Pitx2 (paired-like homeodomain transcription factor 2) - Rat Genome Database

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Gene: Pitx2 (paired-like homeodomain transcription factor 2) Mus musculus
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Symbol: Pitx2
Name: paired-like homeodomain transcription factor 2
RGD ID: 731391
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cardiac neural crest cell migration involved in outflow tract morphogenesis; deltoid tuberosity development; and left/right pattern formation. Acts upstream of or within several processes, including circulatory system development; diencephalon development; and digestive tract morphogenesis. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and musculature. Used to study Axenfeld-Rieger syndrome type 1 and glaucoma. Human ortholog(s) of this gene implicated in Arts syndrome; Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 1; anterior segment dysgenesis 4; and ring dermoid of cornea. Orthologous to human PITX2 (paired like homeodomain 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9430085M16Rik; ALL1-responsive protein ARP1; Brx; Brx1; BRX1 homeoprotein; Brx1a; Brx1b; homeobox protein PITX2; Munc3; Munc30; orthodenticle-like homeobox 2; Otl; Otlx2; paired-like homeodomain transcription factor 2, isoform 2b2; paired-like homeodomain transcription factor Munc 30; Pit; pituitary homeobox 2; Pitx; Pitx2a; Pitx2b; Pitx2c; Pitx2cbeta; Ptx; Ptx2; Ri; Rieg; so; solurshin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393128,993,527 - 129,013,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3128,993,527 - 129,013,240 (+)EnsemblGRCm39 Ensembl
GRCm383129,199,878 - 129,219,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,199,878 - 129,219,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv373128,902,836 - 128,922,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,191,965 - 129,211,613 (+)NCBIMGSCv36mm8
Celera3135,706,515 - 135,726,130 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IBA,IMP)
animal organ morphogenesis  (IMP)
atrial cardiac muscle tissue morphogenesis  (IMP)
atrioventricular valve development  (IMP)
branching involved in blood vessel morphogenesis  (IMP)
camera-type eye development  (ISO)
cardiac muscle cell differentiation  (IMP)
cardiac muscle tissue development  (IMP)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IMP)
cell proliferation involved in outflow tract morphogenesis  (IMP)
deltoid tuberosity development  (IMP,ISO)
determination of left/right symmetry  (IMP)
digestive system development  (IMP)
embryonic camera-type eye development  (IMP)
embryonic digestive tract morphogenesis  (IMP)
embryonic heart tube left/right pattern formation  (IMP)
embryonic hindlimb morphogenesis  (IGI)
endodermal digestive tract morphogenesis  (IMP)
extraocular skeletal muscle development  (IMP)
female gonad development  (ISO)
heart development  (IGI,IMP)
hypothalamus cell migration  (IMP)
in utero embryonic development  (IMP)
iris morphogenesis  (ISO)
left lung morphogenesis  (IMP)
left/right axis specification  (IMP)
lung development  (IMP)
male gonad development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron differentiation  (ISO)
neuron migration  (IMP)
odontogenesis  (IMP,ISO)
odontogenesis of dentin-containing tooth  (ISO)
outflow tract morphogenesis  (IMP)
pituitary gland development  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
pulmonary myocardium development  (IMP)
pulmonary vein morphogenesis  (IMP)
regulation of cell migration  (IMP)
regulation of cell population proliferation  (IMP)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,ISO)
response to hormone  (ISO)
response to vitamin A  (ISO)
skeletal muscle tissue development  (IMP)
spleen development  (IMP)
subthalamic nucleus development  (IMP)
superior vena cava morphogenesis  (IMP)
vascular associated smooth muscle cell differentiation  (IMP)
vasculogenesis  (IMP)
ventricular cardiac muscle cell development  (IMP)
ventricular septum morphogenesis  (IMP)
Wnt signaling pathway  (IDA)

Cellular Component
cytoplasm  (IDA)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)
transcription regulator complex  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis development  (IAGP)
abnormal adenohypophysis morphology  (IAGP)
abnormal ameloblast morphology  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal azygos vein morphology  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cell migration  (IAGP)
abnormal cone electrophysiology  (IEA)
abnormal cornea morphology  (IAGP)
abnormal corneal endothelium morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal digestive system development  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal enamel development  (IAGP)
abnormal enamel mineralization  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal enamel rod pattern  (IAGP)
abnormal extraocular muscle morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eye distance/ position  (IAGP)
abnormal eye electrophysiology  (IEA)
abnormal eye morphology  (IAGP)
abnormal eye muscle development  (IAGP)
