Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Atic (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) Mus musculus
Analyze
Symbol: Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
RGD ID: 731595
MGI Page MGI
Description: Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in purine ribonucleoside monophosphate biosynthetic process. Acts upstream of or within cellular response to interleukin-7. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610509C24Rik; AA536954; AICAR transformylase/inosine monophosphate cyclohydrolase; AW212393; bifunctional purine biosynthesis protein ATIC; bifunctional purine biosynthesis protein PURH
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm15550   Gm21052   Gm5721  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,596,315 - 71,618,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl171,596,309 - 71,618,790 (+)EnsemblGRCm39 Ensembl
GRCm38171,557,156 - 71,579,403 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,557,150 - 71,579,631 (+)EnsemblGRCm38mm10GRCm38
MGSCv37171,603,730 - 71,625,977 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36171,490,382 - 71,512,612 (+)NCBIMGSCv36mm8
Celera172,112,478 - 72,134,887 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
6-propyl-2-thiouracil  (ISO)
actinomycin D  (ISO)
alachlor  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aniline  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
Brodifacoum  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
DDE  (ISO)
deguelin  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
flutamide  (ISO)
folic acid  (EXP)
furfural  (ISO)
genistein  (ISO)
gentamycin  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
menadione  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
Nutlin-3  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
sulfadimethoxine  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
tungsten  (EXP)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IEA,ISO)
mitochondrion  (HDA)
plasma membrane  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Akira T, etal., Gene 1997 Sep 15;197(1-2):289-93.
2. Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. Baggott JE and Morgan SL, Eur J Pharm Sci. 2007 Jun;31(2):95-101. Epub 2007 Mar 1.
3. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Marie S, etal., Am J Hum Genet. 2004 Jun;74(6):1276-81. Epub 2004 Apr 26.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Trafficking of intracellular folates. Stover PJ and Field MS, Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/¿an.111.000596. Epub 2011 Jun 28.
Additional References at PubMed
PMID:6480832   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15582152   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:17937387   PMID:18614015   PMID:19723774   PMID:21267068   PMID:21873635   PMID:24457600   PMID:26144885   PMID:26588576   PMID:28378742   PMID:29581031   PMID:30595499  
PMID:32325033   PMID:32554809   PMID:33601422   PMID:36073366   PMID:36114006   PMID:36721994   PMID:39129491  


Genomics

Comparative Map Data
Atic
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,596,315 - 71,618,562 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl171,596,309 - 71,618,790 (+)EnsemblGRCm39 Ensembl
GRCm38171,557,156 - 71,579,403 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,557,150 - 71,579,631 (+)EnsemblGRCm38mm10GRCm38
MGSCv37171,603,730 - 71,625,977 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36171,490,382 - 71,512,612 (+)NCBIMGSCv36mm8
Celera172,112,478 - 72,134,887 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.03NCBI
ATIC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382215,312,059 - 215,368,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2215,311,956 - 215,349,773 (+)EnsemblGRCh38hg38GRCh38
GRCh372216,176,782 - 216,214,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,885,081 - 215,922,724 (+)NCBINCBI36Build 36hg18NCBI36
Build 342216,002,341 - 216,039,983NCBI
Celera2209,946,316 - 209,984,125 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,033,447 - 208,071,522 (+)NCBIHuRef
CHM1_12216,182,580 - 216,220,395 (+)NCBICHM1_1
T2T-CHM13v2.02215,797,091 - 215,854,273 (+)NCBIT2T-CHM13v2.0
Atic
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,614,311 - 80,634,360 (+)NCBIGRCr8
mRatBN7.2973,164,846 - 73,184,897 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,164,846 - 73,184,889 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,636,634 - 81,656,672 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,765,482 - 86,785,520 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0985,155,750 - 85,175,788 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,862,013 - 78,882,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,862,013 - 78,882,060 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,636,339 - 78,656,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,676,744 - 70,696,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,823,725 - 70,843,846 (+)NCBI
Celera970,582,456 - 70,602,475 (+)NCBICelera
Cytogenetic Map9q33NCBI
Atic
