_1
T2T-CHM13v2.012112,395,849 - 112,486,820 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21235,365,436 - 35,424,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,383,144 - 35,424,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,539,721 - 36,599,487 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,150,921 - 37,210,691 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,203,373 - 36,263,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,895,515 - 40,955,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,895,515 - 40,955,999 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,762,630 - 42,822,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,501,886 - 36,558,055 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,365,273 - 36,421,443 (+)NCBI
Celera1237,029,879 - 37,089,260 (+)NCBICelera
RH 3.4 Map12646.0RGD
Cytogenetic Map12q16NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554828,934,306 - 9,035,203 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,934,734 - 9,031,230 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan112120,507,189 - 120,598,322 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,016,364 - 110,107,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112113,412,077 - 113,503,762 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,435,669 - 113,503,762 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1269,989,218 - 10,072,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,989,425 - 10,067,481 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2610,107,654 - 10,190,288 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,229,100 - 10,311,852 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,229,105 - 10,358,597 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,203,528 - 10,286,110 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,266,437 - 10,349,406 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,314,568 - 10,397,234 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118148,103,369 - 148,189,014 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366682,628,706 - 2,682,448 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366682,602,261 - 2,687,903 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1439,202,169 - 39,292,003 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,202,165 - 39,292,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,703,693 - 41,793,663 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.111107,658,495 - 107,754,457 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,658,453 - 107,752,637 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037137,330,748 - 137,428,997 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474719,721,468 - 19,813,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,721,581 - 19,813,639 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptpn11
1401 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2893
Count of miRNA genes:730
Interacting mature miRNAs:929
Transcripts:ENSMUST00000054547, ENSMUST00000100770, ENSMUST00000148407, ENSMUST00000148871
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,131,183 - 121,131,288UniSTSGRCm38
MGSCv375121,581,192 - 121,581,297UniSTSGRCm37
Celera5118,221,362 - 118,221,467UniSTS
Cytogenetic Map5FUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,133,957 - 121,134,114UniSTSGRCm38
MGSCv375121,583,966 - 121,584,123UniSTSGRCm37
Celera5118,224,136 - 118,224,293UniSTS
Cytogenetic Map5FUniSTS
Whitehead_YAC5 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,131,680 - 121,131,837UniSTSGRCm38
MGSCv375121,581,689 - 121,581,846UniSTSGRCm37
Celera5118,221,859 - 118,222,016UniSTS
Cytogenetic Map5FUniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375121,583,912 - 121,584,044UniSTSGRCm37
Celera5118,224,082 - 118,224,214UniSTS
Cytogenetic Map5FUniSTS
cM Map5 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,133,903 - 121,134,035UniSTSGRCm38
MGSCv375121,583,912 - 121,584,044UniSTSGRCm37
Celera5118,224,082 - 118,224,214UniSTS
Cytogenetic Map5FUniSTS
cM Map5 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,133,916 - 121,134,047UniSTSGRCm38
MGSCv375121,583,925 - 121,584,056UniSTSGRCm37
Celera5118,224,095 - 118,224,226UniSTS
Cytogenetic Map5FUniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001109992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02043572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM899214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF751511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S59187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000054547   ⟹   ENSMUSP00000058757
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,268,604 - 121,329,392 (-)Ensembl
GRCm38.p6 Ensembl5121,130,541 - 121,191,329 (-)Ensembl
RefSeq Acc Id: ENSMUST00000100770   ⟹   ENSMUSP00000098333
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,268,596 - 121,329,460 (-)Ensembl
GRCm38.p6 Ensembl5121,130,533 - 121,191,397 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148407
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,268,598 - 121,329,430 (-)Ensembl
GRCm38.p6 Ensembl5121,130,535 - 121,191,367 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148871
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,271,903 - 121,281,698 (-)Ensembl
GRCm38.p6 Ensembl5121,133,840 - 121,143,635 (-)Ensembl
RefSeq Acc Id: NM_001109992   ⟹   NP_001103462
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm395121,268,596 - 121,329,460 (-)NCBI
GRCm385121,130,533 - 121,191,397 (-)ENTREZGENE
MGSCv375121,580,542 - 121,641,406 (-)RGD
Celera5118,220,712 - 118,281,623 (-)RGD
RefSeq Acc Id: NM_011202   ⟹   NP_035332
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm395121,268,596 - 121,329,460 (-)NCBI
GRCm385121,130,533 - 121,191,397 (-)ENTREZGENE
MGSCv375121,580,542 - 121,641,406 (-)RGD
Celera5118,220,712 - 118,281,623 (-)RGD
RefSeq Acc Id: NP_035332   ⟸   NM_011202
- Peptide Label: isoform a
- UniProtKB: P35235 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001103462   ⟸   NM_001109992
- Peptide Label: isoform b
- UniProtKB: Q64509 (UniProtKB/Swiss-Prot),   Q3TQ84 (UniProtKB/Swiss-Prot),   Q6PCL5 (UniProtKB/Swiss-Prot),   P35235 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000058757   ⟸   ENSMUST00000054547
RefSeq Acc Id: ENSMUSP00000098333   ⟸   ENSMUST00000100770
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35235-F1-model_v2 AlphaFold P35235 1-593 view protein structure

RGD ID:6887904
Promoter ID:EPDNEW_M7403
Type:initiation region
Description:Mus musculus protein tyrosine phosphatase, non-receptor type11 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm385121,191,385 - 121,191,445EPDNEW
RGD ID:6838156
Promoter ID:MM_KWN:43858
SO ACC ID:SO:0000170
Tissues & Cell Lines:Kidney
Mouse AssemblyChrPosition (strand)Source
MGSCv365121,594,371 - 121,594,871 (-)MPROMDB
RGD ID:6838155
Promoter ID:MM_KWN:43860
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_001109992,   NM_011202,   OTTMUST00000039011
Mouse AssemblyChrPosition (strand)Source
MGSCv365121,641,181 - 121,641,681 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99511 AgrOrtholog
Ensembl Genes ENSMUSG00000043733 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000054547 ENTREZGENE
  ENSMUST00000054547.9 UniProtKB/Swiss-Prot
  ENSMUST00000100770.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  Tyr_Pase_non-rcpt_typ-6/11 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19247 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptpn11 PhenoGen
PIRSF Tyr-Ptase_nr_6 UniProtKB/Swiss-Prot
  SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P35235 ENTREZGENE, UniProtKB/Swiss-Prot
  Q63848_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TQ84 UniProtKB/Swiss-Prot
  Q64509 UniProtKB/Swiss-Prot
  Q6PCL5 UniProtKB/Swiss-Prot