Kit (KIT proto-oncogene receptor tyrosine kinase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Kit (KIT proto-oncogene receptor tyrosine kinase) Mus musculus
Analyze
Symbol: Kit
Name: KIT proto-oncogene receptor tyrosine kinase
RGD ID: 731383
MGI Page MGI
Description: Enables SH2 domain binding activity; protease binding activity; and stem cell factor receptor activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; erythropoietin-mediated signaling pathway; and hemopoiesis. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; hematopoietic stem cell migration; and positive regulation of mast cell proliferation. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study gastrointestinal stromal tumor; macrocytic anemia; mastocytosis; and piebaldism. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: belly; belly-spot; Bs; c-KI; c-KIT; c-kit proto-oncogene protein; CD117; dominant spotting; Dominant white spotting; Fdc; Gsfs; Gsfsco1; Gsfsco5; Gsfsow3; kit oncogene; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SC; SCFR; SCO1; SCO5; SO; SOW3; spotted sterile male; Ssm; Steel Factor Receptor; Tr-k; Tr-kit; tyrosine-protein kinase Kit; W
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39575,735,647 - 75,817,382 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl575,735,576 - 75,817,382 (+)EnsemblGRCm39 Ensembl
GRCm38575,574,987 - 75,656,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,574,916 - 75,656,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv37575,971,012 - 76,052,747 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36575,856,721 - 75,938,419 (+)NCBIMGSCv36mm8
Celera572,859,483 - 72,942,690 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map539.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
aplastic anemia  (ISO)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
congenital disorder of glycosylation type IIk  (ISO)
Constipation  (ISO)
cutaneous mastocytosis  (ISO)
diffuse cutaneous mastocytosis  (ISO)
disease of cellular proliferation  (ISO)
dysgerminoma  (ISO)
endometrial stromal sarcoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (IMP)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
Gastric Reperfusion Injury  (ISO)
Gastrointestinal Neoplasms  (ISO)
gastrointestinal stromal tumor  (IAGP,ISO)
gastroschisis  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
granulosa cell tumor  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematologic cancer  (ISO)
Hematologic Neoplasms  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hirschsprung's disease  (ISO)
ileus  (ISO)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
Latent Tuberculosis  (ISO)
leiomyosarcoma  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
macrocytic anemia  (IAGP)
male infertility  (ISO)
malignant mesothelioma  (ISO)
mast-cell leukemia  (ISO)
mastocytosis  (IAGP,ISO)
melanoma  (ISO)
myeloproliferative neoplasm  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
neurofibroma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
oxyphilic adenoma  (ISO)
Phyllodes Tumor  (ISO)
piebaldism  (IAGP,ISO)
primary immunodeficiency disease  (IMP)
Primitive Peripheral Neuroectodermal Tumors  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
systemic mastocytosis  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
thymoma  (ISO)
Transplant Rejection  (ISO)
urinary bladder cancer  (ISO)
urticaria pigmentosa  (ISO)
uterine carcinosarcoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rg3  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
2-acetamidofluorene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetic acid  (EXP)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
alvocidib  (ISO)
ammonium chloride  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromochloroacetic acid  (EXP)
busulfan  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcitriol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
compound 48/80  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crizotinib  (ISO)
curcumin  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dextromethorphan  (EXP)
Diacetoxyscirpenol  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
endrin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (EXP)
fenvalerate  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
ibuprofen  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
maneb  (ISO)
masitinib  (EXP,ISO)
mechlorethamine  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
morin  (ISO)
N,O-dimethyltyramine  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitrofen  (ISO)
orantinib  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pexidartinib  (ISO)
phosgene  (EXP)
pifithrin-?  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium iodide  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rosmarinic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simazine  (EXP)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
T-2 toxin  (ISO)
tanespimycin  (ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiram  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
uranium atom  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
B cell differentiation  (IBA)
cell chemotaxis  (ISO)
cell differentiation  (TAS)
cell population proliferation  (IGI)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
chemotaxis  (TAS)
cytokine-mediated signaling pathway  (IDA,ISO)
detection of mechanical stimulus involved in sensory perception of sound  (IMP)
developmental pigmentation  (IGI,IMP)
digestive tract development  (IMP)
ectopic germ cell programmed cell death  (IGI,IMP)
embryonic hemopoiesis  (IMP)
epithelial cell proliferation  (ISO)
erythrocyte differentiation  (IMP,TAS)
