F2rl3 (F2R like thrombin or trypsin receptor 3)

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Gene: F2rl3 (F2R like thrombin or trypsin receptor 3) Mus musculus

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Symbol:

F2rl3

Name:

F2R like thrombin or trypsin receptor 3

RGD ID:

731394

MGI Page

MGI

Description:

Predicted to enable G protein-coupled receptor activity and protease binding activity. Acts upstream of or within platelet aggregation. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; immune system; liver lobe; lung; and retina. Orthologous to human F2RL3 (F2R like thrombin or trypsin receptor 3).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

coagulation factor II (thrombin) receptor-like 3; coagulation factor II receptor-like 3; P; PAR-4; PAR4; proteinase-activated receptor 4; thrombin receptor-like 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	F2RL3 (F2R like thrombin or trypsin receptor 3)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	F2rl3 (F2R like thrombin or trypsin receptor 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	F2RL3 (F2R like thrombin or trypsin receptor 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-132p1.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gnrr-4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	f2rl3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	73,488,287 - 73,490,526 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	73,488,508 - 73,490,502 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	72,761,659 - 72,763,898 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,761,880 - 72,763,874 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	75,285,779 - 75,287,784 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	75,657,952 - 75,659,957 (+)	NCBI		MGSCv36	mm8
Celera	8	77,077,985 - 77,079,990 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	35.08	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

peliosis hepatis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (EXP)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3',5'-cyclic AMP (EXP)

4,4'-diaminodiphenylmethane (EXP)

6-propyl-2-thiouracil (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bivalirudin (ISO)

C60 fullerene (ISO)

cadmium atom (ISO)

calcium atom (EXP,ISO)

calcium(0) (EXP,ISO)

chromium(6+) (ISO)

colforsin daropate hydrochloride (EXP)

copper atom (ISO)

copper(0) (ISO)

cyclophosphamide (ISO)

Dibutyl phosphate (ISO)

diquat (EXP)

fluorene (ISO)

flusilazole (ISO)

lidocaine (ISO)

lipopolysaccharide (EXP,ISO)

methimazole (ISO)

oxaliplatin (ISO)

paracetamol (ISO)

potassium dichromate (EXP)

progesterone (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (EXP)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (ISO)

Thrombin (ISO)

topotecan (ISO)

triadimefon (ISO)

trichloroethene (EXP)

trimellitic anhydride (EXP)

triphenyl phosphate (ISO)

Triptolide (EXP)

triptonide (EXP)

valproic acid (ISO)

XL147 (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

G protein-coupled receptor signaling pathway (IEA)

hemostasis (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IBA)

platelet activation (ISO)

platelet aggregation (IDA)

positive regulation of release of sequestered calcium ion into cytosol (IEA,ISO)

positive regulation of Rho protein signal transduction (IBA)

signal transduction (IEA)

thrombin-activated receptor signaling pathway (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

G protein-coupled receptor activity (IBA)

protease binding (IEA,ISO)

thrombin-activated receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

protease mediated signaling via protease-activated receptor 4 (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased susceptibility to induced thrombosis (IAGP)

embryonic lethality (IAGP)

