Lyst (lysosomal trafficking regulator) - Rat Genome Database

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Gene: Lyst (lysosomal trafficking regulator) Mus musculus
Analyze
Symbol: Lyst
Name: lysosomal trafficking regulator
RGD ID: 731450
MGI Page MGI
Description: Predicted to enable protein kinase binding activity. Acts upstream of or within several processes, including defense response to other organism; phospholipid homeostasis; and vesicle organization. Located in cytosol. Is expressed in axial skeleton. Used to study Chediak-Higashi syndrome; exfoliation syndrome; and platelet storage pool deficiency. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beige; bg; CHS1 homolog; D13Sfk1; D13Sfk13; lysosomal-trafficking regulator
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391313,764,896 - 13,953,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1313,764,982 - 13,953,388 (+)EnsemblGRCm39 Ensembl
GRCm381313,590,311 - 13,778,803 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1313,590,397 - 13,778,803 (+)EnsemblGRCm38mm10GRCm38
MGSCv371313,682,676 - 13,869,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361313,382,535 - 13,569,566 (+)NCBIMGSCv36mm8
Celera1313,893,712 - 14,083,127 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior uvea morphology  (IAGP)
abnormal choroid melanin granule morphology  (IAGP)
abnormal choroid pigmentation  (IAGP)
abnormal ciliary body pigmentation  (IAGP)
abnormal coat/hair pigmentation  (IEA)
abnormal complement pathway  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal dermal mast cell morphology  (IAGP)
abnormal eosinophil morphology  (IAGP)
abnormal eye anterior chamber morphology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal foot pigmentation  (IEA)
abnormal gait  (IEA)
abnormal granulocyte morphology  (IAGP)
abnormal hair cycle  (IEA)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal hair shaft melanin granule shape  (IAGP)
abnormal hippocampal mossy fiber morphology  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal iris morphology  (IAGP)
abnormal iris pigment epithelium  (IAGP)
abnormal iris pigmentation  (IAGP)
abnormal iris stroma morphology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lung development  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphocyte morphology  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal lysosome physiology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal melanogenesis  (IAGP)
abnormal melanosome morphology  (IAGP)
abnormal metastatic potential  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal NK cell physiology  (IAGP)
abnormal Peyer's patch morphology  (IAGP)
abnormal retina layer morphology  (IAGP)
abnormal retina melanin granule morphology  (IAGP)
abnormal retina morphology  (IEA)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal skin morphology  (IAGP)
abnormal skin pigmentation  (IEA)
abnormal spleen white pulp morphology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal tumor susceptibility  (IAGP)
abnormal type II pneumocyte morphology  (IAGP)
abnormal urine enzyme level  (IAGP)
abnormal vestibuloocular reflex  (IAGP)
absent hair follicle melanin granules  (IAGP)
absent NK T cells  (IEA)
accumulation of giant lysosomes in kidney/renal tubule cells  (IAGP)
alveolitis  (IAGP)
atelectasis  (IAGP)
decreased B cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased ear pigmentation  (IEA)
decreased eye pigmentation  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased locomotor activity  (IEA)
decreased lymphocyte cell number  (IAGP)
decreased lysosomal enzyme secretion  (IAGP)
decreased macrophage cell number  (IAGP)
decreased metastatic potential  (IAGP)
decreased platelet ADP level  (IAGP)
decreased platelet ATP level  (IAGP)
decreased platelet serotonin level  (IAGP)
decreased pre-B cell number  (IAGP)
decreased prepulse inhibition  (IEA)
decreased Purkinje cell number  (IEA)
decreased susceptibility to fungal infection  (IAGP)
decreased T cell number  (IAGP)
decreased tail pigmentation  (IEA)
delayed hair regrowth  (IEA)
diluted coat color  (IAGP)
ectopic Bergmann glia cells  (IAGP)
ectopic cerebellar granule cells  (IAGP)
ectopic hippocampus pyramidal cells  (IAGP)