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955457704,213 - 730,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955457704,213 - 729,702 (-)NCBIChiLan1.0ChiLan1.0
ATIC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213117,940,800 - 118,001,222 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B117,955,739 - 118,005,747 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B102,574,700 - 102,612,492 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B221,159,439 - 221,197,360 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,159,439 - 221,197,360 (+)Ensemblpanpan1.1panPan2
ATIC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13722,420,645 - 22,446,769 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3722,420,603 - 22,446,697 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,247,318 - 23,273,326 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03722,443,734 - 22,469,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3722,443,400 - 22,469,837 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13722,332,320 - 22,358,260 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03722,283,592 - 22,309,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03722,300,293 - 22,326,226 (+)NCBIUU_Cfam_GSD_1.0
Atic
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303170,816,360 - 170,843,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365861,782,528 - 1,810,010 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365861,782,581 - 1,809,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATIC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,617,502 - 117,649,107 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,617,584 - 117,649,063 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215130,321,702 - 130,348,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATIC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,128,583 - 101,166,668 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604098,215,624 - 98,252,491 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atic
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624765782,701 - 809,448 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624765782,703 - 809,461 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atic
1518 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:680
Count of miRNA genes:436
Interacting mature miRNAs:491
Transcripts:ENSMUST00000027384, ENSMUST00000136443, ENSMUST00000148077, ENSMUST00000154855, ENSMUST00000155769
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14127539975275399Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6807134586235027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170133533104139557Mouse
1357824Estoq4_membryo survival total QTL 4 (mouse)Not determined13476013873976915Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15794135191941351Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15799197791992080Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15089021684890216Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14889234582892485Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15672692290727077Mouse
1357759W3q12_mweight 3 weeks QTL 12 (mouse)Not determined13476013873976915Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15854919192549443Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14888900682889210Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14594675579946882Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15597494889975057Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15799197791992080Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15626621490266360Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14127312475273271Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15672692290727077Mouse
1357524W6q14_mweight 6 weeks QTL 14 (mouse)Not determined13476013873976915Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14293803176938167Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5142160585421605Mouse
1357651Lgq5_mlate growth QTL 5 (mouse)Not determined13476013873976915Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14888900682889210Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1558855Eae30_mexperimental allergic encephalomyelitis susceptibility 30 (mouse)Not determined14541777372975057Mouse
1301954Lrnx11_mlearning-contextual 11 (mouse)Not determined13913280874516365Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15626621490266360Mouse
1357506W10q6_mweight 10 weeks QTL 6 (mouse)Not determined13476013873976915Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4225966776259667Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15854919192549443Mouse
39128207Lwq16_mliver weight QTL 16 (mouse)13476013873976915Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
14747009Manh49_mmandible shape 49 (mouse)15794135191941351Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14685469080854839Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14734989481350013Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16588900688496101Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14685469080854839Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15799197791992080Mouse

Markers in Region
