Gck (glucokinase) - Rat Genome Database

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Gene: Gck (glucokinase) Mus musculus
Analyze
Symbol: Gck
Name: glucokinase
RGD ID: 731555
MGI Page MGI
Description: Enables glucokinase activity. Involved in calcium ion import; intracellular glucose homeostasis; and positive regulation of insulin secretion. Acts upstream of or within several processes, including NADP metabolic process; carbohydrate phosphorylation; and regulation of insulin secretion. Located in cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Used to study familial hyperinsulinemic hypoglycemia 3; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young type 2; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gk; GLK; Gls0; Gls006; hexokinase 4; hexokinase type IV; hexokinase-4; hexokinase-D; HK IV; HK4; HKIV; Hlb6; Hlb62; HXKP; MODY; MODY2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,850,816 - 5,900,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,850,820 - 5,900,081 (-)EnsemblGRCm39 Ensembl
GRCm38115,900,816 - 5,950,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,900,820 - 5,950,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,800,826 - 5,849,602 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,800,826 - 5,849,602 (-)NCBIMGSCv36mm8
Celera116,392,658 - 6,441,626 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP,ISO)
aconitine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP,ISO)
ammonium chloride  (ISO)
anthracen-2-amine  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
bellidifolin  (EXP)
benzamide  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boric acid  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chloroform  (ISO)
chlorothalonil  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
clofibrate  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (ISO)
Cuprizon  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
duvoglustat  (EXP)
ebselen  (EXP)
epoxiconazole  (EXP)
erythromycin estolate  (ISO)
ethanol  (EXP)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ginsenoside Rh4  (EXP,ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glycine betaine  (EXP)
herbicide  (EXP)
hesperidin  (EXP)
hydrazine  (ISO)
inulin  (EXP)
ketoconazole  (ISO)
L-methionine  (EXP)
lead(0)  (EXP)
metformin  (ISO)
methidathion  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
naringin  (EXP)
nefazodone  (ISO)
nerolidol  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP)
penconazole  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (EXP)
Repaglinide  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
selenomethionine  (EXP)
sevoflurane  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
tamoxifen  (EXP)
taurine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
Triptolide  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vanillic acid  (ISO)
WIN 55212-2  (EXP)
zaragozic acid A  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (ISO)
basal cortex  (ISO)
cell cortex  (ISO)
cytoplasm  (ISO)
cytosol  (IBA,IDA,ISO,TAS)
mitochondrion  (HDA,IBA,IDA)
nucleoplasm  (ISO)
nucleus  (IDA,ISO)
secretory granule  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal circulating cholesterol level  (IAGP)
abnormal circulating insulin level  (IAGP)
abnormal endocrine pancreas physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal insulin secretion  (IAGP)
abnormal mitochondrial crista morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
cardiac fibrosis  (IAGP)
decreased body weight  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased fasting circulating glucose level  (IAGP)
decreased glucokinase activity  (IAGP)
decreased glycogen level  (IAGP)
decreased insulin secretion  (IAGP)
decreased liver glycogen level  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
hepatic steatosis  (IAGP)
hyperglycemia  (IAGP)
hypoglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased body weight  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased circulating free fatty acids level  (IAGP)
increased circulating fructosamine level  (IEA)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased fasting circulating glucose level  (IAGP)
increased glycosylated hemoglobin level  (IAGP)
increased insulin secretion  (IAGP)
increased mitochondrial number  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased urine glucose level  (IAGP)
insulin resistance  (IAGP)
ketosis  (IAGP)
microvesicular hepatic steatosis  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
pancreatic islet hyperplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
small pancreatic islets  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differences in regulatory properties between human and rat glucokinase regulatory protein. Brocklehurst KJ, etal., Biochem J. 2004 Mar 1;378(Pt 2):693-7.
2. Evolution and regulatory role of the hexokinases. Cardenas ML, etal., Biochim Biophys Acta. 1998 Mar 5;1401(3):242-64.
3. Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension. Chiang FT, etal., Am J Hypertens. 1997 Sep;10(9 Pt 1):1049-52.
4. Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans. De Ceuninck F, etal., Br J Pharmacol. 2013 Jan;168(2):339-53. doi: 10.1111/j.1476-5381.2012.02184.x.
5. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs. Eiki J, etal., Mol Pharmacol. 2011 Dec;80(6):1156-65. doi: 10.1124/mol.111.074401. Epub 2011 Sep 21.
6. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
7. Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat. Futamura M, etal., Diabetologia. 2012 Apr;55(4):1071-80. doi: 10.1007/s00125-011-2439-3. Epub 2012 Jan 11.
8. Familial hyperinsulinism caused by an activating glucokinase mutation. Glaser B, etal., N Engl J Med. 1998 Jan 22;338(4):226-30.
9. Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Gunn JM and Taylor CB, Biochem J. 1973 Nov;136(3):455-65.
10. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
11. Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese rats. Jiang M, etal., Endocrinology. 2011 Apr;152(4):1284-9. doi: 10.1210/en.2010-1162. Epub 2011 Jan 14.
12. Iron increases liver injury through oxidative/nitrative stress in diabetic rats: Involvement of nitrotyrosination of glucokinase. Li X, etal., Biochimie. 2012 Dec;94(12):2620-7. doi: 10.1016/j.biochi.2012.07.019. Epub 2012 Aug 1.
13. Islet adaptive changes to fructose-induced insulin resistance: beta-cell mass, glucokinase, glucose metabolism, and insulin secretion. Maiztegui B, etal., J Endocrinol. 2009 Feb;200(2):139-49. doi: 10.1677/JOE-08-0386. Epub 2008 Nov 27.
14. G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus. Marz W, etal., Circulation. 2004 Jun 15;109(23):2844-9. Epub 2004 Jun 1.
15. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects. Nishi S, etal., Diabet Med. 1994 Mar;11(2):193-7.
19. Neonatal diabetes mellitus due to complete glucokinase deficiency. Njolstad PR, etal., N Engl J Med. 2001 May 24;344(21):1588-92.
20. Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese. Noda K, etal., Diabetes. 1993 Aug;42(8):1147-52.
21. The islet beta-cell: fuel responsive and vulnerable. Nolan CJ and Prentki M, Trends Endocrinol Metab. 2008 Oct;19(8):285-91. Epub 2008 Sep 6.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Common variants in MODY genes increase the risk of gestational diabetes mellitus. Shaat N, etal., Diabetologia. 2006 Jul;49(7):1545-51. Epub 2006 Apr 26.
30. Identification of glucokinase mutations in subjects with gestational diabetes mellitus. Stoffel M, etal., Diabetes. 1993 Jun;42(6):937-40.
31. Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus. Tanizawa Y, etal., Diabetologia. 1993 May;36(5):409-13.
32. A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Toye AA, etal., Diabetes. 2004 Jun;53(6):1577-83.
33. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Vionnet N, etal., Nature. 1992 Apr 23;356(6371):721-2.
34. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
Additional References at PubMed
PMID:141272   PMID:1999433   PMID:3931624   PMID:6354813   PMID:7510884   PMID:7553875   PMID:7556622   PMID:7665557   PMID:7698769   PMID:8530440   PMID:8575768   PMID:8575769  
PMID:8954920   PMID:8976376   PMID:9062343   PMID:9339375   PMID:9357804   PMID:9584121   PMID:9662046   PMID:9662407   PMID:9867845   PMID:9873043   PMID:10349636   PMID:10615953  
PMID:10713097   PMID:10818208   PMID:10823833   PMID:10932192   PMID:11042159   PMID:11076861   PMID:11118007   PMID:11217851   PMID:11246883   PMID:11912494   PMID:12189444   PMID:12237329  
PMID:12420138   PMID:12466851   PMID:12477932   PMID:12707306   PMID:12931191   PMID:14610273   PMID:14651853   PMID:14662765   PMID:14681479   PMID:14985368   PMID:15102714   PMID:15331544  
PMID:15489334   PMID:15569412   PMID:15587270   PMID:15616563   PMID:15729571   PMID:15761081   PMID:16141072   PMID:16141073   PMID:16498401   PMID:16602821   PMID:16804059   PMID:17200721  
PMID:17215356   PMID:17218412   PMID:17267763   PMID:17287461   PMID:17339028   PMID:17353190   PMID:17360442   PMID:17415548   PMID:17626619   PMID:17627282   PMID:17768029   PMID:17994217  
PMID:18034843   PMID:18039179   PMID:18056790   PMID:18165236   PMID:18223655   PMID:18313669   PMID:18477811   PMID:18554416   PMID:18805788   PMID:19008318   PMID:19952346   PMID:20185832  
PMID:20390404   PMID:20413507   PMID:20623219   PMID:20702580   PMID:20855893   PMID:20857084   PMID:20954077   PMID:21267068   PMID:21330637   PMID:21454584   PMID:21459328   PMID:21613229  
PMID:21828183   PMID:21873635   PMID:21921030   PMID:22013016   PMID:22177951   PMID:22323595   PMID:22406641   PMID:22521878   PMID:22569791   PMID:22698525   PMID:23085254   PMID:23217261  
PMID:23260145   PMID:23291412   PMID:23297408   PMID:23519111   PMID:23560040   PMID:23801577   PMID:23884891   PMID:24028089   PMID:24187134   PMID:24258027   PMID:24333860   PMID:24447392  
PMID:24506868   PMID:24517226   PMID:24706750   PMID:24712877   PMID:24726366   PMID:24772483   PMID:24772484   PMID:24838824   PMID:24874427   PMID:25074928   PMID:25817793   PMID:26015548  
PMID:26220403   PMID:26620281   PMID:26698632   PMID:26752353   PMID:26901059   PMID:26904944   PMID:27133129   PMID:27146480   PMID:27215380   PMID:27292642   PMID:27422385   PMID:27520373  
PMID:27568557   PMID:27689697   PMID:28100774   PMID:28245920   PMID:28648619   PMID:29028997   PMID:29166588   PMID:29416045   PMID:29885841   PMID:29915142   PMID:30038292   PMID:30146176  
PMID:30818059   PMID:30949516   PMID:31142783   PMID:31227231   PMID:31524221   PMID:31923647   PMID:33527355   PMID:33558985   PMID:33610858   PMID:33638884   PMID:33852861   PMID:34325016  
PMID:34622169   PMID:35046471   PMID:35303367   PMID:35585240   PMID:35663017   PMID:35966593   PMID:37545422   PMID:38355793   PMID:38466355   PMID:38505613  


Genomics

Comparative Map Data
Gck
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,850,816 - 5,900,081 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,850,820 - 5,900,081 (-)EnsemblGRCm39 Ensembl
GRCm38115,900,816 - 5,950,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,900,820 - 5,950,081 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,800,826 - 5,849,602 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,800,826 - 5,849,602 (-)NCBIMGSCv36mm8
Celera116,392,658 - 6,441,626 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.88NCBI
GCK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38744,143,213 - 44,189,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl744,143,213 - 44,198,170 (-)EnsemblGRCh38hg38GRCh38
GRCh37744,182,812 - 44,229,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36744,150,395 - 44,195,563 (-)NCBINCBI36Build 36hg18NCBI36
Build 34743,957,109 - 43,972,127NCBI
Celera744,281,829 - 44,326,987 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef744,069,141 - 44,114,301 (-)NCBIHuRef
CHM1_1744,187,724 - 44,232,886 (-)NCBICHM1_1
T2T-CHM13v2.0744,301,768 - 44,348,026 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2744,223,370 - 44,268,527 (-)NCBI
Gck
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,999,019 - 85,041,098 (-)NCBIGRCr8