erythropoietin-mediated signaling pathway  (IMP)
Fc receptor signaling pathway  (ISO)
germ cell development  (TAS)
germ cell migration  (ISO)
glycosphingolipid metabolic process  (IMP)
hematopoietic progenitor cell differentiation  (IBA)
hematopoietic stem cell migration  (IMP)
hemopoiesis  (IMP)
immature B cell differentiation  (IMP)
inflammatory response  (IMP)
intracellular signal transduction  (IDA)
Kit signaling pathway  (IBA,ISO)
lamellipodium assembly  (IDA)
lymphoid progenitor cell differentiation  (IGI)
male gonad development  (ISO)
mast cell chemotaxis  (ISO)
mast cell degranulation  (ISO)
mast cell differentiation  (IMP)
mast cell proliferation  (IGI)
megakaryocyte development  (IMP)
melanocyte adhesion  (IDA)
melanocyte differentiation  (IMP)
melanocyte migration  (IMP)
myeloid progenitor cell differentiation  (IGI)
negative regulation of developmental process  (IMP)
negative regulation of programmed cell death  (IGI,IMP)
negative regulation of reproductive process  (IMP)
ovarian follicle development  (IMP)
peptidyl-tyrosine phosphorylation  (ISO)
pigmentation  (IGI,IMP)
positive regulation of cell migration  (IBA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of colon smooth muscle contraction  (ISO)
positive regulation of dendritic cell cytokine production  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell cytokine production  (ISO)
positive regulation of mast cell proliferation  (IGI)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of pyloric antrum smooth muscle contraction  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,ISO)
positive regulation of small intestine smooth muscle contraction  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
programmed cell death  (IGI)
protein autophosphorylation  (ISO)
regulation of bile acid metabolic process  (ISO)
regulation of cell shape  (IDA)
response to cadmium ion  (ISO)
response to radiation  (IMP)
somatic stem cell population maintenance  (ISO)
spermatid development  (IMP)
spermatogenesis  (IMP,ISO)
stem cell differentiation  (IMP)
T cell differentiation  (IMP)
tongue development  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal B cell differentiation  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal body temperature  (IAGP)
abnormal caput epididymis morphology  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal circulating complement protein level  (IAGP)
abnormal circulating histamine level  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear ganglion morphology  (IAGP)
abnormal cochlear outer hair cell morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal ear pigmentation  (IAGP)
abnormal erythrocyte cell number  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythroid progenitor cell morphology  (IAGP)
abnormal esophagus morphology  (IAGP)
abnormal eye pigmentation  (IAGP)
abnormal female germ cell morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal foot pigmentation  (IAGP)
abnormal gastrointestinal motility  (IAGP)
abnormal hair follicle melanocyte morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal hypodermis morphology  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal internal male genitalia morphology  (IAGP)
abnormal interstitial cell of Cajal morphology  (IAGP)
abnormal intestinal peristalsis  (IAGP)
abnormal intestinal transit time  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal male reproductive system morphology  (IAGP)
abnormal male reproductive system physiology  (IAGP)
abnormal mast cell physiology  (IAGP)
abnormal melanoblast migration  (IAGP)
abnormal melanoblast morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal melanogenesis  (IAGP)
abnormal melanosome morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myenteric nerve plexus morphology  (IAGP)
abnormal oocyte morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal otolith morphology  (IAGP)
abnormal ovarian follicle number  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal primordial germ cell migration  (IAGP)
abnormal primordial germ cell morphology  (IAGP)
abnormal primordial ovarian follicle morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal response to cardiac infarction  (IAGP)
abnormal response to transplant  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal skin pigmentation  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermatogonia proliferation  (IAGP)
abnormal stress erythropoiesis  (IAGP)
abnormal stria vascularis morphology  (IAGP)
abnormal stria vascularis vasculature morphology  (IAGP)
abnormal strial basal cell morphology  (IAGP)
abnormal strial marginal cell morphology  (IAGP)
abnormal survival  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell number  (IAGP)
abnormal tectorial membrane morphology  (IAGP)
abnormal vascular permeability  (IAGP)
abnormal ventral coat pigmentation  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
absent coat pigmentation  (IAGP)
absent endocochlear potential  (IAGP)
absent mast cells  (IAGP)
absent oocytes  (IAGP)
absent ovarian follicles  (IAGP)
absent skin pigmentation  (IAGP)
absent strial intermediate cells  (IAGP)
albuminuria  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
arrest of spermatogenesis  (IAGP)
arrested B cell differentiation  (IAGP)
arrested T cell differentiation  (IAGP)
asthenozoospermia  (IAGP)
azoospermia  (IAGP)
belly blaze  (IEA)
belly spot  (IAGP)
belted  (IAGP)
cochlear ganglion degeneration  (IAGP)
cochlear hair cell degeneration  (IAGP)
constricted vagina orifice  (IEA)
deafness  (IAGP)
decreased airway responsiveness  (IAGP)
decreased B cell number  (IAGP)
