MYC (MYC proto-oncogene, bHLH transcription factor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MYC (MYC proto-oncogene, bHLH transcription factor) Homo sapiens
Analyze
Symbol: MYC
Name: MYC proto-oncogene, bHLH transcription factor
RGD ID: 731438
HGNC Page HGNC:7553
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; SCF ubiquitin ligase complex binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of DNA-templated transcription; and regulation of fibroblast proliferation. Acts upstream of with a positive effect on negative regulation of gene expression via chromosomal CpG island methylation. Acts upstream of or within positive regulation of cell population proliferation and regulation of gene expression. Located in chromatin; nucleus; and rough endoplasmic reticulum. Part of Myc-Max complex and RNA polymerase II transcription repressor complex. Implicated in several diseases, including angiosarcoma; demyelinating disease; hematologic cancer (multiple); lung adenocarcinoma; and prostate cancer (multiple). Biomarker of several diseases, including hepatitis C; leukemia (multiple); liver disease (multiple); polycystic kidney disease 1; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: avian myelocytomatosis viral oncogene homolog; bHLHe39; c-Myc; class E basic helix-loop-helix protein 39; cMyc; MRTL; myc proto-oncogene protein; myc-related translation/localization regulatory factor; MYCC; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: PRSTS2_H PRSTS136_H PRSTS140_H PRSTS139_H PRSTS141_H PRSTS137_H PRSTS138_H PRSTS135_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388127,735,434 - 127,742,951 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8127,735,434 - 127,742,951 (+)EnsemblGRCh38hg38GRCh38
GRCh378128,747,680 - 128,755,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368128,817,498 - 128,822,856 (+)NCBINCBI36Build 36hg18NCBI36
Build 348128,817,685 - 128,822,853NCBI
Celera8124,928,812 - 124,934,177 (+)NCBICelera
Cytogenetic Map8q24.21NCBI
HuRef8124,069,829 - 124,075,195 (+)NCBIHuRef
CHM1_18128,788,551 - 128,793,916 (+)NCBICHM1_1
T2T-CHM13v2.08128,862,888 - 128,870,405 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model