Dll3 (delta like canonical Notch ligand 3) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dll3 (delta like canonical Notch ligand 3) Mus musculus
Analyze
Symbol: Dll3
Name: delta like canonical Notch ligand 3
RGD ID: 731402
MGI Page MGI
Description: Predicted to enable Notch binding activity. Involved in skeletal system development. Acts upstream of or within anterior/posterior pattern specification; negative regulation of neurogenesis; and paraxial mesoderm development. Located in plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; future brain; paraxial mesenchyme; and sensory organ. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delta-like 3; delta-like 3 (Drosophila); delta-like protein 3; delta3; drosophila Delta homolog 3; M-Delta-3; pu; pudgy
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,992,980 - 28,001,210 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,992,978 - 28,001,663 (-)EnsemblGRCm39 Ensembl
GRCm38728,293,555 - 28,301,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,293,553 - 28,302,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,078,574 - 29,086,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,002,336 - 28,010,544 (-)NCBIMGSCv36mm8
Celera722,855,195 - 22,863,426 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal brain ependyma morphology  (IAGP)
abnormal caudal vertebrae morphology  (IEA)
abnormal cervical vertebrae morphology  (IEA)
abnormal cranium morphology  (IEA)
abnormal dermomyotome development  (IEA)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal lumbar vertebrae morphology  (IEA)
abnormal multifidus muscle morphology  (IAGP)
abnormal paravertebral ganglion morphology  (IAGP)
abnormal parturition  (IEA)
abnormal presomitic mesoderm morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal rostral-caudal patterning of the somites  (IAGP)
abnormal sclerotome morphology  (IEA)
abnormal sexual interaction  (IEA)
abnormal skeleton morphology  (IAGP)
abnormal somite border morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal somite segmentation clock  (IAGP)
abnormal somite shape  (IAGP)
abnormal somite size  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal tail morphology  (IEA)
abnormal thoracic vertebrae morphology  (IEA)
abnormal trabecular bone morphology  (IEA)
abnormal vertebrae development  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral arch morphology  (IAGP)
curly tail  (IEA)
decreased body length  (IAGP)
decreased caudal vertebrae number  (IAGP)
decreased compact bone thickness  (IEA)
decreased litter size  (IEA)
decreased rib number  (IAGP)
decreased vertebrae number  (IAGP)
delayed somite formation  (IAGP)
fused dorsal root ganglion  (IAGP)
hindlimb paralysis  (IEA)
kinked neural tube  (IAGP)
kinked tail  (IAGP)
kyphosis  (IEA)
lordosis  (IEA)
postnatal lethality, incomplete penetrance  (IAGP)
rib bifurcation  (IAGP)
rib fusion  (IAGP)
short limbs  (IEA)
short tail  (IAGP)
short vertebral column  (IEA)
splayed ribs  (IEA)
sternebra fusion  (IEA)
thin tail  (IEA)
vertebral compression  (IEA)
vertebral fusion  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Bulman MP, etal., Nat Genet. 2000 Apr;24(4):438-41.
2. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9272948   PMID:9662403   PMID:9690472   PMID:9690473   PMID:9876181   PMID:10080181   PMID:10196361   PMID:10330372   PMID:10349636   PMID:10556054   PMID:10615124   PMID:10837027  
PMID:10878608   PMID:10906448   PMID:11042159   PMID:11076861   PMID:11118901   PMID:11124811   PMID:11171333   PMID:11217851   PMID:11262239   PMID:11412999   PMID:11578869   PMID:11739954  
PMID:11747084   PMID:11807030   PMID:11893554   PMID:11923214   PMID:11934853   PMID:11937492   PMID:12001066   PMID:12141422   PMID:12175503   PMID:12421720   PMID:12441287   PMID:12466851  
PMID:12477932   PMID:12617809   PMID:12620991   PMID:12670869   PMID:12697902   PMID:12900443   PMID:12971992   PMID:14610273   PMID:14701881   PMID:14732396   PMID:14757642   PMID:15033168  
PMID:15153675   PMID:15155583   PMID:15170697   PMID:15186480   PMID:15465494   PMID:15489334   PMID:15689374   PMID:15821257   PMID:15893969   PMID:15976074   PMID:15979417   PMID:16000382  
PMID:16110338   PMID:16127714   PMID:16141072   PMID:16141073   PMID:16245338   PMID:16342160   PMID:16412699   PMID:16537572   PMID:16766699   PMID:16914494   PMID:17015435   PMID:17141158  
PMID:17257418   PMID:17362910   PMID:17476283   PMID:17600782   PMID:17605079   PMID:17664336   PMID:17823936   PMID:17849441   PMID:18374910   PMID:18505817   PMID:18676613   PMID:18694942  
PMID:18725516   PMID:18832397   PMID:19191219   PMID:19268448   PMID:19389376   PMID:19520072   PMID:19686682   PMID:19723505   PMID:20558143   PMID:20727173   PMID:21147753   PMID:21151194  
PMID:21172336   PMID:21252157   PMID:21311046   PMID:21402740   PMID:21677750   PMID:21750033   PMID:21750544   PMID:21873635   PMID:22095884   PMID:22464328   PMID:22484060   PMID:22675208  
PMID:23070814   PMID:23665443   PMID:23699523   PMID:24337118   PMID:24552588   PMID:24859004   PMID:24952961   PMID:25813538   PMID:25856312   PMID:26450967   PMID:26651607   PMID:26745185  
PMID:26911688   PMID:26912775   PMID:27655002   PMID:27894818   PMID:28007595   PMID:28402857   PMID:28656980   PMID:29445148   PMID:30843783   PMID:31590629   PMID:32499648   PMID:32561646  
PMID:33795231   PMID:34321999   PMID:34635817   PMID:35103284   PMID:35124175   PMID:35247391   PMID:35429490   PMID:35815610   PMID:36064547   PMID:36253375  


Genomics

Comparative Map Data
Dll3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,992,980 - 28,001,210 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,992,978 - 28,001,663 (-)EnsemblGRCm39 Ensembl
GRCm38728,293,555 - 28,301,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,293,553 - 28,302,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,078,574 - 29,086,804 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,002,336 - 28,010,544 (-)NCBIMGSCv36mm8
Celera722,855,195 - 22,863,426 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
DLL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,498,947 - 39,508,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,498,895 - 39,508,481 (+)EnsemblGRCh38hg38GRCh38
GRCh371939,989,587 - 39,999,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,681,427 - 44,690,949 (+)NCBINCBI36Build 36hg18NCBI36
Build 341944,681,426 - 44,690,948NCBI
Celera1936,791,266 - 36,800,828 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,435,871 - 36,445,452 (+)NCBIHuRef
CHM1_11939,990,197 - 39,999,736 (+)NCBICHM1_1
T2T-CHM13v2.01942,303,204 - 42,312,726 (+)NCBIT2T-CHM13v2.0
Dll3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2183,562,011 - 83,570,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,562,014 - 83,569,750 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,973,668 - 88,982,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,431,999 - 97,440,363 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,729,526 - 90,737,881 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,485,875 - 85,493,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,485,289 - 85,493,685 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,697,034 - 86,704,826 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,373,482 - 83,381,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,451,593 - 83,459,330 (-)NCBI
Celera177,961,035 - 77,968,719 (-)NCBICelera
Cytogenetic Map1q21NCBI
Dll3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546871,004 - 78,827 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546870,714 - 78,831 (-)NCBIChiLan1.0ChiLan1.0
DLL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11947,665,162 - 47,674,775 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,597,420 - 36,607,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,144,641 - 45,154,854 (+)NCBIpanpan1.1PanPan1.1panPan2
DLL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,737,662 - 113,745,936 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,141,459 - 113,149,451 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,338,412 - 114,346,404 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,338,408 - 114,346,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,897,659 - 113,905,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,530,679 - 113,538,682 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,525,073 - 114,533,065 (-)NCBIUU_Cfam_GSD_1.0