abnormal eye muscle morphology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal facial muscle morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal fibula morphology  (IAGP)
abnormal heart and great artery attachment  (IAGP)
abnormal heart and great vessel attachment  (IAGP)
abnormal heart atrium morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left atrium auricular region morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart position or orientation  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hepatic portal vein morphology  (IAGP)
abnormal Hertwig epithelial root sheath morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal incisor color  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal interatrial septum morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal intraocular muscle morphology  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal iris pigmentation  (IEA)
abnormal left-right axis patterning  (IAGP)
abnormal lens development  (IAGP)
abnormal lens epithelium morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal molar crown morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal molar root morphology  (IAGP)
abnormal nervous system tract morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal optic disk morphology  (IEA)
abnormal optic fissure closure  (IAGP)
abnormal optic stalk morphology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal periorbital region morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal placement of pupils  (IAGP)
abnormal pupil morphology  (IAGP)
abnormal Rathke's pouch apoptosis  (IAGP)
abnormal Rathke's pouch development  (IAGP)
abnormal retina layer morphology  (IEA)
abnormal retina pigmentation  (IAGP)
abnormal rib development  (IAGP)
abnormal rod electrophysiology  (IEA)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal stomach position or orientation  (IAGP)
abnormal superior vena cava morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal vein morphology  (IAGP)
abnormal vena cava morphology  (IAGP)
abnormal ventral body wall morphology  (IAGP)
absent ciliary body  (IAGP)
absent corneal endothelium  (IAGP)
absent coronary sinus  (IAGP)
absent extraocular muscles  (IAGP)
absent eye anterior chamber  (IAGP)
absent femur  (IAGP)
absent gonadotrophs  (IAGP)
absent optic nerve  (IAGP)
absent sclera  (IAGP)
absent tibia  (IAGP)
absent trabecular meshwork  (IAGP)
adenohypophysis hypoplasia  (IAGP)
anisocoria  (IAGP)
anomalous pulmonary venous connection  (IAGP)
anophthalmia  (IAGP)
anterior iris synechia  (IEA)
arrest of tooth development  (IAGP)
atrial fibrillation  (IAGP)
atrial septal defect  (IAGP)
atrioventricular septal defect  (IAGP)
axial mesoderm hypoplasia  (IAGP)
cataract  (IAGP)
cleft palate  (IAGP)
common atrioventricular valve  (IAGP)
common atrium  (IAGP)
corneal opacity  (IAGP)
cyanosis  (IAGP)
decreased b-wave amplitude  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased corneal stroma thickness  (IAGP)
decreased embryo size  (IAGP)
decreased follicle stimulating hormone level  (IAGP)
decreased luteinizing hormone level  (IAGP)
decreased molar number  (IAGP)
decreased somatotroph cell number  (IAGP)
decreased thyrotroph cell number  (IAGP)
decreased total retina thickness  (IEA)
delayed optic fissure closure  (IAGP)
dextrocardia  (IAGP)
double aortic arch  (IAGP)
double outlet right ventricle  (IAGP)
double outlet right ventricle with atrioventricular septal defect  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged eye anterior chamber  (IEA)
enlarged heart  (IAGP)
enophthalmos  (IAGP)
exencephaly  (IAGP)
failure of atrioventricular cushion closure  (IAGP)
heart right ventricle hypoplasia  (IAGP)
incomplete embryo turning  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased corneal epithelium thickness  (IAGP)
increased grip strength  (IEA)
increased heart left atrium size  (IAGP)
iris hypoplasia  (IAGP)
irregular heartbeat  (IAGP)
irregularly shaped pupil  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lordosis  (IAGP)
macrophthalmia  (IEA)
malocclusion  (IAGP)
microphthalmia  (IAGP)
misaligned incisors  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertension  (IEA)
oligodactyly  (IAGP)
omphalocele  (IAGP)
optic nerve cupping  (IEA)
pituitary gland hypoplasia  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality  (IEA)
preweaning lethality, complete penetrance  (IEA)
prolonged QRS complex duration  (IAGP)
reduced enamel thickness  (IAGP)
right aortic arch  (IAGP)
right atrial isomerism  (IAGP)
right pulmonary isomerism  (IAGP)
situs inversus  (IAGP)
small hindlimb buds  (IAGP)
small lens  (IAGP)
small limb buds  (IAGP)
small Meckel's cartilage  (IAGP)
small Rathke's pouch  (IAGP)
small spleen  (IAGP)
small testis  (IEA)
small thyroid gland  (IAGP)
splayed ribs  (IAGP)
spleen hypoplasia  (IAGP)
supernumerary teeth  (IAGP)
supravalvar pulmonary trunk stenosis  (IAGP)
taurodontia  (IAGP)
thoracoabdominoschisis  (IAGP)
transposition of great arteries  (IAGP)
ventricular hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Arts syndrome is caused by loss-of-function mutations in PRPS1. de Brouwer AP, etal., Am J Hum Genet. 2007 Sep;81(3):507-18. Epub 2007 Aug 3.