mRatBN7.21480,785,060 - 80,829,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,785,060 - 80,826,995 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,187,142 - 85,229,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01486,427,238 - 86,469,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,876,552 - 82,918,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,149,146 - 86,191,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,148,928 - 86,190,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,832,735 - 86,875,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,572,518 - 86,587,723 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11486,591,662 - 86,606,868 (-)NCBI
Celera1479,669,432 - 79,710,739 (-)NCBICelera
Cytogenetic Map14q21NCBI
Gck
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,783,760 - 7,842,129 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,784,269 - 7,838,260 (+)NCBIChiLan1.0ChiLan1.0
GCK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,055,783 - 49,100,854 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,380,522 - 97,425,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0744,857,604 - 44,903,683 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1744,924,922 - 44,971,365 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,926,848 - 44,937,751 (-)Ensemblpanpan1.1panPan2
GCK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha162,080,944 - 2,123,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,737,904 - 14,781,009 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1614,738,733 - 14,780,998 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.01614,369,169 - 14,412,232 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01614,349,631 - 14,392,705 (+)NCBIUU_Cfam_GSD_1.0
Gck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511899,892,708 - 99,947,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,105,361 - 19,158,733 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,104,477 - 19,118,915 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12114,475,723 - 14,523,086 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2114,507,902 - 14,523,850 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660627,992,041 - 8,048,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gck
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247407,852,390 - 7,886,758 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247407,844,496 - 7,885,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gck
1614 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1101
Count of miRNA genes:416
Interacting mature miRNAs:472
Transcripts:ENSMUST00000102920, ENSMUST00000109822, ENSMUST00000109823, ENSMUST00000125434
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
L41631  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,901,061 - 5,901,211UniSTSGRCm38
MGSCv37115,801,064 - 5,801,214UniSTSGRCm37
Celera116,392,896 - 6,393,046UniSTS
Cytogenetic Map11A1UniSTS
cM Map111.0UniSTS
Whitehead/MRC_RH1126.7UniSTS
Gk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,900,885 - 5,901,143UniSTSGRCm38
MGSCv37115,800,888 - 5,801,146UniSTSGRCm37
Celera116,392,720 - 6,392,978UniSTS
Cytogenetic Map11A1UniSTS
cM Map110.7UniSTS
cM Map1178.0UniSTS
cM MapUN UniSTS
cM Map11 UniSTS
PMC86435P5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,914,006 - 5,914,235UniSTSGRCm38
MGSCv37115,814,009 - 5,814,238UniSTSGRCm37
Celera116,405,967 - 6,406,196UniSTS
Cytogenetic Map11A1UniSTS
cM Map111.0UniSTS
Gck  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,901,156 - 5,902,307UniSTSGRCm38
MGSCv37115,801,159 - 5,802,310UniSTSGRCm37
Celera116,392,991 - 6,394,142UniSTS
Cytogenetic Map11A1UniSTS
cM Map111.0UniSTS
Gck  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
Gk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
cM Map1178.0UniSTS
cM MapUN UniSTS
cM Map110.7UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001287386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB255658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB255659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL645469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC935119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000102920   ⟹   ENSMUSP00000099984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,850,823 - 5,900,081 (-)Ensembl
GRCm38.p6 Ensembl115,900,823 - 5,950,081 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109822   ⟹   ENSMUSP00000105447
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,850,820 - 5,865,124 (-)Ensembl
GRCm38.p6 Ensembl115,900,820 - 5,915,124 (-)Ensembl
Ensembl Acc Id: ENSMUST00000109823   ⟹   ENSMUSP00000105448
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,850,820 - 5,865,124 (-)Ensembl
