EPHX2 (epoxide hydrolase 2) - Rat Genome Database

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Gene: EPHX2 (epoxide hydrolase 2) Homo sapiens
Analyze
Symbol: EPHX2
Name: epoxide hydrolase 2
RGD ID: 731054
HGNC Page HGNC:3402
Description: Enables several functions, including magnesium ion binding activity; phosphatase activity; and protein homodimerization activity. Involved in several processes, including cholesterol homeostasis; phospholipid dephosphorylation; and stilbene catabolic process. Located in cytosol and peroxisome. Implicated in coronary artery disease; familial hypercholesterolemia; and hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ABHD20; bifunctional epoxide hydrolase 2; CEH; cytosolic epoxide hydrolase; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2, cytosolic; epoxide hydrolase, soluble; SEH; soluble epoxide hydrolase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,491,143 - 27,548,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,490,781 - 27,545,564 (+)EnsemblGRCh38hg38GRCh38
GRCh37827,348,660 - 27,406,143 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,404,562 - 27,458,403 (+)NCBINCBI36Build 36hg18NCBI36
Build 34827,404,561 - 27,458,403NCBI
Celera826,308,750 - 26,362,585 (+)NCBICelera
Cytogenetic Map8p21.2-p21.1NCBI
HuRef825,893,566 - 25,947,482 (+)NCBIHuRef
CHM1_1827,550,382 - 27,604,304 (+)NCBICHM1_1
T2T-CHM13v2.0827,768,490 - 27,825,967 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
14,15-EET  (ISO)
16-alpha,17-Epoxypregn-4-ene-3,20-dione  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dichloroindophenol  (EXP)
2-(4-chloro-2-methylphenoxy)propanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,6-EET  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
6-propyl-2-thiouracil  (ISO)
8,9-EET  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
arachidonic acid  (ISO)
arsenite ion  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
aspartame  (ISO)
benzil  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (EXP)
bexarotene  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butylated hydroxyanisole  (ISO)
cadmium acetate  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
cerium trichloride  (EXP)
CGP 52608  (EXP)
CGS-21680  (ISO)
chlordecone  (ISO)
chlorobenzene  (EXP)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corn oil  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cylindrospermopsin  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dicyclanil  (ISO)
dieldrin  (ISO)
dihydroxyacetone  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
edaravone  (ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
felbamate  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (EXP)
furan  (ISO)
gemfibrozil  (EXP)
genistein  (EXP)
gentamycin  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
GW 7647  (ISO)
Heliotrine  (EXP)
Heptachlor epoxide  (ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (EXP,ISO)
icosanoid  (ISO)
indirubin-3'-monoxime  (EXP)
indometacin  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (ISO)
lanosterol  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
limonin  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
mecoprop  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naphthalene  (EXP)
nickel atom  (EXP)
nomilin  (ISO)
O-methyleugenol  (EXP)
oxycodone  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
selenium atom  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
stilbene oxide  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
Tridiphane  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urea  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zaragozic acid A  (ISO)
zinc pyrithione  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IDA,TAS)
extracellular exosome  (HDA)
peroxisomal matrix  (TAS)
peroxisome  (IBA,IDA,IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat. Corenblum MJ, etal., Hypertension. 2008 Feb;51(2):567-73. Epub 2007 Dec 17.
3. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Dorrance AM, etal., J Cardiovasc Pharmacol. 2005 Dec;46(6):842-8.
4. The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension. Dreisbach AW, etal., Am J Hypertens. 2005 Oct;18(10):1276-81.
5. Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes. Elmarakby AA, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1307-17. Epub 2011 Aug 10.
6. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Farin FM, etal., Pharmacogenetics. 2001 Nov;11(8):703-8.
7. Homozygosity for the EPHX2 K55R polymorphism increases the long-term risk of ischemic stroke in men: a study in Swedes. Fava C, etal., Pharmacogenet Genomics. 2010 Feb;20(2):94-103.
8. Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Fornage M, etal., Circulation. 2004 Jan 27;109(3):335-9. Epub 2004 Jan 19.
9. The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke. Fornage M, etal., Hum Mol Genet. 2005 Oct 1;14(19):2829-37. Epub 2005 Aug 22.
10. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
11. Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans. Gschwendtner A, etal., Stroke. 2008 May;39(5):1593-6. Epub 2008 Mar 6.
12. Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats. Honetschlagerova Z, etal., J Hypertens. 2011 Aug;29(8):1590-601.
13. Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation. Hutchens MP, etal., Resuscitation. 2008 Jan;76(1):89-94. Epub 2007 Aug 28.
14. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Imig JD, etal., Hypertension. 2005 Oct;46(4):975-81. Epub 2005 Sep 12.
15. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Inceoglu B, etal., Life Sci. 2006 Nov 10;79(24):2311-9. Epub 2006 Aug 2.
16. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Iyer A, etal., Exp Diabetes Res. 2012;2012:758614. Epub 2011 Oct 10.
17. In vivo optical imaging of revascularization after brain trauma in mice. Jia Y, etal., Microvasc Res. 2011 Jan;81(1):73-80. Epub 2010 Nov 12.
18. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. Jung O, etal., PLoS One. 2010 Aug 4;5(8):e11979.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Lee CR, etal., Hum Mol Genet. 2006 May 15;15(10):1640-9. Epub 2006 Apr 4.
21. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. Li N, etal., J Mol Cell Cardiol. 2009 Dec;47(6):835-45. Epub 2009 Aug 28.
22. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Liu JY, etal., Br J Pharmacol. 2009 Jan;156(2):284-96. Epub 2009 Jan 13.
23. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Manhiani M, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F740-8. Epub 2009 Jun 24.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. Alleviation of lung injury by glycyrrhizic acid in benzo(a)pyrene exposed rats: Probable role of soluble epoxide hydrolase and thioredoxin reductase. Qamar W, etal., Toxicology. 2012 Jan 27;291(1-3):25-31. Epub 2011 Oct 25.
28. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Revermann M, etal., Arterioscler Thromb Vasc Biol. 2010 May;30(5):909-14. Epub 2010 Mar 11.
29. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. Revermann M, etal., J Hypertens. 2009 Feb;27(2):322-31.
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
33. Sequence variation in the soluble epoxide hydrolase gene and subclinical coronary atherosclerosis: interaction with cigarette smoking. Wei Q, etal., Atherosclerosis. 2007 Jan;190(1):26-34. Epub 2006 Mar 20.
34. Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia. Zhang W, etal., J Cereb Blood Flow Metab. 2009 Aug;29(8):1475-81. Epub 2009 May 27.
Additional References at PubMed
PMID:1349227   PMID:1423213   PMID:1809223   PMID:2329521   PMID:2995393   PMID:3222228   PMID:6185139   PMID:6667124   PMID:7840649   PMID:7868134   PMID:8224376   PMID:8342951  
PMID:8619856   PMID:10862610   PMID:12107410   PMID:12477932   PMID:12574508   PMID:12574510   PMID:14634838   PMID:14673705   PMID:14702039   PMID:15096040   PMID:15196990   PMID:15489334  
PMID:15845398   PMID:16169070   PMID:16314446   PMID:16322563   PMID:16414022   PMID:16957870   PMID:17460077   PMID:17495027   PMID:17498780   PMID:17919073   PMID:18029348   PMID:18078836  
PMID:18216721   PMID:18319271   PMID:18510611   PMID:18513744   PMID:18537101   PMID:18589104   PMID:18632753   PMID:18636124   PMID:18676680   PMID:18775727   PMID:18784359   PMID:18818748  
PMID:18974052   PMID:19019335   PMID:19056867   PMID:19074885   PMID:19170196   PMID:19343046   PMID:19420105   PMID:19527514   PMID:19575027   PMID:19578796   PMID:19625176   PMID:19692168  
PMID:19704161   PMID:19814804   PMID:19913121   PMID:19940276   PMID:20140262   PMID:20178365   PMID:20237496   PMID:20379614   PMID:20485444   PMID:20628086   PMID:20819778   PMID:20888937  
PMID:21044950   PMID:21098312   PMID:21217101   PMID:21281786   PMID:21429967   PMID:21642892   PMID:21704394   PMID:21873635   PMID:21988832   PMID:22199357   PMID:22217705   PMID:22336502  
PMID:22354938   PMID:22387545   PMID:22739108   PMID:22798687   PMID:22986331   PMID:23011468   PMID:23152298   PMID:23160182   PMID:23259602   PMID:23362272   PMID:23376485   PMID:23533145  
PMID:23576437   PMID:23711456   PMID:23999524   PMID:24404629   PMID:24681163   PMID:24771868   PMID:25056061   PMID:25173047   PMID:25216066   PMID:25388680   PMID:25659109   PMID:25824304  
PMID:25839935   PMID:25947240   PMID:25966114   PMID:26230946   PMID:26341485   PMID:26344197   PMID:26453326   PMID:26976569   PMID:27009944   PMID:27087514   PMID:27266621   PMID:27381900  
PMID:28409162   PMID:28552948   PMID:28835580   PMID:28973302   PMID:29058492   PMID:29193961   PMID:29196978   PMID:29295935   PMID:29568061   PMID:29580941   PMID:29629376   PMID:29665449  
PMID:30096423   PMID:31041817   PMID:31306370   PMID:31536960   PMID:32687069   PMID:33038829   PMID:33374956   PMID:33512081   PMID:33580125   PMID:34040693   PMID:34278494   PMID:35183688  
PMID:35831314   PMID:36215168   PMID:36470481   PMID:36636821   PMID:38013165   PMID:38334954   PMID:39197248  


Genomics

Comparative Map Data
EPHX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,491,143 - 27,548,626 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,490,781 - 27,545,564 (+)EnsemblGRCh38hg38GRCh38
GRCh37827,348,660 - 27,406,143 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,404,562 - 27,458,403 (+)NCBINCBI36Build 36hg18NCBI36
Build 34827,404,561 - 27,458,403NCBI
Celera826,308,750 - 26,362,585 (+)NCBICelera
Cytogenetic Map8p21.2-p21.1NCBI
HuRef825,893,566 - 25,947,482 (+)NCBIHuRef
CHM1_1827,550,382 - 27,604,304 (+)NCBICHM1_1
T2T-CHM13v2.0827,768,490 - 27,825,967 (+)NCBIT2T-CHM13v2.0
Ephx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,321,821 - 66,361,971 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,321,823 - 66,361,949 (-)EnsemblGRCm39 Ensembl
GRCm381466,084,372 - 66,124,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1466,084,374 - 66,124,500 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,703,214 - 66,743,337 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361465,038,487 - 65,078,610 (-)NCBIMGSCv36mm8
Celera1463,832,362 - 63,872,496 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Ephx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,465,447 - 44,503,157 (-)NCBIGRCr8
mRatBN7.21540,289,901 - 40,327,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,289,902 - 40,327,615 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1542,154,869 - 42,194,845 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,305,067 - 43,345,042 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,750,237 - 41,787,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,757,241 - 42,794,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,757,235 - 42,794,279 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01548,799,823 - 48,836,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,497,660 - 45,556,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,513,439 - 45,571,881 (-)NCBI
Celera1539,961,087 - 40,000,936 (-)NCBICelera
Cytogenetic Map15p12NCBI
Ephx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540349,999,563 - 50,041,572 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540349,999,563 - 50,038,800 (+)NCBIChiLan1.0ChiLan1.0
EPHX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,021,291 - 46,079,005 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,735,517 - 21,793,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,761,090 - 26,818,436 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1823,964,094 - 24,017,749 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl823,964,094 - 24,017,749 (+)Ensemblpanpan1.1panPan2