2. Involvement of Pitx2, a homeodomain transcription factor, in hypothyroidism associated reproductive disorders. Ghosh P, etal., Cell Physiol Biochem. 2007;20(6):887-98.
3. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Ito Y, etal., Development. 2003 Nov;130(21):5269-80.
4. A novel PITX2 mutation and a polymorphism in a 5-generation family with Axenfeld-Rieger anomaly and coexisting Fuchs' endothelial dystrophy. Kniestedt C, etal., Ophthalmology. 2006 Oct;113(10):1791.e1-8. Epub 2006 Jul 31.
5. Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling. Kugita M, etal., Am J Physiol Renal Physiol. 2011 Jan;300(1):F177-88. Epub 2010 Oct 6.
6. A novel PITX2 mutation in a Chinese family with Axenfeld-Rieger syndrome. Li D, etal., Mol Vis. 2008;14:2205-10. Epub 2008 Dec 5.
7. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Lu MF, etal., Nature 1999 Sep 16;401(6750):276-8.
8. Pitx2-mediated cardiac outflow tract remodeling. Ma HY, etal., Dev Dyn. 2013 May;242(5):456-68. doi: 10.1002/dvdy.23934. Epub 2013 Mar 12.
9. lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Meno C, etal., Cell 1998 Aug 7;94(3):287-97.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1303248   PMID:7581385   PMID:7760812   PMID:8751862   PMID:8944018   PMID:9026314   PMID:9147650   PMID:9299120   PMID:9347917   PMID:9539779   PMID:9541211   PMID:9707115  
PMID:9708732   PMID:9708733   PMID:9708734   PMID:9716414   PMID:9889116   PMID:9922405   PMID:9988215   PMID:10021341   PMID:10049363   PMID:10098408   PMID:10220415   PMID:10349636  
PMID:10373301   PMID:10385121   PMID:10395790   PMID:10411502   PMID:10415326   PMID:10498698   PMID:10499586   PMID:10500184   PMID:10521397   PMID:10545241   PMID:10572050   PMID:10574770  
PMID:10585561   PMID:10603343   PMID:10603349   PMID:10625557   PMID:10660670   PMID:10677256   PMID:10700179   PMID:10809672   PMID:10822271   PMID:10861284   PMID:11042159   PMID:11076861  
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PMID:25315894   PMID:25377219   PMID:25428587   PMID:25451153   PMID:25482882   PMID:25511461   PMID:25645944   PMID:25668206   PMID:25715397   PMID:25888893   PMID:25896281   PMID:25912687  
PMID:25915474   PMID:26055324   PMID:26057579   PMID:26208718   PMID:26243430   PMID:26295701   PMID:26321200   PMID:26387456   PMID:26411685   PMID:26439398   PMID:26525672   PMID:26674308  
PMID:26718003   PMID:26801181   PMID:26968737   PMID:26984772   PMID:27180262   PMID:27226320   PMID:27251288   PMID:27270438   PMID:27272319   PMID:27305836   PMID:27369589   PMID:27582060  
PMID:27606604   PMID:27626380   PMID:27631552   PMID:27654429   PMID:27660324   PMID:27697592   PMID:27699212   PMID:27701636   PMID:27771509   PMID:27798109   PMID:27927890   PMID:27934886  
PMID:28174244   PMID:28250050   PMID:28253399   PMID:28346476   PMID:28494873   PMID:28538179   PMID:28639940   PMID:28669819   PMID:28807898   PMID:28854362   PMID:29028795   PMID:29194452  
PMID:29273440   PMID:29292502   PMID:29509905   PMID:29641992   PMID:29650695   PMID:29796621   PMID:29992973   PMID:30063881   PMID:30070635   PMID:30106373   PMID:30134070   PMID:30143541  
PMID:30174180   PMID:30237319   PMID:30254276   PMID:30286078   PMID:30352686   PMID:30366904   PMID:30414844   PMID:30570432   PMID:30692221   PMID:30872278   PMID:30894556   PMID:30959515  
PMID:30982661   PMID:31024075   PMID:31107948   PMID:31201182   PMID:31226309   PMID:31340933   PMID:31427537   PMID:31474533   PMID:31636200   PMID:31678627   PMID:31688894   PMID:31845891  
PMID:31850343   PMID:31887266   PMID:32034090   PMID:32105214   PMID:32439755   PMID:32620779   PMID:32662771   PMID:32714157   PMID:32760291   PMID:32814717   PMID:32868762   PMID:33053343  
PMID:33171097   PMID:33201874   PMID:33529466   PMID:33587761   PMID:33846290   PMID:33869166   PMID:33887179   PMID:33905720   PMID:34003541   PMID:34095148   PMID:34318750   PMID:34383890  
PMID:34518367   PMID:34715025   PMID:34716303   PMID:34818545   PMID:34861058   PMID:34988124   PMID:34994686   PMID:35044906   PMID:35127681   PMID:35471998   PMID:35700056   PMID:35831953  
PMID:35853870   PMID:35872015   PMID:35874842   PMID:35944701   PMID:36108627   PMID:36137018   PMID:36476860   PMID:36476878   PMID:37080203   PMID:37081156   PMID:37180804   PMID:37267426  
