KDR (kinase insert domain receptor) - Rat Genome Database

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Gene: KDR (kinase insert domain receptor) Homo sapiens
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Symbol: KDR
Name: kinase insert domain receptor
RGD ID: 731018
HGNC Page HGNC:6307
Description: Enables several functions, including cell adhesion molecule binding activity; vascular endothelial growth factor binding activity; and vascular endothelial growth factor receptor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of endothelial cell migration; and protein phosphorylation. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of mitochondrial depolarization; and positive regulation of mitochondrial fission. Located in several cellular components, including Golgi apparatus; endosome; and membrane raft. Implicated in several diseases, including artery disease (multiple); breast angiosarcoma; gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Biomarker of several diseases, including carcinoma (multiple); cerebrovascular disease (multiple); eye disease (multiple); inflammatory bowel disease (multiple); and systemic scleroderma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD309; fetal liver kinase 1; fetal liver kinase-1; FLK1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; vascular endothelial growth factor receptor 2; VEGFR; VEGFR2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,078,481 - 55,125,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl455,078,481 - 55,125,595 (-)EnsemblGRCh38hg38GRCh38
GRCh37455,944,648 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,639,406 - 55,686,519 (-)NCBINCBI36Build 36hg18NCBI36
Build 34455,785,576 - 55,832,690NCBI
Celera453,446,341 - 53,493,673 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,893,013 - 51,940,346 (-)NCBIHuRef
CHM1_1455,979,683 - 56,027,015 (-)NCBICHM1_1
T2T-CHM13v2.0458,566,962 - 58,614,067 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenocarcinoma  (EXP)
adhesions of uterus  (IEP,ISO)
allergic contact dermatitis  (IEP)
amyotrophic lateral sclerosis  (IEP)
angiosarcoma  (EXP)
Animal Mammary Neoplasms  (ISO)
arteriosclerosis  (IEP,ISO)
arteriovenous malformations of the brain  (IEP)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
brain glioma  (IEP)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast angiosarcoma  (IAGP)
breast cancer  (IEP)
breast carcinoma  (IEP)
Breast Neoplasms  (EXP,ISO)
cerebral cavernous malformation  (IEP)
Cerebral Hemorrhage  (EXP)
Choroidal Neovascularization  (IDA,ISO)
chronic obstructive pulmonary disease  (IEP)
colitis  (ISO)
colon carcinoma  (IAGP,ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (IDA,IMP)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP)
congenital disorder of glycosylation type IIk  (IAGP)
contact dermatitis  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (IEP)
Crohn's disease  (IEP)
cystitis  (ISO)
decubitus ulcer  (IEP)
Diabetic Nephropathies  (EXP)
diffuse scleroderma  (IEP)
Endometrial Neoplasms  (IEP)
Endometrioid Carcinomas  (IEP)
endometriosis  (ISO)
Esophageal Neoplasms  (EXP)
esophagus adenocarcinoma  (IAGP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (EXP)
Experimental Mammary Neoplasms  (IMP,ISO)
Eye Neoplasms  (EXP)
gastrointestinal stromal tumor  (IAGP)
glioblastoma  (IMP)
Hand-Foot Syndrome  (IAGP)
hemangiopericytoma  (IEP)
hepatoblastoma  (IAGP)
hepatocellular carcinoma  (IAGP,IEP)
herpes simplex virus keratitis  (ISO)
high grade glioma  (IEP,ISO)
High Myopia  (IAGP)
Hirschsprung's disease  (IAGP)
hydrophthalmos  (ISO)
hypertension  (IAGP,ISO)
impotence  (ISO)
Infantile Capillary Hemangioma  (EXP,IAGP)
inverted papilloma  (IEP)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (IAGP)
Lathyrism  (ISO)
limited scleroderma  (IEP)
liver cirrhosis  (IEP)
lung carcinoma  (ISO)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IAGP,IEP,ISO)
lymphangioma  (IEP)
Lymphatic Metastasis  (ISO)
macular degeneration  (IAGP,ISO)
macular retinal edema  (IEP)
melanoma  (IEP,ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (EXP)