EPHX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12530,045,040 - 30,107,110 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2530,045,291 - 30,107,110 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,631,771 - 30,693,869 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02530,235,290 - 30,297,630 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,232,724 - 30,297,642 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,165,721 - 30,227,963 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02530,046,546 - 30,108,832 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,212,901 - 30,275,213 (-)NCBIUU_Cfam_GSD_1.0
Ephx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,193,232 - 8,235,694 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675350,342 - 392,551 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675350,357 - 392,919 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,216,978 - 11,293,410 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,217,125 - 11,293,018 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,397,646 - 12,473,595 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,603,668 - 25,659,232 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,603,735 - 25,659,345 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,482,843 - 16,540,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ephx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,221,314 - 22,254,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,216,462 - 22,252,467 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EPHX2
67 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001979.6(EPHX2):c.860G>A (p.Arg287Gln) single nucleotide variant Hypercholesterolemia, familial, 1 [RCV000018074] Chr8:27516348 [GRCh38]
Chr8:27516348..27516349 [GRCh38]
Chr8:27373865 [GRCh37]
Chr8:27373865..27373866 [GRCh37]
Chr8:8p21.1		 risk factor
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.3-21.1(chr8:2475295-27504279)x1 copy number loss See cases [RCV000050297] Chr8:2475295..27504279 [GRCh38]
Chr8:2292235..27361796 [GRCh37]
Chr8:2121457..27417713 [NCBI36]
Chr8:8p23.3-21.1		 pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3 copy number gain See cases [RCV000051145] Chr8:12383584..36370018 [GRCh38]
Chr8:12241093..36227536 [GRCh37]
Chr8:12285464..36347088 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12750796-29445409)x3 copy number gain See cases [RCV000053633] Chr8:12750796..29445409 [GRCh38]
Chr8:12608305..29302926 [GRCh37]
Chr8:12652676..29358845 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3 copy number gain See cases [RCV000053629] Chr8:12609975..37892000 [GRCh38]
Chr8:12467484..37749518 [GRCh37]
Chr8:12511855..37868676 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:96310-30614703)x3 copy number gain See cases [RCV000053599] Chr8:96310..30614703 [GRCh38]
Chr8:46310..30472220 [GRCh37]
Chr8:36310..30591762 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31210737)x1 copy number loss See cases [RCV000054237] Chr8:24910364..31210737 [GRCh38]
Chr8:24767877..31068253 [GRCh37]
Chr8:24823781..31187795 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormal fetal cardiovascular morphology [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31196357)x1 copy number loss See cases [RCV000136120] Chr8:24910364..31196357 [GRCh38]
Chr8:24767877..31053873 [GRCh37]
Chr8:24823781..31173415 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12725750-30180521)x3 copy number gain See cases [RCV000136825] Chr8:12725750..30180521 [GRCh38]
Chr8:12583259..30038037 [GRCh37]
Chr8:12627630..30157579 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3 copy number gain See cases [RCV000138058] Chr8:12698495..35476082 [GRCh38]
Chr8:12556004..35333600 [GRCh37]
Chr8:12600375..35453142 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:25171103-31750600)x1 copy number loss See cases [RCV000138081] Chr8:25171103..31750600 [GRCh38]
Chr8:25028618..31608116 [GRCh37]
Chr8:25084535..31727658 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3 copy number gain See cases [RCV000138831] Chr8:241605..31091074 [GRCh38]
Chr8:191605..30948590 [GRCh37]
Chr8:181605..31068132 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.1-21.1(chr8:12382844-28625564)x3 copy number gain See cases [RCV000138244] Chr8:12382844..28625564 [GRCh38]
Chr8:12240353..28483081 [GRCh37]
Chr8:12284724..28539000 [NCBI36]
Chr8:8p23.1-21.1		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3 copy number gain See cases [RCV000139549] Chr8:11851113..37216333 [GRCh38]
Chr8:11708622..37073851 [GRCh37]
Chr8:11746031..37193009 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3 copy number gain See cases [RCV000141410] Chr8:226452..34491890 [GRCh38]
Chr8:176452..34349408 [GRCh37]
Chr8:166452..34468950 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-29033946)x1 copy number loss See cases [RCV000142516] Chr8:12383584..29033946 [GRCh38]
Chr8:12241093..28891463 [GRCh37]
Chr8:12285464..28947382 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1 copy number loss See cases [RCV000142747] Chr8:18972996..33619264 [GRCh38]
Chr8:18830506..33476782 [GRCh37]
Chr8:18874786..33596324 [NCBI36]
Chr8:8p22-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.2-21.1(chr8:2475295-27504279)x1 copy number loss See cases [RCV000148252] Chr8:2475295..27504279 [GRCh38]
Chr8:2292235..27361796 [GRCh37]
Chr8:2121457..27417713 [NCBI36]
Chr8:8p23.2-21.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh37/hg19 8p21.3-12(chr8:20478546-28986438)x3 copy number gain See cases [RCV000203434] Chr8:20478546..28986438 [GRCh37]
Chr8:8p21.3-12		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30262760)x3 copy number gain See cases [RCV000449225] Chr8:158048..30262760 [GRCh37]
Chr8:8p23.3-12		 pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p21.2-12(chr8:24514488-34808438) copy number gain See cases [RCV000448582] Chr8:24514488..34808438 [GRCh37]
Chr8:8p21.2-12		 pathogenic
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1 copy number loss not provided [RCV000509389] Chr8:16992973..32612724 [GRCh37]
Chr8:8p22-12		 not provided
