Il2rg (interleukin 2 receptor, gamma chain) - Rat Genome Database

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Gene: Il2rg (interleukin 2 receptor, gamma chain) Mus musculus
Analyze
Symbol: Il2rg
Name: interleukin 2 receptor, gamma chain
RGD ID: 731534
MGI Page MGI
Description: Enables interleukin-2 binding activity. Acts upstream of or within positive regulation of gene expression and positive regulation of lymphocyte differentiation. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: [g]c; CD132; common cytokine receptor gamma chain; common cytokine receptor gamma chain variant b; common gamma chain; cytokine receptor common subunit gamma; gamm; gamma C receptor; gamma(; gamma(c); gammaC; gc; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; interleukin-2 receptor subunit gamma; p64
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,307,991 - 100,311,861 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,307,984 - 100,311,861 (-)EnsemblGRCm39 Ensembl
GRCm38X101,264,385 - 101,268,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,264,378 - 101,268,255 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,459,726 - 98,463,545 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,467,106 - 97,470,925 (-)NCBIMGSCv36mm8
CeleraX88,180,558 - 88,184,377 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX43.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Brevianamide A  (EXP)
C60 fullerene  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
ceric oxide  (ISO)
chloroprene  (EXP)
clothianidin  (ISO)
Cuprizon  (ISO)
DDE  (ISO)
dextran sulfate  (EXP)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP)
ethylbenzene  (ISO)
fluvastatin  (ISO)
gentamycin  (ISO)
lipopolysaccharide  (EXP)
methimazole  (ISO)
methotrexate  (EXP)
mycophenolic acid  (EXP)
N-nitrosodimethylamine  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nickel subsulfide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (EXP)
phosgene  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
prostaglandin E2  (ISO)
resveratrol  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
silicon dioxide  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sterigmatocystin  (EXP)
sulfadimethoxine  (ISO)
tamibarotene  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
TMC-120A  (EXP)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
zoledronic acid  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adaptive immunity  (IAGP)
abnormal alpha-beta intraepithelial T cell morphology  (IAGP)
abnormal B cell number  (IAGP)
abnormal basophil physiology  (IAGP)
abnormal CD4-positive, alpha beta T cell morphology  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal cell-mediated immunity  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal decidua basalis morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal estrous cycle  (IAGP)
abnormal gamma-delta T cell differentiation  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gut-associated lymphoid tissue morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal immune serum protein physiology  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interferon secretion  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal maternal decidual layer morphology  (IAGP)
abnormal mesenteric lymph node morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal placenta metrial gland morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal response to transplant  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal thymocyte activation  (IAGP)
abnormal thymus morphology  (IAGP)
absent B cells  (IAGP)
absent gamma-delta intraepithelial T cell  (IAGP)
absent gamma-delta T cells  (IAGP)
absent NK cells  (IAGP)
absent NK T cells  (IAGP)
absent peripheral lymph nodes  (IAGP)
absent Peyer's patches  (IAGP)
absent spleen germinal center  (IAGP)
absent spleen white pulp  (IAGP)
absent T cells  (IAGP)
absent thymus cortex  (IAGP)
absent thymus medulla  (IAGP)
absent uterine NK cells  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
cecum inflammation  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immature B cell number  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased incidence of tumors by ionizing radiation induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased myeloid dendritic cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased plasma cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased spleen B cell follicle number  (IAGP)
decreased spleen white pulp amount  (IAGP)
decreased splenocyte number  (IAGP)
decreased susceptibility to graft versus host disease  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
enlarged Peyer's patches  (IAGP)
enlarged spleen  (IAGP)
hyperglycemia  (IAGP)
impaired natural killer cell mediated cytotoxicity  (IAGP)
increased activated T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cellular sensitivity to X-ray irradiation  (IAGP)
increased macrophage cell number  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to Retroviridae infection  (IAGP)
lung inflammation  (IAGP)
lymph node hypoplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
premature death  (IAGP)
prolonged diestrus  (IAGP)
prolonged estrous cycle  (IAGP)
prolonged metestrus  (IAGP)
small lymph nodes  (IAGP)
small thymus  (IAGP)
small thymus cortex  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
thrombocytopenia  (IAGP)
thymus cortex hypoplasia  (IAGP)
thymus cyst  (IAGP)
thymus hyperplasia  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Screening for mutations causing X-linked severe combined immunodeficiency in the IL-2R gamma chain gene by single-strand conformation polymorphism analysis. Clark PA, etal., Hum Genet. 1995 Oct;96(4):427-32.
2. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
3. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
4. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. Mashimo T, etal., PLoS One. 2010 Jan 25;5(1):e8870.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models. Ménoret S, etal., Transplantation. 2018 Apr 24. doi: 10.1097/TP.0000000000002251.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
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PMID:26785948   PMID:26787820   PMID:26796361   PMID:26809508   PMID:26831077   PMID:26847546   PMID:26849055   PMID:26863197   PMID:26879149   PMID:26884167   PMID:26886799   PMID:27010363  
PMID:27064285   PMID:27099312   PMID:27139822   PMID:27158907   PMID:27184849   PMID:27197203   PMID:27197263   PMID:27256700   PMID:27292632   PMID:27300437   PMID:27307565   PMID:27323875  
PMID:27341123   PMID:27373157   PMID:27438770   PMID:27478039   PMID:27496730   PMID:27499200   PMID:27521341   PMID:27535619   PMID:27545889   PMID:27564380   PMID:27581357   PMID:27622331  
PMID:27634757   PMID:27671674   PMID:27698445   PMID:27699249   PMID:27705792   PMID:27708334   PMID:27723723   PMID:27752043   PMID:27783956   PMID:27856754   PMID:27872496   PMID:27905395  
PMID:28069805   PMID:28077418   PMID:28087712   PMID:28089909   PMID:28108611   PMID:28111009   PMID:28115719   PMID:28264908   PMID:28331303   PMID:28424516   PMID:28426964   PMID:28512240  
PMID:28561023   PMID:28585539   PMID:28591638   PMID:28606987   PMID:28617827   PMID:28665271   PMID:28678791   PMID:28698286   PMID:28715505   PMID:28727820   PMID:28747424   PMID:28783663  
PMID:28783664   PMID:28814715   PMID:28827518   PMID:28844693   PMID:28869974   PMID:28874533   PMID:28945245   PMID:28959975   PMID:28960205   PMID:28963568   PMID:29032169   PMID:29056343  
PMID:29070650   PMID:29136504   PMID:29146734   PMID:29150564   PMID:29150659   PMID:29151581   PMID:29159199   PMID:29166590   PMID:29183988   PMID:29222435   PMID:29266841   PMID:29287229  
PMID:29290617   PMID:29298866   PMID:29334357   PMID:29361613   PMID:29387068   PMID:29391257   PMID:29396470   PMID:29409495   PMID:29429633   PMID:29431745   PMID:29446074   PMID:29474906  
PMID:29496881   PMID:29533781   PMID:29533787   PMID:29540197   PMID:29549333   PMID:29551267   PMID:29559473   PMID:29594927   PMID:29624673   PMID:29700358   PMID:29719266   PMID:29720662  
PMID:29725010   PMID:29858012   PMID:29861285   PMID:29894694   PMID:29910151   PMID:29915428   PMID:29925696   PMID:29942093   PMID:29950446   PMID:29975766   PMID:30010246   PMID:30021144  
PMID:30049704   PMID:30065364   PMID:30134157   PMID:30154103   PMID:30174304   PMID:30258450   PMID:30352428   PMID:30383447   PMID:30487575   PMID:30504915   PMID:30540841   PMID:30590049  
PMID:30651344   PMID:30664659   PMID:30679796   PMID:30720218   PMID:30778347   PMID:30800133   PMID:30883740   PMID:30888052   PMID:30894377   PMID:30905671   PMID:30936486   PMID:30937919  
PMID:30943405   PMID:31091443   PMID:31103381   PMID:31127091   PMID:31160568   PMID:31171792   PMID:31185213   PMID:31230747   PMID:31269440   PMID:31341106   PMID:31353223   PMID:31371796  
PMID:31375314   PMID:31378988   PMID:31415243   PMID:31434684   PMID:31515941   PMID:31534216   PMID:31537642   PMID:31558757   PMID:31609965   PMID:31613796   PMID:31665636   PMID:31672934  
PMID:31745215   PMID:31758089   PMID:31772172   PMID:31810881   PMID:31852888   PMID:31873294   PMID:31913286   PMID:31915293   PMID:31982409   PMID:32075728   PMID:32101749   PMID:32130954  
PMID:32142680   PMID:32144163   PMID:32213588   PMID:32381589   PMID:32484802   PMID:32522871   PMID:32632165   PMID:32730753   PMID:32735605   PMID:32763164   PMID:32768387   PMID:32814027  
PMID:32814902   PMID:32817334   PMID:32817844   PMID:32884084   PMID:32905799   PMID:32948777   PMID:32949466   PMID:32968282   PMID:33027513   PMID:33087935   PMID:33097708   PMID:33104171  