Nasal Polyps  (IEP)
nasopharynx carcinoma  (IEP)
Neoplasm Metastasis  (IEP)
Neovascularization, Pathologic  (EXP)
Neuralgia  (ISO)
neurilemmoma  (IEP)
neurofibrosarcoma  (ISO)
osteochondrodysplasia  (EXP)
Otitis Media with Effusion  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Ovarian Neoplasms  (EXP,IEP)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (EXP,IDA)
pancreatic carcinoma  (IMP)
primary ovarian insufficiency  (IAGP)
prostate adenocarcinoma  (IEP,ISO)
prostate cancer  (IAGP)
prostatic hypertrophy  (ISO)
psoriasis  (IEP,ISO)
pterygium  (IEP)
renal cell carcinoma  (ISO)
Reperfusion Injury  (EXP,ISO)
retinal telangiectasia  (IEP)
retinopathy of prematurity  (IEP,ISO)
salivary gland carcinoma  (IEP)
sarcoma  (IEP)
schizophrenia  (EXP)
Seasonal Allergic Rhinitis  (IEP)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (IAGP)
Stroke  (ISO)
systemic scleroderma  (IEP)
temporal lobe epilepsy  (EXP)
teratoma  (IAGP)
tetralogy of Fallot  (IAGP)
thyroid gland carcinoma  (IEP)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (IEP)
Transplant Rejection  (ISO)
Tufted Angioma  (IAGP)
type 2 diabetes mellitus  (IEP)
ulcerative colitis  (IEP)
uremia  (EXP)
urinary bladder cancer  (IEP,IMP)
Uterine Cervical Neoplasms  (IEP)
uveal melanoma  (IEP)
Venous Thrombosis  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-Bis(3-hydroxybenzyl)butane-1,4-diol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-tert-butylhydroquinone  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (EXP)
3,3'-diindolylmethane  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
andrographolide  (EXP)
apigenin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
aspartame  (EXP)
Auriculasin  (EXP)
baicalin  (ISO)
belinostat  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bortezomib  (EXP)
cadmium atom  (EXP)
calcidiol  (ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium silicate  (EXP)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (EXP)
corticosterone  (ISO)
coumarin  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
deguelin  (EXP)
demethoxycurcumin  (EXP)
desferrioxamine B  (EXP)
diarsenic trioxide  (EXP)
diethylstilbestrol  (ISO)
dihydrogen  (ISO)
dioscin  (EXP)
dioxygen  (EXP,ISO)
diprotium  (ISO)
diquat  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
embelin  (EXP)
enalapril  (ISO)
Enterolactone  (ISO)
entinostat  (EXP,ISO)
ethanol  (ISO)
ethyl trans-caffeate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furosemide  (ISO)
Fusaproliferin  (ISO)
galaxolide  (EXP)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glafenine  (ISO)
glucose  (EXP,ISO)
glycidol  (ISO)
glyphosate  (EXP)
haloperidol  (EXP)
harmaline  (ISO)
hexachlorobenzene  (EXP)
indoles  (ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (EXP)
L-ethionine  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
losartan  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (EXP)
melittin  (EXP)
methimazole  (ISO)
methoxychlor  (ISO)
methyl caffeate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
MK-2206  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
Morroniside  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
nitrofen  (ISO)
O-methyleugenol  (EXP)
omeprazole  (ISO)
orantinib  (EXP)
orlistat  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
p-menthan-3-ol  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
PD123319  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phosgene  (ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
ponatinib  (EXP)
Ponicidin  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP)
quercitrin  (EXP)
quinacrine  (EXP)
quinazolines  (EXP)
resveratrol  (EXP)
Rhein  (ISO)
riddelliine  (ISO)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
saccharin  (ISO)
sarpogrelate  (ISO)
SB 431542  (EXP)
semaxanib  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (EXP)
sphingosine 1-phosphate  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (EXP)
superoxide  (EXP)
tanespimycin  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urea  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
