Soat1 (sterol O-acyltransferase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Soat1 (sterol O-acyltransferase 1) Mus musculus
Analyze
Symbol: Soat1
Name: sterol O-acyltransferase 1
RGD ID: 731039
MGI Page MGI
Description: Enables sterol O-acyltransferase activity. Acts upstream of or within cholesterol metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; genitourinary system; heart; and viscerocranium. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human SOAT1 (sterol O-acyltransferase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 8430426K15Rik; Aca; Acact; ACAT; ACAT-1; acyl coenzyme A:cholesterol acyltransferase 1; acyl-coenzyme A:cholesterol acyltransferase 1; adrenocortical lipid depletion; ald; AW550831; cholesterol acyltransferase 1; expressed sequence AW550831; hi; hid
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18345  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,255,678 - 156,301,898 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,252,095 - 156,301,901 (-)EnsemblGRCm39 Ensembl
GRCm381156,428,108 - 156,474,328 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,424,525 - 156,474,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv371158,358,239 - 158,404,459 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,265,149 - 158,310,920 (-)NCBIMGSCv36mm8
Celera1158,822,751 - 158,868,673 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloroprene  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibric acid  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
folic acid  (EXP)
FR900359  (ISO)
griseofulvin  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lidocaine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
omega-6 fatty acid  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
troglitazone  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ACAT-1 gene rs1044925 SNP and its relation with different clinical forms of chronic Chagas disease. Carvalho TB, etal., Parasitol Res. 2019 Aug;118(8):2343-2351. doi: 10.1007/s00436-019-06377-9. Epub 2019 Jun 24.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia. Lu Z, etal., PLoS One. 2011;6(10):e25344. doi: 10.1371/journal.pone.0025344. Epub 2011 Oct 14.
4. Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions. Melton EM, etal., J Biol Chem. 2019 Oct 25;294(43):15836-15849. doi: 10.1074/jbc.RA119.010564. Epub 2019 Sep 8.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Amelioration of Hyperglycemia with a Sodium-Glucose Cotransporter 2 Inhibitor Prevents Macrophage-Driven Atherosclerosis through Macrophage Foam Cell Formation Suppression in Type 1 and Type 2 Diabetic Mice. Terasaki M, etal., PLoS One. 2015 Nov 25;10(11):e0143396. doi: 10.1371/journal.pone.0143396. eCollection 2015.
13. Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome. Vaziri ND and Liang K, Kidney Int 2002 May;61(5):1769-75.
14. Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow. Wakabayashi T, etal., Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2576-2589. doi: 10.1161/ATVBAHA.118.311648.
15. Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells. Yamazaki H, etal., J Atheroscler Thromb. 2019 Mar 1;26(3):246-259. doi: 10.5551/jat.44040. Epub 2018 Oct 4.
Additional References at PubMed
PMID:281712   PMID:540002   PMID:1225763   PMID:2176177   PMID:2993224   PMID:4192329   PMID:4348256   PMID:4451118   PMID:5693089   PMID:6230784   PMID:6934364   PMID:7165695  
PMID:7592824   PMID:8049528   PMID:8579615   PMID:8672144   PMID:8827514   PMID:8943057   PMID:9250876   PMID:9323603   PMID:9422770   PMID:9651528   PMID:9756919   PMID:10349636  
PMID:10594239   PMID:10725249   PMID:10727439   PMID:10777503   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11160132   PMID:12114523   PMID:12477932   PMID:14375655   PMID:14610273  
PMID:14681479   PMID:15782199   PMID:15845358   PMID:15845870   PMID:15851589   PMID:15995174   PMID:16141072   PMID:16141073   PMID:16144700   PMID:16387874   PMID:16602821   PMID:17576822  
PMID:17916774   PMID:18464936   PMID:18772481   PMID:18799693   PMID:19295613   PMID:19522984   PMID:20133765   PMID:20574437   PMID:21267068   PMID:21873635   PMID:21945903   PMID:22474282  
PMID:22669916   PMID:22811412   PMID:23251662   PMID:23846496   PMID:24457600   PMID:24657401   PMID:25339759   PMID:25446841   PMID:25522268   PMID:25930235   PMID:26321246   PMID:26801614  
PMID:26982734   PMID:27113764   PMID:27514747   PMID:29097366   PMID:29453986   PMID:29533741   PMID:29549095   PMID:29567472   PMID:31329164   PMID:32133736   PMID:32397995   PMID:32554809  
PMID:32646003   PMID:33031913   PMID:33064661   PMID:33557318   PMID:34914638   PMID:35507892   PMID:36691048   PMID:37585190   PMID:38761895   PMID:38833481   PMID:38953847  