increased bleeding time (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Cross Talk Pathways Between Coagulation and Inflammation.	Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9716134	PMID:9722561	PMID:10085414	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11381262	PMID:11544528	PMID:11850418	PMID:12384423	PMID:12466851
PMID:12477932	PMID:12775717	PMID:12869501	PMID:12918424	PMID:14504091	PMID:14973136	PMID:14980205	PMID:15031212	PMID:15304051	PMID:15877079	PMID:16141072	PMID:16141073
PMID:16434493	PMID:16602821	PMID:17095716	PMID:17158345	PMID:17190826	PMID:17438064	PMID:17606903	PMID:17641206	PMID:18268094	PMID:18292814	PMID:18310501	PMID:18347074
PMID:18412955	PMID:18490515	PMID:18983510	PMID:18987429	PMID:19012179	PMID:19248120	PMID:19387006	PMID:19413681	PMID:19437337	PMID:19528350	PMID:19566587	PMID:19586901
PMID:19859967	PMID:20087365	PMID:20829647	PMID:20930120	PMID:21106537	PMID:21267068	PMID:21860019	PMID:21873635	PMID:22044612	PMID:22517275	PMID:23024330	PMID:23325830
PMID:23348738	PMID:23516969	PMID:23783078	PMID:24030758	PMID:24434483	PMID:24830314	PMID:24888424	PMID:25118784	PMID:25239438	PMID:25278288	PMID:25353084	PMID:25733582
PMID:25890453	PMID:25954015	PMID:26020638	PMID:26179083	PMID:26204458	PMID:26341257	PMID:26643815	PMID:27010488	PMID:27402844	PMID:28032533	PMID:29357418	PMID:30186877
PMID:30655274	PMID:30870413	PMID:31337508	PMID:31912235	PMID:32489148	PMID:33158859	PMID:33159803	PMID:35041705	PMID:35144762	PMID:35152546	PMID:35700057	PMID:36716976
PMID:37471144	PMID:37675637	PMID:38031732	PMID:38036085	PMID:38164021	PMID:38508397	PMID:38814792

Genomics

Comparative Map Data

F2rl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	73,488,287 - 73,490,526 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	73,488,508 - 73,490,502 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	72,761,659 - 72,763,898 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,761,880 - 72,763,874 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	75,285,779 - 75,287,784 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	75,657,952 - 75,659,957 (+)	NCBI		MGSCv36	mm8
Celera	8	77,077,985 - 77,079,990 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	35.08	NCBI

F2RL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	16,888,999 - 16,892,606 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	16,888,999 - 16,892,606 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	16,999,810 - 17,003,417 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	16,860,826 - 16,863,830 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	16,860,825 - 16,870,516	NCBI
Celera	19	16,901,357 - 16,904,361 (+)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	16,568,368 - 16,571,379 (+)	NCBI		HuRef
CHM1_1	19	16,999,569 - 17,002,573 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	17,023,836 - 17,027,443 (+)	NCBI		T2T-CHM13v2.0

F2rl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,151,516 - 17,153,509 (-)	NCBI		GRCr8
mRatBN7.2	16	17,117,441 - 17,119,434 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,117,441 - 17,119,472 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	17,185,458 - 17,187,486 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,317,104 - 18,319,112 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,238,362 - 17,240,390 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	18,817,797 - 18,819,790 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	18,814,622 - 18,819,833 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	18,687,984 - 18,689,977 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	16	17,341,816 - 17,343,823 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

F2rl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,044,792 - 1,047,819 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	1,045,493 - 1,047,924 (-)	NCBI	ChiLan1.0	ChiLan1.0

F2RL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	21,757,541 - 21,762,253 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	20,764,020 - 20,768,733 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	16,375,572 - 16,379,587 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	17,355,542 - 17,357,628 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	17,355,542 - 17,357,628 (+)	Ensembl	panpan1.1		panPan2

F2RL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	45,738,587 - 45,740,564 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	45,738,587 - 45,740,473 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	45,652,073 - 45,655,003 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	46,224,593 - 46,227,523 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	46,225,014 - 46,226,479 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	45,460,781 - 45,463,709 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	45,871,392 - 45,874,323 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	46,146,994 - 46,149,271 (-)	NCBI		UU_Cfam_GSD_1.0

F2RL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	60,742,996 - 60,744,864 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	60,742,978 - 60,747,014 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	60,307,031 - 60,309,288 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

F2RL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	15,397,552 - 15,400,708 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666074	4,036,812 - 4,040,135 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