PMID:33117338   PMID:33119032   PMID:33125370   PMID:33177175   PMID:33205073   PMID:33253759   PMID:33295943   PMID:33305354   PMID:33311516   PMID:33373620   PMID:33428661   PMID:33536623  
PMID:33537102   PMID:33724364   PMID:33857287   PMID:33929319   PMID:33951431   PMID:33953190   PMID:34010296   PMID:34076685   PMID:34077722   PMID:34133926   PMID:34289373   PMID:34303658  
PMID:34326208   PMID:34388391   PMID:34429328   PMID:34437840   PMID:34555336   PMID:34678150   PMID:34813502   PMID:34847378   PMID:34848557   PMID:34961794   PMID:34971407   PMID:35021100  
PMID:35039332   PMID:35075279   PMID:35089323   PMID:35090595   PMID:35145162   PMID:35418601   PMID:35443177   PMID:35444206   PMID:35525247   PMID:35550508   PMID:35587733   PMID:35709757  
PMID:35840625   PMID:35959876   PMID:36044899   PMID:36045118   PMID:36070233   PMID:36192757   PMID:36211388   PMID:36352193   PMID:36476935   PMID:36494354   PMID:36584406   PMID:36630911  
PMID:36693372   PMID:36720957   PMID:36868194   PMID:36868208   PMID:36924493   PMID:37043562   PMID:37185464   PMID:37192000   PMID:37192295   PMID:37248289   PMID:37392737   PMID:37550517  
PMID:37582369   PMID:37591854   PMID:37616368   PMID:37624843   PMID:37626903   PMID:37651888   PMID:37652013   PMID:37708282   PMID:37715782   PMID:37729060   PMID:37730988   PMID:37771584  
PMID:37802055   PMID:37877672   PMID:37891179   PMID:37904191   PMID:37922313   PMID:37932447   PMID:37992684   PMID:38015204   PMID:38295788   PMID:38388173   PMID:38428396   PMID:38433905  
PMID:38461214   PMID:38473822   PMID:38518774   PMID:38538608   PMID:38569552   PMID:38579682   PMID:38591006   PMID:38670091   PMID:38713510   PMID:38723629   PMID:38723638  


Genomics

Comparative Map Data
Il2rg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,307,991 - 100,311,861 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,307,984 - 100,311,861 (-)EnsemblGRCm39 Ensembl
GRCm38X101,264,385 - 101,268,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,264,378 - 101,268,255 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,459,726 - 98,463,545 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,467,106 - 97,470,925 (-)NCBIMGSCv36mm8
CeleraX88,180,558 - 88,184,377 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX43.9NCBI
IL2RG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,107,404 - 71,111,577 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,107,404 - 71,112,108 (-)EnsemblGRCh38hg38GRCh38
GRCh37X70,327,254 - 70,331,427 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,243,984 - 70,248,128 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X70,110,279 - 70,114,424NCBI
CeleraX70,681,159 - 70,685,386 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,146,973 - 64,150,762 (-)NCBIHuRef
CHM1_1X70,219,589 - 70,223,820 (-)NCBICHM1_1
T2T-CHM13v2.0X69,541,496 - 69,545,673 (-)NCBIT2T-CHM13v2.0
Il2rg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,435,340 - 70,439,052 (-)NCBIGRCr8
mRatBN7.2X66,395,330 - 66,399,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,392,542 - 66,399,823 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,878,691 - 67,882,351 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,379,079 - 71,382,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,939,986 - 68,943,646 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,165,378 - 71,169,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,162,585 - 71,169,865 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,017,856 - 72,021,516 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,342,055 - 89,345,715 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,416,495 - 89,419,068 (-)NCBI
CeleraX66,751,239 - 66,754,899 (-)NCBICelera
Cytogenetic MapXq22NCBI
