Fgf20 (fibroblast growth factor 20) - Rat Genome Database

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Gene: Fgf20 (fibroblast growth factor 20) Mus musculus
Analyze
Symbol: Fgf20
Name: fibroblast growth factor 20
RGD ID: 731458
MGI Page MGI
Description: Predicted to enable fibroblast growth factor receptor binding activity; growth factor activity; and receptor-receptor interaction. Involved in regulation of neuron differentiation. Acts upstream of or within inner ear auditory receptor cell differentiation and regulation of cardiac muscle cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including cranium; jaw; limb; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human FGF20 (fibroblast growth factor 20).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FGF-20; Fgf4a; fibroblast growth factor 4a
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39840,732,206 - 40,740,060 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl840,732,207 - 40,761,372 (-)EnsemblGRCm39 Ensembl
GRCm38840,279,166 - 40,286,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl840,279,166 - 40,308,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv37841,364,520 - 41,372,307 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36841,778,574 - 41,785,524 (-)NCBIMGSCv36mm8
Celera842,929,830 - 42,937,595 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auchene hair morphology  (IAGP)
abnormal autopod morphology  (IEA)
abnormal awl hair morphology  (IAGP)
abnormal bone structure  (IEA)
abnormal cochlear hair cell development  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal digit morphology  (IEA)
abnormal hair follicle development  (IAGP)
abnormal heart morphology  (IEA)
abnormal kidney morphology  (IEA)
abnormal liver morphology  (IEA)
abnormal lymph node morphology  (IEA)
abnormal nail morphology  (IEA)
abnormal organ of Corti morphology  (IAGP)
abnormal pillar cell morphology  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal skin morphology  (IEA)
abnormal spleen morphology  (IEA)
abnormal startle reflex  (IEA)
abnormal stomach morphology  (IEA)
abnormal thoracic cage shape  (IEA)
abnormal thymus morphology  (IEA)
abnormal tooth morphology  (IEA)
abnormal uterus morphology  (IEA)
abnormal vertebrae morphology  (IEA)
abnormal vertebral arch morphology  (IEA)
abnormal zigzag hair morphology  (IAGP)
absent guard hair  (IAGP)
cornea opacity  (IEA)
deafness  (IAGP)
decreased cochlear hair cell number  (IAGP)
decreased cochlear outer hair cell number  (IAGP)
decreased kidney weight  (IEA)
decreased organ of Corti supporting cell number  (IAGP)
decreased prepulse inhibition  (IEA)
decreased startle reflex  (IEA)
enlarged heart  (IEA)
enlarged lymph nodes  (IEA)
enlarged spleen  (IEA)
enlarged stomach  (IEA)
enlarged thymus  (IEA)
fusion of vertebral arches  (IEA)
increased blood urea nitrogen level  (IEA)
increased circulating cholesterol level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased circulating total protein level  (IEA)
increased or absent threshold for auditory brainstem response  (IAGP)
small kidney  (IEA)
vertebral fusion  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11900978   PMID:12477932   PMID:14517998   PMID:14681479   PMID:15122513   PMID:15621532   PMID:16123981   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:16818445   PMID:17141159   PMID:18287559   PMID:18524904   PMID:18816849   PMID:19000842   PMID:19544582   PMID:20040496   PMID:20348033   PMID:20713518  
PMID:21087601   PMID:21386911   PMID:21873635   PMID:21876757   PMID:22235191   PMID:22627288   PMID:22698282   PMID:22833125   PMID:22911456   PMID:22962329   PMID:22973011   PMID:23133671  
PMID:23322300   PMID:23431057   PMID:23946445   PMID:24145799   PMID:24198358   PMID:24550112   PMID:25721301   PMID:25915623   PMID:26387953   PMID:26460946   PMID:26611327   PMID:26658320  
PMID:26748348   PMID:27414798   PMID:27621364   PMID:28698625   PMID:29217079   PMID:29784808   PMID:29899403   PMID:30063206   PMID:30100263   PMID:30228991   PMID:30595537   PMID:31276493  
PMID:31570588   PMID:32492250   PMID:32735383   PMID:32753399   PMID:34032268   PMID:34042944   PMID:35020897   PMID:35351862   PMID:35421372   PMID:35451126   PMID:35451473   PMID:36764291  
PMID:37318953   PMID:37982496   PMID:38355793   PMID:38733994   PMID:39129916   PMID:39217880  