decreased basophil cell number  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased Cajal-Retzius cell number  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating LDL cholesterol level  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased ear pigmentation  (IEA)
decreased epididymis weight  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased fetal size  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased inflammatory response  (IAGP)
decreased litter size  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased male germ cell number  (IAGP)
decreased mast cell degranulation  (IAGP)
decreased mast cell number  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased pre-B cell number  (IAGP)
decreased primordial germ cell proliferation  (IAGP)
decreased primordial ovarian follicle number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
decreased survivor rate  (IEA)
decreased susceptibility to induced arthritis  (IAGP)
decreased susceptibility to induced hypothermia  (IAGP)
decreased susceptibility to type I hypersensitivity reaction  (IAGP)
decreased tail pigmentation  (IEA)
decreased tertiary ovarian follicle number  (IAGP)
decreased testis weight  (IAGP)
decreased thymocyte number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor-free survival time  (IAGP)
decreased vascular permeability  (IAGP)
delayed female fertility  (IAGP)
diluted coat color  (IAGP)
distended abdomen  (IAGP)
distended cecum  (IAGP)
distended ileum  (IAGP)
distended stomach  (IAGP)
embryonic lethality before implantation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IEA)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged cecum  (IAGP)
enlarged otoliths  (IAGP)
enlarged spleen  (IAGP)
epididymis degeneration  (IAGP)
female infertility  (IAGP)
glomerular crescent  (IAGP)
glomerulonephritis  (IAGP)
head blaze  (IAGP)
head spot  (IAGP)
hepatic steatosis  (IAGP)
high mean erythrocyte cell number  (IAGP)
hyperglycemia  (IAGP)
hyperpigmentation  (IAGP)
hypopigmentation  (IAGP)
impaired behavioral response to xenobiotic  (IAGP)
impaired gastric peristalsis  (IAGP)
impaired neutrophil recruitment  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased B cell number  (IAGP)
increased basophil cell number  (IAGP)
increased bleeding time  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased erythroblast number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased erythrocyte protoporphyrin level  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased esophageal papilloma incidence  (IAGP)
increased gastrointestinal stromal tumor incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin content  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IAGP)
increased IgG2b level  (IAGP)
increased IgM level  (IAGP)
increased Leydig cell number  (IAGP)
increased mast cell degranulation  (IAGP)
increased mast cell number  (IAGP)
increased mean corpuscular hemoglobin  (IAGP)
increased mean corpuscular hemoglobin concentration  (IAGP)
increased mean corpuscular volume  (IAGP)
increased mean platelet volume  (IAGP)
increased megakaryocyte cell number  (IAGP)
increased melanoma incidence  (IAGP)
increased myocardial infarct size  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased ovary adenoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased tumor growth/size  (IAGP)
increased urine protein level  (IAGP)
infertility  (IAGP)
interstitial cells of Cajal hyperplasia  (IAGP)
intestinal obstruction  (IAGP)
irregular coat pigmentation  (IAGP)
kidney inflammation  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IEA)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
low mean erythrocyte cell number  (IAGP)
macrocytic anemia  (IAGP)
macrocytosis  (IAGP)
male infertility  (IAGP)
meteorism  (IAGP)
microcytic anemia  (IEA)
mosaic coat color  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
non-pigmented tail tip  (IAGP)
obese  (IAGP)
oligozoospermia  (IAGP)
organ of Corti degeneration  (IAGP)
ovary cyst  (IAGP)
ovary hyperplasia  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
pallor  (IAGP)
peptic ulcer  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polycythemia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IEA)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
reddish skin  (IAGP)
reduced female fertility  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
reversion by mitotic recombination  (IAGP)
sex reversal  (IAGP)
skin fibrosis  (IAGP)
slow postnatal weight gain  (IAGP)
small cecum  (IAGP)
small ovary  (IAGP)
small testis  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
testis hypoplasia  (IAGP)
thin stria vascularis  (IAGP)
thrombocytosis  (IAGP)
thymus hypoplasia  (IAGP)
tight skin  (IAGP)
true hermaphroditism  (IAGP)
variable body spotting  (IAGP)
variable depigmentation  (IAGP)
vestibular hair cell degeneration  (IAGP)
white spotting  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: identification of a human hepatic progenitor cell? Baumann U, etal., Hepatology. 1999 Jul;30(1):112-7.
2. c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma. Biermann K, etal., J Pathol. 2007 Nov;213(3):311-8.
3. A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Bodek G, etal., Neoplasia. 2005 May;7(5):497-508.
4. Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors. Chu S, etal., Gynecol Oncol. 2008 Jan;108(1):182-90. Epub 2007 Oct 29.
5. Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus. Deng JJ, etal., Acupunct Med. 2019 Apr;37(2):125-132. doi: 10.1177/0964528419829755. Epub 2019 Mar 11.
6. C-kit expression in high-risk breast cancer subgroup treated with high-dose or conventional dose-dense chemotherapy. Diallo R, etal., Verh Dtsch Ges Pathol. 2006;90:177-85.
7. c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. Edwards ST, etal., J Pathol. 2005 Jul;206(3):279-90.
8. C-kit protein expression in uterine and ovarian mesenchymal tumours. Erdogan G, etal., APMIS. 2007 Mar;115(3):204-9.
9. Expression of c-kit proto-oncogene product in breast cancer tissues. Eroglu A and Sari A, Med Oncol. 2007;24(2):169-74.
10. Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Giebel LB and Spritz RA, Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8696-9.
11. C-kit protein expression in Wilms' tumour: an immunohistochemical study. Giordano G, etal., Eur J Surg Oncol. 2009 Jun;35(6):629-35. doi: 10.1016/j.ejso.2008.09.014. Epub 2008 Nov 17.
12. Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissues. Hirota S, etal., Arch Pathol Lab Med. 1993 Oct;117(10):996-9.
13. The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium. Ko CD, etal., Clin Exp Metastasis. 2003;20(7):593-7.
14. Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors. Koelz M, etal., Int J Oncol. 2011 Feb;38(2):503-11. doi: 10.3892/ijo.2010.857. Epub 2010 Dec 3.
15. Expression of c-kit in common benign and malignant breast lesions. Kondi-Pafiti A, etal., Tumori. 2010 Nov-Dec;96(6):978-84.
16. S100A1 and KIT gene expressions in common subtypes of renal tumours. Li G, etal., Eur J Surg Oncol. 2005 Apr;31(3):299-303.
17. A distinct expression pattern and point mutation of c-kit in papillary renal cell carcinomas. Lin ZH, etal., Mod Pathol. 2004 Jun;17(6):611-6.
18. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, etal., PeerJ. 2019 Oct 31;7:e7968. doi: 10.7717/peerj.7968. eCollection 2019.
19. Lack of c-kit receptor promotes mammary tumors in N-nitrosomethylurea-treated Ws/Ws rats. Maffini MV, etal., Cancer Cell Int. 2008 Apr 29;8:5.
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
22. Gastroschisis in the rat model is associated with a delayed maturation of intestinal pacemaker cells and smooth muscle cells. Midrio P, etal., J Pediatr Surg. 2004 Oct;39(10):1541-7.
23. Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression. Montone KT, etal., Mod Pathol. 1997 Sep;10(9):939-44.
24. Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit. Morimoto M, etal., Blood. 1993 Dec 1;82(11):3315-20.
25. Elevated expression of the proto-oncogene c-kit in patients with mastocytosis. Nagata H, etal., Leukemia. 1998 Feb;12(2):175-81.
26. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nishida T, etal., Nat Genet. 1998 Aug;19(4):323-4.
27. Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus. Niwa Y, etal., Blood. 1991 Oct 15;78(8):1936-41.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. c-kit Expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications. Pan CX, etal., Mod Pathol. 2005 Mar;18(3):320-3.
30. A new c-kit mutation in a case of aggressive mast cell disease. Pignon JM, etal., Br J Haematol. 1997 Feb;96(2):374-6.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Expression of proto-oncogene c-kit receptor in rats (Rattus norvegicus) and identification of a mutant mRNA transcript implicated in spermatogenic failure. Prasanth SG and Ali S, DNA Cell Biol. 2003 Jul;22(7):447-56.
33. c-KIT expression and correlation with chemotherapy resistance in ovarian carcinoma: an immunocytochemical study. Raspollini MR, etal., Ann Oncol. 2004 Apr;15(4):594-7.
34. The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility. Ravegnini G, etal., Epigenetics. 2019 Jun;14(6):545-557. doi: 10.1080/15592294.2019.1595997. Epub 2019 Apr 13.
35. Mouse MP Annotation Import Pipeline RGD automated import pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice. Russi AE, etal., J Immunol. 2015 Jun 15;194(12):5609-13. doi: 10.4049/jimmunol.1500068. Epub 2015 May 13.
39. Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan. Sakuma Y, etal., Cancer Lett. 2008 Jan 18;259(1):119-26. Epub 2007 Nov 14.
40. Involvement of interstitial cells of Cajal in experimental severe acute pancreatitis in rats. Shi LL, etal., World J Gastroenterol. 2013;19(14):2179-86. doi: 10.3748/wjg.v19.i14.2179.
41. Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism. Spritz RA, etal., Am J Hum Genet. 1992 Feb;50(2):261-9.
42. Delayed gastric emptying and disruption of the interstitial cells of Cajal network after gastric ischaemia and reperfusion. Suzuki S, etal., Neurogastroenterol Motil. 2010 May;22(5):585-93, e126. doi: 10.1111/j.1365-2982.2009.01444.x. Epub 2009 Dec 23.
43. Activating c-kit gene mutations in human germ cell tumors. Tian Q, etal., Am J Pathol. 1999 Jun;154(6):1643-7.
44. Expression of transcription factors and precursor cell markers during regeneration of beta cells in pancreata of rats treated with streptozotocin. Tiemann K, etal., Virchows Arch. 2007 Mar;450(3):261-6. Epub 2007 Jan 18.
45. Increased c-kit (CD117) expression in malignant mammary phyllodes tumors. Tse GM, etal., Mod Pathol. 2004 Jul;17(7):827-31.