PMID:37532091   PMID:37806494   PMID:37852253   PMID:38344749   PMID:38404688  


Genomics

Comparative Map Data
Pitx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393128,993,527 - 129,013,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3128,993,527 - 129,013,240 (+)EnsemblGRCm39 Ensembl
GRCm383129,199,878 - 129,219,594 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,199,878 - 129,219,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv373128,902,836 - 128,922,509 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,191,965 - 129,211,613 (+)NCBIMGSCv36mm8
Celera3135,706,515 - 135,726,130 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.84NCBI
PITX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,617,423 - 110,642,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4110,617,423 - 110,642,123 (-)EnsemblGRCh38hg38GRCh38
GRCh374111,538,579 - 111,563,279 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,758,028 - 111,777,957 (-)NCBINCBI36Build 36hg18NCBI36
Build 344111,896,185 - 111,916,112NCBI
Celera4108,832,403 - 108,852,329 (-)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4107,270,120 - 107,294,817 (-)NCBIHuRef
CHM1_14111,515,486 - 111,540,182 (-)NCBICHM1_1
T2T-CHM13v2.04113,919,284 - 113,943,981 (-)NCBIT2T-CHM13v2.0
Pitx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,391,417 - 220,411,588 (+)NCBIGRCr8
mRatBN7.22217,717,738 - 217,737,293 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,717,693 - 217,737,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,392,106 - 225,411,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,291,763 - 223,311,312 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,149,443 - 218,168,994 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,602,732 - 233,621,129 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Celera2210,013,296 - 210,033,592 (+)NCBICelera
Cytogenetic Map2q42NCBI
Pitx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545715,803,219 - 15,823,310 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545715,803,493 - 15,823,193 (+)NCBIChiLan1.0ChiLan1.0
PITX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,707,912 - 108,728,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14109,000,309 - 109,020,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04103,112,624 - 103,137,356 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14113,676,846 - 113,696,518 (-)NCBIpanpan1.1PanPan1.1panPan2
PITX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,710,161 - 30,730,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,710,685 - 30,730,273 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,306,508 - 11,326,539 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,931,178 - 30,951,191 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,931,702 - 30,947,061 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,916,988 - 30,937,021 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,667,533 - 30,687,592 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,167,168 - 9,187,192 (+)NCBIUU_Cfam_GSD_1.0
Pitx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,214,001 - 10,237,701 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365631,713,294 - 1,732,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PITX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,698,757 - 111,723,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18111,697,364 - 111,723,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,906,708 - 119,926,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PITX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1758,501,669 - 58,526,413 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl758,501,559 - 58,507,318 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603737,182,289 - 37,203,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pitx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248384,871,511 - 4,886,384 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248384,872,279 - 4,889,780 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pitx2
602 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3206