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3 copy number gain See cases [RCV000510571] Chr8:12528482..33684786 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3 copy number gain See cases [RCV000510899] Chr8:11945855..34875355 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_001979.6(EPHX2):c.1478C>T (p.Ala493Val) single nucleotide variant not specified [RCV004330948] Chr8:27543777 [GRCh38]
Chr8:27401294 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3 copy number gain not provided [RCV000683043] Chr8:12552775..35935825 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p21.2(chr8:27381918-27390246)x1 copy number loss not provided [RCV000747494] Chr8:27381918..27390246 [GRCh37]
Chr8:8p21.2		 benign
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3 copy number gain not provided [RCV000762735] Chr8:12556004..34374150 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
NM_001979.6(EPHX2):c.1218_1219del (p.Ser407fs) deletion not provided [RCV000999009] Chr8:27536829..27536830 [GRCh38]
Chr8:27394346..27394347 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1251A>G (p.Leu417=) single nucleotide variant not provided [RCV000929034] Chr8:27538667 [GRCh38]
Chr8:27396184 [GRCh37]
Chr8:8p21.1		 likely benign
Single allele duplication not provided [RCV000768452] Chr8:12546855..35816855 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
NM_001979.6(EPHX2):c.63C>A (p.Gly21=) single nucleotide variant not provided [RCV000960155] Chr8:27491271 [GRCh38]
Chr8:27348788 [GRCh37]
Chr8:8p21.2		 benign|likely benign
NM_001979.6(EPHX2):c.1298C>T (p.Pro433Leu) single nucleotide variant not provided [RCV000999010] Chr8:27540575 [GRCh38]
Chr8:27398092 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1650G>A (p.Pro550=) single nucleotide variant not provided [RCV000999012] Chr8:27544504 [GRCh38]
Chr8:27402021 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.155G>A (p.Arg52Gln) single nucleotide variant not provided [RCV000965444] Chr8:27500979 [GRCh38]
Chr8:27358496 [GRCh37]
Chr8:8p21.1		 benign|likely benign
GRCh37/hg19 8p21.3-21.2(chr8:22442548-27369334)x1 copy number loss not provided [RCV000847074] Chr8:22442548..27369334 [GRCh37]
Chr8:8p21.3-21.2		 pathogenic
GRCh37/hg19 8p21.2-21.1(chr8:24305969-28673405)x1 copy number loss not provided [RCV001006090] Chr8:24305969..28673405 [GRCh37]
Chr8:8p21.2-21.1		 pathogenic
NM_001979.6(EPHX2):c.910+5G>A single nucleotide variant not provided [RCV000999008] Chr8:27516403 [GRCh38]
Chr8:27373920 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_001979.6(EPHX2):c.946-5C>T single nucleotide variant not provided [RCV000956580] Chr8:27520878 [GRCh38]
Chr8:27378395 [GRCh37]
Chr8:8p21.1		 benign
NM_001979.6(EPHX2):c.1450-4C>A single nucleotide variant not provided [RCV000999011] Chr8:27543745 [GRCh38]
Chr8:27401262 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p21.2-12(chr8:27064033-28832392)x3 copy number gain not provided [RCV002472907] Chr8:27064033..28832392 [GRCh37]
Chr8:8p21.2-12		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-29886483)x3 copy number gain not provided [RCV001260030] Chr8:12528482..29886483 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
NM_001979.6(EPHX2):c.590G>C (p.Gly197Ala) single nucleotide variant Hypercholesterolemia, familial, 1 [RCV001332067] Chr8:27506924 [GRCh38]
Chr8:27364441 [GRCh37]
Chr8:8p21.1		 uncertain significance
NC_000008.10:g.(?_27319146)_(28608383_?)dup duplication Autosomal dominant nocturnal frontal lobe epilepsy [RCV003107941]|not provided [RCV002043387] Chr8:27319146..28608383 [GRCh37]
Chr8:8p21.2-21.1		 uncertain significance|no classifications from unflagged records
Single allele complex See cases [RCV002292428] Chr8:6999114..11935023 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30187456)x1 copy number loss See cases [RCV002286343] Chr8:158048..30187456 [GRCh37]
Chr8:8p23.3-12		 pathogenic
Single allele complex 8p inverted duplication/deletion syndrome [RCV002280753] Chr8:158048..43019304 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p21.2-11.22(chr8:26808969-38346383)x1 copy number loss not provided [RCV002472596] Chr8:26808969..38346383 [GRCh37]
Chr8:8p21.2-11.22		 pathogenic
NM_001979.6(EPHX2):c.1207C>T (p.Arg403Trp) single nucleotide variant not provided [RCV004696272]|not specified [RCV004234036] Chr8:27536820 [GRCh38]
Chr8:27394337 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.311C>G (p.Pro104Arg) single nucleotide variant not specified [RCV004138972] Chr8:27503728 [GRCh38]
Chr8:27361245 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1445G>A (p.Arg482Gln) single nucleotide variant not specified [RCV004141553] Chr8:27541538 [GRCh38]
Chr8:27399055 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.160A>T (p.Met54Leu) single nucleotide variant not specified [RCV004169510] Chr8:27500984 [GRCh38]
Chr8:27358501 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.704G>A (p.Ser235Asn) single nucleotide variant not specified [RCV004238073] Chr8:27511879 [GRCh38]
Chr8:27369396 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.745C>T (p.Arg249Cys) single nucleotide variant not specified [RCV004206418] Chr8:27515727 [GRCh38]
Chr8:27373244 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1517A>G (p.His506Arg) single nucleotide variant not specified [RCV004234979] Chr8:27543816 [GRCh38]
Chr8:27401333 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1061C>T (p.Ala354Val) single nucleotide variant not specified [RCV004087354] Chr8:27525364 [GRCh38]
Chr8:27382881 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1125C>G (p.Ile375Met) single nucleotide variant not specified [RCV004185684] Chr8:27525428 [GRCh38]
Chr8:27382945 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.335T>G (p.Leu112Arg) single nucleotide variant not specified [RCV004155588] Chr8:27503752 [GRCh38]
Chr8:27361269 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.395A>T (p.Glu132Val) single nucleotide variant not specified [RCV004199016] Chr8:27505004 [GRCh38]