ectopic Purkinje cell  (IAGP)
emphysema  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
enlarged alveolar lamellar bodies  (IAGP)
enlarged hair follicle melanin granules  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged melanosome  (IAGP)
enlarged spleen  (IAGP)
hypopigmentation  (IEA)
impaired balance  (IEA)
impaired lung alveolus development  (IAGP)
impaired macrophage phagocytosis  (IEA)
impaired natural killer cell mediated cytotoxicity  (IAGP)
impaired swimming  (IEA)
increased bleeding time  (IAGP)
increased eosinophil cell number  (IAGP)
increased fasting circulating glucose level  (IEA)
increased granulocyte number  (IAGP)
increased grip strength  (IEA)
increased incidence of induced tumors  (IAGP)
increased kidney weight  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased mean corpuscular volume  (IEA)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased NK cell number  (IAGP)
increased susceptibility to bacterial infection  (IEA)
increased susceptibility to Herpesvirales infection  (IEA)
increased susceptibility to infection  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
interstitial pneumonia  (IAGP)
irregular coat pigmentation  (IEA)
lung inflammation  (IAGP)
lysosomal protein accumulation  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
paraparesis  (IEA)
premature death  (IEA)
premature hair loss  (IEA)
preweaning lethality, incomplete penetrance  (IEA)
pulmonary fibrosis  (IAGP)
small Peyer's patches  (IAGP)
small thymus  (IAGP)
spleen hypoplasia  (IAGP)
thymus cyst  (IAGP)
tremors  (IEA)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:408   PMID:102659   PMID:187062   PMID:489978   PMID:580786   PMID:624833   PMID:686157   PMID:1113502   PMID:1278263   PMID:1434498   PMID:1488056   PMID:1516572  
PMID:1523694   PMID:1548087   PMID:1592442   PMID:1632468   PMID:1639480   PMID:1672300   PMID:1682216   PMID:1818124   PMID:1936982   PMID:2307475   PMID:2369371   PMID:2513223  
PMID:2806196   PMID:2895730   PMID:2985510   PMID:3014003   PMID:3033418   PMID:3058198   PMID:3297105   PMID:3512758   PMID:3584547   PMID:3902123   PMID:3910518   PMID:3965401  
PMID:4031470   PMID:4039611   PMID:4129802   PMID:4589319   PMID:4601767   PMID:4634048   PMID:4643821   PMID:4697831   PMID:5367369   PMID:5590154   PMID:6170520   PMID:6218091  
PMID:6272291   PMID:6334024   PMID:6467382   PMID:6494907   PMID:6573537   PMID:6696991   PMID:6699433   PMID:6971254   PMID:6977094   PMID:7089489   PMID:7366733   PMID:7366734  
PMID:7642266   PMID:7658072   PMID:7717446   PMID:7769315   PMID:7875735   PMID:7988496   PMID:7994754   PMID:8075241   PMID:8093859   PMID:8140728   PMID:8166647   PMID:8167906  
PMID:8267959   PMID:8291023   PMID:8320959   PMID:8329195   PMID:8391609   PMID:8418200   PMID:8421432   PMID:8473734   PMID:8479118   PMID:8509222   PMID:8605727   PMID:8650191  
PMID:8673129   PMID:8696010   PMID:8709573   PMID:8717042   PMID:8751863   PMID:8757756   PMID:8780155   PMID:8781712   PMID:8806787   PMID:8825628   PMID:8830098   PMID:8854868  
PMID:8872993   PMID:8912013   PMID:8950022   PMID:8952226   PMID:8962121   PMID:9027500   PMID:9041176   PMID:9070932   PMID:9070936   PMID:9082976   PMID:9175014   PMID:9192864  
PMID:9215680   PMID:9234770   PMID:9328433   PMID:9368050   PMID:9417888   PMID:9533653   PMID:9673277   PMID:9735600   PMID:9821307   PMID:9922217   PMID:10193444   PMID:10202929  
PMID:10225324   PMID:10349636   PMID:10358203   PMID:10527680   PMID:10607900   PMID:10630568   PMID:10727609   PMID:10742052   PMID:10841521   PMID:11042159   PMID:11076861   PMID:11152110  
PMID:11217851   PMID:11359810   PMID:11383882   PMID:11472062   PMID:11780064   PMID:11924817   PMID:12144812   PMID:12171798   PMID:12399426   PMID:12446740   PMID:12466851   PMID:13943454  
PMID:14610273   PMID:15175354   PMID:15356152   PMID:15383569   PMID:15743322   PMID:16141072   PMID:16141073   PMID:16418262   PMID:16518687   PMID:16791600   PMID:17027894   PMID:17259968  
PMID:17392156   PMID:17438029   PMID:17982137   PMID:17982459   PMID:18558092   PMID:18715234   PMID:18757424   PMID:18799693   PMID:18927622   PMID:19029039   PMID:19249873   PMID:20061169  