Genomics

Comparative Map Data
Soat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,255,678 - 156,301,898 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,252,095 - 156,301,901 (-)EnsemblGRCm39 Ensembl
GRCm381156,428,108 - 156,474,328 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,424,525 - 156,474,331 (-)EnsemblGRCm38mm10GRCm38
MGSCv371158,358,239 - 158,404,459 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,265,149 - 158,310,920 (-)NCBIMGSCv36mm8
Celera1158,822,751 - 158,868,673 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.71NCBI
SOAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,293,797 - 179,358,680 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,293,714 - 179,358,680 (+)EnsemblGRCh38hg38GRCh38
GRCh371179,262,932 - 179,327,815 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,529,640 - 177,591,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 341175,994,673 - 176,056,109NCBI
Celera1152,371,279 - 152,432,730 (+)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1150,490,026 - 150,555,022 (+)NCBIHuRef
CHM1_11180,686,373 - 180,751,320 (+)NCBICHM1_1
T2T-CHM13v2.01178,648,799 - 178,713,729 (+)NCBIT2T-CHM13v2.0
Soat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81371,105,178 - 71,147,776 (-)NCBIGRCr8
mRatBN7.21368,552,274 - 68,597,529 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,552,317 - 68,597,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1371,134,597 - 71,176,925 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,454,344 - 72,496,807 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,715,839 - 69,758,305 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01374,035,258 - 74,077,759 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,035,080 - 74,077,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01378,956,528 - 78,999,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41371,420,862 - 71,463,365 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11371,435,049 - 71,477,553 (-)NCBI
Celera1368,416,482 - 68,458,206 (-)NCBICelera
Cytogenetic Map13q22NCBI
Soat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540618,655,894 - 18,706,891 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540618,644,351 - 18,708,666 (+)NCBIChiLan1.0ChiLan1.0
SOAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2170,405,471 - 70,466,287 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1170,065,689 - 70,130,644 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,776,305 - 154,840,594 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,464,886 - 158,529,952 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,464,886 - 158,524,909 (+)Ensemblpanpan1.1panPan2
SOAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1720,481,386 - 20,556,706 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl720,486,069 - 20,546,055 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha720,005,887 - 20,081,197 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0720,217,662 - 20,292,968 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl720,220,698 - 20,293,045 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1720,126,140 - 20,201,100 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0720,232,924 - 20,307,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0720,368,010 - 20,443,005 (-)NCBIUU_Cfam_GSD_1.0
Soat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,767,856 - 91,822,797 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364819,616,850 - 9,669,705 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364819,614,605 - 9,669,705 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9121,045,234 - 121,113,692 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19121,045,211 - 121,112,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29132,895,468 - 132,952,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12549,998,197 - 50,061,433 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2550,001,910 - 50,061,173 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605551,485,709 - 51,549,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Soat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247712,994,696 - 3,055,916 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247712,992,752 - 3,055,842 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Soat1
2950 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1077
Count of miRNA genes:572
Interacting mature miRNAs:708
Transcripts:ENSMUST00000051396
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
14700780Syncq3_msynovial calcification QTL 3 (mouse)1155424746156585570Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
1300611Tlln_mtail length (mouse)Not determined1155837814159390372Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
1301135Pas8_mpulmonary adenoma susceptibility 8 (mouse)Not determined1147125258158233272Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
1301818Ap1q_malcohol preference 1 QTL (mouse)Not determined1146908199167586222Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
4141075Bmd1a_mbone mineral density 1a (mouse)Not determined1155837814162145325Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
1357567Nidd3k_mNidd3 on KK-A<y> (mouse)Not determined7147125258169038913Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
12903996Cfq5_mconditioned fear QTL 5 (mouse)1150606337159307464Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse

Markers in Region
Soat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381156,432,227 - 156,432,868UniSTSGRCm38
MGSCv371158,362,358 - 158,362,999UniSTSGRCm37
Celera1158,826,858 - 158,827,499UniSTS
Cytogenetic Map1G3UniSTS
cM Map181.6UniSTS
cM Map181.6UniSTS
Soat1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1G3UniSTS
cM Map181.6UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006496719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011238778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC161221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ164331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ903181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000051396   ⟹   ENSMUSP00000058344
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,257,363 - 156,294,374 (-)Ensembl
GRCm38.p6 Ensembl1156,429,793 - 156,466,804 (-)Ensembl
Ensembl Acc Id: ENSMUST00000186420
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,258,295 - 156,260,143 (-)Ensembl
GRCm38.p6 Ensembl1156,430,725 - 156,432,573 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187073
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,273,981 - 156,301,767 (-)Ensembl
GRCm38.p6 Ensembl1156,446,411 - 156,474,197 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187507   ⟹   ENSMUSP00000139431
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,268,146 - 156,301,866 (-)Ensembl
GRCm38.p6 Ensembl1156,440,576 - 156,474,296 (-)Ensembl
Ensembl Acc Id: ENSMUST00000187987
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,258,553 - 156,260,589 (-)Ensembl
GRCm38.p6 Ensembl1156,430,983 - 156,433,019 (-)Ensembl
Ensembl Acc Id: ENSMUST00000188027   ⟹   ENSMUSP00000141074
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,274,214 - 156,301,834 (-)Ensembl
GRCm38.p6 Ensembl1156,446,644 - 156,474,264 (-)Ensembl
Ensembl Acc Id: ENSMUST00000189661   ⟹   ENSMUSP00000140721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,252,095 - 156,301,901 (-)Ensembl
GRCm38.p6 Ensembl1156,424,525 - 156,474,331 (-)Ensembl
Ensembl Acc Id: ENSMUST00000191379
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1156,267,720 - 156,301,810 (-)Ensembl
GRCm38.p6 Ensembl1156,440,150 - 156,474,240 (-)Ensembl
RefSeq Acc Id: NM_009230   ⟹   NP_033256
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391156,255,678 - 156,301,898 (-)NCBI
GRCm381156,428,108 - 156,474,328 (-)ENTREZGENE
MGSCv371158,358,239 - 158,404,459 (-)RGD
Celera1158,822,751 - 158,868,673 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496719   ⟹   XP_006496782
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391156,255,719 - 156,301,876 (-)NCBI
GRCm381156,428,145 - 156,474,308 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011238778   ⟹   XP_011237080
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391156,255,719 - 156,301,876 (-)NCBI
GRCm381156,428,145 - 156,474,308 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033256   ⟸   NM_009230
- UniProtKB: Q5XK32 (UniProtKB/Swiss-Prot),   Q64180 (UniProtKB/Swiss-Prot),   Q61263 (UniProtKB/Swiss-Prot),   Q06EZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496782   ⟸   XM_006496719
- Peptide Label: isoform X1
- UniProtKB: Q06EZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237080   ⟸   XM_011238778
- Peptide Label: isoform X1
- UniProtKB: Q06EZ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000058344   ⟸   ENSMUST00000051396
Ensembl Acc Id: ENSMUSP00000141074   ⟸   ENSMUST00000188027
Ensembl Acc Id: ENSMUSP00000139431   ⟸   ENSMUST00000187507
Ensembl Acc Id: ENSMUSP00000140721   ⟸   ENSMUST00000189661

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61263-F1-model_v2 AlphaFold Q61263 1-540 view protein structure

Promoters
RGD ID:6875352
Promoter ID:EPDNEW_M1127
Type:initiation region
Name:Soat1_1
Description:Mus musculus sterol O-acyltransferase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381156,474,240 - 156,474,300EPDNEW
RGD ID:6818507
Promoter ID:MM_KWN:2531
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009230,   UC007DCK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361158,404,179 - 158,404,679 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104665 AgrOrtholog
Ensembl Genes ENSMUSG00000026600 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051396.13 UniProtKB/Swiss-Prot
  ENSMUST00000189661 ENTREZGENE
  ENSMUST00000189661.7 UniProtKB/Swiss-Prot
InterPro MBOAT_fam UniProtKB/Swiss-Prot
  Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot
  Sterol_acyltranf_meta UniProtKB/Swiss-Prot
KEGG Report mmu:20652 UniProtKB/Swiss-Prot
MGD MGI:104665 ENTREZGENE
NCBI Gene 20652 ENTREZGENE
PANTHER PTHR10408 UniProtKB/Swiss-Prot
  STEROL O-ACYLTRANSFERASE 1 UniProtKB/Swiss-Prot
Pfam MBOAT UniProtKB/Swiss-Prot
PhenoGen Soat1 PhenoGen
PIRSF Oat_ACAT_DAG_ARE UniProtKB/Swiss-Prot
  Sterol_acyltranf_ACAT UniProtKB/Swiss-Prot
UniProt A0A087WNN8_MOUSE UniProtKB/TrEMBL
  A0A087WSJ5_MOUSE UniProtKB/TrEMBL
  Q06EZ3 ENTREZGENE, UniProtKB/TrEMBL
  Q5XK32 ENTREZGENE
  Q61263 ENTREZGENE
  Q64180 ENTREZGENE
  Q8C795_MOUSE UniProtKB/TrEMBL
  SOAT1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q5XK32 UniProtKB/Swiss-Prot
  Q64180 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Soat1  sterol O-acyltransferase 1  AW550831  expressed sequence AW550831  Data merged from RGD:1607272 737654 PROVISIONAL