Gja4 (gap junction protein, alpha 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gja4 (gap junction protein, alpha 4) Mus musculus
Analyze
Symbol: Gja4
Name: gap junction protein, alpha 4
RGD ID: 731519
MGI Page MGI
Description: Predicted to enable gap junction channel activity. Acts upstream of or within blood vessel development. Predicted to be located in gap junction. Predicted to be part of connexin complex. Is expressed in several structures, including central nervous system; eye; gonad; heart; and vascular system. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human GJA4 (gap junction protein alpha 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU020209; AW558810; Cnx3; Cnx37; connexin 37; connexin h1; connexin-37; Cx37; Cxnh1; gap junction alpha-4 protein; gap junction membrane channel protein alpha 4; Gja-; Gja-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,205,213 - 127,207,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,205,214 - 127,207,832 (-)EnsemblGRCm39 Ensembl
GRCm384127,311,420 - 127,314,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,311,421 - 127,314,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,988,665 - 126,991,222 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,813,725 - 126,816,282 (-)NCBIMGSCv36mm8
Celera4125,645,767 - 125,648,324 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-carnitine  (EXP)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
aldrin  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (ISO)
atenolol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cyclophosphamide  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (ISO)
fonofos  (ISO)
gentamycin  (ISO)
lycopene  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
SCH 23390  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
undecane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
connexin complex  (IBA,IEA,ISO)
gap junction  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Connexins: gaps in our knowledge of vascular function. Figueroa XF, etal., Physiology (Bethesda). 2004 Oct;19:277-84.
2. Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping. Haefliger JA, etal., J Biol Chem 1992 Jan 25;267(3):2057-64.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily. Listi F, etal., Int J Cardiol. 2005 Jul 10;102(2):269-71.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Expression of connexins in the normal and obstructed developing kidney. Silverstein DM, etal., Pediatr Nephrol. 2003 Mar;18(3):216-24. Epub 2003 Feb 7.
13. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Yamada Y, etal., Mol Genet Metab. 2004 Apr;81(4):282-90.
Additional References at PubMed
PMID:1332196   PMID:1651942   PMID:1964417   PMID:8164742   PMID:8586454   PMID:8601030   PMID:8631157   PMID:8834803   PMID:9020357   PMID:9049631   PMID:9070944   PMID:9285645  
PMID:9344659   PMID:9486664   PMID:9508777   PMID:9861669   PMID:9922113   PMID:10079505   PMID:10099690   PMID:10196667   PMID:10349636   PMID:10751663   PMID:10842360   PMID:10903175  
PMID:10922068   PMID:11004519   PMID:11023678   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11309658   PMID:12011587   PMID:12435353   PMID:12477932   PMID:12697838   PMID:14610273  
PMID:14627725   PMID:14681012   PMID:14681045   PMID:14732399   PMID:15081111   PMID:15138288   PMID:15184386   PMID:15234427   PMID:15255617   PMID:15326356   PMID:15466159   PMID:15466892  
PMID:15836950   PMID:15850572   PMID:15895417   PMID:15977181   PMID:16105048   PMID:16107612   PMID:16135542   PMID:16141072   PMID:16141073   PMID:16226732   PMID:16254245   PMID:16505993  
PMID:16602821   PMID:16862155   PMID:16964442   PMID:17618853   PMID:17640036   PMID:18032785   PMID:18559979   PMID:18753315   PMID:18790841   PMID:18829945   PMID:19073828   PMID:19087347  
PMID:19222873   PMID:19345950   PMID:19429814   PMID:19672618   PMID:19828678   PMID:20133625   PMID:21515254   PMID:21677750   PMID:21793101   PMID:21810657   PMID:21856908   PMID:21873635  
PMID:21986401   PMID:22306086   PMID:22513384   PMID:22528526   PMID:22659288   PMID:22783020   PMID:22798963   PMID:23142761   PMID:23603510   PMID:24509854   PMID:24639196   PMID:24804968  
PMID:25264302   PMID:25545736   PMID:25802403   PMID:26027726   PMID:26079578   PMID:26198171   PMID:26342936   PMID:26389677   PMID:26539488   PMID:26542011   PMID:26953188   PMID:27255725  
PMID:27313318   PMID:27899284   PMID:28096061   PMID:28122731   PMID:28449099   PMID:28818996   PMID:28857417   PMID:28924218   PMID:29025706   PMID:29035278   PMID:29247167   PMID:30355030  
PMID:30943815   PMID:31112136   PMID:31202927   PMID:31415243   PMID:31574503   PMID:31582413   PMID:32078368   PMID:32323401   PMID:33332450   PMID:33454003   PMID:33525532   PMID:34272244  
PMID:34403370   PMID:35297995   PMID:35328350   PMID:35831318   PMID:36193415   PMID:36202789   PMID:37072338   PMID:37197981   PMID:37551717   PMID:39334940  