PMID:20080755   PMID:20395436   PMID:20617205   PMID:20739949   PMID:20971735   PMID:21267068   PMID:21403131   PMID:21606480   PMID:21677750   PMID:21873635   PMID:21878672   PMID:22327079  
PMID:22387558   PMID:22542159   PMID:22617213   PMID:23043085   PMID:23094018   PMID:23251662   PMID:23792169   PMID:23885715   PMID:25446841   PMID:25917818   PMID:26720279   PMID:27488533  
PMID:27626380   PMID:27703030   PMID:27881733   PMID:28003381   PMID:28082402   PMID:29242210   PMID:29419647   PMID:29858571   PMID:29946151   PMID:31043676   PMID:32419134   PMID:32554809  
PMID:32968282   PMID:35167491   PMID:35239671   PMID:35364055   PMID:35864246   PMID:38355793   PMID:38722309   PMID:38788720  


Genomics

Comparative Map Data
Lyst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391313,764,896 - 13,953,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1313,764,982 - 13,953,388 (+)EnsemblGRCm39 Ensembl
GRCm381313,590,311 - 13,778,803 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1313,590,397 - 13,778,803 (+)EnsemblGRCm38mm10GRCm38
MGSCv371313,682,676 - 13,869,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361313,382,535 - 13,569,566 (+)NCBIMGSCv36mm8
Celera1313,893,712 - 14,083,127 (+)NCBICelera
Cytogenetic Map13A1NCBI
cM Map135.28NCBI
LYST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381235,661,031 - 235,883,713 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1235,661,041 - 235,883,724 (-)EnsemblGRCh38hg38GRCh38
GRCh371235,824,331 - 236,047,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361233,890,966 - 234,096,843 (-)NCBINCBI36Build 36hg18NCBI36
Celera1209,067,680 - 209,273,532 (-)NCBICelera
Cytogenetic Map1q42.3NCBI
HuRef1206,276,078 - 206,498,442 (-)NCBIHuRef
CHM1_11237,097,073 - 237,319,731 (-)NCBICHM1_1
T2T-CHM13v2.01235,057,704 - 235,280,316 (-)NCBIT2T-CHM13v2.0
Lyst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81793,225,509 - 93,427,650 (+)NCBIGRCr8
mRatBN7.21786,241,384 - 86,443,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1786,241,384 - 86,443,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1790,517,628 - 90,679,857 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01794,353,524 - 94,515,764 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01788,370,050 - 88,532,284 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01790,323,055 - 90,522,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01792,156,826 - 92,183,054 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01791,983,426 - 92,113,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41766,569,478 - 66,735,402 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11766,580,310 - 66,746,235NCBI
Celera1785,172,435 - 85,333,653 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
Lyst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554924,209,749 - 4,369,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554924,161,976 - 4,371,637 (+)NCBIChiLan1.0ChiLan1.0
LYST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,294,609 - 13,516,764 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,506,415 - 13,728,594 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01211,229,800 - 211,451,947 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,231,824 - 216,436,293 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,231,824 - 216,436,293 (-)Ensemblpanpan1.1panPan2
LYST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.144,106,869 - 4,296,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl44,089,837 - 4,294,593 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha44,153,555 - 4,342,677 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.044,128,097 - 4,317,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl44,128,101 - 4,316,523 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.144,140,014 - 4,329,208 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,257,740 - 4,446,788 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,478,809 - 4,668,078 (+)NCBIUU_Cfam_GSD_1.0