Count of miRNA genes:772
Interacting mature miRNAs:1019
Transcripts:ENSMUST00000029657, ENSMUST00000042587, ENSMUST00000106382, ENSMUST00000172645, ENSMUST00000173645, ENSMUST00000174623, ENSMUST00000174661
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
26884415Bzwq11_mbi-zygomatic width QTL 11, 16 week (mouse)3124993649137205761Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse

Markers in Region
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv373128,921,310 - 128,921,542UniSTSGRCm37
MGSCv373128,922,009 - 128,922,050UniSTSGRCm37
Celera3135,724,931 - 135,725,163UniSTS
Celera3135,725,630 - 135,725,671UniSTS
Cytogenetic Map3G3UniSTS
cM Map357.7UniSTS
PITX2_380  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383129,218,744 - 129,219,598UniSTSGRCm38
MGSCv373128,921,662 - 128,922,516UniSTSGRCm37
Celera3135,725,283 - 135,726,137UniSTS
Cytogenetic Map3G3UniSTS
cM Map357.7UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383129,218,392 - 129,218,624UniSTSGRCm38
MGSCv373128,921,310 - 128,921,542UniSTSGRCm37
Celera3135,724,931 - 135,725,163UniSTS
Cytogenetic Map3G3UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383129,219,091 - 129,219,132UniSTSGRCm38
MGSCv373128,922,009 - 128,922,050UniSTSGRCm37
Celera3135,725,630 - 135,725,671UniSTS
Cytogenetic Map3G3UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
Pitx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001042504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB006320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB006321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF048723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF048724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF201091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ243597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM940438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AM940439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV306733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB626986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY775551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ177526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC342809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U70132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U80036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000029657   ⟹   ENSMUSP00000029657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3128,993,571 - 129,013,227 (+)Ensembl
GRCm38.p6 Ensembl3129,199,922 - 129,219,578 (+)Ensembl
RefSeq Acc Id: ENSMUST00000042587   ⟹   ENSMUSP00000047359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,007,621 - 129,013,237 (+)Ensembl
GRCm38.p6 Ensembl3129,213,972 - 129,219,588 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106382   ⟹   ENSMUSP00000101990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3128,993,575 - 129,013,240 (+)Ensembl
GRCm38.p6 Ensembl3129,199,926 - 129,219,591 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172645   ⟹   ENSMUSP00000134692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3128,997,596 - 129,012,546 (+)Ensembl
GRCm38.p6 Ensembl3129,203,947 - 129,218,897 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173645   ⟹   ENSMUSP00000134301
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3128,993,618 - 128,998,226 (+)Ensembl
GRCm38.p6 Ensembl3129,199,969 - 129,204,577 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174623   ⟹   ENSMUSP00000139328
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,007,924 - 129,010,273 (+)Ensembl
GRCm38.p6 Ensembl3129,214,275 - 129,216,624 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174661   ⟹   ENSMUSP00000133756
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3128,993,527 - 129,013,239 (+)Ensembl
GRCm38.p6 Ensembl3129,199,878 - 129,219,590 (+)Ensembl
RefSeq Acc Id: ENSMUST00000187145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3129,007,581 - 129,010,423 (+)Ensembl
GRCm38.p6 Ensembl3129,213,932 - 129,216,774 (+)Ensembl
RefSeq Acc Id: NM_001042502   ⟹   NP_001035967
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,007,581 - 129,013,243 (+)NCBI
GRCm383129,213,932 - 129,219,594 (+)NCBI