46. A loss of c-kit expression is associated with an advanced stage and poor prognosis in breast cancer. Tsutsui S, etal., Br J Cancer. 2006 Jun 19;94(12):1874-8. Epub 2006 May 23.
47. Differential gene expression in fetal mouse germ cells. Urven LE, etal., Biol Reprod 1993 Mar;48(3):564-74.
48. Interstitial cells of Cajal in human colon and in Hirschsprung's disease. Vanderwinden JM, etal., Gastroenterology. 1996 Oct;111(4):901-10.
49. Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Waskow C, etal., Immunity. 2002 Sep;17(3):277-88.
50. Expression of the c-kit proto-oncogene in rat hepatic allografts during acute rejection. Yamaguchi Y, etal., Hepatology. 1999 Jan;29(1):133-9.
51. Intestinal pacemaker C-KIT+ cells and synapses in allied Hirschsprung's disorders. Yamataka A, etal., J Pediatr Surg. 1997 Jul;32(7):1069-74.
52. miR-222 regulates cell growth, apoptosis, and autophagy of interstitial cells of Cajal isolated from slow transit constipation rats by targeting c-kit. Zheng H, etal., Indian J Gastroenterol. 2021 Apr;40(2):198-208. doi: 10.1007/s12664-020-01143-7. Epub 2021 Apr 1.
Additional References at PubMed
PMID:28803   PMID:42904   PMID:367470   PMID:389712   PMID:469221   PMID:469229   PMID:536714   PMID:590660   PMID:658175   PMID:779174   PMID:892229   PMID:1183807  
PMID:1280449   PMID:1280558   PMID:1280559   PMID:1280935   PMID:1281492   PMID:1282111   PMID:1310954   PMID:1315306   PMID:1370584   PMID:1370639   PMID:1371080   PMID:1371359  
PMID:1372540   PMID:1372902   PMID:1374037   PMID:1374104   PMID:1374312   PMID:1374350   PMID:1376329   PMID:1377625   PMID:1378327   PMID:1378413   PMID:1379243   PMID:1380168  
PMID:1381627   PMID:1381628   PMID:1382631   PMID:1382713   PMID:1440585   PMID:1454829   PMID:1490901   PMID:1493857   PMID:1533802   PMID:1559233   PMID:1614869   PMID:1647018  
PMID:1673105   PMID:1683707   PMID:1685988   PMID:1686280   PMID:1688471   PMID:1692559   PMID:1693331   PMID:1698553   PMID:1698557   PMID:1698611   PMID:1699718   PMID:1707031  
PMID:1709486   PMID:1710023   PMID:1711568   PMID:1712289   PMID:1712701   PMID:1713863   PMID:1714375   PMID:1714377   PMID:1715096   PMID:1717995   PMID:1720867   PMID:1726043  
PMID:1726456   PMID:1726563   PMID:1754391   PMID:1764248   PMID:1782869   PMID:1787005   PMID:1793671   PMID:1811937   PMID:1846043   PMID:1869533   PMID:1924386   PMID:1979024  
PMID:2022965   PMID:2069871   PMID:2133555   PMID:2247150   PMID:2341029   PMID:2380119   PMID:2456920   PMID:2457811   PMID:2458842   PMID:2460075   PMID:2480529   PMID:2565278  
PMID:2612372   PMID:2895445   PMID:3007997   PMID:3085740   PMID:3200849   PMID:3297105   PMID:3384223   PMID:3618172   PMID:3708055   PMID:3910518   PMID:4067076   PMID:4337905  
PMID:4392283   PMID:4404581   PMID:4595403   PMID:4596202   PMID:4696472   PMID:4761674   PMID:4869340   PMID:4870185   PMID:4876023   PMID:4920403   PMID:5424503   PMID:5473311  
PMID:5529676   PMID:5661165   PMID:5929249   PMID:6031677   PMID:6031678   PMID:6127714   PMID:6279728   PMID:6352297   PMID:6352298   PMID:6510711   PMID:6628990   PMID:6696991  
PMID:6863898   PMID:6971254   PMID:7000343   PMID:7117838   PMID:7274658   PMID:7380470   PMID:7508100   PMID:7509015   PMID:7509207   PMID:7513208   PMID:7513517   PMID:7513835  
PMID:7514200   PMID:7514900   PMID:7515099   PMID:7515715   PMID:7515811   PMID:7519481   PMID:7520149   PMID:7520886   PMID:7521050   PMID:7521281   PMID:7522185   PMID:7524330  
PMID:7528277   PMID:7529964   PMID:7530333   PMID:7531500   PMID:7532131   PMID:7534619   PMID:7536655   PMID:7537079   PMID:7537231   PMID:7537375   PMID:7537638   PMID:7538451  
PMID:7540588   PMID:7541320   PMID:7542059   PMID:7542761   PMID:7545201   PMID:7545788   PMID:7552996   PMID:7565742   PMID:7579892   PMID:7587381   PMID:7619726   PMID:7621074  