Lyst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934440,585,775 - 40,750,794 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648416,763,511 - 16,916,022 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648416,750,976 - 16,915,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LYST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1455,433,597 - 55,633,484 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11455,433,163 - 55,634,011 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21459,508,449 - 59,679,488 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LYST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12572,827,997 - 73,048,645 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2572,828,006 - 72,991,970 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605574,871,183 - 75,097,795 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lyst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477514,705,693 - 14,898,660 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477514,670,498 - 14,900,501 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lyst
6436 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:163
Interacting mature miRNAs:177
Transcripts:ENSMUST00000110559
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse

Markers in Region
U70015  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381313,777,178 - 13,777,258UniSTSGRCm38
MGSCv371313,869,445 - 13,869,525UniSTSGRCm37
Celera1314,082,865 - 14,082,945UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead/MRC_RH13210.47UniSTS
U52461  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381313,777,264 - 13,777,418UniSTSGRCm38
MGSCv371313,869,531 - 13,869,685UniSTSGRCm37
Celera1314,082,951 - 14,083,105UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Whitehead_YAC13 UniSTS
Lyst  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381313,638,105 - 13,638,193UniSTSGRCm38
MGSCv371313,730,372 - 13,730,460UniSTSGRCm37
Celera1313,941,589 - 13,941,677UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
D13Sfk15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381313,726,148 - 13,726,207UniSTSGRCm38
MGSCv371313,818,415 - 13,818,474UniSTSGRCm37
Celera1314,030,623 - 14,030,682UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
D13Sfk16  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381313,599,223 - 13,599,298UniSTSGRCm38
MGSCv371313,691,490 - 13,691,565UniSTSGRCm37
Celera1313,902,616 - 13,902,691UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Lyst  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381313,777,113 - 13,777,361UniSTSGRCm38
MGSCv371313,869,380 - 13,869,628UniSTSGRCm37
Celera1314,082,800 - 14,083,048UniSTS
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS
Lyst  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A1UniSTS
cM Map137.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004937943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC171200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L77884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC508235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U78038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000110559   ⟹   ENSMUSP00000106188
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,764,982 - 13,953,388 (+)Ensembl
GRCm38.p6 Ensembl1313,590,397 - 13,778,803 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,764,994 - 13,824,702 (+)Ensembl
GRCm38.p6 Ensembl1313,590,409 - 13,650,117 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221483
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,921,321 - 13,928,557 (+)Ensembl
GRCm38.p6 Ensembl1313,746,736 - 13,753,972 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221587
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,935,354 - 13,935,917 (+)Ensembl
GRCm38.p6 Ensembl1313,760,769 - 13,761,332 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221717
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,883,936 - 13,922,114 (+)Ensembl
GRCm38.p6 Ensembl1313,709,351 - 13,747,529 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,764,982 - 13,810,844 (+)Ensembl
GRCm38.p6 Ensembl1313,590,397 - 13,636,259 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223527
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,814,496 - 13,818,171 (+)Ensembl
GRCm38.p6 Ensembl1313,639,911 - 13,643,586 (+)Ensembl
RefSeq Acc Id: ENSMUST00000231064   ⟹   ENSMUSP00000155251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1313,858,676 - 13,862,214 (+)Ensembl