Chr8:27362521 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1349A>G (p.Tyr450Cys) single nucleotide variant not specified [RCV004130288] Chr8:27540626 [GRCh38]
Chr8:27398143 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1547G>T (p.Arg516Met) single nucleotide variant not specified [RCV004182993] Chr8:27544202 [GRCh38]
Chr8:27401719 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.746G>A (p.Arg249His) single nucleotide variant not specified [RCV004148828] Chr8:27515728 [GRCh38]
Chr8:27373245 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.926G>T (p.Cys309Phe) single nucleotide variant not specified [RCV004131628] Chr8:27518053 [GRCh38]
Chr8:27375570 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.556A>G (p.Ile186Val) single nucleotide variant not specified [RCV004270563] Chr8:27506890 [GRCh38]
Chr8:27364407 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001979.6(EPHX2):c.1583T>C (p.Met528Thr) single nucleotide variant not specified [RCV004269300] Chr8:27544238 [GRCh38]
Chr8:27401755 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.287T>A (p.Ile96Asn) single nucleotide variant not specified [RCV004279513] Chr8:27503704 [GRCh38]
Chr8:27361221 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.859C>T (p.Arg287Trp) single nucleotide variant not specified [RCV004256597] Chr8:27516347 [GRCh38]
Chr8:27373864 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1616T>C (p.Ile539Thr) single nucleotide variant not specified [RCV004277844] Chr8:27544470 [GRCh38]
Chr8:27401987 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1217A>G (p.Lys406Arg) single nucleotide variant not specified [RCV004327705] Chr8:27536830 [GRCh38]
Chr8:27394347 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh38/hg38 8p23.1-12(chr8:12721809-30183737)x1 copy number loss Microcephaly [RCV003327707] Chr8:12721809..30183737 [GRCh38]
Chr8:8p23.1-12		 pathogenic
NM_001979.6(EPHX2):c.142G>T (p.Gly48Cys) single nucleotide variant not specified [RCV004362906] Chr8:27500966 [GRCh38]
Chr8:27358483 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1344G>C (p.Gln448His) single nucleotide variant not specified [RCV004360517] Chr8:27540621 [GRCh38]
Chr8:27398138 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p23.2-11.21(chr8:2201405-41723095)x3 copy number gain not provided [RCV003484713] Chr8:2201405..41723095 [GRCh37]
Chr8:8p23.2-11.21		 pathogenic
Single allele duplication not provided [RCV003448693] Chr8:12530550..43483193 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.23(chr8:11945856-37902453)x3 copy number gain not provided [RCV003484722] Chr8:11945856..37902453 [GRCh37]
Chr8:8p23.1-11.23		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12560782-38748763)x3 copy number gain not provided [RCV003484724] Chr8:12560782..38748763 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p22-11.1(chr8:14240573-43824035)x3 copy number gain not provided [RCV003484725] Chr8:14240573..43824035 [GRCh37]
Chr8:8p22-11.1		 pathogenic
GRCh37/hg19 8p23.1-21.1(chr8:12490999-28150620)x1 copy number loss not provided [RCV003483018] Chr8:12490999..28150620 [GRCh37]
Chr8:8p23.1-21.1		 pathogenic
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3 copy number gain not specified [RCV003986754] Chr8:27024288..89410121 [GRCh37]
Chr8:8p21.2-q21.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.21(chr8:158048-41600696)x3 copy number gain not specified [RCV003986756] Chr8:158048..41600696 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p21.3-11.1(chr8:20136266-43786723)x3 copy number gain not specified [RCV003986767] Chr8:20136266..43786723 [GRCh37]
Chr8:8p21.3-11.1		 pathogenic
GRCh37/hg19 8p21.2-12(chr8:23754939-30219110)x1 copy number loss not specified [RCV003986748] Chr8:23754939..30219110 [GRCh37]
Chr8:8p21.2-12		 pathogenic
NM_001979.6(EPHX2):c.1275G>A (p.Ala425=) single nucleotide variant EPHX2-related disorder [RCV003972138] Chr8:27538691 [GRCh38]
Chr8:27396208 [GRCh37]
Chr8:8p21.1		 benign
NM_001979.6(EPHX2):c.1081C>T (p.Pro361Ser) single nucleotide variant EPHX2-related disorder [RCV003976975] Chr8:27525384 [GRCh38]
Chr8:27382901 [GRCh37]
Chr8:8p21.1		 benign
NM_001979.6(EPHX2):c.674C>T (p.Pro225Leu) single nucleotide variant EPHX2-related disorder [RCV003937068] Chr8:27511849 [GRCh38]
Chr8:27369366 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001979.6(EPHX2):c.266A>G (p.Lys89Arg) single nucleotide variant EPHX2-related disorder [RCV003979204] Chr8:27503683 [GRCh38]
Chr8:27361200 [GRCh37]
Chr8:8p21.1		 benign
NM_001979.6(EPHX2):c.810T>C (p.Ser270=) single nucleotide variant EPHX2-related disorder [RCV003923965] Chr8:27515792 [GRCh38]
Chr8:27373309 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001979.6(EPHX2):c.1236C>T (p.Ser412=) single nucleotide variant EPHX2-related disorder [RCV003977368] Chr8:27536849 [GRCh38]
Chr8:27394366 [GRCh37]
Chr8:8p21.1		 benign
NM_001979.6(EPHX2):c.1154T>C (p.Leu385Pro) single nucleotide variant not specified [RCV004378059] Chr8:27525457 [GRCh38]
Chr8:27382974 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1642A>G (p.Asn548Asp) single nucleotide variant not specified [RCV004378060] Chr8:27544496 [GRCh38]
Chr8:27402013 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001979.6(EPHX2):c.1664T>G (p.Met555Arg) single nucleotide variant not specified [RCV004378061] Chr8:27544518 [GRCh38]
Chr8:27402035 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.524C>A (p.Ala175Asp) single nucleotide variant not specified [RCV004378062] Chr8:27505133 [GRCh38]
Chr8:27362650 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.62G>A (p.Gly21Asp) single nucleotide variant not specified [RCV004378063] Chr8:27491270 [GRCh38]
Chr8:27348787 [GRCh37]
Chr8:8p21.2		 uncertain significance
NM_001979.6(EPHX2):c.775C>T (p.Pro259Ser) single nucleotide variant not specified [RCV004378064] Chr8:27515757 [GRCh38]
Chr8:27373274 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.909C>T (p.Pro303=) single nucleotide variant EPHX2-related disorder [RCV003949147] Chr8:27516397 [GRCh38]
Chr8:27373914 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001979.6(EPHX2):c.164A>G (p.Lys55Arg) single nucleotide variant EPHX2-related disorder [RCV003974480] Chr8:27500988 [GRCh38]
Chr8:27358505 [GRCh37]
Chr8:8p21.1		 benign
NM_001979.6(EPHX2):c.1207C>G (p.Arg403Gly) single nucleotide variant not specified [RCV004620620] Chr8:27536820 [GRCh38]
Chr8:27394337 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.53C>T (p.Ala18Val) single nucleotide variant not specified [RCV004620622] Chr8:27491261 [GRCh38]
Chr8:27348778 [GRCh37]
Chr8:8p21.2		 uncertain significance
NM_001979.6(EPHX2):c.1516C>A (p.His506Asn) single nucleotide variant not specified [RCV004620617] Chr8:27543815 [GRCh38]
Chr8:27401332 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1301A>G (p.Glu434Gly) single nucleotide variant not specified [RCV004620616] Chr8:27540578 [GRCh38]
Chr8:27398095 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.176C>A (p.Thr59Lys) single nucleotide variant not specified [RCV004620618] Chr8:27501000 [GRCh38]
Chr8:27358517 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.442G>A (p.Asp148Asn) single nucleotide variant not specified [RCV004620619] Chr8:27505051 [GRCh38]
Chr8:27362568 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1406T>C (p.Met469Thr) single nucleotide variant not specified [RCV004620614] Chr8:27541499 [GRCh38]
Chr8:27399016 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.1202T>C (p.Leu401Pro) single nucleotide variant not specified [RCV004620615] Chr8:27536815 [GRCh38]
Chr8:27394332 [GRCh37]
Chr8:8p21.1		 uncertain significance
NM_001979.6(EPHX2):c.458C>T (p.Ser153Leu) single nucleotide variant not specified [RCV004620621] Chr8:27505067 [GRCh38]
Chr8:27362584 [GRCh37]
Chr8:8p21.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2366
Count of miRNA genes:854
Interacting mature miRNAs:1015
Transcripts:ENST00000380476, ENST00000517536, ENST00000518328, ENST00000518379, ENST00000520623, ENST00000520666, ENST00000521400, ENST00000521684, ENST00000521780, ENST00000521924, ENST00000523326, ENST00000523827
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298482BP2_HBlood pressure QTL 2 (human)1.8Blood pressurediastolic8695325632953256Human
1558703SCL6_HSerum cholesterol level QTL 1 (human)1.2Lipid levelHDL cholesterol81246863538468635Human

Markers in Region
D8S1839  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,382,561 - 27,382,741UniSTSGRCh37
Build 36827,438,478 - 27,438,658RGDNCBI36
Celera826,342,660 - 26,342,840RGD
Cytogenetic Map8p21UniSTS
HuRef825,927,601 - 25,927,785UniSTS
Marshfield Genetic Map854.28RGD
Marshfield Genetic Map854.28UniSTS
Genethon Genetic Map852.9UniSTS
TNG Radiation Hybrid Map814036.0UniSTS
deCODE Assembly Map846.42UniSTS
Stanford-G3 RH Map81239.0UniSTS
NCBI RH Map8339.8UniSTS
GeneMap99-G3 RH Map81329.0UniSTS
SHGC-85787  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,381,924 - 27,382,237UniSTSGRCh37
Build 36827,437,841 - 27,438,154RGDNCBI36
Celera826,342,023 - 26,342,336RGD
Cytogenetic Map8p21UniSTS
HuRef825,926,964 - 25,927,277UniSTS
TNG Radiation Hybrid Map814036.0UniSTS
D8S1569E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,402,252 - 27,402,362UniSTSGRCh37
Build 36827,458,169 - 27,458,279RGDNCBI36
Celera826,362,351 - 26,362,461RGD
Cytogenetic Map8p21UniSTS
HuRef825,947,295 - 25,947,405UniSTS
SHGC-35790  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,402,064 - 27,402,263UniSTSGRCh37
Build 36827,457,981 - 27,458,180RGDNCBI36
Celera826,362,163 - 26,362,362RGD
Cytogenetic Map8p21UniSTS
HuRef825,947,107 - 25,947,306UniSTS
Stanford-G3 RH Map81248.0UniSTS
GeneMap99-GB4 RH Map8108.5UniSTS
Whitehead-RH Map8109.8UniSTS
NCBI RH Map8339.8UniSTS
GeneMap99-G3 RH Map81338.0UniSTS
STS-AA011480  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,386,081 - 27,386,213UniSTSGRCh37
Build 36827,441,998 - 27,442,130RGDNCBI36
Celera826,346,180 - 26,346,312RGD
Cytogenetic Map8p21UniSTS
HuRef825,931,125 - 25,931,257UniSTS
GeneMap99-GB4 RH Map8108.39UniSTS
NCBI RH Map8337.7UniSTS
STS-L05779  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,402,116 - 27,402,240UniSTSGRCh37
Build 36827,458,033 - 27,458,157RGDNCBI36
Celera826,362,215 - 26,362,339RGD
Cytogenetic Map8p21UniSTS
HuRef825,947,159 - 25,947,283UniSTS
GeneMap99-GB4 RH Map8108.6UniSTS
NCBI RH Map8333.4UniSTS
D8S131  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8p21UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2437 2788 2244 4962 1725 2345 5 624 1894 464 2263 7253 6422 44 3728 1 851 1739 1612 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001256484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_182233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001745491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF233334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF233335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF233336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF311103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ272362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX103698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA397329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC331720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU584434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L05779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000380476   ⟹   ENSP00000369843
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,166 - 27,544,913 (+)Ensembl
Ensembl Acc Id: ENST00000517536   ⟹   ENSP00000428875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,125 - 27,544,919 (+)Ensembl
Ensembl Acc Id: ENST00000518328   ⟹   ENSP00000430779
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,490,781 - 27,505,084 (+)Ensembl