Genomics

Comparative Map Data
Gja4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394127,205,213 - 127,207,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4127,205,214 - 127,207,832 (-)EnsemblGRCm39 Ensembl
GRCm384127,311,420 - 127,314,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,311,421 - 127,314,039 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,988,665 - 126,991,222 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364126,813,725 - 126,816,282 (-)NCBIMGSCv36mm8
Celera4125,645,767 - 125,648,324 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.47NCBI
GJA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38134,792,999 - 34,795,747 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl134,792,999 - 34,795,747 (+)EnsemblGRCh38hg38GRCh38
GRCh37135,258,600 - 35,261,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36135,031,186 - 35,033,935 (+)NCBINCBI36Build 36hg18NCBI36
Build 34134,927,714 - 34,930,439NCBI
Celera133,532,323 - 33,535,072 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,376,201 - 33,378,950 (+)NCBIHuRef
CHM1_1135,374,168 - 35,376,917 (+)NCBICHM1_1
T2T-CHM13v2.0134,655,628 - 34,658,374 (+)NCBIT2T-CHM13v2.0
Gja4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,917,791 - 144,920,324 (-)NCBIGRCr8
mRatBN7.25139,633,324 - 139,635,857 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,633,287 - 139,635,925 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5142,328,532 - 142,331,068 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05144,098,526 - 144,101,062 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05144,099,313 - 144,101,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,374,688 - 145,377,221 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,374,690 - 145,377,221 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05149,142,702 - 149,145,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45146,755,061 - 146,757,594 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15146,765,101 - 146,767,633 (-)NCBI
Celera5138,127,254 - 138,129,787 (-)NCBICelera
RH 3.4 Map5934.8RGD
Cytogenetic Map5q36NCBI
Gja4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545212,902,773 - 12,905,337 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545212,902,764 - 12,905,337 (+)NCBIChiLan1.0ChiLan1.0
GJA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21192,050,029 - 192,052,939 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,171,197 - 191,174,108 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,059,901 - 34,063,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1135,241,402 - 35,244,191 (+)NCBIpanpan1.1PanPan1.1panPan2
GJA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1157,167,665 - 7,170,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gja4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505851,613,628 - 51,616,047 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647417,439,327 - 17,440,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647417,439,250 - 17,440,829 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,045,394 - 91,048,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1691,045,430 - 91,048,161 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GJA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12098,092,282 - 98,095,036 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2098,092,785 - 98,093,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603318,746,427 - 18,749,170 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476417,836,180 - 17,845,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476417,842,566 - 17,845,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gja4
121 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:188
Interacting mature miRNAs:199
Transcripts:ENSMUST00000053753
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115030777129465915Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
RH136385  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,311,581 - 127,311,779UniSTSGRCm38
MGSCv374126,988,825 - 126,989,023UniSTSGRCm37
Celera4125,645,927 - 125,646,125UniSTS
Cytogenetic Map4D2.2UniSTS
AW558810  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,311,757 - 127,311,882UniSTSGRCm38
MGSCv374126,989,001 - 126,989,126UniSTSGRCm37
Celera4125,646,103 - 125,646,228UniSTS
Cytogenetic Map4D2.2UniSTS
Whitehead/MRC_RH41651.55UniSTS
Gja4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv374126,989,189 - 126,989,453UniSTSGRCm37
MGSCv374126,989,141 - 126,989,634UniSTSGRCm37
Celera4125,646,243 - 125,646,736UniSTS
Celera4125,646,291 - 125,646,555UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map457.6UniSTS
X57971  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,311,427 - 127,311,600UniSTSGRCm38
MGSCv374126,988,671 - 126,988,844UniSTSGRCm37
Celera4125,645,773 - 125,645,946UniSTS
Cytogenetic Map4D2.2UniSTS
Whitehead/MRC_RH41646.54UniSTS
UniSTS:235032  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,311,612 - 127,311,798UniSTSGRCm38
MGSCv374126,988,856 - 126,989,042UniSTSGRCm37
Celera4125,645,958 - 125,646,144UniSTS
Cytogenetic Map4D2.2UniSTS
PMC197251P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,312,555 - 127,312,880UniSTSGRCm38
MGSCv374126,989,799 - 126,990,124UniSTSGRCm37
Celera4125,646,901 - 125,647,226UniSTS
Cytogenetic Map4D2.2UniSTS
Gja4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,311,945 - 127,312,209UniSTSGRCm38
MGSCv374126,989,189 - 126,989,453UniSTSGRCm37
Celera4125,646,291 - 125,646,555UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map457.6UniSTS
Gja4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
Gja4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384127,311,897 - 127,312,390UniSTSGRCm38
MGSCv374126,989,141 - 126,989,634UniSTSGRCm37
Celera4125,646,243 - 125,646,736UniSTS
Cytogenetic Map4D2.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000053753   ⟹   ENSMUSP00000062320
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4127,205,214 - 127,207,832 (-)Ensembl
GRCm38.p6 Ensembl4127,311,421 - 127,314,039 (-)Ensembl
RefSeq Acc Id: NM_008120   ⟹   NP_032146
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394127,205,213 - 127,207,832 (-)NCBI
GRCm384127,311,420 - 127,314,039 (-)NCBI
MGSCv374126,988,665 - 126,991,222 (-)RGD
Celera4125,645,766 - 125,648,385 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032146   ⟸   NM_008120
- UniProtKB: P28235 (UniProtKB/Swiss-Prot),   Q3UPZ2 (UniProtKB/TrEMBL),   Q6PHB9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000062320   ⟸   ENSMUST00000053753
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28235-F1-model_v2 AlphaFold P28235 1-333 view protein structure

Promoters
RGD ID:6847806
Promoter ID:MM_ACW:35742
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:GJA4.BSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364126,989,606 - 126,990,106 (-)MPROMDB
RGD ID:6835361
Promoter ID:MM_KWN:39711
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:ENSMUST00000053753
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364126,990,961 - 126,991,461 (-)MPROMDB
RGD ID:6884690
Promoter ID:EPDNEW_M5796
Type:multiple initiation site
Name:Gja4_1
Description:Mus musculus gap junction protein, alpha 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384127,313,989 - 127,314,049EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95715 AgrOrtholog
Ensembl Genes ENSMUSG00000050234 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000053753 ENTREZGENE
  ENSMUST00000053753.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin37 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95715 ENTREZGENE
NCBI Gene 14612 ENTREZGENE
PANTHER GAP JUNCTION ALPHA-4 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gja4 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CXA4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UPZ2 ENTREZGENE, UniProtKB/TrEMBL
  Q6PHB9 ENTREZGENE, UniProtKB/TrEMBL