PMID:7678927   PMID:7680877   PMID:7681989   PMID:7682073   PMID:7682413   PMID:7683286   PMID:7683920   PMID:7686505   PMID:7686845   PMID:7691001   PMID:7691275   PMID:7691834  
PMID:7694702   PMID:7695919   PMID:7704626   PMID:7713516   PMID:7909665   PMID:7919654   PMID:7920028   PMID:7924983   PMID:7948002   PMID:7958926   PMID:7959767   PMID:7961179  
PMID:7992888   PMID:7999045   PMID:8006601   PMID:8034315   PMID:8041773   PMID:8043948   PMID:8050362   PMID:8058356   PMID:8136523   PMID:8157970   PMID:8200475   PMID:8221886  
PMID:8255927   PMID:8288218   PMID:8364198   PMID:8369223   PMID:8376770   PMID:8382938   PMID:8390964   PMID:8417345   PMID:8440339   PMID:8449042   PMID:8491376   PMID:8499630  
PMID:8535092   PMID:8547652   PMID:8562971   PMID:8589683   PMID:8605335   PMID:8611693   PMID:8620856   PMID:8625802   PMID:8626794   PMID:8631931   PMID:8661727   PMID:8673130  
PMID:8695840   PMID:8703124   PMID:8704204   PMID:8765479   PMID:8769478   PMID:8783939   PMID:8786143   PMID:8806824   PMID:8812411   PMID:8892610   PMID:8896402   PMID:8898216  
PMID:8903361   PMID:8951075   PMID:8962111   PMID:9006068   PMID:9058795   PMID:9062348   PMID:9062349   PMID:9064328   PMID:9075927   PMID:9142989   PMID:9178764   PMID:9183385  
PMID:9199364   PMID:9203987   PMID:9207021   PMID:9215907   PMID:9216738   PMID:9269751   PMID:9324354   PMID:9368764   PMID:9405100   PMID:9409486   PMID:9416832   PMID:9431802  
PMID:9434954   PMID:9438424   PMID:9440696   PMID:9472924   PMID:9488729   PMID:9493833   PMID:9510032   PMID:9510253   PMID:9511739   PMID:9527878   PMID:9540971   PMID:9558284  
PMID:9575306   PMID:9590173   PMID:9607807   PMID:9620281   PMID:9645225   PMID:9700464   PMID:9778516   PMID:9802970   PMID:9811459   PMID:9811881   PMID:9814978   PMID:9846489  
PMID:9851691   PMID:9872323   PMID:9988212   PMID:10029587   PMID:10036976   PMID:10079228   PMID:10082294   PMID:10090150   PMID:10210438   PMID:10229862   PMID:10349636   PMID:10364428  
PMID:10365813   PMID:10389693   PMID:10397738   PMID:10452990   PMID:10477673   PMID:10497345   PMID:10515869   PMID:10525351   PMID:10542373   PMID:10560917   PMID:10611339   PMID:10613820  
PMID:10614578   PMID:10620616   PMID:10648413   PMID:10655061   PMID:10679064   PMID:10679268   PMID:10704463   PMID:10706124   PMID:10712252   PMID:10716931   PMID:10725747   PMID:10769236  
PMID:10817584   PMID:10837915   PMID:10842060   PMID:10864470   PMID:10872802   PMID:10922068   PMID:10932191   PMID:10934234   PMID:10943840   PMID:10943842   PMID:10981960   PMID:10982396  
PMID:11027359   PMID:11042159   PMID:11076759   PMID:11076861   PMID:11084657   PMID:11085746   PMID:11109539   PMID:11114734   PMID:11118213   PMID:11124544   PMID:11146434   PMID:11156606  
PMID:11200065   PMID:11217851   PMID:11226047   PMID:11251061   PMID:11259383   PMID:11290586   PMID:11297512   PMID:11356688   PMID:11388751   PMID:11413198   PMID:11438492   PMID:11441111  
PMID:11520465   PMID:11521507   PMID:11543611   PMID:11563879   PMID:11578866   PMID:11602622   PMID:11604102   PMID:11696590   PMID:11725039   PMID:11777945   PMID:11784036   PMID:11804789  
PMID:11805142   PMID:11828013   PMID:11874911   PMID:11900972   PMID:11937563   PMID:11964302   PMID:11986385   PMID:11989784   PMID:12004082   PMID:12010880   PMID:12019292   PMID:12021251  
PMID:12036870   PMID:12051830   PMID:12060068   PMID:12060722   PMID:12080001   PMID:12135759   PMID:12140361   PMID:12149208   PMID:12163398   PMID:12165531   PMID:12170272   PMID:12208551  
PMID:12215644   PMID:12218095   PMID:12239153   PMID:12242245   PMID:12370375   PMID:12374739   PMID:12384151   PMID:12393491   PMID:12393498   PMID:12393643   PMID:12405181   PMID:12406368  