Dll3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,893,682 - 13,904,131 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,322,531 - 2,329,953 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366612,322,531 - 2,330,150 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,147,635 - 48,155,292 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,135,738 - 48,155,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,998,228 - 44,008,477 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,102,433 - 34,114,558 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,103,854 - 34,114,103 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,125,291 - 12,136,981 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dll3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,806,868 - 12,815,582 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479412,806,299 - 12,816,048 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dll3
240 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:488
Count of miRNA genes:346
Interacting mature miRNAs:374
Transcripts:ENSMUST00000108315, ENSMUST00000138721, ENSMUST00000145512
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse

Markers in Region
Dll3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,293,818 - 28,294,369UniSTSGRCm38
MGSCv37729,078,837 - 29,079,388UniSTSGRCm37
Celera722,855,458 - 22,856,009UniSTS
Cytogenetic Map7A3UniSTS
cM Map710.0UniSTS
cM Map710.0UniSTS
Y11895  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,293,824 - 28,293,918UniSTSGRCm38
MGSCv37729,078,843 - 29,078,937UniSTSGRCm37
Celera722,855,464 - 22,855,558UniSTS
Cytogenetic Map7A3UniSTS
cM Map710.0UniSTS
Whitehead/MRC_RH7392.76UniSTS
D7Mit266  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,301,044 - 28,301,161UniSTSGRCm38
MGSCv37729,086,063 - 29,086,180UniSTSGRCm37
Celera722,862,684 - 22,862,802UniSTS
Cytogenetic Map7A3UniSTS
cM Map710.0UniSTS
Whitehead Genetic710.9UniSTS
Dll3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,301,265 - 28,301,382UniSTSGRCm38
MGSCv37729,086,284 - 29,086,401UniSTSGRCm37
Celera722,862,906 - 22,863,023UniSTS
Cytogenetic Map7A3UniSTS
cM Map710.0UniSTS
Dll3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000108315   ⟹   ENSMUSP00000103951
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,992,978 - 28,001,663 (-)Ensembl
GRCm38.p6 Ensembl728,293,553 - 28,302,238 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,993,024 - 27,993,906 (-)Ensembl
GRCm38.p6 Ensembl728,293,599 - 28,294,481 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145512
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl727,998,097 - 28,001,197 (-)Ensembl
GRCm38.p6 Ensembl728,298,672 - 28,301,772 (-)Ensembl
RefSeq Acc Id: NM_007866   ⟹   NP_031892
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39727,992,980 - 28,001,210 (-)NCBI
GRCm38728,293,555 - 28,301,785 (-)ENTREZGENE
MGSCv37729,078,574 - 29,086,804 (-)RGD
Celera722,855,195 - 22,863,426 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031892   ⟸   NM_007866
- Peptide Label: precursor
- UniProtKB: Q9QWZ7 (UniProtKB/Swiss-Prot),   Q9QWL9 (UniProtKB/Swiss-Prot),   Q80W06 (UniProtKB/Swiss-Prot),   O35675 (UniProtKB/Swiss-Prot),   O88516 (UniProtKB/Swiss-Prot),   Q3UND5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000103951   ⟸   ENSMUST00000108315
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88516-F1-model_v2 AlphaFold O88516 1-592 view protein structure

Promoters
RGD ID:6840946
Promoter ID:MM_KWN:49627
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000070775
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,079,441 - 29,079,941 (-)MPROMDB
RGD ID:6840945
Promoter ID:MM_KWN:49628
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000050191,   ENSMUST00000094650,   OTTMUST00000053925,   OTTMUST00000053926
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,086,841 - 29,087,341 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1096877 AgrOrtholog
Ensembl Genes ENSMUSG00000003436 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000103951 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000108315 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.3510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13389 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1096877 ENTREZGENE
NCBI Gene 13389 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MNNL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dll3 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DLL3_MOUSE UniProtKB/Swiss-Prot
  O35675 ENTREZGENE
  O88515_MOUSE UniProtKB/TrEMBL
  O88516 ENTREZGENE
  Q3UND5 ENTREZGENE, UniProtKB/TrEMBL
  Q80W06 ENTREZGENE
  Q9QWL9 ENTREZGENE
  Q9QWZ7 ENTREZGENE
UniProt Secondary O35675 UniProtKB/Swiss-Prot
  Q80W06 UniProtKB/Swiss-Prot
  Q9QWL9 UniProtKB/Swiss-Prot
  Q9QWZ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Dll3  delta like canonical Notch ligand 3    delta-like 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED