Kit (KIT proto-oncogene receptor tyrosine kinase) - Rat Genome Database

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Gene: Kit (KIT proto-oncogene receptor tyrosine kinase) Mus musculus
Symbol: Kit
Name: KIT proto-oncogene receptor tyrosine kinase
RGD ID: 731383
Description: Enables SH2 domain binding activity; protease binding activity; and stem cell factor receptor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; erythropoietin-mediated signaling pathway; and hemopoiesis. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; hematopoietic stem cell migration; and positive regulation of mast cell proliferation. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study gastrointestinal stromal tumor; macrocytic anemia; mastocytosis; and piebaldism. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: belly; belly-spot; Bs; c-KI; c-KIT; c-kit proto-oncogene protein; CD117; dominant spotting; Dominant white spotting; Fdc; Gsfs; Gsfsco1; Gsfsco5; Gsfsow3; kit oncogene; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SC; SCFR; SCO1; SCO5; SO; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-k; Tr-kit; tyrosine-protein kinase Kit; W
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39575,735,647 - 75,817,382 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl575,735,576 - 75,817,382 (+)EnsemblGRCm39 Ensembl
GRCm38575,574,987 - 75,656,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,574,916 - 75,656,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv37575,971,012 - 76,052,747 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36575,856,721 - 75,938,419 (+)NCBIMGSCv36mm8
Celera572,859,483 - 72,942,690 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map539.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
aplastic anemia  (ISO)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
congenital disorder of glycosylation type IIk  (ISO)
Constipation  (ISO)
cutaneous mastocytosis  (ISO)
diffuse cutaneous mastocytosis  (ISO)
disease of cellular proliferation  (ISO)
dysgerminoma  (ISO)
endometrial stromal sarcoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
Gastric Reperfusion Injury  (ISO)
Gastrointestinal Neoplasms  (ISO)
gastrointestinal stromal tumor  (IAGP,ISO)
gastroschisis  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
granulosa cell tumor  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematologic cancer  (ISO)
Hematologic Neoplasms  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hirschsprung's disease  (ISO)
ileus  (ISO)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
Latent Tuberculosis  (ISO)
leiomyosarcoma  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
macrocytic anemia  (IAGP)
male infertility  (ISO)
malignant mesothelioma  (ISO)
mast-cell leukemia  (ISO)
mastocytosis  (IAGP,ISO)
melanoma  (ISO)
myeloproliferative neoplasm  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
neurofibroma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
oxyphilic adenoma  (ISO)
Phyllodes Tumor  (ISO)
piebaldism  (IAGP,ISO)
primary immunodeficiency disease  (IMP)
Primitive Peripheral Neuroectodermal Tumors  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
systemic mastocytosis  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
thymoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
urticaria pigmentosa  (ISO)
uterine carcinosarcoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rg3  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
2-acetamidofluorene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetic acid  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
alvocidib  (ISO)
ammonium chloride  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromochloroacetic acid  (EXP)
busulfan  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
compound 48/80  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dextromethorphan  (EXP)
Diacetoxyscirpenol  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
endrin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (EXP)
fenvalerate  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
ibuprofen  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
maneb  (ISO)
masitinib  (EXP,ISO)
mechlorethamine  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morin  (ISO)
N,O-dimethyltyramine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitrofen  (ISO)
orantinib  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pexidartinib  (ISO)
phosgene  (EXP)
pifithrin-?  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium iodide  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rosmarinic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simazine  (EXP)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
T-2 toxin  (ISO)
tanespimycin  (ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
uranium atom  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
B cell differentiation  (IBA)
cell chemotaxis  (ISO)
cell differentiation  (TAS)
cell population proliferation  (IGI)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
chemotaxis  (TAS)
cytokine-mediated signaling pathway  (IDA,ISO)