GRCm38.p6 Ensembl115,900,820 - 5,915,124 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125434   ⟹   ENSMUSP00000123016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,851,569 - 5,852,087 (-)Ensembl
GRCm38.p6 Ensembl115,901,569 - 5,902,087 (-)Ensembl
RefSeq Acc Id: NM_001287386   ⟹   NP_001274315
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,850,820 - 5,865,135 (-)NCBI
GRCm38115,900,820 - 5,915,135 (-)NCBI
Celera116,392,655 - 6,442,108 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010292   ⟹   NP_034422
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,850,823 - 5,900,081 (-)NCBI
GRCm38115,900,823 - 5,950,081 (-)NCBI
MGSCv37115,800,826 - 5,849,602 (-)RGD
Celera116,392,655 - 6,442,108 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514443   ⟹   XP_006514506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,850,816 - 5,865,140 (-)NCBI
GRCm38115,900,816 - 5,915,182 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006514444   ⟹   XP_006514507
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,850,816 - 5,900,078 (-)NCBI
GRCm38115,900,816 - 5,950,076 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156199   ⟹   XP_036012092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,850,816 - 5,854,014 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936675
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,851,259 - 5,865,153 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936676
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,851,259 - 5,900,080 (-)NCBI
Sequence:
RefSeq Acc Id: NP_034422   ⟸   NM_010292
- Peptide Label: isoform 1
- UniProtKB: P52792 (UniProtKB/Swiss-Prot),   P52791 (UniProtKB/Swiss-Prot),   Q5SVI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514507   ⟸   XM_006514444
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006514506   ⟸   XM_006514443
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001274315   ⟸   NM_001287386
- Peptide Label: isoform 2
- UniProtKB: Q5SVI6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000123016   ⟸   ENSMUST00000125434
Ensembl Acc Id: ENSMUSP00000105447   ⟸   ENSMUST00000109822
Ensembl Acc Id: ENSMUSP00000105448   ⟸   ENSMUST00000109823
Ensembl Acc Id: ENSMUSP00000099984   ⟸   ENSMUST00000102920
RefSeq Acc Id: XP_036012092   ⟸   XM_036156199
- Peptide Label: isoform X3
Protein Domains
Hexokinase   Hexokinase C-terminal   Hexokinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52792-F1-model_v2 AlphaFold P52792 1-465 view protein structure

Promoters
RGD ID:6821889
Promoter ID:MM_KWN:6330
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000011412,   OTTMUST00000014370,   UC007HXM.1,   UC007HXO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36115,814,226 - 5,815,077 (+)MPROMDB
RGD ID:8673872
Promoter ID:EPDNEW_M14966
Type:initiation region
Name:Gck_1
Description:Mus musculus glucokinase , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14967  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38115,915,133 - 5,915,193EPDNEW
RGD ID:8673874
Promoter ID:EPDNEW_M14967
Type:multiple initiation site
Name:Gck_2
Description:Mus musculus glucokinase , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14966  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38115,950,057 - 5,950,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1270854 AgrOrtholog
Ensembl Genes ENSMUSG00000041798 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102920 ENTREZGENE
  ENSMUST00000102920.4 UniProtKB/Swiss-Prot
  ENSMUST00000109822.8 UniProtKB/Swiss-Prot
  ENSMUST00000109823 ENTREZGENE
  ENSMUST00000109823.9 UniProtKB/Swiss-Prot
  ENSMUST00000125434.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.367.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:103988 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1270854 ENTREZGENE
NCBI Gene Gck ENTREZGENE
PANTHER PTHR19443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19443:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hexokinase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GCK RGD
PhenoGen Gck PhenoGen
PRINTS HEXOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEXOKINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEXOKINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6V339_MOUSE UniProtKB/TrEMBL
  HXK4_MOUSE UniProtKB/Swiss-Prot
  P52791 ENTREZGENE
  P52792 ENTREZGENE
  Q5SVI5 ENTREZGENE, UniProtKB/TrEMBL
  Q5SVI6 ENTREZGENE, UniProtKB/TrEMBL
  Q6LE83_MOUSE UniProtKB/TrEMBL
UniProt Secondary P52791 UniProtKB/Swiss-Prot