WIN 55212-2  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,IEA,TAS)
blood vessel endothelial cell differentiation  (IEA,ISO)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
branching involved in blood vessel morphogenesis  (IMP)
branching morphogenesis of an epithelial tube  (IEA,ISO)
calcium ion homeostasis  (IEA,ISO)
cell differentiation  (IEA)
cell fate commitment  (IEA,ISO)
cell migration  (IBA,IEA,ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISS)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA,TAS)
cellular response to hydrogen sulfide  (IDA)
cellular response to vascular endothelial growth factor stimulus  (IDA)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
embryonic hemopoiesis  (IEA,ISS)
endocardium development  (IEA)
endochondral bone growth  (ISO)
endothelial cell differentiation  (IBA,IEA,ISO)
endothelial tube morphogenesis  (ISO)
endothelium development  (IEA,ISS)
ephrin receptor signaling pathway  (IEA)
epidermal growth factor receptor signaling pathway  (IEA)
epithelial cell maturation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA)
hemopoiesis  (IEA,ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
lung alveolus development  (IEA,ISO)
lung development  (IEA,ISO)
lymph vessel development  (IEA,ISO)
macrophage colony-stimulating factor signaling pathway  (IEA)
male gonad development  (ISO)
mesenchymal cell proliferation  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IDA)
negative regulation of gene expression  (IDA)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (ISO)
neuron projection morphogenesis  (ISO)
ovarian follicle development  (IEA,ISO)
peptidyl-tyrosine autophosphorylation  (ISS)
peptidyl-tyrosine phosphorylation  (IDA)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of angiogenesis  (IBA,IDA,IEA,IMP,ISO)
positive regulation of blood vessel endothelial cell migration  (IMP)
positive regulation of BMP signaling pathway  (IEA)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell migration  (IBA,IDA,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IMP)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of endothelial cell chemotaxis  (IDA)
positive regulation of endothelial cell migration  (IMP)
positive regulation of endothelial cell proliferation  (IMP,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of focal adhesion assembly  (IDA)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of macroautophagy  (IGI)
positive regulation of MAPK cascade  (IDA)
positive regulation of mesenchymal cell proliferation  (IEA,ISO)
positive regulation of mitochondrial depolarization  (IGI)
positive regulation of mitochondrial fission  (IGI)
positive regulation of neurogenesis  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (IDA,IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IDA,IMP,ISO)
positive regulation of positive chemotaxis  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of stem cell proliferation  (IEA,ISO)
positive regulation of TOR signaling  (ISO)
positive regulation of vasculogenesis  (IEA,ISS)
post-embryonic camera-type eye morphogenesis  (IEA,ISO)
protein autophosphorylation  (IDA,ISO)
regulation of bone development  (IEA,ISO)
regulation of cell population proliferation  (IEA)
regulation of cell shape  (IDA)
regulation of hematopoietic progenitor cell differentiation  (IEA,ISO)
regulation of MAPK cascade  (IBA)
response to axon injury  (ISO)
response to hypoxia  (ISO)
response to oxygen levels  (ISO)
response to xenobiotic stimulus  (ISO)
semaphorin-plexin signaling pathway  (IEA)
stem cell proliferation  (IEA,ISO)
surfactant homeostasis  (IEA,ISO)
vascular endothelial growth factor receptor signaling pathway  (IDA,IEA,IMP,ISO,TAS)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor receptor-2 signaling pathway  (IMP)
vascular endothelial growth factor signaling pathway  (IDA,IEA,IMP)
vascular wound healing  (IMP)
vasculogenesis  (IEA,ISO,ISS)
vasodilation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Angelov L, etal., Cancer Res. 1999 Nov 1;59(21):5536-41.
2. Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma. Arita S, etal., Int J Gynecol Cancer. 2005 Mar-Apr;15(2):329-36.
3. Vascular endothelial growth factor receptor 2 expression in non-tumorous cirrhotic liver is higher when hepatoma is beyond Milan criteria. Aucejo F, etal., Liver Transpl. 2009 Feb;15(2):169-76. doi: 10.1002/lt.21678.
4. Post-infarct treatment with [Pyr(1)]apelin-13 improves myocardial function by increasing neovascularization and overexpression of angiogenic growth factors in rats. Azizi Y, etal., Eur J Pharmacol. 2015 Aug 15;761:101-8. doi: 10.1016/j.ejphar.2015.04.034. Epub 2015 May 1.
5. EGFR and VEGFR2 protein expressions in bone metastases of clear cell renal cancer. Badalian G, etal., Anticancer Res. 2007 Mar-Apr;27(2):889-94.
6. [Expression of kinase insert domain-containing receptor in prostate adenocarcinoma] Bai AS, etal., Zhonghua Nan Ke Xue. 2007 Apr;13(4):324-6.
7. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
8. Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
9. Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. Brockington A, etal., J Neuropathol Exp Neurol. 2006 Jan;65(1):26-36.
10. Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions. Brown LF, etal., J Immunol. 1995 Mar 15;154(6):2801-7.
11. Combined administration of G-CSF and GM-CSF stimulates monocyte-derived pro-angiogenic cells in patients with acute myocardial infarction. Bruno S, etal., Cytokine. 2006 Apr;34(1-2):56-65. Epub 2006 May 15.
12. The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer. Butkiewicz D, etal., Int J Cancer. 2015 Nov 15;137(10):2332-42. doi: 10.1002/ijc.29605. Epub 2015 Jun 3.
13. Evidence for reduced angiogenesis in bone marrow in SSc: immunohistochemistry and multiparametric computerized imaging analysis. Carrai V, etal., Rheumatology (Oxford). 2012 Jun;51(6):1042-8. doi: 10.1093/rheumatology/ker447. Epub 2012 Jan 23.
14. KDR activation in astrocytic neoplasms. Carroll RS, etal., Cancer. 1999 Oct 1;86(7):1335-41.
15. Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Chae SS, etal., Clin Cancer Res. 2010 Jul 15;16(14):3618-27. Epub 2010 May 25.
16. Expression of vascular endothelial growth factor receptors in experimental otitis media in the rat. Chae SW, etal., Acta Otolaryngol. 2003 Jun;123(5):559-63.
17. The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway. Chen JX, etal., Braz J Med Biol Res. 2019 Oct 7;52(10):e8324. doi: 10.1590/1414-431X20198324. eCollection 2019.
18. Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 following acute spinal cord contusion in rats. Choi JS, etal., J Histochem Cytochem. 2007 Aug;55(8):821-30. Epub 2007 Apr 4.
19. Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 in rat hippocampus after transient forebrain ischemia. Choi JS, etal., J Neurotrauma. 2007 Mar;24(3):521-31.
20. Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model. Conrad C, etal., Anticancer Drugs. 2007 Jun;18(5):569-79. doi: 10.1097/CAD.0b013e3280147d13.
21. rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice. Davidoff AM, etal., Cancer Res. 2002 Jun 1;62(11):3077-83.
22. Arteriogenic erectile dysfunction alters protein expression within the cavernosal tissue in an animal model. De Young L, etal., J Sex Med. 2005 Mar;2(2):199-206.
23. [Expression of vascular endothelial growth factor receptor kinase inser domain containing receptor in human cervical carcinoma]. Di H, etal., Zhonghua Fu Chan Ke Za Zhi. 2000 Nov;35(11):670-2.
24. Expression of VEGFR2 and NRP-1 in non-small cell lung cancer and their clinical significance. Ding M, etal., Chin J Cancer Res. 2014 Dec;26(6):669-77. doi: 10.3978/j.issn.1000-9604.2014.12.04.
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