F2rl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	762,356 - 766,563 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	761,067 - 764,562 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in F2rl3
71 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	163
Count of miRNA genes:	152
Interacting mature miRNAs:	157
Transcripts:	ENSMUST00000058099
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	66326836	100326976	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36630154	93455280	Mouse
1301717	Adip4_m	adiposity 4 (mouse)			Not determined		8	48090064	82090180	Mouse
1357715	Alaa3_m	alopecia areata 3 (mouse)			Not determined		8	49245591	83245673	Mouse
11353828	Gf7_m	gonadal fat pad weight 7 (mouse)					8	58928107	92928107	Mouse
14746987	Manh64_m	mandible shape 64 (mouse)					8	50505958	84505958	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	35109930	115563747	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	66084397	100084549	Mouse
10766453	Char11_m	P. chabaudi malaria resistance QTL 11 (mouse)					8	48090064	82090180	Mouse
1301506	Aevm1_m	autoimmune extremity vasculitis in MRL mice 1 (mouse)			Not determined		8	54740461	88740637	Mouse
1301441	Skull11_m	skull morphology 11 (mouse)			Not determined		8	48190168	82190288	Mouse
1301952	Im3_m	immunoregulatory 3 (mouse)			Not determined		8	55159258	89159407	Mouse
1301767	Fcsa2_m	femoral cross-sectional area 2 (mouse)			Not determined		8	71032003	105032123	Mouse
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32506572	117965439	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71740461	124622354	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			64186736	98186736	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	64666176	98666325	Mouse
14747005	Mancz7_m	mandible centroid size 7 (mouse)					8	50505958	84505958	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37867154	110326632	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	59136404	93136404	Mouse
10412287	Carg3_m	Candida albicans resistance gene 3 (mouse)			Not determined		8	56298872	90298872	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	72122809	106123021	Mouse
10766466	Char12_m	P. chabaudi malaria resistance QTL 12 (mouse)					8	68722479	83326976	Mouse
11039503	Ccc4_m	colitis susceptibility in the Collaborative Cross 4 (mouse)					8	65174237	78002730	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	61513479	95513605	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71829531	105829637	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	40162297	95416226	Mouse
4141395	Char2a_m	P. chabaudi malaria resistance QTL 2a (mouse)			Not determined			71589427	90929226	Mouse
14700686	Civq3_m	cerebral infarct volume QTL 3 (mouse)					8	52334843	86334843	Mouse
4142283	Imraq2_m	immune response to AAV2 QTL 2 (mouse)			Not determined		8	71032003	105032123	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71740461	124622354	Mouse
1301544	Iba3_m	induction of brown adipocytes 3 (mouse)			Not determined		8	44747914	78748059	Mouse

Markers in Region

AI413964

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	72,763,528 - 72,763,628	UniSTS	GRCm38
MGSCv37	8	75,287,427 - 75,287,527	UniSTS	GRCm37
Celera	8	77,079,633 - 77,079,733	UniSTS
Cytogenetic Map	8	B3.3	UniSTS
Whitehead/MRC_RH	8	776.6	UniSTS

D8Mit133

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	72,763,829 - 72,763,978	UniSTS	GRCm38
MGSCv37	8	75,287,728 - 75,287,877	UniSTS	GRCm37
Celera	8	77,079,934 - 77,080,085	UniSTS
Cytogenetic Map	8	B3.3	UniSTS
cM Map	8	33.0	UniSTS
Whitehead Genetic	8	35.0	UniSTS
Whitehead_YAC	8		UniSTS

UniSTS:484863

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	72,761,884 - 72,763,387	UniSTS	GRCm38
MGSCv37	8	75,285,783 - 75,287,286	UniSTS	GRCm37
Celera	8	77,077,989 - 77,079,492	UniSTS
Cytogenetic Map	8	B3.3	UniSTS

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_007975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC171917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF080215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI413964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK036427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK153720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK156729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC119461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY344718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000058099 ⟹ ENSMUSP00000054426

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	73,488,508 - 73,490,502 (+)	Ensembl
GRCm38.p6 Ensembl	8	72,761,880 - 72,763,874 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000212755

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	8	73,488,512 - 73,490,015 (+)	Ensembl
GRCm38.p6 Ensembl	8	72,761,884 - 72,763,387 (+)	Ensembl