PMID:12430844   PMID:12444107   PMID:12444173   PMID:12454859   PMID:12456501   PMID:12466851   PMID:12477932   PMID:12511554   PMID:12520002   PMID:12533025   PMID:12535195   PMID:12540363  
PMID:12560232   PMID:12585235   PMID:12591275   PMID:12594828   PMID:12609607   PMID:12617826   PMID:12618313   PMID:12644274   PMID:12646235   PMID:12648490   PMID:12697809   PMID:12703978  
PMID:12714518   PMID:12714519   PMID:12753155   PMID:12754375   PMID:12761576   PMID:12773427   PMID:12780683   PMID:12781694   PMID:12805065   PMID:12810580   PMID:12816741   PMID:12817015  
PMID:12833143   PMID:12865418   PMID:12867261   PMID:12879016   PMID:12890724   PMID:12900455   PMID:12904583   PMID:12907433   PMID:12909618   PMID:13428952   PMID:14170406   PMID:14276177  
PMID:14500772   PMID:14514874   PMID:14555281   PMID:14567980   PMID:14595438   PMID:14610273   PMID:14611631   PMID:14612394   PMID:14625290   PMID:14645004   PMID:14651600   PMID:14660547  
PMID:14681479   PMID:14707129   PMID:14731133   PMID:14869351   PMID:14871802   PMID:14966572   PMID:14990792   PMID:15024050   PMID:15050750   PMID:15062057   PMID:15065000   PMID:15067077  
PMID:15067126   PMID:15126319   PMID:15128785   PMID:15138166   PMID:15158462   PMID:15162515   PMID:15166028   PMID:15172970   PMID:15178584   PMID:15199406   PMID:15211465   PMID:15226823  
PMID:15232618   PMID:15236182   PMID:15237212   PMID:15258580   PMID:15271653   PMID:15277223   PMID:15302855   PMID:15322209   PMID:15322542   PMID:15326356   PMID:15388331   PMID:15393917  
PMID:15458971   PMID:15465492   PMID:15466618   PMID:15474495   PMID:15486346   PMID:15498858   PMID:15501797   PMID:15542581   PMID:15542837   PMID:15543132   PMID:15546883   PMID:15548576  
PMID:15592099   PMID:15611228   PMID:15649271   PMID:15650768   PMID:15659488   PMID:15665828   PMID:15689535   PMID:15696191   PMID:15731517   PMID:15737933   PMID:15768389   PMID:15784538  
PMID:15820307   PMID:15840693   PMID:15840716   PMID:15845873   PMID:15857912   PMID:15893705   PMID:15894120   PMID:15899871   PMID:15909309   PMID:15914553   PMID:15937924   PMID:15938716  
PMID:15947484   PMID:15951838   PMID:15956216   PMID:15990278   PMID:16002264   PMID:16009682   PMID:16009716   PMID:16029418   PMID:16054310   PMID:16061643   PMID:16111637   PMID:16123204  
PMID:16127161   PMID:16129701   PMID:16141072   PMID:16141073   PMID:16166340   PMID:16172157   PMID:16174759   PMID:16176929   PMID:16180252   PMID:16204383   PMID:16226710   PMID:16237060  
PMID:16282458   PMID:16285014   PMID:16287714   PMID:16322423   PMID:16330751   PMID:16357321   PMID:16410786   PMID:16423887   PMID:16425238   PMID:16427619   PMID:16428769   PMID:16444258  
PMID:16455951   PMID:16456533   PMID:16461458   PMID:16461896   PMID:16467148   PMID:16482516   PMID:16493075   PMID:16498503   PMID:16516881   PMID:16533754   PMID:16540512   PMID:16547246  
PMID:16547250   PMID:16547276   PMID:16564520   PMID:16570351   PMID:16577810   PMID:16585966   PMID:16598026   PMID:16602821   PMID:16606664   PMID:16622030   PMID:16627753   PMID:16628252  
PMID:16673016   PMID:16709868   PMID:16710480   PMID:16724059   PMID:16740658   PMID:16760463   PMID:16790476   PMID:16820414   PMID:16823487   PMID:16847336   PMID:16849485   PMID:16873377  
PMID:16873664   PMID:16891301   PMID:16894356   PMID:16902192   PMID:16908864   PMID:16912273   PMID:16920970   PMID:16921386   PMID:16931795   PMID:16937373   PMID:16942767   PMID:16964442  
PMID:16966487   PMID:17016561   PMID:17035642   PMID:17038523   PMID:17060458   PMID:17069792   PMID:17071594   PMID:17079689   PMID:17101148   PMID:17114491   PMID:17142795   PMID:17151600  
PMID:17154261   PMID:17158654   PMID:17158962   PMID:17159898   PMID:17197430   PMID:17200408   PMID:17208599   PMID:17222061   PMID:17244738   PMID:17246829   PMID:17246952   PMID:17258070  