MGSCv373128,902,836 - 128,922,509 (+)RGD
Celera3135,706,475 - 135,726,133 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001042504   ⟹   NP_001035969
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393128,993,527 - 129,013,243 (+)NCBI
GRCm383129,199,878 - 129,219,594 (+)NCBI
MGSCv373128,902,836 - 128,922,509 (+)RGD
Celera3135,706,475 - 135,726,133 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286942   ⟹   NP_001273871
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393128,993,527 - 129,013,243 (+)NCBI
GRCm383129,199,878 - 129,219,594 (+)NCBI
Celera3135,706,475 - 135,726,133 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001287048   ⟹   NP_001273977
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393129,007,581 - 129,013,243 (+)NCBI
GRCm383129,213,932 - 129,219,594 (+)NCBI
Celera3135,706,475 - 135,726,133 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011098   ⟹   NP_035228
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393128,993,527 - 129,013,243 (+)NCBI
GRCm383129,199,878 - 129,219,594 (+)NCBI
MGSCv373128,902,836 - 128,922,509 (+)RGD
Celera3135,706,475 - 135,726,133 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501131   ⟹   XP_006501194
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393128,997,003 - 129,013,243 (+)NCBI
GRCm383129,203,353 - 129,219,594 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501132   ⟹   XP_006501195
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393128,997,009 - 129,013,243 (+)NCBI
GRCm383129,203,360 - 129,219,594 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501133   ⟹   XP_006501196
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393128,996,926 - 129,013,243 (+)NCBI
GRCm383129,202,799 - 129,219,594 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001035967 (Get FASTA)   NCBI Sequence Viewer  
  NP_001035969 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273871 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273977 (Get FASTA)   NCBI Sequence Viewer  
  NP_035228 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501194 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501195 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501196 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB38505 (Get FASTA)   NCBI Sequence Viewer  
  AAB38864 (Get FASTA)   NCBI Sequence Viewer  
  AAC40086 (Get FASTA)   NCBI Sequence Viewer  
  AAC40087 (Get FASTA)   NCBI Sequence Viewer  
  AAC53119 (Get FASTA)   NCBI Sequence Viewer  
  AAC53120 (Get FASTA)   NCBI Sequence Viewer  
  AAF44618 (Get FASTA)   NCBI Sequence Viewer  
  AAH75660 (Get FASTA)   NCBI Sequence Viewer  
  BAA75247 (Get FASTA)   NCBI Sequence Viewer  
  BAA75248 (Get FASTA)   NCBI Sequence Viewer  
  BAC28939 (Get FASTA)   NCBI Sequence Viewer  
  CAB65259 (Get FASTA)   NCBI Sequence Viewer  
  CAP79627 (Get FASTA)   NCBI Sequence Viewer  
  CAP91067 (Get FASTA)   NCBI Sequence Viewer  
  CDM63603 (Get FASTA)   NCBI Sequence Viewer  
  EDL12244 (Get FASTA)   NCBI Sequence Viewer  
  EDL12245 (Get FASTA)   NCBI Sequence Viewer  
  EDL12246 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000029657.10
  ENSMUSP00000047359
  ENSMUSP00000047359.10
  ENSMUSP00000101990
  ENSMUSP00000101990.5
  ENSMUSP00000133756
  ENSMUSP00000133756.2
  ENSMUSP00000134301.3
  ENSMUSP00000134692
  ENSMUSP00000134692.2
  ENSMUSP00000139328.2
GenBank Protein P97474 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_035228   ⟸   NM_011098
- Peptide Label: isoform b
- UniProtKB: Q9R1V9 (UniProtKB/Swiss-Prot),   Q9QXB8 (UniProtKB/Swiss-Prot),   Q9JLA0 (UniProtKB/Swiss-Prot),   P97933 (UniProtKB/Swiss-Prot),   O70336 (UniProtKB/Swiss-Prot),   O08646 (UniProtKB/Swiss-Prot),   Q9Z141 (UniProtKB/Swiss-Prot),   P97474 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001035969   ⟸   NM_001042504
- Peptide Label: isoform a
- UniProtKB: P97474 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001035967   ⟸   NM_001042502
- Peptide Label: isoform c
- UniProtKB: Q6DIA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273871   ⟸   NM_001286942
- Peptide Label: isoform d
- UniProtKB: B1VD84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273977   ⟸   NM_001287048