RefSeq Acc Id:

NM_007975 ⟹ NP_032001

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	73,488,287 - 73,490,526 (+)	NCBI
GRCm38	8	72,761,659 - 72,763,898 (+)	NCBI
MGSCv37	8	75,285,779 - 75,287,784 (+)	RGD
Celera	8	77,077,985 - 77,079,990 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GTTCTTTATGAGACATTTTGGAGAGAGAGACCTAGGCAGGACACCCAGACCTCCTGAGTGCACA
CAGGGACCTTCGATGGGCTCCAGGGTGAGCAAGCAGATCCCAATGGGTCTATGGGGGTGGGAGC
TCTGCTGTCTCCCCGAAGGTGCAGTTGCTCCCCACAAGGACTCCGGAAGCCGAGGGTGGAGTTG
ACAGGGCAGGAAGTCCCAGGCTGCAGCCCAGAAAGCTTCTGATCCTGGCAGCATGTGCTGGCCG
CTGCTGTATCCTTTGGTGCTGGGGCTCAGCATCAGCCTGGCAGAGGGCATCCAGACCCCCAGCA
TCTACGATGATGTAGAGAGTACCAGGGGAAGCCATGAAGGCCCTCTGGGTCCCACAGTAGAACT
CAAGGAGCCGAAGTCCTCAGACAAGCCTAATCCACGAGGCTACCCGGGCAAATTCTGTGCCAAC
GACAGTGACACGCTGGAGCTCCCGGCCAGCTCTCAAGCACTGCTGCTGGGGTGGGTCCCCACGA
GGCTGGTACCTGCCCTCTATGGGCTTGTGGTGGCTGTGGGGCTGCCTGCCAATGGGCTGGCGCT
GTGGGTGCTGGCCACAAGGGTGCCACGCCTGCCATCCACCATTCTGCTCATGAACCTGGCAGTG
GCTGATCTGCTGTTGGCCCTGGTGCTGCCACCACGACTGGCTTACCACTTGCGTGGCCAGCGCT
GGCCATTTGGTGAGGCTGCCTGCCGGGTGGCCACAGCTGCCCTCTATGGCCACATGTATGGTTC
AGTGTTGCTGCTGGCTGCAGTCAGCTTGGACAGATACCTGGCCCTGGTGCATCCTTTGCGGGCC
CGTGCACTGCGTGGTCAACGCCTCACTACTGGACTCTGTTTGGTGGCCTGGCTCTCTGCAGCCA
CCCTGGCCTTGCCTCTCACTCTGCATCGGCAGACCTTCCGATTAGCTGGCTCCGATCGCATGCT
GTGTCATGATGCGCTGCCCCTGACTGAGCAGACCTCCCACTGGAGACCGGCCTTCATCTGCCTG
GCTGTCCTGGGCTGCTTCGTGCCACTGCTGGCCATGGGCCTGTGCTATGGAGCCACCCTTCGTG
CACTGGCGGCCAATGGCCAGCGCTACAGCCATGCACTCAGACTGACAGCCCTGGTACTGTTCTC
GGCAGTGGCCTCTTTCACACCTAGCAATGTGCTGCTGGTGCTGCACTATTCAAACCCGAGCCCT
GAGGCCTGGGGCAATCTCTATGGAGCCTATGTGCCCAGCCTGGCACTCAGCACCCTCAACAGCT
GCGTAGACCCTTTCATCTACTACTATGTGTCCCATGAGTTCAGGGAGAAGGTACGCGCTATGTT
GTGTCGCCAGCCGGAGGCCAGCAGCTCCTCTCAGGCCTCCAGGGAGGCTGGAAGCCGAGGGACT
GCCATTTGCTCCTCTACACTTCTGTGACTGGTAGCTGAGGTGGGAAGGGGGCATTCTGGCTTGA
CTGGGTCTCCCCTTAAACTACATCCCTCTTGAACCCTCAGGACATGACCTTATTTGGATATGCA
GTTGGTGCGACCTTCATTAGTGGAGCTGAGGTCCACTGGAAATGCTTTTGTAAAAGGTCTGGGT
ACTATACGTCTGTCACTCCAGCACTAGGGAGGTGGAGAAGAGGATCAGGAGTTCAGGATTATCT
TTGACTGTAGTGAATTTGGAGCTAGGCTGGGCTATGTGAGAGTCCAGAGGCAGAAAGGAGTTAT
GAGGTCACTAGCTAGAGGATGCTGAGAAACCAGAATGGAGTTTCCCTTAGAGCTTCAGGGGATC
CAGCCCTAGACACCCTGATTTTGTCAAGGTGCCTCTTAGAACTTCAAACCTTTGTGCTTAGCAT
GTGTCTGCACAGTGTAGATGTGTCTGCACACATATATTGTATGTGCCTGCGGGTACACAGAGAG
GCCAAAGGATGATGGGTGTCTACCTCAATTCCTTCTCTACCATTAAATTTTTAAAAAAATGCTA
TATATATATATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_032001	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC28861	(Get FASTA)	NCBI Sequence Viewer
	AAI19462	(Get FASTA)	NCBI Sequence Viewer
	BAC29423	(Get FASTA)	NCBI Sequence Viewer
	BAE32155	(Get FASTA)	NCBI Sequence Viewer
	BAE33823	(Get FASTA)	NCBI Sequence Viewer
	EDL10818	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000054426
	ENSMUSP00000054426.9
GenBank Protein	O88634	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_032001 ⟸ NM_007975
- Peptide Label:	preproprotein
- UniProtKB:	Q8BZ77 (UniProtKB/Swiss-Prot), O88634 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MCWPLLYPLVLGLSISLAEGIQTPSIYDDVESTRGSHEGPLGPTVELKEPKSSDKPNPRGYPGK FCANDSDTLELPASSQALLLGWVPTRLVPALYGLVVAVGLPANGLALWVLATRVPRLPSTILLM NLAVADLLLALVLPPRLAYHLRGQRWPFGEAACRVATAALYGHMYGSVLLLAAVSLDRYLALVH PLRARALRGQRLTTGLCLVAWLSAATLALPLTLHRQTFRLAGSDRMLCHDALPLTEQTSHWRPA FICLAVLGCFVPLLAMGLCYGATLRALAANGQRYSHALRLTALVLFSAVASFTPSNVLLVLHYS NPSPEAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSHEFREKVRAMLCRQPEASSSSQASREAG SRGTAICSSTLL hide sequence

