Mrgprf (MAS-related GPR, member F) - Rat Genome Database

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Gene: Mrgprf (MAS-related GPR, member F) Mus musculus
Analyze
Symbol: Mrgprf
Name: MAS-related GPR, member F
RGD ID: 731633
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in nuclear membrane. Predicted to be active in plasma membrane. Orthologous to human MRGPRF (MAS related GPR family member F).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BC019711; G protein-coupled receptor RTA; Mas-related G protein-coupled receptor c; mas-related G-protein coupled receptor member F; mas-related gene F protein; MGC18825; Mgrc; Mrg; MrgF
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,854,646 - 144,863,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,854,565 - 144,863,294 (+)EnsemblGRCm39 Ensembl
GRCm387145,300,909 - 145,309,557 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7145,300,828 - 145,309,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,486,814 - 152,495,462 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367145,110,299 - 145,118,947 (+)NCBIMGSCv36mm8
Celera7145,068,810 - 145,077,498 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map789.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
nuclear membrane  (ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11551509   PMID:12397184   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17634244  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:21912971   PMID:24583173   PMID:28621310  


Genomics

Comparative Map Data
Mrgprf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397144,854,646 - 144,863,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7144,854,565 - 144,863,294 (+)EnsemblGRCm39 Ensembl
GRCm387145,300,909 - 145,309,557 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7145,300,828 - 145,309,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv377152,486,814 - 152,495,462 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367145,110,299 - 145,118,947 (+)NCBIMGSCv36mm8
Celera7145,068,810 - 145,077,498 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map789.05NCBI
MRGPRF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381169,004,398 - 69,013,633 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1169,004,398 - 69,013,246 (-)EnsemblGRCh38hg38GRCh38
GRCh371168,771,866 - 68,780,714 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361168,771,862 - 68,780,850 (-)NCBINCBI36Build 36hg18NCBI36
Build 341168,528,442 - 68,537,311NCBI
Celera1166,111,592 - 66,120,578 (-)NCBICelera
Cytogenetic Map11q13.3NCBI
HuRef1165,111,051 - 65,120,036 (-)NCBIHuRef
CHM1_11168,655,094 - 68,664,084 (-)NCBICHM1_1
T2T-CHM13v2.01169,014,626 - 69,023,860 (-)NCBIT2T-CHM13v2.0
Mrgprf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81209,893,384 - 209,902,852 (+)NCBIGRCr8
mRatBN7.21200,464,100 - 200,473,588 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,463,973 - 200,473,660 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1208,839,505 - 208,848,971 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,926,053 - 215,935,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,600,265 - 208,609,733 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,465,642 - 218,476,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,466,289 - 218,476,224 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,334,082 - 225,344,027 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41205,750,528 - 205,759,996 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11205,903,980 - 205,912,991 (+)NCBI
Celera1198,018,612 - 198,028,080 (+)NCBICelera
Cytogenetic Map1q42NCBI
Mrgprf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542216,950,136 - 16,958,623 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542216,950,136 - 16,957,971 (+)NCBIChiLan1.0ChiLan1.0
MRGPRF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2969,963,160 - 69,972,597 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,999,791 - 71,015,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01164,090,299 - 64,103,063 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11167,391,018 - 67,403,745 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1167,391,018 - 67,403,746 (-)Ensemblpanpan1.1panPan2
MRGPRF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,006,789 - 49,015,080 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,006,888 - 49,015,080 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1847,614,138 - 47,622,328 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01849,681,469 - 49,689,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1849,681,575 - 49,689,779 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,127,505 - 49,135,689 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01848,713,846 - 48,722,033 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01849,460,520 - 49,468,710 (+)NCBIUU_Cfam_GSD_1.0
Mrgprf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049474,919,441 - 4,926,928 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,361,823 - 1,369,300 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,361,858 - 1,369,277 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRGPRF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,123,829 - 4,132,938 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,123,786 - 4,132,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MRGPRF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115,559,186 - 5,569,839 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15,563,977 - 5,568,959 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038102,842,174 - 102,851,394 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrgprf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476717,972,076 - 17,980,047 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476717,971,523 - 17,979,956 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrgprf
163 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1628
Count of miRNA genes:577
Interacting mature miRNAs:678
Transcripts:ENSMUST00000033386, ENSMUST00000117718
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse


Sequence


Ensembl Acc Id: ENSMUST00000033386   ⟹   ENSMUSP00000033386
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7144,854,565 - 144,863,294 (+)Ensembl
GRCm38.p6 Ensembl7145,300,828 - 145,309,557 (+)Ensembl
Ensembl Acc Id: ENSMUST00000117718   ⟹   ENSMUSP00000113822
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7144,854,636 - 144,863,086 (+)Ensembl
GRCm38.p6 Ensembl7145,300,899 - 145,309,349 (+)Ensembl
RefSeq Acc Id: NM_145379   ⟹   NP_663354
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397144,854,646 - 144,863,294 (+)NCBI
GRCm387145,300,909 - 145,309,557 (+)ENTREZGENE
MGSCv377152,486,814 - 152,495,462 (+)RGD
Celera7145,068,810 - 145,077,498 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508537   ⟹   XP_006508600
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397144,861,119 - 144,863,289 (+)NCBI
GRCm387145,307,376 - 145,309,552 (+)NCBI
Sequence:
RefSeq Acc Id: NP_663354   ⟸   NM_145379
- UniProtKB: Q91ZB6 (UniProtKB/Swiss-Prot),   Q8VCJ6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006508600   ⟸   XM_006508537
- Peptide Label: isoform X1
- UniProtKB: Q3TZA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000033386   ⟸   ENSMUST00000033386
Ensembl Acc Id: ENSMUSP00000113822   ⟸   ENSMUST00000117718
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCJ6-F1-model_v2 AlphaFold Q8VCJ6 1-343 view protein structure

Promoters
RGD ID:8666305
Promoter ID:EPDNEW_M11184
Type:initiation region
Name:Mrgprf_1
Description:Mus musculus MAS-related GPR, member F , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387145,300,898 - 145,300,958EPDNEW
RGD ID:6841569
Promoter ID:MM_KWN:53455
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   Brain,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000117718,   OTTMUST00000067348
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367152,486,724 - 152,487,224 (+)MPROMDB
RGD ID:6849228
Promoter ID:MM_XEF:6926
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4
Transcripts:NM_001035470,   NM_001093769
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367152,488,656 - 152,489,156 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384823 AgrOrtholog
Ensembl Genes ENSMUSG00000031070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033386 ENTREZGENE
  ENSMUST00000033386.12 UniProtKB/Swiss-Prot
  ENSMUST00000117718.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:211577 UniProtKB/Swiss-Prot
MGD MGI:2384823 ENTREZGENE
NCBI Gene 211577 ENTREZGENE
PANTHER PTHR11334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11334:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mrgprf PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z3Y0_MOUSE UniProtKB/TrEMBL
  MRGRF_MOUSE UniProtKB/Swiss-Prot
  Q3TZA7 ENTREZGENE, UniProtKB/TrEMBL
  Q8VCJ6 ENTREZGENE
  Q91ZB6 ENTREZGENE
UniProt Secondary Q91ZB6 UniProtKB/Swiss-Prot