AW742740  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38171,579,085 - 71,579,333UniSTSGRCm38
MGSCv37171,625,659 - 71,625,907UniSTSGRCm37
Celera172,134,569 - 72,134,817UniSTS
Cytogenetic Map1C3UniSTS
Whitehead/MRC_RH3503.86UniSTS
RH124506  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38171,562,943 - 71,563,142UniSTSGRCm38
MGSCv37171,609,517 - 71,609,716UniSTSGRCm37
Celera172,118,265 - 72,118,464UniSTS
Cytogenetic Map1C3UniSTS
UniSTS:234146  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38171,556,068 - 71,556,407UniSTSGRCm38
MGSCv37171,602,642 - 71,602,981UniSTSGRCm37
Celera172,111,389 - 72,111,728UniSTS
Cytogenetic Map1C3UniSTS
AW212393  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38171,579,086 - 71,579,213UniSTSGRCm38
MGSCv37171,625,660 - 71,625,787UniSTSGRCm37
Celera172,134,570 - 72,134,697UniSTS
Cytogenetic Map1C3UniSTS
Whitehead/MRC_RH1983.5UniSTS
Atic  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C3UniSTS
cM Map1 UniSTS
Atic  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1C3UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_026195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ178786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF437353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000027384   ⟹   ENSMUSP00000027384
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl171,596,309 - 71,618,790 (+)Ensembl
GRCm38.p6 Ensembl171,557,150 - 71,579,631 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136443
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl171,596,372 - 71,602,357 (+)Ensembl
GRCm38.p6 Ensembl171,557,213 - 71,563,198 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl171,596,338 - 71,602,357 (+)Ensembl
GRCm38.p6 Ensembl171,557,179 - 71,563,198 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154855
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl171,608,025 - 71,612,119 (+)Ensembl
GRCm38.p6 Ensembl171,568,866 - 71,572,960 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl171,596,338 - 71,612,522 (+)Ensembl
GRCm38.p6 Ensembl171,557,179 - 71,573,363 (+)Ensembl
Ensembl Acc Id: ENSMUST00000187982
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl171,596,338 - 71,599,110 (+)Ensembl
GRCm38.p6 Ensembl171,557,179 - 71,559,951 (+)Ensembl
RefSeq Acc Id: NM_026195   ⟹   NP_080471
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39171,596,315 - 71,618,562 (+)NCBI
GRCm38171,557,156 - 71,579,403 (+)ENTREZGENE
MGSCv37171,603,730 - 71,625,977 (+)RGD
Celera172,112,478 - 72,134,887 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080471   ⟸   NM_026195
- UniProtKB: Q9CZW9 (UniProtKB/Swiss-Prot),   Q9CWJ9 (UniProtKB/Swiss-Prot),   Q9CRI1 (UniProtKB/Swiss-Prot),   Q8BQV9 (UniProtKB/Swiss-Prot),   Q8BPF0 (UniProtKB/Swiss-Prot),   Q80UH0 (UniProtKB/Swiss-Prot),   Q3UTQ3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000027384   ⟸   ENSMUST00000027384
Protein Domains
MGS-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CWJ9-F1-model_v2 AlphaFold Q9CWJ9 1-592 view protein structure

Promoters
RGD ID:6874006
Promoter ID:EPDNEW_M454
Type:initiation region
Name:Atic_1
Description:Mus musculus 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMPcyclohydrolase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38171,557,224 - 71,557,284EPDNEW
RGD ID:6817391
Promoter ID:MM_KWN:1098
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000084659,   OTTMUST00000084660,   UC007BJR.1,   UC007BJS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36171,603,424 - 71,603,924 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351352 AgrOrtholog
Ensembl Genes ENSMUSG00000026192 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000027384 ENTREZGENE
  ENSMUST00000027384.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.440 UniProtKB/Swiss-Prot
  3.40.140.20 UniProtKB/Swiss-Prot
  3.40.50.1380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AICAR_Tfase_dup_dom_sf UniProtKB/Swiss-Prot
  AICAR_Tfase_insert_dom_sf UniProtKB/Swiss-Prot
  Cytidine_deaminase-like UniProtKB/Swiss-Prot
  MGS-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MGS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PurH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:108147 UniProtKB/Swiss-Prot
MGD MGI:1351352 ENTREZGENE
NCBI Gene Atic ENTREZGENE
PANTHER BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11692 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AICARFT_IMPCHas UniProtKB/Swiss-Prot
  MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ATIC RGD
PhenoGen Atic PhenoGen
PIRSF AICARFT_IMPCHas UniProtKB/Swiss-Prot
PROSITE MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AICARFT_IMPCHas UniProtKB/Swiss-Prot
  MGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53927 UniProtKB/Swiss-Prot
UniProt B0LAC5_MOUSE UniProtKB/TrEMBL
  PUR9_MOUSE UniProtKB/Swiss-Prot
  Q3UTQ3 ENTREZGENE
  Q80UH0 ENTREZGENE
  Q8BPF0 ENTREZGENE
  Q8BQV9 ENTREZGENE
  Q9CRI1 ENTREZGENE
  Q9CWJ9 ENTREZGENE
  Q9CZW9 ENTREZGENE
UniProt Secondary Q3UTQ3 UniProtKB/Swiss-Prot
  Q80UH0 UniProtKB/Swiss-Prot
  Q8BPF0 UniProtKB/Swiss-Prot
  Q8BQV9 UniProtKB/Swiss-Prot
  Q9CRI1 UniProtKB/Swiss-Prot
  Q9CZW9 UniProtKB/Swiss-Prot