Il2rg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,676,870 - 10,680,517 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547510,676,592 - 10,680,565 (-)NCBIChiLan1.0ChiLan1.0
IL2RG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,785,171 - 70,789,380 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,788,781 - 70,792,982 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,375,815 - 60,386,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,433,355 - 70,437,590 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,433,360 - 70,437,590 (-)Ensemblpanpan1.1panPan2
IL2RG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,480,846 - 55,488,485 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,481,092 - 55,484,751 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,308,162 - 46,311,760 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,449,759 - 56,453,658 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,450,007 - 56,453,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,418,234 - 54,421,830 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,749,655 - 55,753,253 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,676,806 - 55,680,404 (-)NCBIUU_Cfam_GSD_1.0
Dog CytomapXqNCBI
Il2rg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,725,215 - 46,728,870 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762487,380 - 491,044 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936762487,414 - 491,028 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL2RG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,143,570 - 57,147,256 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,143,568 - 57,151,242 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,674,048 - 64,677,372 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq13NCBI
IL2RG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,905,011 - 60,915,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,905,343 - 60,909,149 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660652,765,485 - 2,776,292 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il2rg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,402,481 - 1,406,600 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,402,586 - 1,406,554 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il2rg
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:899
Count of miRNA genes:537
Interacting mature miRNAs:620
Transcripts:ENSMUST00000033664, ENSMUST00000127538, ENSMUST00000135038, ENSMUST00000145074
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse

Markers in Region
D13565  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,264,730 - 101,264,810UniSTSGRCm38
MGSCv37X98,460,069 - 98,460,149UniSTSGRCm37
CeleraX88,180,901 - 88,180,981UniSTS
Cytogenetic MapXDUniSTS
cM MapX38.0UniSTS
Whitehead/MRC_RHX1117.13UniSTS
U21795  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,264,625 - 101,264,800UniSTSGRCm38
MGSCv37X98,459,964 - 98,460,139UniSTSGRCm37
CeleraX88,180,796 - 88,180,971UniSTS
Cytogenetic MapXDUniSTS
cM MapX38.0UniSTS
Whitehead/MRC_RHX1117.13UniSTS
Whitehead_YACX UniSTS
PMC155645P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,266,307 - 101,267,016UniSTSGRCm38
MGSCv37X98,461,646 - 98,462,355UniSTSGRCm37
CeleraX88,182,478 - 88,183,187UniSTS
Cytogenetic MapXDUniSTS
cM MapX38.0UniSTS
Il2rg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,264,987 - 101,265,433UniSTSGRCm38
MGSCv37X98,460,326 - 98,460,772UniSTSGRCm37
CeleraX88,181,158 - 88,181,604UniSTS
Cytogenetic MapXDUniSTS
cM MapX38.0UniSTS
Il2rg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,266,264 - 101,267,811UniSTSGRCm38
MGSCv37X98,461,603 - 98,463,150UniSTSGRCm37
CeleraX88,182,435 - 88,183,982UniSTS
Cytogenetic MapXDUniSTS
Il2rg  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXDUniSTS
U21795  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,264,316 - 101,264,462UniSTSGRCm38
MGSCv37X98,459,655 - 98,459,801UniSTSGRCm37