detection of mechanical stimulus involved in sensory perception of sound  (IMP)
developmental pigmentation  (IGI,IMP)
digestive tract development  (IMP)
ectopic germ cell programmed cell death  (IGI,IMP)
embryonic hemopoiesis  (IMP)
epithelial cell proliferation  (ISO)
erythrocyte differentiation  (IMP,TAS)
erythropoietin-mediated signaling pathway  (IMP)
Fc receptor signaling pathway  (ISO)
germ cell development  (TAS)
germ cell migration  (ISO)
glycosphingolipid metabolic process  (IMP)
hematopoietic progenitor cell differentiation  (IBA)
hematopoietic stem cell migration  (IMP)
hemopoiesis  (IMP)
immature B cell differentiation  (IMP)
inflammatory response  (IMP)
intracellular signal transduction  (IDA)
Kit signaling pathway  (IBA,ISO)
lamellipodium assembly  (IDA)
lymphoid progenitor cell differentiation  (IGI)
male gonad development  (ISO)
mast cell chemotaxis  (ISO)
mast cell degranulation  (ISO)
mast cell differentiation  (IMP)
mast cell proliferation  (IGI)
megakaryocyte development  (IMP)
melanocyte adhesion  (IDA)
melanocyte differentiation  (IMP)
melanocyte migration  (IMP)
myeloid progenitor cell differentiation  (IGI)
negative regulation of developmental process  (IMP)
negative regulation of programmed cell death  (IGI,IMP)
negative regulation of reproductive process  (IMP)
ovarian follicle development  (IMP)
peptidyl-tyrosine phosphorylation  (ISO)
pigmentation  (IGI,IMP)
positive regulation of cell migration  (IBA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of colon smooth muscle contraction  (ISO)
positive regulation of dendritic cell cytokine production  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell cytokine production  (ISO)
positive regulation of mast cell proliferation  (IGI)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of pyloric antrum smooth muscle contraction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,ISO)
positive regulation of small intestine smooth muscle contraction  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
programmed cell death  (IGI)
protein autophosphorylation  (ISO)
regulation of bile acid metabolic process  (ISO)
regulation of cell shape  (IDA)
response to cadmium ion  (ISO)
response to radiation  (IMP)
somatic stem cell population maintenance  (ISO)
spermatid development  (IMP)
spermatogenesis  (IMP,ISO)
stem cell differentiation  (IMP)
T cell differentiation  (IMP)
tongue development  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal body temperature  (IAGP)
abnormal caput epididymis morphology  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal circulating complement protein level  (IAGP)
abnormal circulating histamine level  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear ganglion morphology  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal ear pigmentation  (IAGP)
abnormal erythrocyte cell number  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythroid progenitor cell morphology  (IAGP)
abnormal esophagus morphology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal female germ cell morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal foot pigmentation  (IAGP)
abnormal gastrointestinal motility  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal hypodermis morphology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal internal male genitalia morphology  (IAGP)
abnormal interstitial cell of Cajal morphology  (IAGP)
abnormal intestinal peristalsis  (IAGP)
abnormal intestinal transit time  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal male reproductive system physiology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal melanoblast migration  (IAGP)
abnormal melanoblast morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal melanogenesis  (IAGP)
abnormal melanosome morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myenteric nerve plexus morphology  (IAGP)
abnormal oocyte morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal otolith morphology  (IAGP)
abnormal ovarian follicle number  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal primordial germ cell migration  (IAGP)
abnormal primordial germ cell morphology  (IAGP)
abnormal primordial ovarian follicle morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response to transplant  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermatogonia proliferation  (IAGP)
abnormal stress erythropoiesis  (IAGP)
abnormal stria vascularis morphology  (IAGP)
abnormal stria vascularis vasculature morphology  (IAGP)
abnormal strial basal cell morphology  (IAGP)
abnormal strial marginal cell morphology  (IAGP)
abnormal survival  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell number  (IAGP)
abnormal tectorial membrane morphology  (IAGP)
abnormal vascular permeability  (IAGP)
abnormal ventral coat pigmentation  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
absent coat pigmentation  (IAGP)
absent endocochlear potential  (IAGP)
absent mast cells  (IAGP)
absent oocytes  (IAGP)
absent ovarian follicles  (IAGP)
absent skin pigmentation  (IAGP)
absent strial intermediate cells  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