Ensembl Acc Id: ENST00000518379   ⟹   ENSP00000427956
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,192 - 27,544,892 (+)Ensembl
Ensembl Acc Id: ENST00000520623
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,125 - 27,539,255 (+)Ensembl
Ensembl Acc Id: ENST00000520666
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,195 - 27,506,904 (+)Ensembl
Ensembl Acc Id: ENST00000521400   ⟹   ENSP00000430269
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,143 - 27,545,564 (+)Ensembl
Ensembl Acc Id: ENST00000521684   ⟹   ENSP00000428191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,210 - 27,522,509 (+)Ensembl
Ensembl Acc Id: ENST00000521780   ⟹   ENSP00000430302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,491,151 - 27,544,919 (+)Ensembl
Ensembl Acc Id: ENST00000521924
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,505,047 - 27,512,100 (+)Ensembl
Ensembl Acc Id: ENST00000523326
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,515,463 - 27,522,487 (+)Ensembl
Ensembl Acc Id: ENST00000523827
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,492,842 - 27,503,759 (+)Ensembl
RefSeq Acc Id: NM_001256482   ⟹   NP_001243411
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,545,564 (+)NCBI
GRCh37827,348,519 - 27,402,439 (+)NCBI
HuRef825,893,566 - 25,947,482 (+)NCBI
CHM1_1827,550,382 - 27,604,304 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,905 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001256483   ⟹   NP_001243412
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,545,564 (+)NCBI
GRCh37827,348,519 - 27,402,439 (+)NCBI
HuRef825,893,566 - 25,947,482 (+)NCBI
CHM1_1827,550,382 - 27,604,304 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,905 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001256484   ⟹   NP_001243413
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,545,564 (+)NCBI
GRCh37827,348,519 - 27,402,439 (+)NCBI
HuRef825,893,566 - 25,947,482 (+)NCBI
CHM1_1827,550,548 - 27,604,304 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,905 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001414016   ⟹   NP_001400945
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,544,919 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,260 (+)NCBI
RefSeq Acc Id: NM_001414017   ⟹   NP_001400946
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,548,626 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,825,967 (+)NCBI
RefSeq Acc Id: NM_001414018   ⟹   NP_001400947
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,544,919 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,260 (+)NCBI
RefSeq Acc Id: NM_001414019   ⟹   NP_001400948
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,544,919 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,260 (+)NCBI
RefSeq Acc Id: NM_001414020   ⟹   NP_001400949
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,544,919 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,260 (+)NCBI
RefSeq Acc Id: NM_001414021   ⟹   NP_001400950
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,526,769 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,804,110 (+)NCBI
RefSeq Acc Id: NM_001414022   ⟹   NP_001400951
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,511,375 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,788,714 (+)NCBI
RefSeq Acc Id: NM_001414023   ⟹   NP_001400952
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,508,447 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,785,785 (+)NCBI
RefSeq Acc Id: NM_001979   ⟹   NP_001970
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,545,564 (+)NCBI
GRCh37827,348,519 - 27,402,439 (+)NCBI
Build 36827,404,562 - 27,458,403 (+)NCBI Archive
HuRef825,893,566 - 25,947,482 (+)NCBI
CHM1_1827,550,382 - 27,604,304 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,905 (+)NCBI
Sequence:
RefSeq Acc Id: NR_182231
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,544,919 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,260 (+)NCBI
RefSeq Acc Id: NR_182232
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,544,919 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,260 (+)NCBI
RefSeq Acc Id: NR_182233
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,544,919 (+)NCBI
T2T-CHM13v2.0827,768,490 - 27,822,260 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001243411 (Get FASTA)   NCBI Sequence Viewer  
  NP_001243412 (Get FASTA)   NCBI Sequence Viewer  
  NP_001243413 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400945 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400946 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400947 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400948 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400949 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400950 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400951 (Get FASTA)   NCBI Sequence Viewer  
  NP_001400952 (Get FASTA)   NCBI Sequence Viewer  
  NP_001970 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02756 (Get FASTA)   NCBI Sequence Viewer  
  AAG14966 (Get FASTA)   NCBI Sequence Viewer  
  AAG14967 (Get FASTA)   NCBI Sequence Viewer  
  AAG14968 (Get FASTA)   NCBI Sequence Viewer  
  AAH07708 (Get FASTA)   NCBI Sequence Viewer  
  AAH11628 (Get FASTA)   NCBI Sequence Viewer  
  AAH13874 (Get FASTA)   NCBI Sequence Viewer  
  AAP35531 (Get FASTA)   NCBI Sequence Viewer  
  ACD11487 (Get FASTA)   NCBI Sequence Viewer  
  BAG53210 (Get FASTA)   NCBI Sequence Viewer  
  BAG53362 (Get FASTA)   NCBI Sequence Viewer  
  BAG57410 (Get FASTA)   NCBI Sequence Viewer  
  BAG64834 (Get FASTA)   NCBI Sequence Viewer  
  CAA65751 (Get FASTA)   NCBI Sequence Viewer  
  EAW63547 (Get FASTA)   NCBI Sequence Viewer  
  EAW63548 (Get FASTA)   NCBI Sequence Viewer  
  EAW63549 (Get FASTA)   NCBI Sequence Viewer  
  EAW63550 (Get FASTA)   NCBI Sequence Viewer  
  EAW63551 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000369843