CeleraX88,180,487 - 88,180,633UniSTS
Cytogenetic MapXDUniSTS
Whitehead/MRC_RHX1117.13UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000033664   ⟹   ENSMUSP00000033664
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,307,984 - 100,311,861 (-)Ensembl
GRCm38.p6 EnsemblX101,264,378 - 101,268,255 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127538
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,310,802 - 100,311,764 (-)Ensembl
GRCm38.p6 EnsemblX101,267,196 - 101,268,158 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135038   ⟹   ENSMUSP00000123318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,308,544 - 100,311,040 (-)Ensembl
GRCm38.p6 EnsemblX101,264,938 - 101,267,434 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145074
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,310,272 - 100,311,796 (-)Ensembl
GRCm38.p6 EnsemblX101,266,666 - 101,268,190 (-)Ensembl
RefSeq Acc Id: NM_001308535   ⟹   NP_001295464
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X100,307,991 - 100,311,861 (-)NCBI
GRCm38X101,264,385 - 101,268,255 (-)NCBI
Sequence:
RefSeq Acc Id: NM_013563   ⟹   NP_038591
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X100,307,991 - 100,311,861 (-)NCBI
GRCm38X101,264,385 - 101,268,255 (-)NCBI
MGSCv37X98,459,726 - 98,463,545 (-)RGD
CeleraX88,180,558 - 88,184,377 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017318396   ⟹   XP_017173885
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X100,308,544 - 100,311,856 (-)NCBI
GRCm38X101,264,387 - 101,268,251 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038591   ⟸   NM_013563
- Peptide Label: isoform a precursor
- UniProtKB: P34902 (UniProtKB/Swiss-Prot),   Q3UPA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295464   ⟸   NM_001308535
- Peptide Label: isoform b precursor
- UniProtKB: V5SIM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017173885   ⟸   XM_017318396
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000033664   ⟸   ENSMUST00000033664
RefSeq Acc Id: ENSMUSP00000123318   ⟸   ENSMUST00000135038
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34902-F1-model_v2 AlphaFold P34902 1-369 view protein structure

Promoters
RGD ID:6845860
Promoter ID:MM_KWN:61304
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:OTTMUST00000043981
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,462,331 - 98,463,372 (-)MPROMDB
RGD ID:6845862
Promoter ID:MM_KWN:61305
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:OTTMUST00000043978,   OTTMUST00000043980,   UC009TXD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,463,431 - 98,464,162 (-)MPROMDB
RGD ID:13681062
Promoter ID:EPDNEW_M24680
Type:initiation region
Name:Il2rg_1
Description:Mus musculus interleukin 2 receptor, gamma chain , transcriptvariant b, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X101,268,201 - 101,268,261EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96551 AgrOrtholog
Ensembl Genes ENSMUSG00000031304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033664 ENTREZGENE
  ENSMUST00000033664.14 UniProtKB/Swiss-Prot
  ENSMUST00000135038.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRLF2-like_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRLF2_D1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16186 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96551 ENTREZGENE
NCBI Gene 16186 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOKINE RECEPTOR-LIKE FACTOR 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CRLF2-like_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRLF2_D1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il2rg PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B0QZX1_MOUSE UniProtKB/TrEMBL
  IL2RG_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UPA9 ENTREZGENE, UniProtKB/TrEMBL
  V5SIM2 ENTREZGENE, UniProtKB/TrEMBL