- Peptide Label: isoform e
- UniProtKB: B1VD85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501196   ⟸   XM_006501133
- Peptide Label: isoform X2
- UniProtKB: P97474 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501194   ⟸   XM_006501131
- Peptide Label: isoform X1
- UniProtKB: Q9R1V9 (UniProtKB/Swiss-Prot),   Q9QXB8 (UniProtKB/Swiss-Prot),   Q9JLA0 (UniProtKB/Swiss-Prot),   P97933 (UniProtKB/Swiss-Prot),   O70336 (UniProtKB/Swiss-Prot),   O08646 (UniProtKB/Swiss-Prot),   Q9Z141 (UniProtKB/Swiss-Prot),   P97474 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501195   ⟸   XM_006501132
- Peptide Label: isoform X2
- UniProtKB: P97474 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000029657   ⟸   ENSMUST00000029657
RefSeq Acc Id: ENSMUSP00000134692   ⟸   ENSMUST00000172645
RefSeq Acc Id: ENSMUSP00000101990   ⟸   ENSMUST00000106382
RefSeq Acc Id: ENSMUSP00000139328   ⟸   ENSMUST00000174623
RefSeq Acc Id: ENSMUSP00000133756   ⟸   ENSMUST00000174661
RefSeq Acc Id: ENSMUSP00000047359   ⟸   ENSMUST00000042587
RefSeq Acc Id: ENSMUSP00000134301   ⟸   ENSMUST00000173645
Protein Domains
Homeobox   OAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97474-F1-model_v2 AlphaFold P97474 1-317 view protein structure

Promoters
RGD ID:6834245
Promoter ID:MM_KWN:36066
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:NM_011098,   UC008RHV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363128,902,456 - 128,903,187 (+)MPROMDB
RGD ID:6834247
Promoter ID:MM_KWN:36067
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:NM_001042502,   UC008RHW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363128,916,811 - 128,917,642 (+)MPROMDB
RGD ID:6847757
Promoter ID:MM_ACW:33266
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Spleen
Transcripts:PITX2.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363128,917,836 - 128,918,907 (+)MPROMDB
RGD ID:6882336
Promoter ID:EPDNEW_M4619
Type:initiation region
Name:Pitx2_2
Description:Mus musculus paired-like homeodomain transcription factor 2 ,transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4620  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383129,199,937 - 129,199,997EPDNEW
RGD ID:6882338
Promoter ID:EPDNEW_M4620
Type:multiple initiation site
Name:Pitx2_1
Description:Mus musculus paired-like homeodomain transcription factor 2 ,transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4619  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383129,213,958 - 129,214,018EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109340 AgrOrtholog
Ensembl Genes ENSMUSG00000028023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029657.16 UniProtKB/TrEMBL
  ENSMUST00000042587 ENTREZGENE
  ENSMUST00000042587.12 UniProtKB/Swiss-Prot
  ENSMUST00000106382 ENTREZGENE
  ENSMUST00000106382.11 UniProtKB/Swiss-Prot
  ENSMUST00000172645 ENTREZGENE
  ENSMUST00000172645.8 UniProtKB/Swiss-Prot
  ENSMUST00000173645.4 UniProtKB/TrEMBL
  ENSMUST00000174623.3 UniProtKB/TrEMBL
  ENSMUST00000174661 ENTREZGENE
  ENSMUST00000174661.9 UniProtKB/Swiss-Prot
Gene3D-CATH Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_Pitx/unc30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18741 UniProtKB/Swiss-Prot
MGD MGI:109340 ENTREZGENE
NCBI Gene 18741 ENTREZGENE
PANTHER PITUITARY HOMEOBOX 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PITUITARY HOMEOBOX HOMOLOG PTX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PITX2 RGD
PhenoGen Pitx2 PhenoGen
PIRSF Homeobox_protein_Pitx/Unc30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1VD84 ENTREZGENE, UniProtKB/TrEMBL
  B1VD85 ENTREZGENE, UniProtKB/TrEMBL
  G3UZ11_MOUSE UniProtKB/TrEMBL
  G3X8Y9_MOUSE UniProtKB/TrEMBL
  O08646 ENTREZGENE
  O70336 ENTREZGENE
  P97474 ENTREZGENE
  P97933 ENTREZGENE
  PITX2_MOUSE UniProtKB/Swiss-Prot
  Q6DIA6 ENTREZGENE, UniProtKB/TrEMBL
  Q8BS64_MOUSE UniProtKB/TrEMBL
  Q9JLA0 ENTREZGENE
  Q9QXB8 ENTREZGENE
  Q9R1V9 ENTREZGENE
  Q9Z141 ENTREZGENE
UniProt Secondary O08646 UniProtKB/Swiss-Prot
  O70336 UniProtKB/Swiss-Prot
  P97933 UniProtKB/Swiss-Prot
  Q9JLA0 UniProtKB/Swiss-Prot
  Q9QXB8 UniProtKB/Swiss-Prot
  Q9R1V9 UniProtKB/Swiss-Prot
  Q9Z141 UniProtKB/Swiss-Prot