  ENSP00000369843.3
  ENSP00000427956
  ENSP00000427956.1
  ENSP00000428191.1
  ENSP00000428875.1
  ENSP00000430269
  ENSP00000430269.1
  ENSP00000430302
  ENSP00000430302.1
  ENSP00000430779.1
GenBank Protein P34913 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001970   ⟸   NM_001979
- Peptide Label: isoform 1
- UniProtKB: Q9HBJ1 (UniProtKB/Swiss-Prot),   Q16764 (UniProtKB/Swiss-Prot),   J3KPH7 (UniProtKB/Swiss-Prot),   G3V134 (UniProtKB/Swiss-Prot),   B3KUA0 (UniProtKB/Swiss-Prot),   B3KTU8 (UniProtKB/Swiss-Prot),   B2Z3B1 (UniProtKB/Swiss-Prot),   Q9HBJ2 (UniProtKB/Swiss-Prot),   P34913 (UniProtKB/Swiss-Prot),   B4DFE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243411   ⟸   NM_001256482
- Peptide Label: isoform 2
- UniProtKB: B4DFE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243412   ⟸   NM_001256483
- Peptide Label: isoform 3
- UniProtKB: B4DFE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001243413   ⟸   NM_001256484
- Peptide Label: isoform 2
- UniProtKB: B4DFE9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000428875   ⟸   ENST00000517536
Ensembl Acc Id: ENSP00000427956   ⟸   ENST00000518379
Ensembl Acc Id: ENSP00000430779   ⟸   ENST00000518328
Ensembl Acc Id: ENSP00000430302   ⟸   ENST00000521780
Ensembl Acc Id: ENSP00000428191   ⟸   ENST00000521684
Ensembl Acc Id: ENSP00000430269   ⟸   ENST00000521400
Ensembl Acc Id: ENSP00000369843   ⟸   ENST00000380476
RefSeq Acc Id: NP_001400946   ⟸   NM_001414017
- Peptide Label: isoform 5
- UniProtKB: B4DFE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400945   ⟸   NM_001414016
- Peptide Label: isoform 4
- UniProtKB: B4DFE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400947   ⟸   NM_001414018
- Peptide Label: isoform 6
- UniProtKB: B4DFE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400948   ⟸   NM_001414019
- Peptide Label: isoform 7
- UniProtKB: E5RFU2 (UniProtKB/TrEMBL),   B4DFE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400949   ⟸   NM_001414020
- Peptide Label: isoform 8
- UniProtKB: B4DFE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001400950   ⟸   NM_001414021
- Peptide Label: isoform 9
RefSeq Acc Id: NP_001400951   ⟸   NM_001414022
- Peptide Label: isoform 10
RefSeq Acc Id: NP_001400952   ⟸   NM_001414023
- Peptide Label: isoform 11
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34913-F1-model_v2 AlphaFold P34913 1-555 view protein structure

Promoters
RGD ID:6806732
Promoter ID:HG_KWN:60996
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000219954,   UC003XFV.1,   UC010LUT.1,   UC010LUU.1,   UC010LUV.1,   UC010LUW.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,404,419 - 27,404,919 (+)MPROMDB
RGD ID:6851758
Promoter ID:EP73684
Type:initiation region
Name:HS_EPHX2
Description:Epoxide hydrolase 2, cytoplasmic.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,404,585 - 27,404,645EPD
RGD ID:7212951
Promoter ID:EPDNEW_H12221
Type:multiple initiation site
Name:EPHX2_3
Description:epoxide hydrolase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12222  EPDNEW_H12223  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,488,093 - 27,488,153EPDNEW
RGD ID:7212953
Promoter ID:EPDNEW_H12222
Type:initiation region
Name:EPHX2_2
Description:epoxide hydrolase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12221  EPDNEW_H12223  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,490,766 - 27,490,826EPDNEW
RGD ID:7212955
Promoter ID:EPDNEW_H12223
Type:initiation region
Name:EPHX2_1
Description:epoxide hydrolase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12221  EPDNEW_H12222  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,491,143 - 27,491,203EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3402 AgrOrtholog
COSMIC EPHX2 COSMIC
Ensembl Genes ENSG00000120915 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000380476 ENTREZGENE
  ENST00000380476.7 UniProtKB/Swiss-Prot
  ENST00000517536.5 UniProtKB/TrEMBL
  ENST00000518328.5 UniProtKB/TrEMBL
  ENST00000518379 ENTREZGENE
  ENST00000518379.5 UniProtKB/TrEMBL
  ENST00000521400 ENTREZGENE
  ENST00000521400.6 UniProtKB/Swiss-Prot
  ENST00000521684.1 UniProtKB/TrEMBL
  ENST00000521780 ENTREZGENE
  ENST00000521780.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000120915 GTEx
HGNC ID HGNC:3402 ENTREZGENE
Human Proteome Map EPHX2 Human Proteome Map
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACAD10-like UniProtKB/TrEMBL
  Epox_hydrolase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-SF_hydro_IA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-SF_ppase_IA/epoxid_hydro_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGP-like_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2053 UniProtKB/Swiss-Prot
NCBI Gene 2053 ENTREZGENE
OMIM 132811 OMIM
PANTHER AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  BIFUNCTIONAL EPOXIDE HYDROLASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPOXIDE HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27830 PharmGKB
PRINTS ABHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPOXHYDRLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HADHALOGNASE UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2Z3B1 ENTREZGENE
  B3KTU8 ENTREZGENE
  B3KUA0 ENTREZGENE
  B4DFE9 ENTREZGENE, UniProtKB/TrEMBL
  E5RFH6_HUMAN UniProtKB/TrEMBL
  E5RFU2 ENTREZGENE, UniProtKB/TrEMBL
  E5RI53_HUMAN UniProtKB/TrEMBL
  G3V134 ENTREZGENE
  H0YAW7_HUMAN UniProtKB/TrEMBL
  HYES_HUMAN UniProtKB/Swiss-Prot
  J3KPH7 ENTREZGENE
  P34913 ENTREZGENE
  Q16764 ENTREZGENE
  Q9HBJ1 ENTREZGENE
  Q9HBJ2 ENTREZGENE
UniProt Secondary B2Z3B1 UniProtKB/Swiss-Prot
  B3KTU8 UniProtKB/Swiss-Prot
  B3KUA0 UniProtKB/Swiss-Prot
  G3V134 UniProtKB/Swiss-Prot
  J3KPH7 UniProtKB/Swiss-Prot
  Q16764 UniProtKB/Swiss-Prot
  Q9HBJ1 UniProtKB/Swiss-Prot
  Q9HBJ2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 EPHX2  epoxide hydrolase 2    epoxide hydrolase 2, cytoplasmic  Symbol and/or name change 5135510 APPROVED