arrest of spermatogenesis  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
asthenozoospermia  (IAGP)
azoospermia  (IAGP)
belly blaze  (IEA)
belly spot  (IAGP)
belted  (IAGP)
cochlear ganglion degeneration  (IAGP)
cochlear hair cell degeneration  (IAGP)
constricted vagina orifice  (IEA)
deafness  (IAGP)
decreased airway responsiveness  (IAGP)
decreased B cell number  (IAGP)
decreased basophil cell number  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased Cajal-Retzius cell number  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased ear pigmentation  (IEA)
decreased epididymis weight  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fetal size  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased inflammatory response  (IAGP)
decreased litter size  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased male germ cell number  (IAGP)
decreased mast cell degranulation  (IAGP)
decreased mast cell number  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased pre-B cell number  (IAGP)
decreased primordial germ cell proliferation  (IAGP)
decreased primordial ovarian follicle number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
decreased survivor rate  (IEA)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced hypothermia  (IAGP)
decreased susceptibility to type I hypersensitivity reaction  (IAGP)
decreased tail pigmentation  (IEA)
decreased tertiary ovarian follicle number  (IAGP)
decreased testis weight  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased vascular permeability  (IAGP)
delayed female fertility  (IAGP)
diluted coat color  (IAGP)
distended abdomen  (IAGP)
distended cecum  (IAGP)
distended ileum  (IAGP)
distended stomach  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IEA)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged cecum  (IAGP)
enlarged otoliths  (IAGP)
enlarged spleen  (IAGP)
epididymis degeneration  (IAGP)
female infertility  (IAGP)
glomerular crescent  (IAGP)
glomerulonephritis  (IAGP)
head blaze  (IAGP)
head spot  (IAGP)
hepatic steatosis  (IAGP)
high mean erythrocyte cell number  (IAGP)
hyperglycemia  (IAGP)
hyperpigmentation  (IAGP)
hypopigmentation  (IAGP)
impaired behavioral response to xenobiotic  (IAGP)
impaired gastric peristalsis  (IAGP)
impaired neutrophil recruitment  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased B cell number  (IAGP)
increased basophil cell number  (IAGP)
increased bleeding time  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased erythroblast number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythrocyte protoporphyrin level  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased esophageal papilloma incidence  (IAGP)
increased gastrointestinal stromal tumor incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin content  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IAGP)
increased IgG2b level  (IAGP)
increased IgM level  (IAGP)
increased Leydig cell number  (IAGP)
increased mast cell degranulation  (IAGP)
increased mast cell number  (IAGP)
increased mean corpuscular hemoglobin  (IAGP)
increased mean corpuscular hemoglobin concentration  (IAGP)
increased mean corpuscular volume  (IAGP)
increased mean platelet volume  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased melanoma incidence  (IAGP)
increased myocardial infarct size  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased ovary adenoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased tumor growth/size  (IAGP)
increased urine protein level  (IAGP)
infertility  (IAGP)
interstitial cells of Cajal hyperplasia  (IAGP)
intestinal obstruction  (IAGP)
irregular coat pigmentation  (IAGP)
kidney inflammation  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IEA)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
low mean erythrocyte cell number  (IAGP)
macrocytic anemia  (IAGP)
macrocytosis  (IAGP)
male infertility  (IAGP)
meteorism  (IAGP)
microcytic anemia  (IEA)
mosaic coat color  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
non-pigmented tail tip  (IAGP)
obese  (IAGP)
oligozoospermia  (IAGP)
organ of Corti degeneration  (IAGP)
ovary cyst  (IAGP)
ovary hyperplasia  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
pallor  (IAGP)
peptic ulcer  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polycythemia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IEA)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
reddish skin  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
reversion by mitotic recombination  (IAGP)
sex reversal  (IAGP)
skin fibrosis  (IAGP)
slow postnatal weight gain  (IAGP)
small cecum  (IAGP)
small ovary  (IAGP)
small testis  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
testis hypoplasia  (IAGP)
thin stria vascularis  (IAGP)
thrombocytosis  (IAGP)
thymus hypoplasia  (IAGP)
tight skin  (IAGP)
true hermaphroditism  (IAGP)
variable body spotting  (IAGP)
variable depigmentation  (IAGP)
vestibular hair cell degeneration  (IAGP)
white spotting  (IAGP)

References - curated
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Additional References at PubMed
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