Ensembl Acc Id:

ENSMUSP00000054426 ⟸ ENSMUST00000058099

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88634-F1-model_v2	AlphaFold	O88634	1-396	view protein structure

Promoters

RGD ID:

8667491

Promoter ID:

EPDNEW_M11777

Type:

multiple initiation site

Name:

F2rl3_1

Description:

Mus musculus coagulation factor II receptor-like 3 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	72,761,889 - 72,761,949	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1298207	AgrOrtholog
Ensembl Genes	ENSMUSG00000050147	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000058099	ENTREZGENE
	ENSMUST00000058099.9	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_act_rcpt_4	UniProtKB/Swiss-Prot
	Protea_act_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:14065	UniProtKB/Swiss-Prot
MGD	MGI:1298207	ENTREZGENE
NCBI Gene	14065	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEINASE-ACTIVATED RECEPTOR 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	F2rl3	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEASEAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEASEAR4	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	O88634	ENTREZGENE, UniProtKB/Swiss-Prot
	Q0VDX1_MOUSE	UniProtKB/TrEMBL
	Q8BZ77	ENTREZGENE
UniProt Secondary	Q8BZ77	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-07-04	F2rl3	F2R like thrombin or trypsin receptor 3	F2rl3	coagulation factor II (thrombin) receptor-like 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

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