Genomics

Comparative Map Data
Fgf20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39840,732,206 - 40,740,060 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl840,732,207 - 40,761,372 (-)EnsemblGRCm39 Ensembl
GRCm38840,279,166 - 40,286,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl840,279,166 - 40,308,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv37841,364,520 - 41,372,307 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36841,778,574 - 41,785,524 (-)NCBIMGSCv36mm8
Celera842,929,830 - 42,937,595 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
FGF20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38816,992,181 - 17,002,345 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl816,992,181 - 17,002,345 (-)EnsemblGRCh38hg38GRCh38
GRCh37816,849,690 - 16,859,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36816,894,705 - 16,904,045 (-)NCBINCBI36Build 36hg18NCBI36
Build 34816,894,704 - 16,904,045NCBI
Celera815,816,530 - 15,825,865 (-)NCBICelera
Cytogenetic Map8p22NCBI
HuRef815,395,521 - 15,404,854 (-)NCBIHuRef
CHM1_1817,051,785 - 17,061,117 (-)NCBICHM1_1
T2T-CHM13v2.0817,260,031 - 17,270,196 (-)NCBIT2T-CHM13v2.0
Fgf20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81658,734,003 - 58,741,650 (+)NCBIGRCr8
mRatBN7.21652,030,549 - 52,038,201 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1652,010,194 - 52,038,204 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1657,345,032 - 57,351,777 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01660,749,898 - 60,756,652 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01655,978,981 - 55,985,730 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01655,152,748 - 55,159,352 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1655,152,748 - 55,159,352 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01654,855,241 - 54,861,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41655,386,987 - 55,393,744 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11655,387,061 - 55,393,819 (+)NCBI
Celera1649,920,516 - 49,927,267 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
Fgf20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955463528,651 - 536,927 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955463528,651 - 536,927 (+)NCBIChiLan1.0ChiLan1.0
FGF20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2735,452,704 - 35,463,170 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1811,187,326 - 11,197,792 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0816,205,791 - 16,216,257 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1813,151,867 - 13,161,216 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl813,151,867 - 13,161,216 (-)Ensemblpanpan1.1panPan2
FGF20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11640,330,793 - 40,339,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1640,331,307 - 40,339,616 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1640,828,018 - 40,838,484 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01642,383,443 - 42,393,916 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1642,385,213 - 42,394,487 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11640,477,114 - 40,487,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01641,020,341 - 41,030,808 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01641,213,558 - 41,224,028 (-)NCBIUU_Cfam_GSD_1.0
Fgf20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494339,079,532 - 39,087,800 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365736,055,261 - 6,062,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365736,055,261 - 6,062,764 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl174,691,448 - 4,700,367 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1174,691,448 - 4,700,367 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2175,085,166 - 5,094,166 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1815,079,507 - 15,089,583 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl815,080,411 - 15,089,451 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605227,190,962 - 27,200,973 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476922,310,396 - 22,334,182 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476922,325,936 - 22,334,608 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf20
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:169
Interacting mature miRNAs:194
Transcripts:ENSMUST00000034014, ENSMUST00000118639
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83532109757797633Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83532109757797633Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83532109757797633Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83532109757797633Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83327701651290537Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse
1301196Mnif1_mmacronutrient intake (mouse)Not determined83510993045305872Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
13524525Bodwtq7_mbody wweight QTL 7 (mouse)82824955647027681Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
Fgf20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38840,279,802 - 40,281,212UniSTSGRCm38
MGSCv37841,365,156 - 41,366,566UniSTSGRCm37
Celera842,930,466 - 42,931,899UniSTS
Cytogenetic Map8B1.2UniSTS
cM Map8 UniSTS
Fgf20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B1.2UniSTS
cM Map8 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000034014   ⟹   ENSMUSP00000034014
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl840,732,207 - 40,739,994 (-)Ensembl
GRCm38.p6 Ensembl840,279,166 - 40,286,953 (-)Ensembl
Ensembl Acc Id: ENSMUST00000118639   ⟹   ENSMUSP00000112756
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl840,732,766 - 40,761,372 (-)Ensembl
GRCm38.p6 Ensembl840,279,725 - 40,308,331 (-)Ensembl
RefSeq Acc Id: NM_030610   ⟹   NP_085113
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39840,732,206 - 40,740,060 (-)NCBI
GRCm38840,279,166 - 40,286,953 (-)ENTREZGENE
MGSCv37841,364,520 - 41,372,307 (-)RGD
Celera842,929,830 - 42,937,595 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_085113   ⟸   NM_030610
- UniProtKB: Q8C7A8 (UniProtKB/Swiss-Prot),   Q9ESL9 (UniProtKB/Swiss-Prot),   A0A7U3L6F4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000112756   ⟸   ENSMUST00000118639
Ensembl Acc Id: ENSMUSP00000034014   ⟸   ENSMUST00000034014

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESL9-F1-model_v2 AlphaFold Q9ESL9 1-211 view protein structure

Promoters
RGD ID:8666917
Promoter ID:EPDNEW_M11490
Type:single initiation site
Name:Fgf20_1
Description:Mus musculus fibroblast growth factor 20 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38840,287,019 - 40,287,079EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891346 AgrOrtholog
Ensembl Genes ENSMUSG00000031603 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034014 ENTREZGENE
  ENSMUST00000034014.14 UniProtKB/Swiss-Prot
  ENSMUST00000118639.2 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1/FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:80857 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1891346 ENTREZGENE
NCBI Gene 80857 ENTREZGENE
PANTHER PTHR11486 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11486:SF72 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgf20 PhenoGen
PRINTS HBGFFGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL1HBGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7U3L6F4 ENTREZGENE, UniProtKB/TrEMBL
  D3YU10_MOUSE UniProtKB/TrEMBL
  FGF20_MOUSE UniProtKB/Swiss-Prot
  Q059W0_MOUSE UniProtKB/TrEMBL
  Q8C7A8 ENTREZGENE
  Q9ESL9 ENTREZGENE
UniProt Secondary Q8C7A8 UniProtKB/Swiss-Prot