GRCm38.p6 Ensembl1313,684,091 - 13,687,629 (+)Ensembl
RefSeq Acc Id: NM_010748   ⟹   NP_034878
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391313,764,994 - 13,952,025 (+)NCBI
GRCm381313,590,409 - 13,777,440 (+)NCBI
MGSCv371313,682,676 - 13,869,707 (+)RGD
Celera1313,893,712 - 14,083,127 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516561   ⟹   XP_006516624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391313,764,896 - 13,953,388 (+)NCBI
GRCm381313,590,311 - 13,778,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006516562   ⟹   XP_006516625
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391313,764,896 - 13,953,388 (+)NCBI
GRCm381313,590,311 - 13,778,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006516563   ⟹   XP_006516626
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391313,764,896 - 13,857,633 (+)NCBI
GRCm381313,590,311 - 13,683,048 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004937943
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391313,764,896 - 13,884,018 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034878   ⟸   NM_010748
- UniProtKB: Q8VBS6 (UniProtKB/Swiss-Prot),   Q62403 (UniProtKB/Swiss-Prot),   P97412 (UniProtKB/Swiss-Prot),   G5E8Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516626   ⟸   XM_006516563
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006516624   ⟸   XM_006516561
- Peptide Label: isoform X1
- UniProtKB: Q8VBS6 (UniProtKB/Swiss-Prot),   Q62403 (UniProtKB/Swiss-Prot),   P97412 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516625   ⟸   XM_006516562
- Peptide Label: isoform X2
- UniProtKB: Q8VBS6 (UniProtKB/Swiss-Prot),   Q62403 (UniProtKB/Swiss-Prot),   P97412 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106188   ⟸   ENSMUST00000110559
RefSeq Acc Id: ENSMUSP00000155251   ⟸   ENSMUST00000231064
Protein Domains
BEACH   BEACH-type PH

Promoters
RGD ID:8679606
Promoter ID:EPDNEW_M17834
Type:initiation region
Name:Lyst_1
Description:Mus musculus lysosomal trafficking regulator , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17835  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381313,590,410 - 13,590,470EPDNEW
RGD ID:8679608
Promoter ID:EPDNEW_M17835
Type:single initiation site
Name:Lyst_2
Description:Mus musculus lysosomal trafficking regulator , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17834  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381313,615,902 - 13,615,962EPDNEW
RGD ID:6824126
Promoter ID:MM_KWN:13260
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_010748,   UC007PMH.1,   UC007PMI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361313,682,311 - 13,682,907 (+)MPROMDB
RGD ID:6824127
Promoter ID:MM_KWN:13262
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:UC007PMK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361313,801,076 - 13,801,576 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107448 AgrOrtholog
Ensembl Genes ENSMUSG00000019726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000110559 ENTREZGENE
  ENSMUST00000110559.3 UniProtKB/TrEMBL
  ENSMUST00000231064.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BEACH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BEACH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-BEACH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107448 ENTREZGENE
NCBI Gene 17101 ENTREZGENE
PANTHER BEIGE/BEACH-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LYSOSOMAL-TRAFFICKING REGULATOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Beach UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_BEACH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lyst PhenoGen
PROSITE BEACH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_BEACH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART Beach UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8W6Q6_MOUSE UniProtKB/TrEMBL
  G5E8Q0 ENTREZGENE, UniProtKB/TrEMBL
  LYST_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TV54_MOUSE UniProtKB/TrEMBL
  Q3U4C2_MOUSE UniProtKB/TrEMBL
  Q3US13_MOUSE UniProtKB/TrEMBL
  Q62403 ENTREZGENE
  Q8BN38_MOUSE UniProtKB/TrEMBL
  Q8VBS6 ENTREZGENE
UniProt Secondary Q62403 UniProtKB/Swiss-Prot
  Q8VBS6 UniProtKB/Swiss-Prot