PMID:17277081   PMID:17289816   PMID:17291484   PMID:17327401   PMID:17327414   PMID:17346996   PMID:17372019   PMID:17372990   PMID:17389381   PMID:17392171   PMID:17393433   PMID:17446350  
PMID:17449582   PMID:17450126   PMID:17483298   PMID:17486547   PMID:17507395   PMID:17510199   PMID:17511665   PMID:17525259   PMID:17540343   PMID:17545544   PMID:17546038   PMID:17554062  
PMID:17554063   PMID:17562354   PMID:17595334   PMID:17599069   PMID:17600127   PMID:17611578   PMID:17612398   PMID:17616727   PMID:17625108   PMID:17643110   PMID:17654122   PMID:17658483  
PMID:17664282   PMID:17673521   PMID:17683512   PMID:17699610   PMID:17706246   PMID:17709538   PMID:17728319   PMID:17767162   PMID:17846329   PMID:17855052   PMID:17904118   PMID:17906636  
PMID:17923505   PMID:17932226   PMID:17932327   PMID:17932568   PMID:17936260   PMID:17960174   PMID:17967925   PMID:17979883   PMID:17981124   PMID:17982059   PMID:17982101   PMID:17993265  
PMID:17998392   PMID:18054864   PMID:18070933   PMID:18077429   PMID:18079585   PMID:18089649   PMID:18096611   PMID:18098338   PMID:18178831   PMID:18179858   PMID:18182570   PMID:18194151  
PMID:18243117   PMID:18250409   PMID:18258601   PMID:18258857   PMID:18287559   PMID:18300366   PMID:18304480   PMID:18308723   PMID:18321981   PMID:18342553   PMID:18346943   PMID:18354188  
PMID:18371352   PMID:18374325   PMID:18376408   PMID:18413817   PMID:18423593   PMID:18423881   PMID:18425129   PMID:18436203   PMID:18444965   PMID:18447649   PMID:18454155   PMID:18454205  
PMID:18461160   PMID:18461563   PMID:18467506   PMID:18467702   PMID:18480244   PMID:18480468   PMID:18483422   PMID:18487037   PMID:18490758   PMID:18523250   PMID:18538998   PMID:18549896  
PMID:18550708   PMID:18556249   PMID:18559478   PMID:18591675   PMID:18606918   PMID:18617288   PMID:18624775   PMID:18632627   PMID:18637732   PMID:18640116   PMID:18641651   PMID:18664516  
PMID:18668305   PMID:18671875   PMID:18684862   PMID:18684868   PMID:18697750   PMID:18703590   PMID:18714401   PMID:18725415   PMID:18753636   PMID:18757481   PMID:18768391   PMID:18768889  
PMID:18794339   PMID:18799693   PMID:18832718   PMID:18849567   PMID:18912545   PMID:18927434   PMID:18946470   PMID:18958875   PMID:18971422   PMID:18974296   PMID:18981146   PMID:18983533  
PMID:18984156   PMID:18988802   PMID:19004805   PMID:19014927   PMID:19032955   PMID:19052546   PMID:19079172   PMID:19098141   PMID:19100679   PMID:19109365   PMID:19124833   PMID:19188909  
PMID:19204665   PMID:19211811   PMID:19214986   PMID:19221036   PMID:19247970   PMID:19265199   PMID:19272526   PMID:19273598   PMID:19297327   PMID:19301398   PMID:19359421   PMID:19362019  
PMID:19369648   PMID:19375645   PMID:19380799   PMID:19403609   PMID:19409822   PMID:19414766   PMID:19427361   PMID:19443120   PMID:19447101   PMID:19451265   PMID:19453770   PMID:19473977  
PMID:19493314   PMID:19494266   PMID:19520741   PMID:19525930   PMID:19542434   PMID:19553284   PMID:19554387   PMID:19571261   PMID:19584401   PMID:19618468   PMID:19629596   PMID:19633655  
PMID:19658093   PMID:19659570   PMID:19687122   PMID:19703958   PMID:19713309   PMID:19720934   PMID:19734227   PMID:19734451   PMID:19776388   PMID:19783672   PMID:19818747   PMID:19842175  
PMID:19850030   PMID:19855129   PMID:19861442   PMID:19864318   PMID:19890981   PMID:19898466   PMID:19914172   PMID:19917283   PMID:19926877   PMID:19933217   PMID:19934022   PMID:19955520  
PMID:20004959   PMID:20018751   PMID:20023630   PMID:20024959   PMID:20035049   PMID:20038636   PMID:20042576   PMID:20042577   PMID:20053680   PMID:20063415   PMID:20074534   PMID:20083654  
PMID:20095975   PMID:20096329   PMID:20117079   PMID:20117247   PMID:20130208   PMID:20138013   PMID:20139274   PMID:20142273